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Virus-induced deconjugation of ISG15 dysregulates innate immunity and cellular metabolism

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1. scibot 09 Aug 2026
  
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  DOI: 10.1016/j.immuni.2026.07.007
  
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sciencedirect.com/science/article/pii/S1074761326003067
Apr 2026
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An interactome-based framework for DDB1- and CUL4-associated factor prioritization in targeted protein degradation

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1. scibot 09 Apr 2026
  
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  DOI: 10.1016/j.molcel.2026.03.004
  
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sciencedirect.com/science/article/pii/S1097276526001607
Jan 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

FGFR signaling and neddylation facilitate SARS-CoV-2 infection by modulating interferon induction and viral entry, respectively

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1. scibot 16 Jan 2026
  
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  DOI: 10.1016/j.isci.2025.114566
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12828524/
Jan 2025
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mTORC1 regulates the pyrimidine salvage pathway by controlling UCK2 turnover via the CTLH-WDR26 E3 ligase

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115179
  
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sciencedirect.com/science/article/pii/S2211124724015304
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Neddylation inhibition prevents acetaminophen-induced liver damage by enhancing the anabolic cardiolipin pathway

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1. scibot 17 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101653
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11293357/
May 2024
dx.doi.org dx.doi.org

The Human Intermediate Prolactin Receptor I-tail Contributes Breast Oncogenesis by Targeting Ras/MAPK Pathway

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1. scibot 09 May 2024
  
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  DOI: 10.1210/endocr/bqae039
  
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dx.doi.org/10.1210/endocr/bqae039
52.53.155.43 52.53.155.43

bqae039-html.html

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1. scibot 09 May 2024
  
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  DOI: 10.6084/m9.figshare.24398467.v2
  
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2. scibot 09 May 2024
  
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  DOI: 10.6084/m9.figshare.24398467.v2
  
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52.53.155.43/ab567994747ba987c62f3a62774a1442bfaf3557/bqae039 (1)-html.html
Feb 2024
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Pharmacological inhibition of neddylation impairs long interspersed element 1 retrotransposition

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1. scibot 08 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113749
  
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sciencedirect.com/science/article/pii/S2211124724000779
Dec 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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1. scibot 16 Dec 2022
  
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  DOI: 10.1126/sciadv.abq0648
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9733930/
www.science.org www.science.org

NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

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1. scibot 13 Dec 2022
  
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  DOI: 10.1126/sciadv.abq0648
  
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science.org/doi/10.1126/sciadv.abq0648
Sep 2022
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Identification of CUL4A-DDB1-WDFY1 as an E3 ubiquitin ligase complex involved in initiation of lysophagy

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1. scibot 15 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111349
  
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sciencedirect.com/science/article/pii/S2211124722011779
Sep 2020
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Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer

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1. scibot 23 Sep 2020
  
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  DOI: 10.1016/j.ccell.2020.01.011
  
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  Curator: @ethanbadger
  
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  RRIDCUR:Validated RRID:AB_10695300
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sciencedirect.com/science/article/pii/S1535610820300507
Nov 2017
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Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9

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1. scibot 08 Nov 2017
  
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  RRID:AB_10695300 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276517303131
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Two Distinct Types of E3 Ligases Work in Unison to Regulate Substrate Ubiquitylation

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S0092867416309734