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FBXO45-mediated K63 ubiquitination of HYOU1 sustains UPR signaling and promotes chemoresistance in gastric cancer

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Sep 2026
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5-Azacytosine induces cytotoxicity via 5-methylcytosine depletion on chromatin-associated RNA in leukemia

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Jul 2026
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Uridine cytidine kinase 1 promotes phosphatidylcholine biosynthesis, facilitating SARS-CoV-2 infection

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Targeted antibody-drug conjugates for rhabdomyosarcoma and other FGFR4-expressing cancers

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Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity

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aacrjournals.org/cancerres/article/86/5/1252/774876/Antibody-Mediated-Targeting-of-Secretory-Protein
May 2026
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PARP1 suppression drives ROS resistance in aneuploid cancer cells

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Feb 2026
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1-s2.0-S2589004226003755-main-html.html

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54.241.53.176/7febf2f611c81ceceb7992509075443acaa6a3e6/1-s2.0-S2589004226003755-main-html.html
May 2025
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Trichosanthes kirilowii Maxim. and Bioactive Compound Cucurbitacin D Alleviate Cisplatin-Induced Peripheral Neuropathy In Vitro and In Vivo

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1. scibot 22 May 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12089711/
Mar 2025
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Preclinical evaluation of a novel antibody–drug conjugate OBI-992 for Cancer therapy

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Feb 2025
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A non-catalytic function for Rad18 in sustaining glioblastoma proliferation

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  DOI: 10.1101/2024.09.05.611406
  
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52.53.155.43/bd241f9d9f184fcec259e1abcded858c2c8c9686/2024.09.05.611406.full-html.html
Dec 2024
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Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

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1. scibot 27 Dec 2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11648251/
Jun 2024
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CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer

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cell.com/iscience/abstract/S2589-0042(24)01200-8
May 2024
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ol_28_1_14449_PDF-html.html

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Neoadjuvant radiotherapy in ER+, HER2+, and triple-negative -specific breast cancer based humanized tumor mice enhances anti-PD-L1 treatment efficacy

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ncbi.nlm.nih.gov/pmc/articles/PMC11089195/
Apr 2024
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DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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1. scibot 25 Apr 2024
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
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Spatial organization and functions of Chk1 activation by TopBP1 biomolecular condensates

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1. scibot 09 Apr 2024
  
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Mar 2024
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SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis

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Feb 2024
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RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma

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ncbi.nlm.nih.gov/pmc/articles/PMC10844834/
Dec 2023
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Design, synthesis and mechanistic anticancer activity of new acetylated 5-aminosalicylate-thiazolinone hybrid derivatives

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Nov 2023
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Adavosertib Enhances Antitumor Activity of Trastuzumab Deruxtecan in HER2-Expressing Cancers

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Oct 2023
52.53.155.43 52.53.155.43

ccr-23-0103-html.html

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Aug 2023
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ccr-23-0103-html.html

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Jul 2023
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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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52.53.155.43 52.53.155.43

ccr-23-0103-html.html

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Jun 2023
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Detection of endogenous translesion DNA synthesis in single mammalian cells

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  DOI: 10.1016/j.crmeth.2023.100501
  
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sciencedirect.com/science/article/pii/S2667237523001303
Apr 2023
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IRE1α drives lung epithelial progenitor dysfunction to establish a niche for pulmonary fibrosis

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  DOI: 10.1152/ajplung.00408.2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8957349/
Dec 2022
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NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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  DOI: 10.1126/sciadv.abq0648
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9733930/
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NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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  DOI: 10.1126/sciadv.abq0648
  
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science.org/doi/10.1126/sciadv.abq0648
Nov 2022
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Autophagy promotes cell survival by maintaining NAD levels

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May 2022
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Systematic discovery of mutation-directed neo-protein-protein interactions in cancer

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  DOI: 10.1016/j.cell.2022.04.014
  
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cell.com/cell/fulltext/S0092-8674(22)00461-5
Aug 2021
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Oncogenic Amplification of Zygotic Dux Factors in Regenerating p53-Deficient Muscle Stem Cells Defines a Molecular Cancer Subtype

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  DOI: 10.1016/j.stem.2018.10.011
  
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sciencedirect.com/science/article/pii/S1934590918304922
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Mechanism and function of DNA replication-independent DNA-protein crosslink repair via the SUMO-RNF4 pathway

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  DOI: 10.15252/embj.2020107413
  
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A Novel Benzopyrane Derivative Targeting Cancer Cell Metabolic and Survival Pathways

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Neutrophil elastase selectively kills cancer cells and attenuates tumorigenesis

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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Hyperactive CDK2 Activity in Basal-like Breast Cancer Imposes a Genome Integrity Liability that Can Be Exploited by Targeting DNA Polymerase ε

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TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

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Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier

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The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis

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PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells

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Fibroblasts from patients with idiopathic pulmonary fibrosis are resistant to cisplatin-induced cell death via enhanced CK2-dependent XRCC1 activity

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FXR Regulates Intestinal Cancer Stem Cell Proliferation

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ASF1a Promotes Non-homologous End Joining Repair by Facilitating Phosphorylation of MDC1 by ATM at Double-Strand Breaks

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Two subunits of human ORC are dispensable for DNA replication and proliferation

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