136 Matching Annotations
  1. Nov 2024
  2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BRG1 programs PRC2-complex repression and controls oligodendrocyte differentiation and remyelination
    1
    1. scibot 07 Nov 2024
      RRID:AB_10694683

      DOI: 10.1083/jcb.202310143

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    pmc.ncbi.nlm.nih.gov/articles/PMC11040499/
  3. Sep 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Sex-dependent effects in the aged melanoma tumor microenvironment influence invasion and resistance to targeted therapy
    1
    1. scibot 10 Sep 2024
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      DOI: 10.1016/j.cell.2024.08.013

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    sciencedirect.com/science/article/pii/S0092867424009048
  5. Aug 2024
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.celrep.2024.114484

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    ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
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    Thyroid hormone suppresses medulloblastoma progression through promoting terminal differentiation of tumor cells
    1
    1. scibot 21 Aug 2024
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      DOI: 10.1016/j.ccell.2024.07.008

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    sciencedirect.com/science/article/pii/S1535610824002733
  8. Jul 2024
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    H3 K27M and EZHIP Impede H3K27-Methylation Spreading by Inhibiting Allosterically Stimulated PRC2
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1016/j.molcel.2020.09.028

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    ncbi.nlm.nih.gov/pmc/articles/PMC7680438/
  10. May 2024
  11. www.nature.com www.nature.com
    Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer
    1
    1. scibot 30 May 2024
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      DOI: 10.1038/s41416-024-02697-5

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    nature.com/articles/s41416-024-02697-5
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    Enhanced ApcMin/+ adenoma formation after epithelial CUL4B deletion by recruitment of myeloid-derived suppressor cells
    1
    1. scibot 21 May 2024
      Cell Signaling Technology, Cat# 5246S

      DOI: 10.1016/j.neo.2024.101005

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    sciencedirect.com/science/article/pii/S1476558624000472
  13. Apr 2024
  14. aacrjournals.org aacrjournals.org
    miR-217 regulates normal and tumor cell fate following induction of Endoplasmic Reticulum Stress
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1158/1541-7786.MCR-23-0676

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    aacrjournals.org/mcr/article/22/4/360/741846/miR-217-Regulates-Normal-and-Tumor-Cell-Fate
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 as a major histone methyltransferase in PDGF-BB-activated orbital fibroblast in the pathogenesis of Graves’ ophthalmopathy
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1038/s41598-024-57926-x

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    ncbi.nlm.nih.gov/pmc/articles/PMC10994939/
  16. www.sciencedirect.com www.sciencedirect.com
    A senescence restriction point acting on chromatin integrates oncogenic signals
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114044

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    sciencedirect.com/science/article/pii/S2211124724003723
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    Telomere dysfunction alters intestinal stem cell dynamics to promote cancer
    1
    1. scibot 04 Apr 2024
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      DOI: 10.1016/j.devcel.2024.03.020

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    sciencedirect.com/science/article/pii/S1534580724001886
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Select EZH2 inhibitors enhance viral mimicry effects of DNMT inhibition through a mechanism involving NFAT:AP-1 signaling
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1126/sciadv.adk4423

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    ncbi.nlm.nih.gov/pmc/articles/PMC10971413/
  19. Mar 2024
  20. www.sciencedirect.com www.sciencedirect.com
    MTOR modulation induces selective perturbations in histone methylation which influence the anti-proliferative effects of mTOR inhibitors
    2
    1. scibot 07 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    2. scibot 06 Mar 2024
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      DOI: 10.1016/j.isci.2024.109188

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    sciencedirect.com/science/article/pii/S2589004224004097
  21. Feb 2024
  22. www.sciencedirect.com www.sciencedirect.com
    Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA
    1
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113888

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    sciencedirect.com/science/article/pii/S221112472400216X
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    Sustained antidepressant effects of ketamine metabolite involve GABAergic inhibition-mediated molecular dynamics in aPVT glutamatergic neurons
    1
    1. scibot 23 Feb 2024
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      DOI: 10.1016/j.neuron.2024.01.023

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    sciencedirect.com/science/article/pii/S0896627324000497
  24. www.sciencedirect.com www.sciencedirect.com
    Denaturing purifications demonstrate that PRC2 and other widely reported chromatin proteins do not appear to bind directly to RNA in vivo
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1016/j.molcel.2024.01.026

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    sciencedirect.com/science/article/pii/S1097276524000935
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
    1
    1. scibot 15 Feb 2024
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      DOI: 10.1158/2767-9764.CRC-23-0399

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    ncbi.nlm.nih.gov/pmc/articles/PMC10863487/
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    EZH2/G9a interact to mediate drug resistance in non-small-cell lung cancer by regulating the SMAD4/ERK/c-Myc signaling axis
    1
    1. scibot 09 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113714

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    sciencedirect.com/science/article/pii/S2211124724000421
  27. Jan 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Antitumor efficacy of a sequence-specific DNA-targeted γPNA-based c-Myc inhibitor
    1
    1. scibot 09 Jan 2024
      RRID:AB_10694683

      DOI: 10.1016/j.xcrm.2023.101354

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    sciencedirect.com/science/article/pii/S2666379123005712
  29. www.sciencedirect.com www.sciencedirect.com
    Metabolic switch regulates lineage plasticity and induces synthetic lethality in triple-negative breast cancer
    1
    1. scibot 06 Jan 2024
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      DOI: 10.1016/j.cmet.2023.12.003

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    sciencedirect.com/science/article/pii/S1550413123004552
  30. www.sciencedirect.com www.sciencedirect.com
    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
    2
    1. scibot 04 Jan 2024
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      DOI: 10.1016/j.devcel.2023.07.025

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      DOI: 10.1016/j.devcel.2023.07.025

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    sciencedirect.com/science/article/pii/S1534580723003945
  31. Nov 2023
  32. www.sciencedirect.com www.sciencedirect.com
    Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells
    1
    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.chembiol.2023.10.005

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    sciencedirect.com/science/article/pii/S2451945623003665
  33. Sep 2023
  34. www.sciencedirect.com www.sciencedirect.com
    Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.isci.2023.107964

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    sciencedirect.com/science/article/pii/S2589004223020412
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer
    1
    1. scibot 06 Sep 2023
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      DOI: 10.1016/j.isci.2023.107630

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    ncbi.nlm.nih.gov/pmc/articles/PMC10475482/
  36. Aug 2023
  37. www.sciencedirect.com www.sciencedirect.com
    G-quadruplexes associated with R-loops promote CTCF binding
    1
    1. scibot 10 Aug 2023
      RRID:AB_10694683

      DOI: 10.1016/j.molcel.2023.07.009

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    sciencedirect.com/science/article/abs/pii/S1097276523005233
  38. Jul 2023
  39. www.sciencedirect.com www.sciencedirect.com
    Tissue factor is a critical regulator of radiation therapy-induced glioblastoma remodeling
    1
    1. scibot 14 Jul 2023
      RRID:AB_10694683

      DOI: 10.1016/j.ccell.2023.06.007

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    sciencedirect.com/science/article/pii/S1535610823002179
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    Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn
    1
    1. scibot 13 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112803

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    sciencedirect.com/science/article/pii/S2211124723008148
  41. Jun 2023
  42. www.sciencedirect.com www.sciencedirect.com
    An EZH2-NF-κB Regulatory Axis Drives Expression of Pro-Oncogenic Gene Signatures in Triple Negative Breast Cancer
    1
    1. scibot 27 Jun 2023
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      DOI: 10.1016/j.isci.2023.107115

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    sciencedirect.com/science/article/pii/S2589004223011926
  43. www.sciencedirect.com www.sciencedirect.com
    METTL14 regulates chromatin bivalent domains in mouse embryonic stem cells
    1
    1. scibot 22 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112650

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    sciencedirect.com/science/article/pii/S2211124723006617
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    Haploinsufficiency of NFKBIA reshapes the epigenome antipodal to the IDH mutation and imparts disease fate in diffuse gliomas
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.xcrm.2023.101082

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    sciencedirect.com/science/article/pii/S266637912300201X
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Deconstructing olfactory epithelium developmental pathways in olfactory neuroblastoma
    1
    1. scibot 08 Jun 2023
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      DOI: 10.1158/2767-9764.CRC-23-0013

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    ncbi.nlm.nih.gov/pmc/articles/PMC10243222/
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    Targeted deprivation of methionine with engineered Salmonella leads to oncolysis and suppression of metastasis in broad types of animal tumor models
    1
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      DOI: 10.1016/j.xcrm.2023.101070

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    sciencedirect.com/science/article/pii/S2666379123001891
  47. May 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis
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    1. scibot 24 May 2023
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      DOI: 10.1016/j.celrep.2023.112550

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    sciencedirect.com/science/article/pii/S2211124723005612
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    Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer
    1
    1. scibot 03 May 2023
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      DOI: 10.1016/j.chom.2023.04.010

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    sciencedirect.com/science/article/abs/pii/S1931312823001610
  50. Apr 2023
  51. www.sciencedirect.com www.sciencedirect.com
    A hyper-quiescent chromatin state formed during aging is reversed by regeneration
    1
    1. scibot 29 Apr 2023
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      DOI: 10.1016/j.molcel.2023.04.005

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    sciencedirect.com/science/article/pii/S1097276523002496
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    Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.isci.2023.106570

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    sciencedirect.com/science/article/pii/S2589004223006478
  53. Jan 2023
  54. www.sciencedirect.com www.sciencedirect.com
    Dual-specificity RNA aptamers enable manipulation of target-specific O-GlcNAcylation and unveil functions of O-GlcNAc on β-catenin
    1
    1. scibot 11 Jan 2023
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      DOI: 10.1016/j.cell.2022.12.016

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    sciencedirect.com/science/article/pii/S009286742201529X
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    Decreased expression of EZH2 in granulosa cells contributes to endometriosis-associated infertility by targeting IL-1R2
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    1. scibot 06 Jan 2023
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      DOI: 10.1210/endocr/bqac210

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    PALI1 promotes tumor growth through competitive recruitment of PRC2 to G9A-target chromatin for dual epigenetic silencing
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    Dual Acting Peptides Target EZH2 and AR: a New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer
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    Table 1 Antibodies and dyes compatible with mLSR-3D
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    Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma
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  66. Sep 2022
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    Single-cell sequencing reveals activation of core transcription factors in PRC2-deficient malignant peripheral nerve sheath tumor
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    A TET1-PSPC1-Neat1 molecular axis modulates PRC2 functions in controlling stem cell bivalency
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    Dysregulated lipid metabolism blunts the sensitivity of cancer cells to EZH2 inhibitor
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    Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction
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    ASH1L haploinsufficiency results in autistic-like phenotypes in mice and links Eph receptor gene to autism spectrum disorder
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    Targeting Wnt/EZH2/microRNA-708 signaling pathway inhibits neuroendocrine differentiation in prostate cancer
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    Epigenetic Restoration of Fetal-like IGF1 Signaling Inhibits Leukemia Stem Cell Activity
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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  114. May 2021
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    Inhibition of EZH2 Catalytic Activity Selectively Targets a Metastatic Subpopulation in Triple-Negative Breast Cancer
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    EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
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    Dual Regulation of Histone Methylation by mTOR Complexes Controls Glioblastoma Tumor Cell Growth via EZH2 and SAM
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    Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters
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  139. Jan 2020
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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    PDGFR-β Signaling Regulates Cardiomyocyte Proliferation and Myocardial Regeneration
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    Degradation of Polycomb Repressive Complex 2 with an EED-Targeted Bivalent Chemical Degrader
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    Antagonistic interaction between Ezh2 and Arid1a coordinates root patterning and development via Cdkn2a in mouse molars
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    EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex
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    DEAD-Box Helicase 18 Counteracts PRC2 to Safeguard Ribosomal DNA in Pluripotency Regulation
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    ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures
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    Transsulfuration Activity Can Support Cell Growth upon Extracellular Cysteine Limitation
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    lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA
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    Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis
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    Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation
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    Notch Signaling Controls Transdifferentiation of Pulmonary Neuroendocrine Cells in Response to Lung Injury
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  160. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Multiple polycomb epigenetic regulatory proteins are active in normal and regenerating adult olfactory epithelium
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  161. www.cell.com www.cell.com
    Targeting Epigenetic Crosstalk as a Therapeutic Strategy for EZH2-Aberrant Solid Tumors
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    EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation
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    MicroRNAs Overcome Cell Fate Barrier by Reducing EZH2-Controlled REST Stability during Neuronal Conversion of Human Adult Fibroblasts
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    Unique Structural Platforms of Suz12 Dictate Distinct Classes of PRC2 for Chromatin Binding
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    The Transcriptionally Permissive Chromatin State of Embryonic Stem Cells Is Acutely Tuned to Translational Output
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    Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2
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    Allosteric Activation Dictates PRC2 Activity Independent of Its Recruitment to Chromatin
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  169. pdfs.semanticscholar.org pdfs.semanticscholar.org
    lncRNA Functional Networks in Oligodendrocytes Reveal Stage-Specific Myelination Control by an lncOL1/Suz12 Complex in the CNS
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    Replication Stress Shapes a Protective Chromatin Environment across Fragile Genomic Regions
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    The Elongation Factor Spt6 Maintains ESC Pluripotency by Controlling Super-Enhancers and Counteracting Polycomb Proteins
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  172. Nov 2017
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    Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations
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    Delayed Accumulation of H3K27me3 on Nascent DNA Is Essential for Recruitment of Transcription Factors at Early Stages of Stem Cell Differentiation
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    Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance
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    Destabilization of B2 RNA by EZH2 Activates the Stress Response
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