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  1. Last 7 days
  2. www.cell.com www.cell.com
    CHK1 inhibitor SRA737 is active in PARP inhibitor resistant and CCNE1 amplified ovarian cancer
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    cell.com/iscience/abstract/S2589-0042(24)01200-8
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DDX56 promotes EMT and cancer stemness via MELK-FOXM1 axis in hepatocellular carcinoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC11141150/
  5. molecular-cancer.biomedcentral.com molecular-cancer.biomedcentral.com
    Diversifying the anthracycline class of anti-cancer drugs identifies aclarubicin for superior survival of acute myeloid leukemia patients
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  6. May 2024
  7. www.sciencedirect.com www.sciencedirect.com
    Glial fibrillary acidic protein is pathologically modified in Alexander disease
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    An Orally Efficacious Thyrotropin Receptor Ligand Inhibits Growth and Metastatic Activity of Thyroid Cancers
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    1. scibot 22 May 2024
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    The Janus kinase 1 is critical for pancreatic cancer initiation and progression
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    sciencedirect.com/science/article/pii/S2211124724005308
  10. Apr 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer-associated fibroblasts promote enzalutamide resistance and PD-L1 expression in prostate cancer through CCL5-CCR5 paracrine axis
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  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Arachidonic acid released by PIK3CA mutant tumor cells triggers malignant transformation of colonic epithelium by inducing chromatin remodeling
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    Pharmacological induction of chromatin remodeling drives chemosensitization in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2666379124001733
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    Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stages
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  15. Mar 2024
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    Autofluorescence is a biomarker of neural stem cell activation state
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    sciencedirect.com/science/article/pii/S1934590924000547
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    Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma
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  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis
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    Light-mediated intracellular polymerization
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    nature.com/articles/s41596-024-00970-8
  20. stemcellres.biomedcentral.com stemcellres.biomedcentral.com
    Conditioned medium from induced pluripotent stem cell-derived mesenchymal stem cells accelerates cutaneous wound healing through enhanced angiogenesis
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      vimentin

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  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stromal-derived NRG1 enables oncogenic KRAS bypass in pancreas cancer
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  23. Feb 2024
  24. aacrjournals.org aacrjournals.org
    A novel irreversible TEAD inhibitor, SWTX-143, blocks Hippo pathway transcriptional output and causes tumor regression in preclinical mesothelioma models
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      DOI: 10.1158/1535-7163.MCT-22-0681

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  25. 52.53.155.43 52.53.155.43
    can-22-3965-html.html
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  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Hypoxia at 3D organoid establishment selects essential subclones within heterogenous pancreatic cancer
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  27. 52.53.155.43 52.53.155.43
    Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
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  28. Jan 2024
  29. dx.doi.org dx.doi.org
    Crosstalk between PARN and EGFR-STAT3 Signaling Facilitates Self-Renewal and Proliferation of Glioblastoma Stem Cells
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  30. Dec 2023
  31. www.sciencedirect.com www.sciencedirect.com
    AID-induced CXCL12 upregulation enhances castration-resistant prostate cancer cell metastasis by stabilizing β-catenin expression
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  32. www.sciencedirect.com www.sciencedirect.com
    Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses
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    sciencedirect.com/science/article/pii/S0092867423012205
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    Heterogeneity and transcriptional drivers of triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S2211124723015760
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    Integrated multi-omics profiling to dissect the spatiotemporal evolution of metastatic hepatocellular carcinoma
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    sciencedirect.com/science/article/pii/S1535610823004014
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    Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1α/METTL16/lnc-CSMD1-7/RBFOX2 axis
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  36. link.springer.com link.springer.com
    Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
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  37. Nov 2023
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways
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    Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas
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    Intestinal epithelial dopamine receptor signaling drives sex-specific disease exacerbation in a mouse model of multiple sclerosis
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    sciencedirect.com/science/article/abs/pii/S1074761323004569
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    Pan-cancer tRNA-derived fragment CAT1 coordinates RBPMS to stabilize NOTCH2 mRNA to promote tumorigenesis
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    sciencedirect.com/science/article/pii/S2211124723014201
  42. www.biorxiv.org www.biorxiv.org
    Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
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      DOI: 10.1101/2023.11.07.566022

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  43. 52.53.155.43 52.53.155.43
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  44. www.biorxiv.org www.biorxiv.org
    ZNF397 Loss Triggers TET2-driven Epigenetic Rewiring, Lineage Plasticity, and AR-targeted Therapy Resistance in AR-dependent Cancers
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  45. 52.53.155.43 52.53.155.43
    Molecular Oncology - 2023 - Pohlers - Th17 cells target the metabolic miR‐142‐5p succinate dehydrogenase subunit C D SDHC-html.html
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      AB_10695459

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    52.53.155.43/a186f6fbd2a3289ac6933335bf9b0efbe74c0f93/Molecular Oncology - 2023 - Pohlers - Th17 cells target the metabolic miR-142-5p succinate dehydrogenase subunit C D SDHC-html.html
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    Pigmented skin exhibits accelerated wound healing compared to the nonpigmented skin in Guinea pig model
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  47. Oct 2023
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Immunotherapy with STING and TLR9 agonists promotes synergistic therapeutic efficacy with suppressed cancer-associated fibroblasts in colon carcinoma
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      DOI: 10.3389/fimmu.2023.1258691

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    Minichromosome maintenance 6 protects against renal fibrogenesis by regulating DUSP6-mediated ERK/GSK-3β/Snail1 signaling
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  53. Sep 2023
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    Lorazepam Stimulates IL6 Production and Is Associated with Poor Survival Outcomes in Pancreatic Cancer
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    Fusobacterium nucleatum promotes colorectal cancer metastasis by excretion of miR-122-5p from cells via exosomes
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    Cancer-associated mesothelial cells are regulated by the anti-Müllerian hormone axis
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    M2 macrophages mediate fibrotic scar formation in the early stages after cerebral ischemia in rats
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    TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2
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    SMYD3 induces sorafenib resistance by activating SMAD2/3-mediated epithelial-mesenchymal transition in hepatocellular carcinoma
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    Cancer cell-autonomous cGAS-STING response confers drug resistance
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  76. May 2023
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    Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer
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    Snail acetylation by autophagy-derived acetyl-coenzyme A promotes invasion and metastasis of KRAS-LKB1 co-mutated lung cancer cells
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    Decoding the molecular crosstalk between grafted stem cells and the stroke-injured brain
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    Multiplex imaging of breast cancer lymph node metastases identifies prognostic single-cell populations independent of clinical classifiers
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    Loss of VOPP1 Contributes to BET Inhibitor Acquired Resistance in Non–Small Cell Lung Cancer Cells
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    Generation of telomeric repeat binding factor 1 (TRF1)-knockout human embryonic stem cell lines, KRIBBe010-A-95, KRIBBe010-A-96, and KRIBBe010-A-97, using CRISPR/Cas9 technology
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    Goji berry (Lycium barbarum) inhibits the proliferation, adhesion, and migration of oral cancer cells by inhibiting the ERK, AKT, and CyclinD cell signaling pathways: an in-vitro study
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    DDR2 coordinates EMT and metabolic reprogramming as a shared effector of FOXQ1 and SNAI1
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    Epithelial-to-Mesenchymal Transition Supports Ovarian Carcinosarcoma Tumorigenesis and Confers Sensitivity to Microtubule Targeting with Eribulin
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  94. Dec 2022
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    The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response
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    Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads
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    Hedgehog regulation of epithelial cell state and morphogenesis in the larynx
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  98. Nov 2022
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    Molecular classification and biomarkers of clinical outcome in breast ductal carcinoma in situ: Analysis of TBCRC 038 and RAHBT cohorts
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    DDR2 Coordinates EMT and Metabolic Reprogramming as a Shared Effector of FOXQ1 and SNAI1
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  101. Oct 2022
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    Cervical MUC5B and MUC5AC are barriers to ascending pathogens during pregnancy
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    A molecular interactome of the glioblastoma perivascular niche reveals integrin binding sialoprotein as a mediator of tumor cell migration
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    Spatial epitope barcoding reveals clonal tumor patch behaviors
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    Decoding the colorectal cancer ecosystem emphasizes the cooperative role of cancer cells, TAMs and CAFsin tumor progression
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    Ablating Lgr5-expressing prostatic stromal cells activates the ERK-mediated mechanosensory signaling and disrupts prostate tissue homeostasis
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    GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A
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  110. Jul 2022
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    Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines
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    Long non-coding RNA EVADR induced by Fusobacterium nucleatum infection promotes colorectal cancer metastasis
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    PTEN and LKB1 are differentially required in Gli1-expressing mesenchymal cells to suppress gastrointestinal polyposis
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    Poziotinib for EGFR exon 20-mutant NSCLC: Clinical efficacy, resistance mechanisms, and impact of insertion location on drug sensitivity
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    Integrin β3 Promotes Resistance to EGFR-TKI in Non-Small-Cell Lung Cancer by Upregulating AXL through the YAP Pathway
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    Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
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  118. May 2022
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  120. Apr 2022
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    TNFɑ Antagonist in Combination with PD-1 Blocker to Prevent or Retard Malignant Transformation of B[a]P-induced Chronic Lung Inflammation
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    EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer
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    HER2 isoforms uniquely program intratumor heterogeneity and predetermine breast cancer trajectories during the occult tumorigenic phase
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  125. Feb 2022
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    A FBXO7/EYA2-SCFFBXW7 axis promotes AXL-mediated maintenance of mesenchymal and immune evasion phenotypes of cancer cells
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    Radiation induces epithelial to mesenchymal transition via upregulation of PD-L1 in nasopharyngeal carcinoma cell
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    Autophagic and apoptotic cell death induced by the quinoline derivative 2-(6-methoxynaphthalen-2-yl)quinolin-4-amine in pancreatic cancer cells is via ER stress and inhibition of Akt/mTOR signaling pathway
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  129. Jan 2022
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    CXCL4 drives fibrosis by promoting several key cellular and molecular processes
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    The combination of dapagliflozin and statins ameliorates renal injury through attenuating the activation of inflammasome-mediated autophagy in insulin-resistant rats
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    Toxoplasma gondii SAG1 Targeting Host Cell S100A6 for Parasite Invasion and Host Immunity
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    Anorexia disrupts glutamate-glutamine homeostasis associated with astrocytes in the prefrontal cortex of young female rats
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    Artemisinin Mediates Its Tumor-Suppressive Activity in Hepatocellular Carcinoma Through Targeted Inhibition of FoxM1
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  136. Nov 2021
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    Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis
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    A novel jamming phase diagram links tumor invasion to non-equilibrium phase separation
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    MAPK pathway activation selectively inhibits ASCL1-driven small cell lung cancer
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    Multiplexed imaging reveals an IFN-γ-driven inflammatory state in nivolumab-associated gastritis
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    The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment
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  143. Sep 2021
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    The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy
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  145. Aug 2021
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    NF1 regulates mesenchymal glioblastoma plasticity and aggressiveness through the AP-1 transcription factor FOSL1
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    Cdc42 is required for male germline niche development in mice
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    Targeting Aurora B kinase prevents and overcomes resistance to EGFR inhibitors in lung cancer by enhancing BIM- and PUMA-mediated apoptosis
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    Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
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    Vitamin D regulates CXCL12/CXCR4 and epithelial-to-mesenchymal transition in a model of breast cancer metastasis to lung
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    KDM5 Histone Demethylase Activity Links Cellular Transcriptomic Heterogeneity to Therapeutic Resistance
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  152. Jul 2021
  153. www.nature.com www.nature.com
    Mitofusins regulate lipid metabolism to mediate the development of lung fibrosis
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  154. www.sciencedirect.com www.sciencedirect.com
    Simultaneous Multiplexed Imaging of mRNA and Proteins with Subcellular Resolution in Breast Cancer Tissue Samples by Mass Cytometry
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    New Noonan syndrome model mice with RIT1 mutation exhibit cardiac hypertrophy and susceptibility to β-adrenergic stimulation-induced cardiac fibrosis
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  156. academic.oup.com academic.oup.com
    VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess
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    Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy
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  158. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Upregulation of the long noncoding RNA UBOX5 antisense RNA 1 (UBOX5-AS1) under hypoxic conditions promotes epithelial-mesenchymal transition in endometriosis
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  159. www.sciencedirect.com www.sciencedirect.com
    Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis
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    Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
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  161. Jun 2021
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    RAGE Differentially Altered in vitro Responses in Vascular Smooth Muscle Cells and Adventitial Fibroblasts in Diabetes-Induced Vascular Calcification
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  163. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    KSR1- and ERK-dependent translational regulation of the epithelial-to-mesenchymal transition
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  164. www.sciencedirect.com www.sciencedirect.com
    Generation of human induced pluripotent stem cell line EURACi006-A and its isogenic gene-corrected line EURACi006-A-1 from an arrhythmogenic cardiomyopathy patient carrying the c.1643delG PKP2 mutation
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  165. May 2021
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    PD-L1 recruits phospholipase C and enhances tumorigenicity of lung tumors harboring mutant forms of EGFR
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  167. cancerdiscovery.aacrjournals.org cancerdiscovery.aacrjournals.org
    Cell of Origin Influences Pancreatic Cancer Subtype
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    A Specialized Niche in the Pancreatic Microenvironment Promotes Endocrine Differentiation
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    Small Extracellular Vesicle Regulation of Mitochondrial Dynamics Reprograms a Hypoxic Tumor Microenvironment
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    Acto-myosin network geometry defines centrosome position
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  171. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function
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  172. Apr 2021
  173. www.sciencedirect.com www.sciencedirect.com
    Modeling plasticity and dysplasia of pancreatic ductal organoids derived from human pluripotent stem cells
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    Single-Cell Transcriptomics Reveals Early Emergence of Liver Parenchymal and Non-parenchymal Cell Lineages
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    The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells
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    Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer
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      RRID:AB_10695459

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  177. Mar 2021
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    Alisertib inhibits migration and invasion of EGFR-TKI resistant cells by partially reversing the epithelial-mesenchymal transition
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    Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling
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    Profiling of conditionally reprogrammed cell lines for in vitro chemotherapy response prediction of pancreatic cancer
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  181. Feb 2021
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    Modified CRISPR/Cas9 mediated generation of two MKK7 knockout human embryonic stem cell lines
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  183. Dec 2020
  184. www.cell.com www.cell.com
    Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors
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  185. Sep 2020
  186. onlinelibrary.wiley.com onlinelibrary.wiley.com
    ADAM10 mediates ectopic proximal tubule development and renal fibrosis through Notch signalling
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    Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells
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    Periostin Promotes Colorectal Tumorigenesis through Integrin-FAK-Src Pathway-Mediated YAP/TAZ Activation
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    Overexpression of B7-H3 in α-SMA-Positive Fibroblasts Is Associated With Cancer Progression and Survival in Gastric Adenocarcinomas
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    Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer
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    Generation and genetic repair of 2 iPSC clones from a patient bearing a heterozygous c.1120del18 mutation in the ACVRL1 gene leading to Hereditary Hemorrhagic Telangiectasia (HHT) type 2
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  192. academic.oup.com academic.oup.com
    Targeted disruption of Lats1 and Lats2 in mice impairs adrenal cortex development and alters adrenocortical cell fate
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  193. elifesciences.org elifesciences.org
    Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade
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    Vimentin Coordinates Protein Turnover at the Aggresome during Neural Stem Cell Quiescence Exit
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    H1N1 Influenza Virus Cross-Activates Gli1 to Disrupt the Intercellular Junctions of Alveolar Epithelial Cells
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    In Vivo Cell Fate Tracing Provides No Evidence for Mesenchymal to Epithelial Transition in Adult Fallopian Tube and Uterus
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    Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer
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    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
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    Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway
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    Dermal Adipocyte Lipolysis and Myofibroblast Conversion Are Required for Efficient Skin Repair
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    Targeted disruption of Lats1 and Lats2 in mice impairs adrenal cortex development and alters adrenocortical cell fate
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    Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells
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    GRWD1 promotes cell proliferation and migration in non-small cell lung cancer by activating the Notch pathway
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    Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation
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    Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
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    The Polycomb Repressor Complex 1 Drives Double-Negative Prostate Cancer Metastasis by Coordinating Stemness and Immune Suppression
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    Genetic Heterogeneity of BRAF Fusion Kinases in Melanoma Affects Drug Responses
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    Systematic Analysis of Drug Vulnerabilities Conferred by Tumor Suppressor Loss
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    F-Actin Interactome Reveals Vimentin as a Key Regulator of Actin Organization and Cell Mechanics in Mitosis
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    p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors
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    Spatially Restricted Stromal Wnt Signaling Restrains Prostate Epithelial Progenitor Growth through Direct and Indirect Mechanisms
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      RRID:AB_10695459

      DOI: 10.1016/j.stem.2019.03.010

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      DOI: 10.1016/j.molcel.2019.04.009

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      DOI: 10.1016/j.celrep.2018.12.090

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  220. Nov 2018
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    Single Cell and Open Chromatin Analysis Reveals Molecular Origin of Epidermal Cells of the Skin
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    Retinal structure and function in monkeys with fetal alcohol exposure
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    Combinatorial Targeting by MicroRNAs Co-ordinates Post-transcriptional Control of EMT
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    EMT Subtype Influences Epithelial Plasticity and Mode of Cell Migration
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    Acetyl-CoA Carboxylase 1-Dependent Protein Acetylation Controls Breast Cancer Metastasis and Recurrence
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    A Metabolic Basis for Endothelial-to-Mesenchymal Transition
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    Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer
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    Derivation of Human Trophoblast Stem Cells
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  231. Nov 2017
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    Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations
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    Time-Resolved Proteomics Extends Ribosome Profiling-Based Measurements of Protein Synthesis Dynamics
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