220 Matching Annotations
  1. Jul 2026
  2. academic.oup.com academic.oup.com
    Dual Targeting of Orphan Nuclear Receptors NR4A1 and NR4A2 for Non-Hormonal Endometriosis Therapy
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    academic.oup.com/endo/article/166/11/bqaf144/8266318
  3. Jun 2026
  4. www.sciencedirect.com www.sciencedirect.com
    Identification of FXYD5 as an oncogene in pediatric papillary thyroid cancer
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    sciencedirect.com/science/article/pii/S2589004226019358
  5. 54.241.53.176 54.241.53.176
    ssrn-5400340-html.html
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  6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacologic reversion of Merkel cell carcinoma via CBP/p300 inhibition
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    pmc.ncbi.nlm.nih.gov/articles/PMC12772197/
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    Distinct ERK and PI3K dependencies mediate a heterogeneous response to RAS(ON) inhibition in KRAS-mutant colorectal cancer
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    sciencedirect.com/science/article/pii/S2211124726006376
  8. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Proteasomal inhibition compromises microvascular integrity via distinct effects on non-immune endothelial cells and immune cells
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    pmc.ncbi.nlm.nih.gov/articles/PMC13238444/
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    RNF138 promotes cisplatin resistance and PD-L1-mediated immune evasion via JAK2/STAT3 activation in nasopharyngeal carcinoma
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    sciencedirect.com/science/article/pii/S221112472600625X
  10. May 2026
  11. www.sciencedirect.com www.sciencedirect.com
    An appendiceal cancer organoid biobank identifies phenotypic evolution and druggable dependencies of peritoneal carcinomatosis
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    sciencedirect.com/science/article/pii/S1534580726001619
  12. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Wnt3-mediated fibrosis and carcinogenesis of lung squamous cell carcinoma in idiopathic pulmonary fibrosis
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    pmc.ncbi.nlm.nih.gov/articles/PMC13127482/
  13. Apr 2026
  14. 54.241.53.176 54.241.53.176
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  15. aacrjournals.org aacrjournals.org
    QW-5-70 targets the colchicine site and demonstrates antitumor activity in P-gp–overexpressing cancer models
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70426
  17. Mar 2026
  18. www.sciencedirect.com www.sciencedirect.com
    UFMylation-dependent inhibition of AKT signaling by PHLDA3 in lung adenocarcinoma
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    sciencedirect.com/science/article/pii/S2211124726002329
  19. Feb 2026
  20. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pharmacokinetic-pharmacodynamic-efficacy modeling of the MDM2 inhibitor brigimadlin in glioblastoma patient-derived xenografts
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    pmc.ncbi.nlm.nih.gov/articles/PMC12883205/
  21. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting and dissociating HIF2α from the molecular chaperone Hsp70 triggers apoptosis in kidney cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12881505/
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    SERPINA3 mediates liver cancer cells escape from chemotherapy-induced neutrophil extracellular trap killing
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    sciencedirect.com/science/article/pii/S2211124726000343
  23. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Microbial Bile Acid Metabolite 3-oxo-LCA Inhibits Colorectal Cancer Progression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12871761/
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    Delactylation of the tumor suppressor ARHGDIB drives metastasis and chemoresistance in bladder cancer
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    sciencedirect.com/science/article/pii/S2211124726000197
  25. Jan 2026
  26. www.sciencedirect.com www.sciencedirect.com
    Pan-cancer N-glycoproteomic atlas of patient-derived xenografts uncovers FAT2 as an actionable surface target
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    sciencedirect.com/science/article/pii/S2666379125006512
  27. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    A Phase II Multi-Center Trial of Trabectedin in Combination with Olaparib in Patients with Advanced Unresectable or Metastatic Sarcoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12365955/
  28. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    SNAP23 deficiency triggers Trim21 mitochondrial translocation to suppress TFAM-mediated oxidative metabolism and drive chemoresistance in colorectal cancer
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    pmc.ncbi.nlm.nih.gov/articles/PMC12811313/
  29. www.jstage.jst.go.jp www.jstage.jst.go.jp
    IFI6 Downregulation Reverses Oxaliplatin Resistance of Colorectal Cancer Cells by Activating the ROS-Induced p38MAPK Signaling Pathway
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    jstage.jst.go.jp/article/bpb/46/1/46_b22-00439/_html/-char/en
  30. Dec 2025
  31. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Anti-mitotic agent SB-216 overcomes taxane resistance in castration-resistant prostate cancer and exhibits anti-tumour efficacy in pancreatic cancer
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    bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bph.70294
  32. Nov 2025
  33. www.sciencedirect.com www.sciencedirect.com
    CDK7 is a novel therapeutic target in fibrolamellar carcinoma
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  34. Oct 2025
  35. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Dual molecular therapy targeting tumor cell heterogeneity improves therapeutic efficacy in glioblastoma
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    Catenibacterium mitsuokai promotes hepatocellular carcinogenesis by binding to hepatocytes and generating quinolinic acid
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    Inter- and intra-tumoral ALDH1 heterogeneity in breast cancer identifies therapeutic opportunities for ALDH1A-specific inhibitors
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    sciencedirect.com/science/article/pii/S2451945625002685
  38. Sep 2025
  39. www.sciencedirect.com www.sciencedirect.com
    Pharmacological and toxicological profiling of JAMC-4/108: targeted induction of apoptosis in human colorectal cancer cells
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    sciencedirect.com/science/article/pii/S0022356525402407
  40. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Pre-clinical Modeling of Navtemadlin Pharmacokinetics, Pharmacodynamics, and Efficacy in IDH-wildtype Glioblastoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12402800/
  41. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    NF1 Loss Promotes EGFR Activation and Confers Sensitivity to EGFR Inhibition in NF1 Mutant Melanoma
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    pmc.ncbi.nlm.nih.gov/articles/PMC12221223/pdf/can-24-3904.pdf
  42. Aug 2025
  43. www.sciencedirect.com www.sciencedirect.com
    Design of multi-target peptide modulators for protein chaperone networks
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    Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression
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    sciencedirect.com/science/article/pii/S1535610825003186
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    A pan-KRAS inhibitor and its derived degrader elicit multifaceted anti-tumor efficacy in KRAS-driven cancers
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  46. Jul 2025
  47. 52.53.155.43 52.53.155.43
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  48. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting the WSB2–NOXA axis in cancer cells for enhanced sensitivity to BCL-2 family protein inhibitors
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    pmc.ncbi.nlm.nih.gov/articles/PMC12286604/
  49. www.nature.com www.nature.com
    IFNγ augments TKI efficacy by alleviating protein unfolding stress to promote GSDME-mediated pyroptosis in hepatocellular carcinoma
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    nature.com/articles/s41419-025-07839-y
  50. Jun 2025
  51. advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com
    Splicing Shift of RAC1 Accelerates Tumorigenesis and Defines a Potent Therapeutic Target in Lung Cancer
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    advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202503322
  52. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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    pmc.ncbi.nlm.nih.gov/articles/PMC12147910/
  53. 52.53.155.43 52.53.155.43
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  55. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Integrin β6 expression in colorectal cancer cells promotes liver metastasis through enhanced adhesion to endothelial fibronectin
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    onlinelibrary.wiley.com/doi/10.1002/ijc.35504
  56. May 2025
  57. www.sciencedirect.com www.sciencedirect.com
    Bacteroides fragilis promotes chemoresistance in colorectal cancer, and its elimination by phage VA7 restores chemosensitivity
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    sciencedirect.com/science/article/pii/S1931312825001830
  58. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia
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    pmc.ncbi.nlm.nih.gov/articles/PMC12089620/
  59. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Suppressing proteasome activity enhances sensitivity to actinomycin D in diffuse anaplastic Wilms tumor
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  60. Apr 2025
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    Exploiting the therapeutic vulnerability of IDH-mutant gliomas with zotiraciclib
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    sciencedirect.com/science/article/pii/S2589004225005449
  62. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    BCL-XL Protects ASS1-Deficient Cancers from Arginine Starvation–Induced Apoptosis
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  63. Mar 2025
  64. www.sciencedirect.com www.sciencedirect.com
    Screening of patient-derived organoids identifies mitophagy as a cell-intrinsic vulnerability in colorectal cancer during statin treatment
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    sciencedirect.com/science/article/pii/S2666379125001120
  65. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    7 I, a structurally modified sinomenine, exerts dual anti-GBM effects by inhibiting glioblastoma proliferation and inducing necroptosis which further mediates lysosomal cell death
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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.17464
  66. Feb 2025
  67. 52.53.155.43 52.53.155.43
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    FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma
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  69. aacrjournals.org aacrjournals.org
    ASCL1 restrains ERK1/2 to promote survival of a subset of neuroendocrine lung cancers
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    PPM1G dephosphorylates α-catenin to maintain the integrity of adherens junctions and regulates apoptosis in Sertoli cells
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    SLFN11-mediated ribosome biogenesis impairment induces TP53-independent apoptosis
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  73. Jan 2025
  74. www.sciencedirect.com www.sciencedirect.com
    Targeting N-Myc in neuroblastoma with selective Aurora kinase A degraders
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    SLC7A5 is required for cancer cell growth under arginine-limited conditions
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  76. Dec 2024
  77. www.sciencedirect.com www.sciencedirect.com
    A nonsecretory antimicrobial peptide mediates inflammatory organ damage in Drosophila renal tubules
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    RNA sensing induced by chromosome missegregation augments anti-tumor immunity
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  80. Nov 2024
  81. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Identification of ATP-Competitive Human CMG Helicase Inhibitors for Cancer Intervention that Disrupt CMG-Replisome Function
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  82. Oct 2024
  83. www.sciencedirect.com www.sciencedirect.com
    Denosumab stimulates spermatogenesis in infertile men with preserved Sertoli cell capacity
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    Development of an orally bioavailable CDK12/13 degrader and induction of synthetic lethality with AKT pathway inhibition
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  85. Aug 2024
  86. www.biorxiv.org www.biorxiv.org
    Ferroptosis susceptibility of melanoma cells: dependence on cell-type, acquired drug resistance, and medium composition
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    biorxiv.org/content/10.1101/2024.08.12.607529v1
  87. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Potential of GSPT1 as a novel target for glioblastoma therapy
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  88. cellandbioscience.biomedcentral.com cellandbioscience.biomedcentral.com
    Apatinib induces endoplasmic reticulum stress-mediated apoptosis and autophagy and potentiates cell sensitivity to paclitaxel via the IRE-1α–AKT–mTOR pathway in esophageal squamous cell carcinoma
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    cellandbioscience.biomedcentral.com/article/10.1186/s13578-021-00640-2
  89. Jul 2024
  90. www.cell.com www.cell.com
    Peptostreptococcus stomatis promotes colonic tumorigenesis and receptor tyrosine kinase inhibitor resistance by activating ERBB2-MAPK
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    cell.com/cell-host-microbe/fulltext/S1931-3128(24)00254-3
  91. www.cell.com www.cell.com
    Anti-tumor efficacy of HRS-4642 and its potential combination with proteasome inhibition in KRAS G12D-mutant cancer
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    cell.com/cancer-cell/abstract/S1535-6108(24)00226-5
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    Incense-burning smoke ingredient Auramine enhances lincRNA-p21 expression for chemosensitization in p53-mutated non-small cell lung cancer
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Energy‑stress‑mediated activation of AMPK sensitizes MPS1 kinase inhibition in triple‑negative breast cancer
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    ncbi.nlm.nih.gov/pmc/articles/PMC11223027/
  94. www.biorxiv.org www.biorxiv.org
    Actinomycin D and bortezomib disrupt protein homeostasis in Wilms tumor
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    biorxiv.org/content/10.1101/2024.06.11.598518v2
  95. Jun 2024
  96. www.cell.com www.cell.com
    Teriflunomide/leflunomide synergize with chemotherapeutics by decreasing mitochondrial fragmentation via DRP1 in SCLC
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    cell.com/iscience/abstract/S2589-0042(24)01357-9
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    Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
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    link.springer.com/article/10.1038/s41388-024-03081-6
  98. www.biorxiv.org www.biorxiv.org
    A Nonsecretory Antimicrobial Peptide Mediates Inflammatory Organ Damage in Drosophila Renal Tubules
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    biorxiv.org/content/10.1101/2024.06.10.598165v1
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    Metallo-protease Peptidase M84 from Bacillus altitudinis induces ROS-dependent apoptosis in ovarian cancer cells by targeting PAR-1
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    Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer
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  101. May 2024
  102. www.biorxiv.org www.biorxiv.org
    Biological activity of a stable 6-aryl-2-benzoyl-pyridine colchicine-binding site inhibitor, 60c, in metastatic, triple-negative breast cancer
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    Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations
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    Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts
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    SMARCA5 reprograms AKR1B1-mediated fructose metabolism to control leukemogenesis
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  106. www.cell.com www.cell.com
    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
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  107. www.biorxiv.org www.biorxiv.org
    Imipridones inhibit tumor growth and improve survival in an orthotopic liver metastasis mouse model of human uveal melanoma
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  226. May 2021
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  255. Jan 2020
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