90 Matching Annotations
  1. Sep 2024
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GCN2 is a determinant of the response to WEE1 kinase inhibition in small-cell lung cancer
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    1. scibot 25 Sep 2024
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      DOI: 10.1016/j.celrep.2024.114606

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    ncbi.nlm.nih.gov/pmc/articles/PMC11407228/
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cannabinoid combination targets NOTCH1-mutated T-cell acute lymphoblastic leukemia through the integrated stress response pathway
    1
    1. scibot 18 Sep 2024
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      DOI: 10.7554/eLife.90854

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    ncbi.nlm.nih.gov/pmc/articles/PMC11390110/
  4. Aug 2024
  5. www.biorxiv.org www.biorxiv.org
    Ferroptosis susceptibility of melanoma cells: dependence on cell-type, acquired drug resistance, and medium composition
    1
    1. scibot 22 Aug 2024
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      DOI: 10.1101/2024.08.12.607529

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    biorxiv.org/content/10.1101/2024.08.12.607529v1
  6. www.sciencedirect.com www.sciencedirect.com
    OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.molcel.2024.07.020

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    sciencedirect.com/science/article/pii/S109727652400618X
  7. onlinelibrary.wiley.com onlinelibrary.wiley.com
    E3 Ubiquitin Ligase Nedd4-2 Exerts Neuroprotective Effects During Endoplasmic Reticulum Stress
    1
    1. scibot 02 Aug 2024
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      DOI: 10.1111/jnc.15567

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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.15567
  8. Jul 2024
  9. www.cell.com www.cell.com
    Hepatocyte-macrophage crosstalk via the PGRN-EGFR axis modulates ADAR1-mediated immunity in the liver
    1
    1. scibot 19 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114400

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    cell.com/cell-reports/abstract/S2211-1247(24)00728-9
  10. www.sciencedirect.com www.sciencedirect.com
    RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for degradation and cytosolic release
    1
    1. scibot 17 Jul 2024
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      DOI: 10.1016/j.molcel.2024.06.023

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    sciencedirect.com/science/article/pii/S1097276524005306
  11. www.sciencedirect.com www.sciencedirect.com
    Deubiquitylase OTUD3 regulates integrated stress response to suppress progression and sorafenib resistance of liver cancer
    1
    1. scibot 12 Jul 2024
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      DOI: 10.1016/j.celrep.2024.114487

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    sciencedirect.com/science/article/pii/S2211124724008167
  12. May 2024
  13. 52.53.155.43 52.53.155.43
    Targeting eIF2α in TBI-induced traumatic optic neuropathy: Effects of Salubrinal and the Integrated Stress Response Inhibitor
    1
    1. scibot 10 May 2024
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      DOI: 10.1101/2024.02.15.580435

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    52.53.155.43/e49e13012caa173776051da0a73c8b285e75644e/2024.02.15.580435v1.full-html.html
  14. www.sciencedirect.com www.sciencedirect.com
    Inhibition of protein translational machinery in triple-negative breast cancer as a promising therapeutic strategy
    1
    1. scibot 10 May 2024
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      DOI: 10.1016/j.xcrm.2024.101552

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    sciencedirect.com/science/article/pii/S2666379124002441
  15. onlinelibrary.wiley.com onlinelibrary.wiley.com
    GABAergic interneurons in the hippocampal CA1 mediate contextual fear generalization in PTSD rats
    1
    1. scibot 09 May 2024
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      DOI: 10.1111/jnc.16123

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16123
  16. www.sciencedirect.com www.sciencedirect.com
    Obesity disrupts the pituitary-hepatic UPR communication leading to NAFLD progression
    1
    1. scibot 08 May 2024
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      DOI: 10.1016/j.cmet.2024.04.014

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    sciencedirect.com/science/article/pii/S1550413124001347
  17. Apr 2024
  18. dx.doi.org dx.doi.org
    Acute Exercise Increases GDF15 and Unfolded Protein Response/Integrated Stress Response in Muscle in Type 2 diabetes
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1210/clinem/dgae032

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    dx.doi.org/10.1210/clinem/dgae032
  19. www.sciencedirect.com www.sciencedirect.com
    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
    1
    1. scibot 02 Apr 2024
      RRID:AB_10692650

      DOI: 10.1016/j.cell.2024.03.011

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    sciencedirect.com/science/article/pii/S0092867424003039
  20. Mar 2024
  21. www.sciencedirect.com www.sciencedirect.com
    Iron overload in hypothalamic AgRP neurons contributes to obesity and related metabolic disorders
    2
    1. scibot 12 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113900

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    2. scibot 12 Mar 2024
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    sciencedirect.com/science/article/pii/S2211124724002286
  22. Feb 2024
  23. www.sciencedirect.com www.sciencedirect.com
    The HRI branch of the integrated stress response selectively triggers mitophagy
    3
    1. scibot 14 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.016

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    3. scibot 13 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.016

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    sciencedirect.com/science/article/pii/S1097276524000522
  24. www.sciencedirect.com www.sciencedirect.com
    Alternative polyadenylation determines the functional landscape of inverted Alu repeats
    1
    1. scibot 06 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.008

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    sciencedirect.com/science/article/pii/S1097276524000091
  25. Jan 2024
  26. www.sciencedirect.com www.sciencedirect.com
    Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells
    1
    1. scibot 07 Jan 2024
      RRID:AB_10692650

      DOI: 10.1016/j.celrep.2023.113615

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    sciencedirect.com/science/article/pii/S2211124723016273
  27. Dec 2023
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Statin-induced mitochondrial priming sensitizes multiple myeloma cells to BCL2 and MCL1 inhibitors
    1
    1. scibot 13 Dec 2023
      RRID:AB_10692650

      DOI: 10.1158/2767-9764.CRC-23-0350

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    ncbi.nlm.nih.gov/pmc/articles/PMC10704957/
  29. Nov 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tamoxifen for the treatment of myeloproliferative neoplasms: A Phase II clinical trial and exploratory analysis
    1
    1. scibot 30 Nov 2023
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      DOI: 10.1038/s41467-023-43175-5

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    ncbi.nlm.nih.gov/pmc/articles/PMC10673935/
  31. www.sciencedirect.com www.sciencedirect.com
    HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113352

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    sciencedirect.com/science/article/pii/S2211124723013645
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins
    2
    1. scibot 11 Nov 2023
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      DOI: 10.1097/BS9.0000000000000168

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    ncbi.nlm.nih.gov/pmc/articles/PMC10629731/
  33. Aug 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Lysosomal cystine governs ferroptosis sensitivity in cancer via cysteine stress response
    1
    1. scibot 30 Aug 2023
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      DOI: 10.1016/j.molcel.2023.08.004

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    sciencedirect.com/science/article/abs/pii/S1097276523006408
  35. www.sciencedirect.com www.sciencedirect.com
    FoxM1 coordinates cell division, protein synthesis, and mitochondrial activity in a subset of β cells during acute metabolic stress
    1
    1. scibot 18 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112986

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    sciencedirect.com/science/article/pii/S221112472300997X
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting
    1
    1. scibot 03 Aug 2023
      RRID:AB_10692650

      DOI: 10.1016/j.cmet.2023.07.002

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    ncbi.nlm.nih.gov/pmc/articles/PMC10432853/
  37. Jul 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons
    1
    1. scibot 12 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112746

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    sciencedirect.com/science/article/pii/S221112472300757X
  39. www.sciencedirect.com www.sciencedirect.com
    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
    2
    1. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112764

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      DOI: 10.1016/j.celrep.2023.112764

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    sciencedirect.com/science/article/pii/S2211124723007751
  40. Jun 2023
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Brief Oxygen Exposure after Traumatic Brain Injury Hastens Recovery and Promotes Adaptive Chronic Endoplasmic Reticulum Stress Responses
    1
    1. scibot 30 Jun 2023
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      DOI: 10.3390/ijms24129831

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    ncbi.nlm.nih.gov/pmc/articles/PMC10298247/
  42. www.sciencedirect.com www.sciencedirect.com
    A mitochondrial iron-responsive pathway regulated by DELE1
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      DOI: 10.1016/j.molcel.2023.05.031

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    sciencedirect.com/science/article/pii/S1097276523004136
  43. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Astrocytic deletion of protein kinase R-like ER kinase (PERK) does not affect learning and memory in aged mice but worsens outcome from experimental stroke
    1
    1. scibot 15 Jun 2023
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      DOI: 10.1002/jnr.25224

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    onlinelibrary.wiley.com/doi/10.1002/jnr.25224
  44. Apr 2023
  45. link.springer.com link.springer.com
    SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions
    1
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      DOI: 10.1186/s12985-023-02021-2

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    link.springer.com/article/10.1186/s12985-023-02021-2
  46. Dec 2022
  47. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
    1
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      DOI: 10.1016/j.isci.2022.105626

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    ncbi.nlm.nih.gov/pmc/articles/PMC9719099/
  48. Oct 2022
  49. elifesciences.org elifesciences.org
    GCN2 eIF2 kinase promotes prostate cancer by maintaining amino acid homeostasis
    1
    1. scibot 19 Oct 2022
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      DOI: 10.7554/eLife.81083

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    elifesciences.org/articles/81083
  50. Sep 2022
  51. www.sciencedirect.com www.sciencedirect.com
    PSMG2-controlled proteasome-autophagy balance mediates the tolerance for MEK-targeted therapy in triple-negative breast cancer
    1
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      DOI: 10.1016/j.xcrm.2022.100741

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    sciencedirect.com/science/article/pii/S2666379122002907
  52. Aug 2022
  53. www.sciencedirect.com www.sciencedirect.com
    Mitochondrial double-stranded RNAs govern the stress response in chondrocytes to promote osteoarthritis development
    1
    1. scibot 10 Aug 2022
      RRID:AB_10694803

      DOI: 10.1016/j.celrep.2022.111178

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    sciencedirect.com/science/article/pii/S2211124722009913
  54. Jul 2022
  55. www.sciencedirect.com www.sciencedirect.com
    GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment
    1
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      DOI: 10.1016/j.cmet.2022.06.010

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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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  111. www.sciencedirect.com www.sciencedirect.com
    PKR Senses Nuclear and Mitochondrial Signals by Interacting with Endogenous Double-Stranded RNAs
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    Translational Control through Differential Ribosome Pausing during Amino Acid Limitation in Mammalian Cells
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    High-Density Proximity Mapping Reveals the Subcellular Organization of mRNA-Associated Granules and Bodies
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    Intestinal Epithelial Cell Autophagy Is Required to Protect against TNF-Induced Apoptosis during Chronic Colitis in Mice
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    Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
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    Oncogenic KRAS Regulates Amino Acid Homeostasis and Asparagine Biosynthesis via ATF4 and Alters Sensitivity to L-Asparaginase
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  117. Nov 2017
  118. academic.oup.com academic.oup.com
    Angiotensin II Causes β-Cell Dysfunction Through an ER Stress-Induced Proinflammatory Response
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    Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis
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      Curator: @bandrow

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  120. elifesciences.org elifesciences.org
    The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration
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      Curator: @kaitlinsung

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    Mutant KRAS Enhances Tumor Cell Fitness by Upregulating Stress Granules
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      Curator: @Jmenke

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