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Berberine, a natural molecular glue degrader, overcomes CML resistance via TRIM28-mediated HIF1α ubiquitination and subsequent ferroptosis

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1. scibot 09 Sep 2026
  
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  DOI: 10.1016/j.celrep.2026.117889
  
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sciencedirect.com/science/article/pii/S2211124726009678
Jul 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

A sequential dual-drug delivery system for multi-target inhibition of subretinal fibrosis

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1. scibot 24 Jul 2026
  
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  DOI: 10.1186/s12951-026-04390-6
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13390192/
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HDAC5 depletion promotes hyper-acetylation of FOXA1 and potentiates HIF1α transcriptional activation in pancreatic cancer

1
1. scibot 10 Jul 2026
  
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  DOI: 10.1016/j.molcel.2026.06.022
  
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sciencedirect.com/science/article/pii/S1097276526004119
Jun 2026
54.241.53.176 54.241.53.176

Targeting ERLIN1 reveals a coordinated cholesterol-dependent vulnerability in hepatocellular carcinoma

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1. scibot 20 Jun 2026
  
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  DOI: 10.3350/cmh.2025.1157
  
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54.241.53.176/bf88d95789389f32d043367dc0db82344a10fd26/cmh-2025-1157-Supplementary-Table-9-html.html
Mar 2026
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Single-cell spatial transcriptomics reveals tumor microenvironment heterogeneity in primary and lymph node-metastatic small cell lung cancer

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102713
  
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sciencedirect.com/science/article/pii/S2666379126001308
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Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity

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1. scibot 20 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117123
  
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sciencedirect.com/science/article/pii/S2211124726002019
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pH-responsive CaCO3 nanoplatform amplifies SDT via calcium overload-ROS loop for deep tumor therapy

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1. scibot 10 Mar 2026
  
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  DOI: 10.1016/j.isci.2026.115082
  
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sciencedirect.com/science/article/pii/S2589004226004578
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TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer

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1. scibot 05 Mar 2026
  
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  DOI: 10.1016/j.canlet.2026.218396
  
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sciencedirect.com/science/article/pii/S030438352600159X
Feb 2026
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Vascular normalization by erianin unleashes CAR-T immunotherapy in glioblastoma

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1. scibot 26 Feb 2026
  
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  DOI: 10.1007/s10456-026-10031-1
  
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link.springer.com/article/10.1007/s10456-026-10031-1
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1-s2.0-S2589004226002919-main-html.html

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1. scibot 12 Feb 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12936848/
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Shen-Shuai-II-Recipe inhibits aerobic glycolysis through SIRT1 in 5/6 ablation/infarction renal failure model

1
1. scibot 10 Feb 2026
  
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  DOI: 10.1038/s41598-026-35061-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12877090/
Jan 2026
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PDZRN4 suppresses lung adenocarcinoma progression via inhibiting ubiquitin-mediated HIF-1A degradation

1
1. scibot 06 Jan 2026
  
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  DOI: 10.1038/s41388-025-03670-z
  
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nature.com/articles/s41388-025-03670-z
Aug 2025
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Oroxin A suppresses colorectal tumor growth by regulating the TRIM24-mediated ferroptosis and TSPO pathway

1
1. scibot 08 Aug 2025
  
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  DOI: 10.1016/j.isci.2025.113196
  
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sciencedirect.com/science/article/pii/S2589004225014579
May 2025
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Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115771
  
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sciencedirect.com/science/article/pii/S221112472500542X
Apr 2025
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Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription

1
1. scibot 03 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115487
  
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sciencedirect.com/science/article/pii/S221112472500258X
Mar 2025
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Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions

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1. scibot 06 Mar 2025
  
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  DOI: 10.4103/NRR.NRR-D-23-01035
  
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journals.lww.com/nrronline/fulltext/2025/07000/m_ller_cells_are_activated_in_response_to_retinal.32.aspx
Jan 2025
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The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism

1
1. scibot 31 Jan 2025
  
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  DOI: 10.1016/j.molcel.2025.01.006
  
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sciencedirect.com/science/article/pii/S109727652500036X
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Claudin-4 stabilizes the genome via nuclear and cell cycle remodeling to support ovarian cancer cell survival

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1. scibot 15 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0558
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11705808/
Dec 2024
52.53.155.43 52.53.155.43

crc-24-0558-html.html

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1. scibot 24 Dec 2024
  
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  DOI: 10.1158/2767-9764.crc-24-0558
  
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52.53.155.43/84b181f6e67618dcb22aba5ea65de17db9b57a38/crc-24-0558-html.html
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Ras-Related Protein Rab-7a Regulates Glucose Metabolism under Hypoxia by Interacting with Hypoxia-Inducible Factor 1-Alpha in HepG2 Cells

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1. scibot 21 Dec 2024
  
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  20960-1-AP
  
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link.springer.com/article/10.1134/S0026893324060104
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Transposable element exonization generates a reservoir of evolving and functional protein isoforms

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1. scibot 12 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.011
  
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sciencedirect.com/science/article/pii/S009286742401328X
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Novel serous effusion-related risk models and biomarkers for predicting prognosis in T-cell lymphoma patients

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1. scibot 06 Dec 2024
  
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  DOI: 10.1007/s00277-024-06109-9
  
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link.springer.com/article/10.1007/s00277-024-06109-9
Sep 2024
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KRT19 is regulated by miR-642a-5p and promotes pancreatic cancer progression through the Wnt/β-catenin pathway

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.isci.2024.110782
  
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sciencedirect.com/science/article/pii/S2589004224020078
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Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism

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1. scibot 17 Sep 2024
  
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  DOI: 10.1016/j.apsb.2024.09.010
  
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sciencedirect.com/science/article/pii/S2211383524003733
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Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents

1
1. scibot 14 Sep 2024
  
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  DOI: 10.1101/2024.09.04.611120
  
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biorxiv.org/content/10.1101/2024.09.04.611120v1
Aug 2024
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A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer

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  DOI: 10.1016/j.celrep.2024.114633
  
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sciencedirect.com/science/article/pii/S2211124724009835
Jul 2024
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Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110188
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11233973/
Mar 2024
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The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α-ACER2-Ceramide Signaling Axis

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1. scibot 12 Mar 2024
  
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  DOI: 10.1002/advs.202309525
  
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onlinelibrary.wiley.com/doi/10.1002/advs.202309525
Jan 2024
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A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.molcel.2023.11.038
  
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sciencedirect.com/science/article/pii/S1097276523010146
Nov 2023
52.53.155.43 52.53.155.43

JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia

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1. scibot 04 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108242
  
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52.53.155.43/6be56724144b1726399953666c182a50bbffb46a/1-s2.0-S2589004223023192-main-html.html
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis

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1. scibot 25 Jul 2023
  
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  DOI: 10.4103/1673-5374.371366
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10360089/
Jun 2023
www.science.org www.science.org

HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis

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1. scibot 16 Jun 2023
  
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  DOI: 10.1126/sciadv.ade1155
  
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2. scibot 12 Jun 2023
  
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  RRID:AB_10732601
  
  DOI: 10.1126/sciadv.ade1155
  
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science.org/doi/10.1126/sciadv.ade1155
May 2023
www.nature.com www.nature.com

Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype

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1. scibot 18 May 2023
  
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  DOI: 10.1038/s41416-023-02282-2
  
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nature.com/articles/s41416-023-02282-2
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Single-cell transcriptomics of human-skin-equivalent organoids

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1. scibot 17 May 2023
  
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  RRID:AB_10732601
  
  DOI: 10.1016/j.celrep.2023.112511
  
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sciencedirect.com/science/article/pii/S2211124723005223
Oct 2022
journals.lww.com journals.lww.com

Mechanism of piR-1245/PIWI-like protein-2 regulating Janus... : Neural Regeneration Research

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1. scibot 21 Oct 2022
  
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  RRID:AB_10732601
  
  DOI: 10.4103/1673-5374.355819
  
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journals.lww.com/nrronline/Fulltext/2023/05000/Mechanism_of_piR_1245_PIWI_like_protein_2.33.aspx
Aug 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Cell-Type Dependent Regulation of the Electrogenic Na+/HCO3− Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma

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1. scibot 27 Aug 2022
  
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  RRID:AB_10732601
  
  DOI: 10.3390/ijms23168975
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9408864/
Jul 2021
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KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis

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1. scibot 30 Jul 2021
  
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  Rabbit polyclonal antibody anti-HIF-1α
  
  DOI: 10.1016/j.molcel.2019.09.019
  
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  RRID:AB_10732601 RRIDCUR:Missing
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sciencedirect.com/science/article/pii/S1097276519307245
Oct 2020
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Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner

1
1. scibot 02 Oct 2020
  
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  RRID:AB_10732601
  
  DOI: 10.1016/j.redox.2020.101742
  
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sciencedirect.com/science/article/pii/S2213231720309472
Jan 2020
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Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰

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1. scibot 13 Jan 2020
  
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  RRID:AB_10732601
  
  DOI: 10.1016/j.ebiom.2019.09.041
  
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sciencedirect.com/science/article/pii/S2352396419306541
Nov 2018
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Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

1
1. scibot 05 Nov 2018
  
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  RRID:AB_10732601
  
  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S2352396418301506
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Transcriptional Regulation of the Warburg Effect in Cancer by SIX1

1
1. scibot 05 Nov 2018
  
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  AB_10732601
  
  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S1535610818300102