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EZH2 Inhibitors Sensitize Breast Cancer to HER2 Kinase Inhibitors through Cooperative Effects on YAP and Pro-apoptotic Regulators

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-3113
  
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aacrjournals.org/cancerres/article/86/6/1467/775076/EZH2-Inhibitors-Sensitize-Breast-Cancer-to-HER2
Mar 2026
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Lipocalin 2 orchestrates resistance to ferroptosis via AXL

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1. scibot 03 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.116965
  
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sciencedirect.com/science/article/pii/S2211124726000434
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Kinome reprogramming of G2/M kinases and repression of MYCN contribute to superior efficacy of lorlatinib in ALK-driven neuroblastoma

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1. scibot 07 Aug 2025
  
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  RRID:AB_10692515
  
  DOI: 10.1158/1535-7163.MCT-24-0684
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12322148/
Jun 2025
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Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.chembiol.2025.05.005
  
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sciencedirect.com/science/article/pii/S2451945625001667
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inhibition of bromodomain and extra-terminal proteins targets constitutively active NFκB and STAT signaling in lymphoma and influences the expression of the antiapoptotic proteins BCL2A1 and c-MYC

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1. scibot 29 Aug 2024
  
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  DOI: 10.1186/s12964-024-01782-9
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11348570/
May 2024
www.cell.com www.cell.com

The CD8+ T cell tolerance checkpoint triggers a distinct differentiation state defined by protein translation defects

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1. scibot 23 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.026
  
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cell.com/immunity/fulltext/S1074-7613(24)00231-0
Apr 2023
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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1. scibot 08 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101007
  
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sciencedirect.com/science/article/pii/S2666379123001179
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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

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1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112324
  
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sciencedirect.com/science/article/pii/S2211124723003352
Jan 2023
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Artesunate, a new antimalarial clinical drug, exhibits potent anti-AML activity by targeting the ROS/Bim and TFRC/Fe2+ pathways

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1. scibot 14 Jan 2023
  
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  DOI: 10.1111/bph.15986
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15986
Jul 2022
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High-risk neuroblastoma with NF1 loss of function is targetable using SHP2 inhibition

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1. scibot 30 Jul 2022
  
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  DOI: 10.1016/j.celrep.2022.111095
  
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sciencedirect.com/science/article/pii/S221112472200897X
Apr 2022
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Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.cell.2022.03.030
  
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sciencedirect.com/science/article/pii/S0092867422003403
Aug 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Inactivation of oncogenic cAMP-specific phosphodiesterase 4D by miR-139-5p in response to p53 activation

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1. scibot 04 Aug 2021
  
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  AB_10692515
  
  DOI: 10.7554/eLife.15978
  
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2. scibot 04 Aug 2021
  
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  AB_10692515
  
  DOI: 10.7554/eLife.15978
  
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ncbi.nlm.nih.gov/pmc/articles/PMC4959878/
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Combined inhibition of the PI3K/mTOR/MEK pathway induces Bim/Mcl-1-regulated apoptosis in pancreatic cancer cells

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1. scibot 01 Aug 2021
  
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  AB_659953
  
  DOI: 10.1080/15384047.2018.1504718
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6343713/
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BCL-xL/BCL2L1 is a critical anti-apoptotic protein that promotes the survival of differentiating pancreatic cells from human pluripotent stem cells

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1. scibot 11 Sep 2020
  
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  DOI: 10.1038/s41419-020-2589-7
  
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  Curator: @evieth
  
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  RRIDCUR:Validated RRID:AB_10692515
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ncbi.nlm.nih.gov/pmc/articles/PMC7235254/
mcr.aacrjournals.org mcr.aacrjournals.org

Ceramide analog SACLAC modulates sphingolipid levels and Mcl-1 splicing to induce apoptosis in acute myeloid leukemia

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1. scibot 03 Sep 2020
  
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  RRID #AB_10692515
  
  DOI: 10.1158/1541-7786.MCR-19-0619
  
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  Curator: @Naa003
  
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  Curator comments: Anti-Bim Antibody, Unconjugated Cell Signaling Technology Cat# 2819
  
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mcr.aacrjournals.org/content/18/3/352
Jan 2020
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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cell.2019.05.035
  
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  RRID:AB_10692515 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S009286741930563X
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Mitochondrial Reprogramming Underlies Resistance to BCL-2 Inhibition in Lymphoid Malignancies

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1. scibot 13 Jan 2020
  
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  RRID:AB_10692515
  
  DOI: 10.1016/j.ccell.2019.08.005
  
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  Curator: @ethanbadger
  
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sciencedirect.com/science/article/pii/S1535610819303733
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Untitled document

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.devcel.2019.04.015
  
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  RRID:AB_10692515 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1534580719302850
Nov 2018
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Mitofusin 2 Regulates Axonal Transport of Calpastatin to Prevent Neuromuscular Synaptic Elimination in Skeletal Muscles

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118303930
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Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610817305020