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39 Matching Annotations

Jul 2026
aacrjournals.org aacrjournals.org

EZH2 Inhibitors Sensitize Breast Cancer to HER2 Kinase Inhibitors through Cooperative Effects on YAP and Pro-apoptotic Regulators

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-3113
  
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aacrjournals.org/cancerres/article/86/6/1467/775076/EZH2-Inhibitors-Sensitize-Breast-Cancer-to-HER2
Apr 2026
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IAP-based biodegraders can convert necroptosis to apoptosis and eliminate cancer driving protein complexes

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1. scibot 02 Apr 2026
  
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  DOI: 10.1016/j.chembiol.2026.03.005
  
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sciencedirect.com/science/article/pii/S2451945626000759
Oct 2025
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USP9X is a mechanosensitive deubiquitinase that controls tumor cell invasiveness and drug response through YAP stabilization

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1. scibot 02 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116372
  
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sciencedirect.com/science/article/pii/S221112472501143X
Aug 2025
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RNA Pol II inhibition activates cell death independently from the loss of transcription

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.cell.2025.07.034
  
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cell.com/cell/abstract/S0092-8674(25)00856-6
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

De novo pyrimidine biosynthesis inhibition synergizes with BCL-XL targeting in pancreatic cancer

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1. scibot 05 Aug 2025
  
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  DOI: 10.1038/s41467-025-61242-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12311037/
Jun 2025
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CRISPR/Cas9 Screening Highlights PFKFB3 Gene as a Major Contributor to 5-Fluorouracil Resistance in Esophageal Cancer

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1. scibot 12 Jun 2025
  
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  DOI: 10.3390/cancers17101637
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12109790/
May 2025
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JNK1 inhibitors target distal B cell receptor signaling and overcome BTK-inhibitor resistance in CLL

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1. scibot 22 May 2025
  
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  DOI: 10.1084/jem.20230681
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11586660/
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A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to promote infection

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1. scibot 19 May 2025
  
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  DOI: 10.1038/s44318-025-00412-5
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12048508/
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Structural ubiquitin contributes to K48 linkage specificity of the HECT ligase Tom1

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115688
  
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sciencedirect.com/science/article/pii/S2211124725004590
Apr 2025
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ZBP1 senses spliceosome stress through Z-RNA:DNA hybrid recognition

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1. scibot 24 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.04.004
  
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sciencedirect.com/science/article/pii/S1097276525003077
Dec 2024
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Senolysis by ABT-263 is associated with inherent apoptotic dependence of cancer cells derived from the non-senescent state

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1. scibot 24 Dec 2024
  
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  DOI: 10.1038/s41418-024-01439-7
  
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nature.com/articles/s41418-024-01439-7
Jan 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers

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1. scibot 19 Jan 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0275
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10793200/
Nov 2023
www.nature.com www.nature.com

Selective inhibition of CDK9 in triple negative breast cancer

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1. scibot 25 Nov 2023
  
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  DOI: 10.1038/s41388-023-02892-3
  
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nature.com/articles/s41388-023-02892-3
Sep 2023
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CBFA2T3-GLIS2-dependent pediatric acute megakaryoblastic leukemia is driven by GLIS2 and sensitive to navitoclax

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1. scibot 19 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113084
  
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sciencedirect.com/science/article/pii/S2211124723010951
Jun 2023
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Systems-level analyses of protein-protein interaction network dysfunctions via epichaperomics identify cancer-specific mechanisms of stress adaptation

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1. scibot 24 Jun 2023
  
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  DOI: 10.1038/s41467-023-39241-7
  
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nature.com/articles/s41467-023-39241-7
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Endogenous PP2A inhibitor CIP2A degradation by chaperone-mediated autophagy contributes to the antitumor effect of mitochondrial complex I inhibition

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1. scibot 09 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112616
  
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sciencedirect.com/science/article/pii/S2211124723006277
Apr 2023
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USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities

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1. scibot 08 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101007
  
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sciencedirect.com/science/article/pii/S2666379123001179
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Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer

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1. scibot 06 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112324
  
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sciencedirect.com/science/article/pii/S2211124723003352
Feb 2023
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Piperlongumine conjugates induce targeted protein degradation

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1. scibot 09 Feb 2023
  
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  DOI: 10.1016/j.chembiol.2023.01.004
  
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sciencedirect.com/science/article/pii/S2451945623000272
Nov 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex

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1. scibot 18 Nov 2022
  
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  DOI: 10.1016/j.isci.2022.105458
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9663903/
Jun 2022
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BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

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1. scibot 29 Jun 2022
  
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  DOI: 10.1016/j.celrep.2022.111019
  
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sciencedirect.com/science/article/pii/S2211124722008087
Apr 2022
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Mitochondrial dynamics regulate genome stability via control of caspase-dependent DNA damage

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.devcel.2022.03.019
  
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sciencedirect.com/science/article/pii/S1534580722002295
Feb 2022
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

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1. scibot 11 Feb 2022
  
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  DOI: 10.1016/j.immuni.2022.01.003
  
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2. scibot 09 Feb 2022
  
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  RRID:AB_10694494
  
  DOI: 10.1016/j.immuni.2022.01.003
  
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pubmed.ncbi.nlm.nih.gov/35139355/
Nov 2021
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TIAM1-RAC1 promote small-cell lung cancer cell survival through antagonizing Nur77-induced BCL2 conformational change

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109979
  
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sciencedirect.com/science/article/pii/S2211124721014583
Aug 2021
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Genetically variant human pluripotent stem cells selectively eliminate wild-type counterparts through YAP-mediated cell competition

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1. scibot 18 Aug 2021
  
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  DOI: 10.1016/j.devcel.2021.07.019
  
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sciencedirect.com/science/article/pii/S153458072100602X
elifesciences.org elifesciences.org

HOXA9 promotes MYC-mediated leukemogenesis by maintaining gene expression for multiple anti-apoptotic pathways

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1. scibot 15 Aug 2021
  
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  DOI: 10.7554/eLife.64148
  
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elifesciences.org/articles/64148
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Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition

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1. scibot 06 Aug 2021
  
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  DOI: 10.1016/j.molcel.2021.06.032
  
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sciencedirect.com/science/article/pii/S1097276521005438
Jul 2021
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Untitled document

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1. scibot 30 Jul 2021
  
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  DOI: 10.1016/j.celrep.2018.10.103
  
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sciencedirect.com/science/article/pii/S221112471831725X
May 2021
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Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells

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1. scibot 12 May 2021
  
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  DOI: 10.1016/j.immuni.2021.04.012
  
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sciencedirect.com/science/article/pii/S1074761321001746
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Polymer-ritonavir derivate nanomedicine with pH-sensitive activation possesses potent anti-tumor activity in vivo via inhibition of proteasome and STAT3 signaling

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1. scibot 07 May 2021
  
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  DOI: 10.1016/j.jconrel.2021.03.015
  
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sciencedirect.com/science/article/pii/S0168365921001267
Apr 2021
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Reduced Mitochondrial Apoptotic Priming Drives Resistance to BH3 Mimetics in Acute Myeloid Leukemia

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1. scibot 22 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.10.010
  
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sciencedirect.com/science/article/pii/S1535610820305419
Sep 2020
mcr.aacrjournals.org mcr.aacrjournals.org

Ceramide analog SACLAC modulates sphingolipid levels and Mcl-1 splicing to induce apoptosis in acute myeloid leukemia

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1. scibot 14 Sep 2020
  
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  AB_10694494
  
  DOI: 10.1158/1541-7786.MCR-19-0619
  
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mcr.aacrjournals.org/content/18/3/352
Jan 2020
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N6-Isopentenyladenosine Inhibits Colorectal Cancer and Improves Sensitivity to 5-Fluorouracil-Targeting FBXW7 Tumor Suppressor

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1. scibot 13 Jan 2020
  
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  DOI: 10.3390/cancers11101456
  
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  RRID:AB_10694494 RRIDCUR:Validated
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mdpi.com/2072-6694/11/10/1456
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Estrogen-Related Hormones Induce Apoptosis by Stabilizing Schlafen-12 Protein Turnover

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.06.040
  
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  Curator: @ethanbadger
  
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  RRID:AB_10694494 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276519304976
bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com

BPS Publications

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1. scibot 13 Jan 2020
  
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  RRID:AB_10694494
  
  DOI: 10.1111/bph.14773
  
  Resource: (Cell Signaling Technology Cat# 5453, RRID:AB_10694494)
  
  Curator: @Naa003
  
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  RRID:AB_10694494 RRIDCUR:Validated
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bpspubs.onlinelibrary.wiley.com/doi/abs/10.1111/bph.14773
Nov 2018
www.sciencedirect.com www.sciencedirect.com

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance

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1. scibot 05 Nov 2018
  
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  RRID:AB_10694494
  
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sciencedirect.com/science/article/pii/S1535610818301831
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Systematic Functional Annotation of Somatic Mutations in Cancer

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1. scibot 05 Nov 2018
  
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  RRID:AB_10694494
  
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  (Cell Signaling Technology Cat# 5453S, RRID:AB_10694494)
  
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sciencedirect.com/science/article/pii/S1535610818300217
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation

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1. scibot 05 Nov 2018
  
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  RRID:AB_10694494
  
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  (Cell Signaling Technology Cat# 5453S, RRID:AB_10694494)
  
  SciCrunch record: RRID:AB_10694494
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5650077/