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Unbalanced chromatin binding of Polycomb complexes drives neurodevelopmental disorders

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1. scibot 10 Feb 2026
  
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  DOI: 10.1016/j.molcel.2026.01.023
  
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sciencedirect.com/science/article/pii/S1097276526000651
Sep 2025
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A pathological role of O-GlcNAcylation-driven TR11B production and function in lung adenocarcinoma

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1. scibot 11 Sep 2025
  
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  DOI: 10.1016/j.devcel.2025.08.010
  
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sciencedirect.com/science/article/pii/S1534580725005301
Aug 2025
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Distinct specificity and functions of PRC2 subcomplexes in human stem cells and cardiac differentiation

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.molcel.2025.07.014
  
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sciencedirect.com/science/article/pii/S109727652500615X
Jul 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex

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1. scibot 30 Jul 2025
  
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  DOI: 10.1126/sciadv.adw4603
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12292926/
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PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex

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  DOI: 10.1126/sciadv.adw4603
  
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science.org/doi/10.1126/sciadv.adw4603
May 2025
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A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma

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1. scibot 22 May 2025
  
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  DOI: 10.1016/j.molcel.2025.04.026
  
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sciencedirect.com/science/article/pii/S1097276525004058
Mar 2025
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Isogenic comparison of Airn and Xist reveals core principles of Polycomb recruitment by lncRNAs

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1. scibot 23 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.014
  
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cell.com/molecular-cell/fulltext/S1097-2765(25)00145-5
Feb 2025
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mcr-24-0362-html.html

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1. scibot 14 Feb 2025
  
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  DOI: 10.1158/1541-7786.mcr-24-0362
  
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52.53.155.43/207b5fa35418e37cf8e0644578bdc1e4a04283c1/mcr-24-0362-html.html
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Protocol for visualizing the chromatin assembly properties of epigenetic protein complexes via an HTM module-mediated artificial tethering system

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1. scibot 13 Feb 2025
  
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  DOI: 10.1016/j.xpro.2025.103597
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11803143/
Jan 2025
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Nucleosomal asymmetry shapes histone mark binding and promotes poising at bivalent domains

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  DOI: 10.1016/j.molcel.2024.12.002
  
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sciencedirect.com/science/article/pii/S1097276524009973
Dec 2024
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mcr-24-0362-html.html

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52.53.155.43/207b5fa35418e37cf8e0644578bdc1e4a04283c1/mcr-24-0362-html.html
Nov 2024
elifesciences.org elifesciences.org

The E3 ubiquitin ligase RNF220 maintains hindbrain Hox expression patterns through regulation of WDR5 stability

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1. scibot 14 Nov 2024
  
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  DOI: 10.7554/eLife.94657
  
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elifesciences.org/articles/94657
May 2024
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Improved detection of DNA replication fork-associated proteins

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1. scibot 07 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114178
  
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sciencedirect.com/science/article/pii/S2211124724005060
Apr 2024
rupress.org rupress.org

DUX4-induced HSATII transcription causes KDM2A/B-PRC1 nuclear foci and impairs DNA damage response

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1. scibot 25 Apr 2024
  
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  DOI: 10.1083/jcb.202303141
  
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rupress.org/jcb/article/223/5/e202303141/276604/DUX4-induced-HSATII-transcription-causes-KDM2A-B
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CBX7C•PHC2 interaction facilitates PRC1 assembly and modulates its phase separation properties

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1. scibot 11 Apr 2024
  
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  DOI: 10.1016/j.isci.2024.109548
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11004992/
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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

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1. scibot 04 Apr 2024
  
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  DOI: 10.1016/j.devcel.2024.03.020
  
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sciencedirect.com/science/article/pii/S1534580724001886
Mar 2024
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Modularity of PRC1 composition and chromatin interaction define condensate properties

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1. scibot 29 Mar 2024
  
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  DOI: 10.1016/j.molcel.2024.03.001
  
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  DOI: 10.1016/j.molcel.2024.03.001
  
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sciencedirect.com/science/article/pii/S1097276524001813
Nov 2023
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Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.chembiol.2023.10.005
  
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sciencedirect.com/science/article/pii/S2451945623003665
Jul 2023
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Proximity-dependent recruitment of Polycomb repressive complexes by the lncRNA Airn

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1. scibot 13 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112803
  
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sciencedirect.com/science/article/pii/S2211124723008148
Feb 2023
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Recycling of modified H2A-H2B provides short-term memory of chromatin states

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1. scibot 09 Feb 2023
  
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  DOI: 10.1016/j.cell.2023.01.007
  
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sciencedirect.com/science/article/pii/S0092867423000077
Oct 2022
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BCOR and BCORL1 Mutations Drive Epigenetic Reprogramming and Oncogenic Signaling by Unlinking PRC1.1 from Target Genes

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1. scibot 12 Oct 2022
  
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  DOI: 10.1158/2643-3230.BCD-21-0115
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9414116/
Jun 2022
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Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration

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1. scibot 17 Jun 2022
  
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  DOI: 10.1016/j.isci.2022.104519
  
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sciencedirect.com/science/article/pii/S2589004222007908
May 2022
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XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation

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1. scibot 25 May 2022
  
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  DOI: 10.1016/j.cell.2022.04.034
  
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sciencedirect.com/science/article/pii/S0092867422005323
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NSD1 mediates antagonism between SWI/SNF and polycomb complexes and is required for transcriptional activation upon EZH2 inhibition

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1. scibot 12 May 2022
  
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  DOI: 10.1016/j.molcel.2022.04.015
  
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sciencedirect.com/science/article/pii/S1097276522003264
Mar 2022
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BMI-1 regulates DNA end resection and homologous recombination repair

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1. scibot 23 Mar 2022
  
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  DOI: 10.1016/j.celrep.2022.110536
  
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sciencedirect.com/science/article/pii/S2211124722002777
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Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions

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1. scibot 23 Mar 2022
  
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  DOI: 10.7554/eLife.73524
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8933006/
Jan 2022
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Establishment of developmental gene silencing by ordered polycomb complex recruitment in early zebrafish embryos

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1. scibot 26 Jan 2022
  
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  DOI: 10.7554/eLife.67738
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8769650/
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Impaired KDM2B-mediated PRC1 recruitment to chromatin causes defective neural stem cell self-renewal and ASD/ID-like behaviors

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  DOI: 10.1016/j.isci.2022.103742
  
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sciencedirect.com/science/article/pii/S2589004222000128
Oct 2021
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Reprogramming CBX8-PRC1 function with a positive allosteric modulator

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1. scibot 29 Oct 2021
  
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  DOI: 10.1016/j.chembiol.2021.10.003
  
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sciencedirect.com/science/article/pii/S2451945621004372
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A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells

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  DOI: 10.1016/j.molcel.2021.09.018
  
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sciencedirect.com/science/article/pii/S1097276521007528
Sep 2021
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UV-induced reduction in Polycomb repression promotes epidermal pigmentation

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1. scibot 03 Sep 2021
  
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  DOI: 10.1016/j.devcel.2021.08.006
  
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sciencedirect.com/science/article/pii/S1534580721006365
Aug 2021
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Untitled document

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1. scibot 12 Aug 2021
  
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  DOI: 10.1016/j.molcel.2018.12.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6414425/
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Untitled document

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1. scibot 05 Aug 2021
  
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  DOI: 10.7554/eLife.38771
  
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europepmc.org/articles/PMC6037479/
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Untitled document

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  DOI: 10.1016/j.devcel.2018.11.018
  
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sciencedirect.com/science/article/pii/S1534580718309742
Jul 2021
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Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas

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1. scibot 29 Jul 2021
  
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  DOI: 10.1016/j.celrep.2019.10.083
  
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sciencedirect.com/science/article/pii/S2211124719314056
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PRC1 Catalytic Activity Is Central to Polycomb System Function

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1. scibot 27 Jul 2021
  
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  RRID:AB_20705604
  
  DOI: 10.1016/j.molcel.2019.12.001
  
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sciencedirect.com/science/article/pii/S1097276519308925
Sep 2020
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Generation of two RNF2 homozygous knockout human embryonic stem cell lines by CRISPR/Cas9 system

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1. scibot 23 Sep 2020
  
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  RRID:AB_10705604
  
  DOI: 10.1016/j.scr.2020.101885
  
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  RRID:AB_10705604 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1873506120301860
Jan 2020
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lncRNA-Induced Spread of Polycomb Controlled by Genome Architecture, RNA Abundance, and CpG Island DNA

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1. scibot 13 Jan 2020
  
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  RRID:AB_10705604
  
  DOI: 10.1016/j.molcel.2019.05.028
  
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sciencedirect.com/science/article/pii/S1097276519304009
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Untitled document

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1. scibot 13 Jan 2020
  
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  RRID:AB_10705604
  
  DOI: 10.1016/j.molcel.2018.12.016
  
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  Curator: @evieth
  
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  RRID:AB_10705604 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S1097276518310700
Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6037479/
Nov 2017
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RNA Helicase DDX5 Inhibits Reprogramming to Pluripotency by miRNA-Based Repression of RYBP and its PRC1-Dependent and -Independent Functions

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1. scibot 08 Nov 2017
  
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  AB_10705604
  
  Curator: @gabimpine
  
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sciencedirect.com/science/article/pii/S1934590916304581