42 Matching Annotations
  1. Last 7 days
  2. www.science.org www.science.org
    Defining the KRAS- and ERK-dependent transcriptome in KRAS-mutant cancers
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    1. scibot 18 Jul 2024
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      DOI: 10.1126/science.adk0775

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    science.org/doi/10.1126/science.adk0775
  3. Mar 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The effects of Aurora Kinase inhibition on thyroid cancer growth and sensitivity to MAPK-directed therapies
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    1. scibot 27 Mar 2024
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      DOI: 10.1080/15384047.2024.2332000

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    ncbi.nlm.nih.gov/pmc/articles/PMC10962586/
  5. Feb 2024
  6. www.science.org www.science.org
    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
    2
    1. scibot 16 Feb 2024
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      DOI: 10.1126/scisignal.adg5289

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    2. scibot 16 Feb 2024
      RRID AB_10695868

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  7. Jan 2024
  8. www.science.org www.science.org
    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
    1
    1. scibot 20 Jan 2024
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      DOI: 10.1126/scisignal.adg5289

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    science.org/doi/10.1126/scisignal.adg5289
  9. Nov 2023
  10. www.sciencedirect.com www.sciencedirect.com
    Repositioning of Montelukast to inhibit proliferation of mutated KRAS pancreatic cancer through a novel mechanism that interfere the binding between KRAS and GTP/GDP
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.ejphar.2023.176157

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    sciencedirect.com/science/article/pii/S0014299923006714
  11. www.sciencedirect.com www.sciencedirect.com
    Detection of early prognostic biomarkers for metastasis of Ewing's sarcoma in pediatric patients
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    1. scibot 10 Nov 2023
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      DOI: 10.1016/j.lfs.2023.122237

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    sciencedirect.com/science/article/pii/S002432052300872X
  12. Oct 2023
  13. www.sciencedirect.com www.sciencedirect.com
    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
    1
    1. scibot 13 Oct 2023
      RRID:AB_10695868

      DOI: 10.1016/j.molcel.2023.09.007

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    sciencedirect.com/science/article/pii/S1097276523007025
  14. Aug 2023
  15. www.sciencedirect.com www.sciencedirect.com
    Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer
    1
    1. scibot 04 Aug 2023
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      DOI: 10.1016/j.ccell.2023.07.005

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    sciencedirect.com/science/article/pii/S1535610823002453
  16. Jul 2023
  17. www.sciencedirect.com www.sciencedirect.com
    Oncogenic K-Ras suppresses global miRNA function
    1
    1. scibot 06 Jul 2023
      RRID:AB_10695868

      DOI: 10.1016/j.molcel.2023.06.008

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    sciencedirect.com/science/article/pii/S109727652300429X
  18. Jun 2023
  19. www.sciencedirect.com www.sciencedirect.com
    Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
    1
    1. scibot 30 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112696

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    sciencedirect.com/science/article/pii/S2211124723007076
  20. May 2023
  21. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
    1
    1. scibot 31 May 2023
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      DOI: 10.1016/j.celrep.2023.112570

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    sciencedirect.com/science/article/pii/S2211124723005818
  22. www.sciencedirect.com www.sciencedirect.com
    Targeting of Annexin A1 in Tumor-associated Macrophages as a Therapeutic Strategy for Hepatocellular Carcinoma
    1
    1. scibot 20 May 2023
      RRID: AB_10695868

      DOI: 10.1016/j.bcp.2023.115612

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    sciencedirect.com/science/article/pii/S0006295223002034
  23. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibition of BRAF and ERK1/2 has synergistic effects on thyroid cancer growth in vitro and in vivo
    1
    1. scibot 05 May 2023
      RRID:AB_10695868

      DOI: 10.1002/mc.23284

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    onlinelibrary.wiley.com/doi/full/10.1002/mc.23284
  24. Feb 2023
  25. www.nature.com www.nature.com
    Repositioning Lomitapide to block ZDHHC5-dependant palmitoylation on SSTR5 leads to anti-proliferation effect in preclinical pancreatic cancer models
    1
    1. scibot 15 Feb 2023
      RRID:AB_10695868

      DOI: 10.1038/s41420-023-01359-4

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    nature.com/articles/s41420-023-01359-4
  26. Jan 2023
  27. www.sciencedirect.com www.sciencedirect.com
    Plakophilin 3 facilitates G1/S phase transition and enhances proliferation by capturing RB protein in the cytoplasm and promoting EGFR signaling
    1
    1. scibot 24 Jan 2023
      RRID:AB_10695868

      DOI: 10.1016/j.celrep.2023.112031

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    sciencedirect.com/science/article/pii/S2211124723000426
  28. Dec 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Huntingtin exon 1 deletion does not alter the subcellular distribution of huntingtin and gene transcription in mice
    1
    1. scibot 01 Dec 2022
      RRID:AB_10695868

      DOI: 10.3389/fncel.2022.1021592

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    ncbi.nlm.nih.gov/pmc/articles/PMC9684630/
  30. Nov 2022
  31. www.sciencedirect.com www.sciencedirect.com
    Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate
    1
    1. scibot 10 Nov 2022
      RRID:AB_10695868

      DOI: 10.1016/j.cels.2022.10.003

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    sciencedirect.com/science/article/pii/S2405471222004306
  32. May 2022
  33. www.sciencedirect.com www.sciencedirect.com
    ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1
    1
    1. scibot 26 May 2022
      RRID:AB_10695868

      DOI: 10.1016/j.molcel.2022.04.034

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    sciencedirect.com/science/article/pii/S1097276522004348
  34. aacrjournals.org aacrjournals.org
    EGFR inhibition potentiates FGFR inhibitor therapy and overcomes resistance in FGFR2 fusion-positive cholangiocarcinoma
    1
    1. scibot 13 May 2022
      RRID:AB_10695868

      DOI: 10.1158/2159-8290.CD-21-1168

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    aacrjournals.org/cancerdiscovery/article/12/5/1378/694560/EGFR-Inhibition-Potentiates-FGFR-Inhibitor-Therapy
  35. elifesciences.org elifesciences.org
    Cross-species analysis of LZTR1 loss-of-function mutants demonstrates dependency to RIT1 orthologs
    1
    1. scibot 11 May 2022
      RRID:AB_10695868

      DOI: 10.7554/eLife.76495

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    elifesciences.org/articles/76495
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translational Strategies for Repotrectinib in Neuroblastoma
    1
    1. scibot 05 May 2022
      RRID:AB_10695868

      DOI: 10.1158/1535-7163.MCT-21-0126

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    ncbi.nlm.nih.gov/pmc/articles/PMC8571000/
  37. Mar 2022
  38. www.sciencedirect.com www.sciencedirect.com
    Regulation of GTPase function by autophosphorylation
    1
    1. scibot 04 Mar 2022
      RRID:AB_10695868

      DOI: 10.1016/j.molcel.2022.02.011

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    sciencedirect.com/science/article/pii/S1097276522001162
  39. Feb 2022
  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic modifier balances Mapk and Wnt signalling in differentiation of goblet and Paneth cells
    1
    1. scibot 19 Feb 2022
      RRID:AB_10695868

      DOI: 10.26508/lsa.202101187

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    ncbi.nlm.nih.gov/pmc/articles/PMC8807877/
  41. Jan 2022
  42. www.sciencedirect.com www.sciencedirect.com
    Sensing plasma membrane pore formation induces chemokine production in survivors of regulated necrosis
    1
    1. scibot 11 Jan 2022
      RRID:AB_10695868

      DOI: 10.1016/j.devcel.2021.12.015

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    sciencedirect.com/science/article/pii/S1534580721010352
  43. Aug 2021
  44. www.sciencedirect.com www.sciencedirect.com
    A proteomic and phosphoproteomic landscape of KRAS mutant cancers identifies combination therapies
    1
    1. scibot 15 Aug 2021
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      DOI: 10.1016/j.molcel.2021.07.021

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    sciencedirect.com/science/article/pii/S1097276521005906
  45. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 11 Aug 2021
      AB_10695868

      DOI: 10.1210/en.2017-00495

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    ncbi.nlm.nih.gov/pmc/articles/PMC5711380/
  46. Jul 2021
  47. mcr.aacrjournals.org mcr.aacrjournals.org
    KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis
    1
    1. scibot 30 Jul 2021
      MEK1/2

      DOI: 10.1158/1541-7786.MCR-19-0077

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    mcr.aacrjournals.org/content/17/9/1945
  48. www.sciencedirect.com www.sciencedirect.com
    The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression
    1
    1. scibot 09 Jul 2021
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      DOI: 10.1016/j.cub.2021.06.030

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    sciencedirect.com/science/article/pii/S0960982221008253
  49. Jun 2021
  50. www.sciencedirect.com www.sciencedirect.com
    Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition
    1
    1. scibot 30 Jun 2021
      RRID:AB_10695868

      DOI: 10.1016/j.celrep.2021.109291

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    sciencedirect.com/science/article/pii/S2211124721006628
  51. www.sciencedirect.com www.sciencedirect.com
    Targeted mass-spectrometry-based assays enable multiplex quantification of receptor tyrosine kinase, MAP kinase, and AKT signaling
    1
    1. scibot 15 Jun 2021
      RRID:AB_10695868

      DOI: 10.1016/j.crmeth.2021.100015

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    sciencedirect.com/science/article/pii/S2667237521000151
  52. Apr 2021
  53. www.sciencedirect.com www.sciencedirect.com
    PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK
    1
    1. scibot 01 Apr 2021
      RRID:AB_10695868

      DOI: 10.1016/j.celrep.2021.108928

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    sciencedirect.com/science/article/pii/S2211124721002424
  54. Dec 2020
  55. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma
    1
    1. scibot 15 Dec 2020
      total-MEK

      DOI: 10.1016/j.tranon.2020.100982

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    sciencedirect.com/science/article/pii/S1936523320304745
  56. Sep 2020
  57. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System
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    1. scibot 17 Sep 2020
      RRID:AB_10695868

      DOI: 10.1016/j.chembiol.2020.06.012

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    pubmed.ncbi.nlm.nih.gov/32668202/
  58. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 14 Sep 2020
      RRID:AB_10695868

      DOI: 10.1111/bph.14981

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.14981
  59. www.sciencedirect.com www.sciencedirect.com
    Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers
    1
    1. scibot 03 Sep 2020
      RRID:AB_10695868

      DOI: 10.1016/j.celrep.2020.107764

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    sciencedirect.com/science/article/pii/S2211124720307440
  60. Jan 2020
  61. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethal Interaction of SHOC2 Depletion with MEK Inhibition in RAS-Driven Cancers
    1
    1. scibot 13 Jan 2020
      RRID:AB_10695868

      DOI: 10.1016/j.celrep.2019.08.090

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    sciencedirect.com/science/article/pii/S2211124719311520
  62. Nov 2018
  63. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 05 Nov 2018
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    ncbi.nlm.nih.gov/pmc/articles/PMC6039175/
  64. www.sciencedirect.com www.sciencedirect.com
    An Acquired Vulnerability of Drug-Resistant Melanoma with Therapeutic Potential
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    sciencedirect.com/science/article/pii/S0092867418305051
  65. www.sciencedirect.com www.sciencedirect.com
    Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
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    1. scibot 05 Nov 2018
      RRID:AB_10695868

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      RRID:AB_10695868
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    sciencedirect.com/science/article/pii/S1535610817305020
  66. academic.oup.com academic.oup.com
    IL-1β Inhibits Connexin 43 and Disrupts Decidualization of Human Endometrial Stromal Cells Through ERK1/2 and p38 MAP Kinase
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    1. scibot 05 Nov 2018
      AB_10695868

      Curator: @evieth

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      RRID:AB_10695868 RRIDCUR:Validated
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    academic.oup.com/endo/article/158/12/4270/4117214
  67. Nov 2017
  68. www.sciencedirect.com www.sciencedirect.com
    DUSP9 Modulates DNA Hypomethylation in Female Mouse Pluripotent Stem Cells
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    1. scibot 08 Nov 2017
      AB_10695868

      Curator: @gabimpine

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      RRID:AB_10695868 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1934590917300735