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Payload Diversification Overcomes Resistance and Guides Sequential Antibody-Drug Conjugate Therapy in Breast Cancer

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  DOI: 10.1158/1078-0432.CCR-25-3321
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13055631/
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Anti-tumor activity of trastuzumab deruxtecan in pediatric solid tumors with variable HER2 expression

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1. scibot 07 Apr 2026
  
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  DOI: 10.1158/1535-7163.MCT-25-0437
  
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aacrjournals.org/mct/article/25/1/156/771291/Antitumor-Activity-of-Trastuzumab-Deruxtecan-in
Mar 2026
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Paired patient-derived organoids reveal transcription factor-driven epigenetic remodeling in breast cancer metastasis

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.stem.2026.02.007
  
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sciencedirect.com/science/article/pii/S1934590926000779
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Potentiating dendritic cell immunotherapy by interrupting the Semaphorin 4D-induced immune-suppressive barrier

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1. scibot 05 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117050
  
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sciencedirect.com/science/article/pii/S2211124726001282
Feb 2026
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Effects of N361 Glycosylation on Epidermal Growth Factor Receptor Biological Function

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1. scibot 14 Feb 2026
  
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  DOI: 10.3390/cancers18030474
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12896819/
Jan 2026
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Integrative proteogenomic analysis provides molecular insights and clinical significance in gallbladder cancer

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.ccell.2025.12.014
  
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sciencedirect.com/science/article/pii/S1535610825005483
Dec 2025
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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen

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1. scibot 06 Dec 2025
  
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  DOI: 10.1038/s41523-025-00851-7
  
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nature.com/articles/s41523-025-00851-7
Nov 2025
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Trastuzumab Deruxtecan (T-DXd) Resistance via Loss of HER2 Expression and Binding

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1. scibot 23 Nov 2025
  
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  DOI: 10.1158/2159-8290.CD-25-0647
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12631751/
Aug 2025
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AREG and EREG Are Predictive Biomarkers of Response to EGFR Inhibition in Gastroesophageal Cancer

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1. scibot 19 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-0073
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12355176/
Jul 2025
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Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102253
  
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sciencedirect.com/science/article/pii/S266637912500326X
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CINTER-seq: Chemical profiling reveals interaction-dependent cell landscapes and gene signatures in vivo

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1. scibot 17 Jul 2025
  
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  DOI: 10.1016/j.immuni.2025.06.011
  
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sciencedirect.com/science/article/pii/S1074761325002808
Apr 2025
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CD3xHER2 bsAb-Mediated Activation of Resting T-cells at HER2 Positive Tumor Clusters Is Sufficient to Trigger Bystander Eradication of Distant HER2 Negative Clusters Through IFNγ and TNFα

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1. scibot 04 Apr 2025
  
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  DOI: 10.1002/eji.202451589
  
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onlinelibrary.wiley.com/doi/10.1002/eji.202451589
Feb 2025
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BPS Publications

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1. scibot 20 Feb 2025
  
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  DOI: 10.1111/bph.17463
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17463
Jan 2025
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Steroid hormone receptors, exome sequencing and treatment responsiveness of breast cancer patient-derived xenografts originated in a South American country

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1. scibot 23 Jan 2025
  
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  DOI: 10.1038/s41598-025-86389-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11742900/
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

CD3-engaging bispecific antibodies trigger a paracrine regulated wave of T-cell recruitment for effective tumor killing

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1. scibot 22 Aug 2024
  
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  DOI: 10.1038/s42003-024-06682-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11322607/
Jul 2024
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Affimer reagents enable targeted delivery of therapeutic agents and RNA via Virus-Like Particles

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110461
  
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sciencedirect.com/science/article/pii/S2589004224016869
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HER4 Affects Sensitivity to Tamoxifen and Abemaciclib in Luminal Breast Cancer Cells and Restricts Tumor Growth in MCF-7-Based Humanized Tumor Mice

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1. scibot 12 Jul 2024
  
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  DOI: 10.3390/ijms25137475
  
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mdpi.com/1422-0067/25/13/7475
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Define Critical Parameters of Trastuzumab-Mediated ADCC Assays via Assay Optimization Processes, Focusing on the Impact of Cryopreserved Effector Cells on Assay Performance

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1. scibot 04 Jul 2024
  
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  DOI: 10.3390/cancers16132367
  
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mdpi.com/2072-6694/16/13/2367
May 2024
www.nature.com www.nature.com

Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer

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1. scibot 30 May 2024
  
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  DOI: 10.1038/s41416-024-02697-5
  
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nature.com/articles/s41416-024-02697-5
Apr 2024
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AXL/WRNIP1 mediates replication stress response and promotes therapy resistance and metachronous metastasis in HER2+ breast cancer

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1. scibot 19 Apr 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-1459
  
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aacrjournals.org/cancerres/article/84/5/675/734930/AXL-WRNIP1-Mediates-Replication-Stress-Response
Feb 2024
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p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway

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1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.xcrm.2024.101401
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10897550/
Dec 2023
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EGFR-activated myofibroblasts promote metastasis of pancreatic cancer

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1. scibot 29 Dec 2023
  
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  DOI: 10.1016/j.ccell.2023.12.002
  
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sciencedirect.com/science/article/pii/S1535610823004300
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B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling

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1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.ccell.2023.11.008
  
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sciencedirect.com/science/article/pii/S1535610823003999
Apr 2023
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A living biobank of patient-derived ductal carcinoma in situ mouse-intraductal xenografts identifies risk factors for invasive progression

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1. scibot 29 Apr 2023
  
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  DOI: 10.1016/j.ccell.2023.04.002
  
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sciencedirect.com/science/article/pii/S1535610823001289
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Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer

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1. scibot 18 Apr 2023
  
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  DOI: 10.1038/s41416-023-02264-4
  
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nature.com/articles/s41416-023-02264-4
Mar 2023
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Laminin switches terminal differentiation fate of human trophoblast stem cells under chemically defined culture conditions

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1. scibot 28 Mar 2023
  
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  DOI: 10.1016/j.jbc.2023.104650
  
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sciencedirect.com/science/article/pii/S0021925823002922
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Beneficial Effects of Mifepristone Treatment in Patients with Breast Cancer Selected by the Progesterone Receptor Isoform Ratio: Results from the MIPRA Trial

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1. scibot 05 Mar 2023
  
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  DOI: 10.1158/1078-0432.CCR-22-2060
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9975668/
Feb 2023
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Development of a bispecific DNA-aptamer-based lysosome-targeting chimera for HER2 protein degradation

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1. scibot 16 Feb 2023
  
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  DOI: 10.1016/j.xcrp.2023.101296
  
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sciencedirect.com/science/article/pii/S2666386423000553
Dec 2022
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KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition

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  DOI: 10.1016/j.ccell.2022.11.015
  
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sciencedirect.com/science/article/pii/S1535610822005621
Nov 2022
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Neuronal-epithelial cross-talk drives acinar specification via NRG1-ERBB3-mTORC2 signaling

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  DOI: 10.1016/j.devcel.2022.10.011
  
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sciencedirect.com/science/article/pii/S1534580722007638
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CD16+ fibroblasts foster a trastuzumab-refractory microenvironment that is reversed by VAV2 inhibition

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1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.ccell.2022.10.015
  
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sciencedirect.com/science/article/pii/S1535610822005062
Aug 2022
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ABL kinases regulate translation in HER2+ cells through Y-box-binding protein 1 to facilitate colonization of the brain

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1. scibot 31 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111268
  
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sciencedirect.com/science/article/pii/S2211124722010865
May 2022
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A human breast atlas integrating single-cell proteomics and transcriptomics

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1. scibot 26 May 2022
  
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  DOI: 10.1016/j.devcel.2022.05.003
  
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pubmed.ncbi.nlm.nih.gov/35617956/
Apr 2022
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Betacellulin promotes tumor development and EGFR mutant lung cancer growth by stimulating the EGFR pathway and suppressing apoptosis

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1. scibot 26 Apr 2022
  
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  DOI: 10.1016/j.isci.2022.104211
  
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ADAM17 regulates p75NTR–mediated fibrinolysis and nerve remyelination

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Triple targeting of breast tumors driven by hormonal receptors and HER2

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Dysregulation of the NRG1/ERBB pathway causes a developmental disorder with gastrointestinal dysmotility in humans

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Desmosomes polarize and integrate chemical and mechanical signaling to govern epidermal tissue form and function

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Mesenchymal Niche-Derived Neuregulin-1 Drives Intestinal Stem Cell Proliferation and Regeneration of Damaged Epithelium

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Serotonin Receptor 2A Activation Promotes Evolutionarily Relevant Basal Progenitor Proliferation in the Developing Neocortex

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Genome oligopaint via local denaturation fluorescence in situ hybridization

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Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

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Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles

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Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

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BPS Publications

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Embryonic Barcoding of Equipotent Mammary Progenitors Functionally Identifies Breast Cancer Drivers

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HSP90 Inhibitor, 17-DMAG, Alone and in Combination with Lapatinib Attenuates Acquired Lapatinib-Resistance in ER-positive, HER2-Overexpressing Breast Cancer Cell Line

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Tumor Microenvironment-Derived NRG1 Promotes Antiandrogen Resistance in Prostate Cancer

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Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

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CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies

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js.2018-00170.pdf

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Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

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Epidermal Growth Factor Receptor neddylation is regulated by a desmosomal-COP9 (Constitutive Photomorphogenesis 9) signalosome complex.

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Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system

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