133 Matching Annotations
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    Suppression of ATM kinase signaling accelerates cellular senescence
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    sciencedirect.com/science/article/pii/S2213671126001670
  3. May 2026
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Triptolide enhances anti-cancer activities of irinotecan in human colon cancer HT-29 cells in vitro and HT-29 cell xenograft tumor model in nude mice
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    pmc.ncbi.nlm.nih.gov/articles/PMC13201951/
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    mRNA lipid-nanoparticle-mediated mitochondrial apoptosis augments adoptive T cell immunotherapy
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  6. Apr 2026
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  8. Mar 2026
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    A preclinical candidate of cyclophilin D inhibition improves alcohol-associated liver injury
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    Raspberry Polyphenols Target Molecular Pathways of Heart Failure
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  13. Jan 2026
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    CDK4/6 inhibition overcomes venetoclax resistance mechanisms with enhanced combination activity in acute myeloid leukemia
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  15. Dec 2025
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    A 3D in vitro model for studying human implantation and implantation failure
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  17. Oct 2025
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    Cardiomyocyte-specific LARP6 overexpression prevents angiotensin II-induced myocardial dysfunction and interstitial fibrosis
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  19. Aug 2025
  20. 52.53.155.43 52.53.155.43
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  22. Jul 2025
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    Uric Acid Causes Pancreatic β Cell Death and Dysfunction via Modulating CHOP-Mediated Endoplasmic Reticulum Stress Pathways
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    Paclitaxel-induced mitotic arrest results in a convergence of apoptotic dependencies that can be safely exploited by BCL-XL degradation to overcome cancer chemoresistance
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  25. Jun 2025
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    Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
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    Mechanistic Understanding of Dexamethasone-Mediated Protection against Remdesivir-Induced Hepatotoxicity
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  31. May 2025
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  33. Apr 2025
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    BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
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  35. Mar 2025
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    The actin and microtubule network regulator WHAMM is identified as a key kidney disease risk gene
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    Unveiling ODP4: A breakthrough in PCOS treatment via BAT transplantation
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    Microglial pyroptosis drives neuropathic pain and targeting NLRP3 alleviates pain and neuroinflammation
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    Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis
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  44. Aug 2024
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    Chinese medicine Linggui Zhugan formula protects against diabetic kidney disease in close association with inhibition of proteinase 3-mediated podocyte apoptosis in mice
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    Ellagic Acid Prevents α-Synuclein Aggregation and Protects SH-SY5Y Cells from Aggregated α-Synuclein-Induced Toxicity via Suppression of Apoptosis and Activation of Autophagy
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    Monomethyl fumarate attenuates lung Ischemia/Reperfusion injury by disrupting the GAPDH/Siah1 signaling cascade
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    MTFP1 controls mitochondrial fusion to regulate inner membrane quality control and maintain mtDNA levels
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  51. May 2024
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    Ganoderma lucidum extract attenuates corticotropin-releasing hormone induced cellular senescence in human hair follicle cells
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  53. Apr 2024
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    Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome
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  55. Mar 2024
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    Anti-apoptotic MCL-1 promotes long-chain fatty acid oxidation through interaction with ACSL1
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    The BMAL1/HIF2A heterodimer modulates circadian variations of myocardial injury
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  58. Feb 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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    Lumbricus Extract Prevents LPS-Induced Inflammatory Activation of BV2 Microglia and Glutamate-Induced Hippocampal HT22 Cell Death by Suppressing MAPK/NF-κB/NLRP3 Signaling and Oxidative Stress
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  64. Jan 2024
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    Inhibition of PRL2 upregulates PTEN and attenuates tumor growth in Tp53-deficient sarcoma and lymphoma mouse models
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  66. Nov 2023
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    Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14
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  68. Oct 2023
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    Radiotherapy-Induced Neurocognitive Impairment Is Driven by Heightened Apoptotic Priming in Early Life and Prevented by Blocking BAX
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  70. Sep 2023
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    ALKBH5-mediated m6A modification of HS3ST3B1-IT1 prevents osteoarthritis progression
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    Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
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    nature.com/articles/s41422-023-00874-4
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    CCDC50 promotes tumor growth through regulation of lysosome homeostasis
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    URAT1 is expressed in cardiomyocytes and dotinurad attenuates the development of diet-induced metabolic heart disease.
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  75. Aug 2023
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  77. Jun 2023
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    METTL3-mediated m6A modification of IGFBP7-OT promotes osteoarthritis progression by regulating the DNMT1/DNMT3a-IGFBP7 axis
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  79. Apr 2023
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    USP9X mediates an acute adaptive response to MAPK suppression in pancreatic cancer but creates multiple actionable therapeutic vulnerabilities
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  81. Mar 2023
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    A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
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    FAM193A is a positive regulator of p53 activity
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    Echinocystic acid alleviated hypoxic-ischemic brain damage in neonatal mice by activating the PI3K/Akt/Nrf2 signaling pathway
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  85. Feb 2023
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    Cationic amphiphilic antihistamines inhibit STAT3 via Ca2+-dependent lysosomal H+ efflux
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  87. Jan 2023
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    Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization
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    Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect
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    ncbi.nlm.nih.gov/pmc/articles/PMC9838174/
  90. Dec 2022
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    Neuroprotective and Anti-Neuroinflammatory Properties of Vignae Radiatae Semen in Neuronal HT22 and Microglial BV2 Cell Lines
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    Selaginella tamariscina Inhibits Glutamate-Induced Autophagic Cell Death by Activating the PI3K/AKT/mTOR Signaling Pathways
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    The Neuroprotective Effects of Arecae Pericarpium against Glutamate-Induced HT22 Cell Cytotoxicity
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  94. Nov 2022
  95. www.embopress.org www.embopress.org
    LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus
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    Bcl-xL inhibition radiosensitizes PIK3CA/PTEN wild-type triple negative breast cancers with low Mcl-1 expression
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    ncbi.nlm.nih.gov/pmc/articles/PMC9648413/
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    Reciprocal effects of mTOR inhibitors on pro-survival proteins dictate therapeutic responses in tuberous sclerosis complex
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  98. Oct 2022
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    Schwann cells-derived exosomal miR-21 participates in high glucose regulation of neurite outgrowth
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  100. Sep 2022
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    Small molecule SJ572946 activates BAK to initiate apoptosis
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    Sublethal cytochrome c release generates drug-tolerant persister cells
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  104. Aug 2022
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    Analysis of neuroendocrine clones in NSCLCs using an immuno-guided laser-capture microdissection-based approach
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  106. Jul 2022
  107. aacrjournals.org aacrjournals.org
    Bcl-xL Inhibition Radiosensitizes PIK3CA/PTEN Wild-type Triple-negative Breast Cancers with Low Mcl-1 Expression
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    aacrjournals.org/cancerrescommun/article/2/7/679/707059/Bcl-xL-Inhibition-Radiosensitizes-PIK3CA-PTEN-Wild
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    British J Pharmacology - 2022 - Li - Maresin 1 intervention Reverses Experimental Pulmonary Arterial Hypertension in mice-html.html
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  109. Jun 2022
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    Regulating DNA methylation could reduce neuronal ischemia response and apoptosis after ischemia-reperfusion injury
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    Intermittent Theta Burst Stimulation Ameliorates Cognitive Deficit and Attenuates Neuroinflammation via PI3K/Akt/mTOR Signaling Pathway in Alzheimer’s-Like Disease Model
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    Jumonji domain-containing protein-3 (JMJD3/Kdm6b) is critical for normal ovarian function and female fertility
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  113. May 2022
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    Low concentrations of bisphenol A promote the activation of the mitochondrial apoptotic pathway on Beta-TC-6 cells via the generation of intracellular reactive oxygen species and mitochondrial superoxide
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  115. Apr 2022
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    Targeting the miR-34a/LRPPRC/MDR1 axis collapse the chemoresistance in P53 inactive colorectal cancer
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    Augmenting NK cell-based immunotherapy by targeting mitochondrial apoptosis
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