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  1. Last 7 days
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    Canagliflozin Attenuates Post-Resuscitation Myocardial Dysfunction in Diabetic Rats by Inhibiting Autophagy through the PI3K/Akt/mTOR Pathway
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    1. scibot 19 Jul 2024
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    sciencedirect.com/science/article/pii/S2589004224016547
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    PIK3CA mutations enhance the adipogenesis of ADSCs in facial infiltrating lipomatosis through TRPV1
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    sciencedirect.com/science/article/pii/S2589004224016924
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    Metformin synergizes with gilteritinib in treating FLT3-mutated leukemia via targeting PLK1 signaling
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    1. scibot 17 Jul 2024
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    sciencedirect.com/science/article/pii/S2666379124003598
  5. Jun 2024
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    PKD1 mutant clones within cirrhotic livers inhibit steatohepatitis without promoting cancer
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    Selective Translation Orchestrates Key Signaling Pathways in Primed Pluripotency
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  8. May 2024
  9. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    1. scibot 30 May 2024
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16420
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    Adiponectin inhibits the progression of obesity-associated papillary thyroid carcinoma through autophagy
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  11. 52.53.155.43 52.53.155.43
    2024.02.09.579580v1.full-html.html
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    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
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    1. scibot 10 May 2024
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    Tumor mitochondrial oxidative phosphorylation stimulated by the nuclear receptor RORγ represents an effective therapeutic opportunity in osteosarcoma
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    1. scibot 03 May 2024
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    cell.com/cell-reports-medicine/abstract/S2666-3791(24)00188-5
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylation-Driven Epichaperome Assembly: A Critical Regulator of Cellular Adaptability and Proliferation
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    1. scibot 01 May 2024
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      DOI: 10.21203/rs.3.rs-4114038/v1

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    ncbi.nlm.nih.gov/pmc/articles/PMC11030525/
  16. Apr 2024
  17. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
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      DOI: 10.1016/j.immuni.2024.03.021

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    sciencedirect.com/science/article/pii/S1074761324001420
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    Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity
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    Chemically engineered mTOR-nanoparticle blockers enhance antitumour efficacy
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    sciencedirect.com/science/article/pii/S2352396424001348
  20. Mar 2024
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    Discovery of SQSTM1/p62-dependent P-bodies that regulate the NLRP3 inflammasome
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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CircTBC1D22A inhibits the progression of colorectal cancer through autophagy regulated via miR-1825/ATG14 axis
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  23. Feb 2024
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    Trichinella spiralis inhibits myoblast differentiation by targeting SQSTM1/p62 with a secreted E3 ubiquitin ligase
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    sciencedirect.com/science/article/pii/S2589004224003237
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    Inhibition of mGluR5/PI3K-AKT Pathway Alleviates Alzheimer’s Disease-Like Pathology Through the Activation of Autophagy in 5XFAD Mice
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      DOI: 10.3233/JAD-221058

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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  29. Jan 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tumor cell–intrinsic PD-1 promotes Merkel cell carcinoma growth by activating downstream mTOR-mitochondrial ROS signaling
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      DOI: 10.1126/sciadv.adi2012

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    Serine synthesis sustains macrophage IL-1β production via NAD+-dependent protein acetylation
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    Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival
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      DOI: 10.1016/j.isci.2024.108795

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    Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity
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      DOI: 10.1016/j.cmet.2023.12.016

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  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Akt activation ameliorates deficits in hippocampal-dependent memory and activity-dependent synaptic protein synthesis in an Alzheimer’s disease mouse model
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      DOI: 10.1016/j.jbc.2023.105619

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  35. Dec 2023
  36. www.sciencedirect.com www.sciencedirect.com
    KDM5B predicts temozolomide-resistant subclones in glioblastoma
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      DOI: 10.1016/j.isci.2023.108596

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    sciencedirect.com/science/article/pii/S2589004223026731
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    Lysosomal dynamics regulate mammalian cortical neurogenesis
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      DOI: 10.1016/j.devcel.2023.11.021

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    sciencedirect.com/science/article/pii/S1534580723006196
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions
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      DOI: 10.1016/j.isci.2023.108446

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    ncbi.nlm.nih.gov/pmc/articles/PMC10687339/
  39. Nov 2023
  40. www.sciencedirect.com www.sciencedirect.com
    Functional and spatial proteomics profiling reveals intra- and intercellular signaling crosstalk in colorectal cancer
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    sciencedirect.com/science/article/pii/S2589004223024768
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    Astragaloside IV promotes cerebral angiogenesis and neurological recovery after focal ischemic stroke in mice via activating PI3K/Akt/mTOR signaling pathway
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      DOI: 10.1016/j.heliyon.2023.e22800

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    sciencedirect.com/science/article/pii/S2405844023100089
  42. Oct 2023
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Novel ASCT2 Inhibitor, C118P, Blocks Glutamine Transport and Exhibits Antitumour Efficacy in Breast Cancer
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      DOI: 10.3390/cancers15205082

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    ncbi.nlm.nih.gov/pmc/articles/PMC10605716/
  44. www.science.org www.science.org
    Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance
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      DOI: 10.1126/sciadv.abo3610

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    science.org/doi/10.1126/sciadv.abo3610
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    Systematic in vivo candidate evaluation uncovers therapeutic targets for LMNA dilated cardiomyopathy and risk of Lamin A toxicity
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      DOI: 10.1186/s12967-023-04542-4

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    link.springer.com/article/10.1186/s12967-023-04542-4
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    N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes
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  54. Jul 2023
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  66. May 2023
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    KS10076, a chelator for redox-active metal ions, induces ROS-mediated STAT3 degradation in autophagic cell death and eliminates ALDH1+ stem cells
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    FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter
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  136. Aug 2021
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    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
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    Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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      DOI: 10.1016/j.ebiom.2019.03.014

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      DOI: 10.1016/j.cmet.2019.01.002

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      DOI: 10.1002/glia.23583

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  194. Nov 2018
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    Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming
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    Testosterone regulates myosin II isoforms expression and functional activity in the rat prostate
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    Juvenile treatment with mGluR2/3 agonist prevents schizophrenia-like phenotypes in adult by acting through GSK3β
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    Exogenous H2S exerts biphasic effects on porcine mammary epithelial cells proliferation through PI3K/Akt‐mTOR signaling pathway
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    Decreased rates of cerebral protein synthesis measured in vivo in a mouse model of Tuberous Sclerosis Complex: unexpected consequences of reduced tuberin
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    IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase
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    Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity
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    Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria
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    PI(3,4,5)P3 Engagement Restricts Akt Activity to Cellular Membranes
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