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Polymerase iota coordinates adaptation to replication stress in BRCA2-deficient mammary epithelial cells

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1. scibot 11 Oct 2026
  
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  DOI: 10.1016/j.isci.2026.117830
  
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sciencedirect.com/science/article/pii/S2589004226032116
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STING reprogramming by estrogen promotes neutrophil extracellular trap formation and sex-biased resistance to ADC therapy

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1. scibot 08 Oct 2026
  
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  DOI: 10.1016/j.cell.2026.09.031
  
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sciencedirect.com/science/article/pii/S0092867426011335
Jun 2026
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Targeting SUV4-20H Epigenetic Enzymes Enhances Topoisomerase II Poisoning in Prostate Cancer

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1. scibot 30 Jun 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-3974
  
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aacrjournals.org/cancerres/article/86/1/236/771157/Targeting-SUV4-20H-Epigenetic-Enzymes-Enhances
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Suppression of ATM kinase signaling accelerates cellular senescence

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1. scibot 13 Jun 2026
  
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  DOI: 10.1016/j.stemcr.2026.102956
  
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sciencedirect.com/science/article/pii/S2213671126001670
Sep 2025
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Chemotherapy modulation by a cancer-associated microbiota metabolite

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  DOI: 10.1016/j.cels.2025.101397
  
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sciencedirect.com/science/article/pii/S2405471225002303
Aug 2025
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53BP1 regulates p53-E2F7-dependent transcriptional gene repression and participates in the Fanconi anemia pathway

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116152
  
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sciencedirect.com/science/article/pii/S2211124725009234
Jul 2025
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KEAP1 and STK11/LKB1 alterations enhance vulnerability to ATR inhibition in KRAS mutant non-small cell lung cancer

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1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.011
  
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Mar 2025
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p53 enhances DNA repair and suppresses cytoplasmic chromatin fragments and inflammation in senescent cells

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1. scibot 08 Mar 2025
  
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  DOI: 10.1038/s41467-025-57229-3
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11882782/
Feb 2025
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SENP1 decreases RNF168 phase separation to promote DNA damage repair and drug resistance in colon cancer

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.CAN-22-4017
  
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aacrjournals.org/cancerres/article/83/17/2908/728579/SENP1-Decreases-RNF168-Phase-Separation-to-Promote
Nov 2024
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Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms

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1. scibot 07 Nov 2024
  
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  DOI: 10.26508/lsa.202402829
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11463332/
Sep 2024
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Protein UFMylation regulates early events during ribosomal DNA-damage response

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.celrep.2024.114738
  
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sciencedirect.com/science/article/pii/S2211124724010891
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TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival

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1. scibot 12 Sep 2024
  
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sciencedirect.com/science/article/pii/S0092867424009115
Aug 2024
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Histone chaperone HIRA, promyelocytic leukemia protein, and p62/SQSTM1 coordinate to regulate inflammation during cell senescence

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.08.006
  
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sciencedirect.com/science/article/pii/S1097276524006609
May 2024
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Deregulation of multiple mechanisms shapes the onset of LAMA2-congenital muscular dystrophy

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1. scibot 03 May 2024
  
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  DOI: 10.1101/2024.01.20.576409
  
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biorxiv.org/content/10.1101/2024.01.20.576409v1
Apr 2024
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DNA-PK and ATM drive phosphorylation signatures that antagonistically regulate cytokine responses to herpesvirus infection or DNA damage

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1. scibot 12 Apr 2024
  
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  DOI: 10.1016/j.cels.2024.03.003
  
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  DOI: 10.1016/j.cels.2024.03.003
  
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sciencedirect.com/science/article/pii/S2405471224000887
Dec 2023
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IDR-targeting compounds suppress HPV genome replication via disruption of phospho-BRD4 association with DNA damage response factors

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1. scibot 16 Dec 2023
  
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  DOI: 10.1016/j.molcel.2023.11.022
  
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sciencedirect.com/science/article/pii/S109727652300967X
Aug 2023
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Senescent cells form nuclear foci that contain the 26S proteasome

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1. scibot 04 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112880
  
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sciencedirect.com/science/article/pii/S2211124723008914
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can-22-4017-html.html

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1. scibot 04 Aug 2023
  
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  DOI: 10.1158/0008-5472.can-22-4017
  
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52.53.155.43/9095f2133470165b212e6a97c53f24a603903e15/can-22-4017 (1)-html.html
Jul 2023
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Loss of SYNCRIP unleashes APOBEC-driven mutagenesis, tumor heterogeneity, and AR-targeted therapy resistance in prostate cancer

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1. scibot 21 Jul 2023
  
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  DOI: 10.1016/j.ccell.2023.06.010
  
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sciencedirect.com/science/article/pii/S1535610823002350
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Systematic analysis of the molecular and biophysical properties of key DNA damage response factors

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1. scibot 06 Jul 2023
  
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  DOI: 10.7554/eLife.87086
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10319438/
Apr 2023
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Cancer Cell Resistance to IFNγ Can Occur via Enhanced Double-Strand Break Repair Pathway Activity

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1. scibot 21 Apr 2023
  
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  DOI: 10.1158/2326-6066.CIR-22-0056
  
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aacrjournals.org/cancerimmunolres/article/11/3/381/716712/Cancer-Cell-Resistance-to-IFN-Can-Occur-via
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Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models

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1. scibot 21 Apr 2023
  
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  DOI: 10.1158/1078-0432.CCR-22-2977
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10102842/
Feb 2023
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Regulation of DNA damage response by trimeric G-proteins

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1. scibot 09 Feb 2023
  
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  DOI: 10.1016/j.isci.2023.105973
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9900518/
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PARylation of BRCA1 limits DNA break resection through BRCA2 and EXO1

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  DOI: 10.1016/j.celrep.2023.112060
  
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sciencedirect.com/science/article/pii/S2211124723000712
Nov 2022
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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

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  DOI: 10.1016/j.celrep.2022.111600
  
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sciencedirect.com/science/article/pii/S2211124722014656
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Biosensor Cell-Fit-HD4D for correlation of single-cell fate and microscale energy deposition in complex ion beams

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1. scibot 03 Nov 2022
  
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  DOI: 10.1016/j.xpro.2022.101798
  
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sciencedirect.com/science/article/pii/S2666166722006785
Oct 2022
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C9orf72 functions in the nucleus to regulate DNA damage repair

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  DOI: 10.1038/s41418-022-01074-0
  
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nature.com/articles/s41418-022-01074-0
Apr 2022
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Loss of Claudin-4 Reduces DNA Damage Repair and Increases Sensitivity to PARP Inhibitors

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  DOI: 10.1158/1535-7163.MCT-21-0827
  
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aacrjournals.org/mct/article/21/4/647/689566/Loss-of-Claudin-4-Reduces-DNA-Damage-Repair-and
Mar 2022
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Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation

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  DOI: 10.1016/j.molcel.2022.01.020
  
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sciencedirect.com/science/article/pii/S1097276522000855
Feb 2022
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Cellular plasticity upon proton irradiation determines tumor cell radiosensitivity

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  DOI: 10.1016/j.celrep.2022.110422
  
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Biosensor for deconvolution of individual cell fate in response to ion beam irradiation

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  DOI: 10.1016/j.crmeth.2022.100169
  
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sciencedirect.com/science/article/pii/S2667237522000212
Sep 2021
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In situ observation of mitochondrial biogenesis as the early event of apoptosis

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1. scibot 25 Sep 2021
  
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  DOI: 10.1016/j.isci.2021.103038
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8441175/
Aug 2021
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Untitled document

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1. scibot 10 Aug 2021
  
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  DOI: 10.1016/j.molcel.2018.10.045
  
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sciencedirect.com/science/article/pii/S1097276518309390
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 02 Aug 2021
  
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  RRID:AB_10694558
  
  DOI: 10.1016/j.cels.2016.11.013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
Jul 2021
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

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1. scibot 27 Jul 2021
  
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  RRID: AB_10694558
  
  DOI: 10.1016/j.cels.2016.11.013
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5279869/
May 2021
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p97/VCP inhibition causes excessive MRE11-dependent DNA end resection promoting cell killing after ionizing radiation

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1. scibot 26 May 2021
  
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  RRID:AB_10694558
  
  DOI: 10.1016/j.celrep.2021.109153
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8170441/
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Helicobacter pylori CagA elicits BRCAness to induce genome instability that may underlie bacterial gastric carcinogenesis

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1. scibot 14 May 2021
  
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  DOI: 10.1016/j.chom.2021.04.006
  
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TIRR inhibits the 53BP1-p53 complex to alter cell-fate programs

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1. scibot 09 May 2021
  
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  RRID:AB_10694558
  
  DOI: 10.1016/j.molcel.2021.03.039
  
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sciencedirect.com/science/article/pii/S1097276521002343
Sep 2020
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Cooperation of the ATM and Fanconi Anemia/BRCA Pathways in Double-Strand Break End Resection

1
1. scibot 26 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.01.052
  
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Hedgehog signaling enables repair of ribosomal DNA double-strand breaks

1
1. scibot 13 Sep 2020
  
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  53BP1
  
  DOI: 10.1093/nar/gkaa733
  
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academic.oup.com/nar/advance-article/doi/10.1093/nar/gkaa733/5902436
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A high-throughput small molecule screen identifies farrerol as a potentiator of CRISPR/Cas9-mediated genome editing

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1. scibot 05 Sep 2020
  
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  RRID:AB_10694558
  
  DOI: 10.7554/eLife.56008
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7380943/
Jan 2020
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Suppressing Aneuploidy-Associated Phenotypes Improves the Fitness of Trisomy 21 Cells

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1. scibot 13 Jan 2020
  
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  RRID:AB_10694558
  
  DOI: 10.1016/j.celrep.2019.10.059
  
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RUVBL1/RUVBL2 ATPase Activity Drives PAQosome Maturation, DNA Replication and Radioresistance in Lung Cancer

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.chembiol.2019.12.005
  
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Nov 2018
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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency

1
1. scibot 05 Nov 2018
  
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Systematic Functional Annotation of Somatic Mutations in Cancer

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1535610818300217
Nov 2017
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Context Specificity in Causal Signaling Networks Revealed by Phosphoprotein Profiling

1
1. scibot 08 Nov 2017
  
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  AB_10694558
  
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sciencedirect.com/science/article/pii/S2405471216304082