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Jan 2026
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Molecular mechanism of MDA5 nucleation and filament formation by LGP2

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.molcel.2025.12.019
  
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sciencedirect.com/science/article/pii/S1097276525010172
Sep 2025
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Impaired hematopoiesis and embryonic lethality at midgestation of mice lacking both lipid transfer proteins VPS13A and VPS13C

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1. scibot 27 Sep 2025
  
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  DOI: 10.1371/journal.pbio.3003393
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12463328/
Aug 2025
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Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer

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1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.devcel.2025.07.023
  
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sciencedirect.com/science/article/pii/S153458072500499X
Jun 2025
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Defect in hematopoiesis and embryonic lethality at midgestation of Vps13a/Vps13c double knockout mice

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1. scibot 15 Jun 2025
  
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  DOI: 10.1101/2025.05.09.653147
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12132566/
Apr 2025
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SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115588
  
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sciencedirect.com/science/article/pii/S2211124725003596
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Interferon-Inducible ADAR1 p150 Is Essential for the Survival of Oral Squamous Cell Carcinoma

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1. scibot 01 Apr 2025
  
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  DOI: 10.1002/mc.23910
  
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onlinelibrary.wiley.com/doi/10.1002/mc.23910
Feb 2025
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Nucleic-acid-induced ZCCHC3 condensation promotes broad innate immune responses

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1. scibot 21 Feb 2025
  
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  DOI: 10.1016/j.molcel.2025.01.027
  
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sciencedirect.com/science/article/pii/S1097276525000619
Jan 2025
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Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs

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1. scibot 30 Jan 2025
  
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  DOI: 10.1038/s44319-024-00346-9
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11772592/
Dec 2024
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RNA sensing induced by chromosome missegregation augments anti-tumor immunity

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.molcel.2024.11.025
  
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sciencedirect.com/science/article/pii/S109727652400950X
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Pressure to evade cell-autonomous innate sensing reveals interplay between mitophagy, IFN signaling, and SARS-CoV-2 evolution

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1. scibot 21 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115115
  
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sciencedirect.com/science/article/pii/S2211124724014669
Nov 2024
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Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

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1. scibot 08 Nov 2024
  
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  DOI: 10.1158/0008-5472.CAN-24-0134
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
Oct 2024
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Type I IFN drives unconventional IL-1β secretion in lupus monocytes

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.immuni.2024.09.004
  
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sciencedirect.com/science/article/pii/S1074761324004485
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Disruption of cellular plasticity by repeat RNAs in human pancreatic cancer

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1. scibot 09 Oct 2024
  
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  DOI: 10.1016/j.cell.2024.09.024
  
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sciencedirect.com/science/article/pii/S0092867424010729
Sep 2024
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ADARp150 counteracts whole genome duplication

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1. scibot 26 Sep 2024
  
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  DOI: 10.1093/nar/gkae700
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11417406/
Aug 2024
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An ADAR1 dsRBD3-PKR kinase domain interaction on dsRNA inhibits PKR activation

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114618
  
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sciencedirect.com/science/article/pii/S2211124724009689
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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response

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1. scibot 20 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114608
  
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sciencedirect.com/science/article/pii/S2211124724009586
Jul 2024
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

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1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
Apr 2024
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Induction of Viral Mimicry Upon Loss of DHX9 and ADAR1 in Breast Cancer Cells

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1. scibot 10 Apr 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0488
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10993856/
Feb 2024
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RNA methyltransferase FTSJ3 regulates the type I interferon pathway to promote hepatocellular carcinoma immune evasion

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1. scibot 23 Feb 2024
  
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  DOI: 10.1158/0008-5472.CAN-23-2049
  
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2. scibot 23 Feb 2024
  
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  RRID:AB_10694490
  
  DOI: 10.1158/0008-5472.CAN-23-2049
  
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aacrjournals.org/cancerres/article/84/3/405/733849/RNA-Methyltransferase-FTSJ3-Regulates-the-Type-I
Jan 2024
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XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

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1. scibot 23 Jan 2024
  
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  DOI: 10.1016/j.celrep.2023.113600
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10989277/
Nov 2023
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HRS mediates tumor immune evasion by regulating proteostasis-associated interferon pathway activation

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113352
  
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sciencedirect.com/science/article/pii/S2211124723013645
Aug 2023
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XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility

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1. scibot 26 Aug 2023
  
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  DOI: 10.1126/sciadv.adg5211
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10438455/
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XAF1 promotes anti-RNA virus immune responses by regulating chromatin accessibility

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1. scibot 25 Aug 2023
  
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  DOI: 10.1126/sciadv.adg5211
  
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science.org/doi/10.1126/sciadv.adg5211
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization

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1. scibot 07 Jun 2023
  
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  DOI: 10.15698/mic2023.06.797
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10236204/
Jan 2023
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Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner

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1. scibot 21 Jan 2023
  
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  DOI: 10.1016/j.celrep.2023.112002
  
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SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

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1. scibot 12 Jan 2023
  
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  DOI: 10.1158/0008-5472.CAN-21-3523
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9357127/
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Stimulation of interferon-β responses by aberrant SARS-CoV-2 small viral RNAs acting as retinoic acid-inducible gene-I agonists

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1. scibot 06 Jan 2023
  
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  DOI: 10.1016/j.isci.2022.105742
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9726650/
Oct 2022
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Histone methylation antagonism drives tumor immune evasion in squamous cell carcinomas

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1. scibot 07 Oct 2022
  
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  DOI: 10.1016/j.molcel.2022.09.007
  
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sciencedirect.com/science/article/pii/S1097276522008966
Sep 2022
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SAMHD1 controls innate immunity by regulating condensation of immunogenic self RNA

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1. scibot 24 Sep 2022
  
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  DOI: 10.1016/j.molcel.2022.08.031
  
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sciencedirect.com/science/article/pii/S1097276522008516
Jul 2022
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LncNSPL facilitates influenza A viral immune escape by restricting TRIM25-mediated K63-linked RIG-I ubiquitination

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1. scibot 08 Jul 2022
  
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  DOI: 10.1016/j.isci.2022.104607
  
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sciencedirect.com/science/article/pii/S2589004222008793
Jun 2022
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Identifying enhancers of innate immune signaling as broad-spectrum antivirals active against emerging viruses

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1. scibot 22 Jun 2022
  
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  DOI: 10.1016/j.chembiol.2022.05.009
  
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sciencedirect.com/science/article/pii/S245194562200201X
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cGAS and DDX41-STING mediated intrinsic immunity spreads intercellularly to promote neuroinflammation in SOD1 ALS model

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1. scibot 17 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104404
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9194172/
Mar 2022
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PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade

1
1. scibot 30 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110582
  
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sciencedirect.com/science/article/pii/S2211124722003266
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A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis

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1. scibot 27 Mar 2022
  
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  DOI: 10.1016/j.chembiol.2022.03.006
  
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sciencedirect.com/science/article/pii/S2451945622000940
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Histone deacetylase 3 contributes to the antiviral innate immunity of macrophages by interacting with FOXK1 to regulate STAT1/2 transcription

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1. scibot 26 Jan 2022
  
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  RRID:AB_10694490
  
  DOI: 10.1016/j.celrep.2022.110302
  
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Aug 2021
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  DOI: 10.7554/eLife.24425
  
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Jul 2021
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O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

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1. scibot 31 Jul 2021
  
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  DOI: 10.1016/j.chom.2018.11.001
  
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Jun 2021
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DHX15 is required to control RNA virus-induced intestinal inflammation

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  DOI: 10.1016/j.celrep.2021.109205
  
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Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases

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1. scibot 25 Feb 2021
  
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  DOI: 10.1016/j.molcel.2020.11.047
  
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Disruption of DNA polymerase ζ engages an innate immune response

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  DOI: 10.1016/j.celrep.2021.108775
  
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Jan 2021
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The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling

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1. scibot 20 Jan 2021
  
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  RRID:AB_10694490
  
  DOI: 10.1016/j.celrep.2020.108631
  
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Sep 2020
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ADAR1 Facilitates KSHV Lytic Reactivation by Modulating the RLR-Dependent Signaling Pathway

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  DOI: 10.1016/j.celrep.2020.107564
  
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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres

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  DOI: 10.1016/j.celrep.2020.107983
  
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Jan 2020
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Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS

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  RRID:AB_10694490
  
  DOI: 10.1016/j.cell.2019.05.003
  
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  DOI: 10.7554/eLife.41159
  
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  DOI: 10.1016/j.chom.2019.02.015
  
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Nov 2018
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LSD1 Ablation Stimulates Anti-tumor Immunity and Enables Checkpoint Blockade

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Human ADAR1 Prevents Endogenous RNA from Triggering Translational Shutdown

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sciencedirect.com/science/article/pii/S0092867417315180
Nov 2017
elifesciences.org elifesciences.org

Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses

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1. scibot 08 Nov 2017
  
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elifesciences.org/articles/24425