158 Matching Annotations
  1. Last 7 days
  2. www.mdpi.com www.mdpi.com
    Define Critical Parameters of Trastuzumab-Mediated ADCC Assays via Assay Optimization Processes, Focusing on the Impact of Cryopreserved Effector Cells on Assay Performance
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    1. scibot 04 Jul 2024
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      DOI: 10.3390/cancers16132367

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  3. Jun 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Lineage specification in glioblastoma is regulated by METTL7B
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  5. May 2024
  6. journals.asm.org journals.asm.org
    The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
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      DOI: 10.1128/mbio.00499-24

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  7. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Long Non-Coding RNA Gene AC027288.3 Plays a Role in Human Endometrial Stromal Fibroblast Decidualization
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      DOI: 10.3390/cells13090778

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    Contrasting consequences of podocyte IGF1R inhibition
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    1. scibot 09 May 2024
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  9. 52.53.155.43 52.53.155.43
    SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells
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  10. Apr 2024
  11. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Variant-specific effects of GBA1 mutations on dopaminergic neuron proteostasis
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      DOI: 10.1111/jnc.16114

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    The recruitment of TRiC chaperonin in rotavirus viroplasms correlates with virus replication
    1
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  13. Mar 2024
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    Matrilin-3 supports neuroprotection in ischemic stroke by suppressing astrocyte-mediated neuroinflammation
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    sciencedirect.com/science/article/pii/S2211124724003085
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    DNAJB8 oligomerization is mediated by an aromatic-rich motif that is dispensable for substrate activity
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    1. scibot 21 Mar 2024
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    sciencedirect.com/science/article/pii/S0969212624000558
  16. Feb 2024
  17. www.biorxiv.org www.biorxiv.org
    The polyamine transporter ATP13A3 mediates DFMO-induced polyamine uptake in neuroblastoma
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    1. scibot 29 Feb 2024
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  18. 52.53.155.43 52.53.155.43
    RAS isoform specific activities are disrupted by disease associated mutations during cell differentiation
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    1. scibot 22 Feb 2024
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      DOI: 10.1101/2023.10.05.561021

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  19. Jan 2024
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    Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy
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      DOI: 10.1016/j.xcrm.2023.101383

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    RHOAL57V drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling
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    1. scibot 20 Jan 2024
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      DOI: 10.1126/scisignal.adg5289

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  22. Dec 2023
  23. www.sciencedirect.com www.sciencedirect.com
    Subcytoplasmic location of translation controls protein output
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    sciencedirect.com/science/article/pii/S109727652300970X
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    Sequestration of translation initiation factors in p62 condensates
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      DOI: 10.1016/j.celrep.2023.113583

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    sciencedirect.com/science/article/pii/S2211124723015954
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    Smad4 sequestered in SFPQ condensates prevents TGF-β tumor-suppressive signaling
    1
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      DOI: 10.1016/j.devcel.2023.11.020

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    sciencedirect.com/science/article/pii/S1534580723006184
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33
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      DOI: 10.1038/s41420-023-01716-3

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    Nutrient-regulated control of lysosome function by signaling lipid conversion
    1
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      DOI: 10.1016/j.cell.2023.09.027

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    sciencedirect.com/science/article/pii/S0092867423010814
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    Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
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    1. scibot 02 Dec 2023
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      DOI: 10.1186/s13048-023-01312-0

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  29. Nov 2023
  30. www.biorxiv.org www.biorxiv.org
    Adipose-derived exosomal miR-421 targets CBX7 and promotes metastatic potential in ovarian cancer cells
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    1. scibot 17 Nov 2023
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      DOI: 10.1101/2023.11.07.566022

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    biorxiv.org/content/10.1101/2023.11.07.566022v1
  31. Sep 2023
  32. www.sciencedirect.com www.sciencedirect.com
    NAD+ rescues aging-induced blood-brain barrier damage via the CX43-PARP1 axis
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      DOI: 10.1016/j.neuron.2023.08.010

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    sciencedirect.com/science/article/abs/pii/S0896627323006220
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of autophagy deficiency and cytotoxicity in autophagy-deficient human embryonic stem cell-derived neurons
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      DOI: 10.1016/j.xpro.2023.102529

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    ncbi.nlm.nih.gov/pmc/articles/PMC10474488/
  34. Aug 2023
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha
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      DOI: 10.3389/fimmu.2023.1183714

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  36. www.sciencedirect.com www.sciencedirect.com
    Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
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      DOI: 10.1016/j.cmet.2023.07.003

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    sciencedirect.com/science/article/pii/S1550413123002632
  37. Jul 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation
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      DOI: 10.1016/j.celrep.2023.112830

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    Type 2 diabetes susceptibility gene GRK5 regulates physiological pancreatic β-cell proliferation via phosphorylation of HDAC5
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      DOI: 10.1016/j.isci.2023.107311

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    DIRAS3 enhances RNF19B-mediated RAC1 ubiquitination and degradation in non-small-cell lung cancer cells
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      DOI: 10.1016/j.isci.2023.107157

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    sciencedirect.com/science/article/pii/S2589004223012348
  41. Jun 2023
  42. www.biorxiv.org www.biorxiv.org
    The lipid flippase ATP10B enables cellular lipid uptake under stress conditions
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      DOI: 10.1101/2023.06.01.543059

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    The Rab5 effector FERRY links early endosomes with mRNA localization
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    sciencedirect.com/science/article/pii/S1097276523003611
  44. May 2023
  45. www.sciencedirect.com www.sciencedirect.com
    Protocol to determine the subcellular localization of protein interactions in murine keratinocytes
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      DOI: 10.1016/j.xpro.2023.102309

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    sciencedirect.com/science/article/pii/S2666166723002769
  46. Apr 2023
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    NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
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    sciencedirect.com/science/article/pii/S2211124723003832
  48. Mar 2023
  49. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    MFN1 augmentation prevents retinal degeneration in a Charcot-Marie-Tooth type 2A mouse model
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      DOI: 10.1016/j.isci.2023.106270

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    ncbi.nlm.nih.gov/pmc/articles/PMC10014277/
  50. www.mdpi.com www.mdpi.com
    NAADP-Evoked Ca2+ Signaling Leads to Mutant Huntingtin Aggregation and Autophagy Impairment in Murine Astrocytes
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      DOI: 10.3390/ijms24065593

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  51. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Novel Green Fluorescent Polyamines to Analyze ATP13A2 and ATP13A3 Activity in the Mammalian Polyamine Transport System
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      DOI: 10.3390/biom13020337

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      DOI: 10.3390/biom13020337

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    ncbi.nlm.nih.gov/pmc/articles/PMC9953717/
  52. Feb 2023
  53. journals.lww.com journals.lww.com
    Long noncoding RNA H19 regulates degeneration and... : Neural Regeneration Research
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      DOI: 10.4103/1673-5374.363182

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    journals.lww.com/nrronline/Fulltext/2023/08000/Long_noncoding_RNA_H19_regulates_degeneration_and.44.aspx
  54. www.nature.com www.nature.com
    Caldendrin represses neurite regeneration and growth in dorsal root ganglion neurons
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      DOI: 10.1038/s41598-023-29622-9

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    nature.com/articles/s41598-023-29622-9
  55. Jan 2023
  56. www.sciencedirect.com www.sciencedirect.com
    HIF-1α accumulation in response to transient hypoglycemia may worsen diabetic eye disease
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  57. Nov 2022
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    Autophagy promotes cell survival by maintaining NAD levels
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      DOI: 10.1016/j.devcel.2022.10.008

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  59. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      DOI: 10.1111/bph.15971

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  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PGC-1α in the myofibers regulates the balance between myogenic and adipogenic progenitors affecting muscle regeneration
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    Long non-coding RNA PCAT19 safeguards DNA in quiescent endothelial cells by preventing uncontrolled phosphorylation of RPA2
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    Metabolic regulation by p53 prevents R-loop-associated genomic instability
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  63. Oct 2022
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    Targeting RTN4/NoGo-Receptor reduces levels of ALS protein ataxin-2
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    Genome-wide CRISPR screen reveals v-ATPase as a drug target to lower levels of ALS protein ataxin-2
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  66. Sep 2022
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    ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains
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    Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development
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  69. Aug 2022
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    RAD51 protects human cells from transcription-replication conflicts
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    APOE4 drives inflammation in human astrocytes via TAGLN3 repression and NF-κB activation
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  72. Jul 2022
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    Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
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    PDZK1 interacting protein 1 (PDZK1IP1) promotes the progression of papillary thyroid cancer
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    Differentiated glioma cell-derived fibromodulin activates integrin-dependent Notch signaling in endothelial cells to promote tumor angiogenesis and growth
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    Aberrant expression and subcellular localization of ECT2 drives colorectal cancer progression and growth
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  77. Jun 2022
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    The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
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  79. May 2022
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA-PK promotes DNA end resection at DNA double strand breaks in G0 cells
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    Dysfunction of Inflammatory Pathways and Their Relationship With Psychological Factors in Adult Female Patients With Eating Disorders
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    Gene body methylation of the lymphocyte-specific gene CARD11 results in its overexpression and regulates cancer mTOR signaling
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  83. Apr 2022
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    Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling
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    RNA transcription and degradation of Alu retrotransposons depends on sequence features and evolutionary history
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  86. Mar 2022
  87. www.embopress.org www.embopress.org
    Endosomal phosphatidylinositol 3-phosphate controls synaptic vesicle cycling and neurotransmission
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  88. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  89. Feb 2022
  90. www.sciencedirect.com www.sciencedirect.com
    Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling
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    Steroid hormone receptor and infiltrating immune cell status reveals therapeutic vulnerabilities of ESR1 mutant breast cancer.
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  92. Jan 2022
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    Clathrin-independent endocytic retrieval of SV proteins mediated by the clathrin adaptor AP-2 at mammalian central synapses
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  94. Dec 2021
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    Inhibition of extracellular vesicle-associated MMP2 abrogates intercellular hepatic miR-122 transfer to liver macrophages and curtails inflammation
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  96. Nov 2021
  97. www.cell.com www.cell.com
    TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
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  98. Oct 2021
  99. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Synaptotagmin-11 inhibits spontaneous neurotransmission through vti1a
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    Homocysteine inhibits pro-insulin receptor cleavage and causes insulin resistance via protein cysteine-homocysteinylation
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    A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation
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    Effect of retinol dehydrogenase gene transfer in a novel rat model of Stargardt disease
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  103. Sep 2021
  104. www.sciencedirect.com www.sciencedirect.com
    Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK
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    Therapeutic potential of iron modulating drugs in a mouse model of multiple system atrophy
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    Overexpression of α-synuclein inhibits mitochondrial Ca2+ trafficking between the endoplasmic reticulum and mitochondria through MAMs by altering the GRP75–IP3R interaction
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  107. Aug 2021
  108. www.sciencedirect.com www.sciencedirect.com
    Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic
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    CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance
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    The non-canonical target PARP16 contributes to polypharmacology of the PARP inhibitor talazoparib and its synergy with WEE1 inhibitors
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    Fendiline Enhances the Cytotoxic Effects of Therapeutic Agents on PDAC Cells by Inhibiting Tumor-Promoting Signaling Events: A Potential Strategy to Combat PDAC
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    Chemo-proteomics exploration of HDAC degradability by small molecule degraders
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  114. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates
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  117. Jul 2021
  118. academic.oup.com academic.oup.com
    Negative Regulator of Ubiquitin-Like Protein 1 modulates the autophagy-lysosomal pathway via p62 to facilitate the extracellular release of tau following proteasome impairment
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      mouse monoclonal anti-GAPDH

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  119. academic.oup.com academic.oup.com
    Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models
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  120. molecularbrain.biomedcentral.com molecularbrain.biomedcentral.com
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    Neuroplasticity and inflammatory alterations in the nucleus accumbens are corrected after risperidone treatment in a schizophrenia-related developmental model in rats
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    Highly efficient manipulation of nervous system gene expression with NEPTUNE
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  125. Jun 2021
  126. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Enhanced tyrosine hydroxylase activity induces oxidative stress, causes accumulation of autotoxic catecholamine metabolites, and augments amphetamine effects in vivo
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    NADK is activated by oncogenic signaling to sustain pancreatic ductal adenocarcinoma
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  128. May 2021
  129. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood–brain barrier leakage in mice
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      DOI: 10.1111/jnc.15302

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  130. www.sciencedirect.com www.sciencedirect.com
    RhoA/Cdc42 signaling drives cytoplasmic maturation but not endomitosis in megakaryocytes
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      DOI: 10.1016/j.celrep.2021.109102

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    Efficient generation of isogenic primary human myeloid cells using CRISPR-Cas9 ribonucleoproteins
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  132. Apr 2021
  133. www.sciencedirect.com www.sciencedirect.com
    p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR)
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      DOI: 10.1016/j.cell.2020.12.025

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  134. Mar 2021
  135. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Pimavanserin, a 5HT2A receptor inverse agonist, rapidly suppresses Aβ production and related pathology in a mouse model of Alzheimer’s disease
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      mouse‐anti‐GAPDH

      DOI: 10.1111/jnc.15260

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  136. Feb 2021
  137. academic.oup.com academic.oup.com
    A Positive Feedback Loop Between TGFβ and Androgen Receptor Supports Triple-Negative Breast Cancer Anoikis Resistance
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      DOI: 10.1210/endocr/bqaa226

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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
    1
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      RRID:AB_1078991

      DOI: 10.1016/j.celrep.2020.107537

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  139. cancerandmetabolism.biomedcentral.com cancerandmetabolism.biomedcentral.com
    The PD-L1 metabolic interactome intersects with choline metabolism and inflammation
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      DOI: 10.1186/s40170-021-00245-w

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  140. www.sciencedirect.com www.sciencedirect.com
    Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype
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    Aquaporin 1 and the Na+/K+/2Cl− cotransporter 1 are present in the leptomeningeal vasculature of the adult rodent central nervous system
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      AB_1078991

      DOI: 10.1186/s12987-020-0176-z

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  142. elifesciences.org elifesciences.org
    Iron derived from autophagy-mediated ferritin degradation induces cardiomyocyte death and heart failure in mice
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      DOI: 10.7554/eLife.62174

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  143. Dec 2020
  144. www.sciencedirect.com www.sciencedirect.com
    Capture of Mouse and Human Stem Cells with Features of Formative Pluripotency
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  145. Nov 2020
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    G9a Promotes Breast Cancer Recurrence through Repression of a Pro-inflammatory Program
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  147. Sep 2020
  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Knocking Out Non-muscle Myosin II in Retinal Ganglion Cells Promotes Long-Distance Optic Nerve Regeneration
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      RRID:AB_1078991

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  149. www.sciencedirect.com www.sciencedirect.com
    A Highly Conserved Circular RNA Is Required to Keep Neural Cells in a Progenitor State in the Mammalian Brain
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  150. www.cell.com www.cell.com
    SUPT4H1 Depletion Leads to a Global Reduction in RNA
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    cell.com/cell-reports/abstract/S2211-1247(18)31915-6
  151. elifesciences.org elifesciences.org
    Molecular pathway analysis towards understanding tissue vulnerability in spinocerebellar ataxia type 1
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      DOI: 10.7554/eLife.39981

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    A Quantitative Genetic Interaction Map of HIV Infection
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      RRID:AB_1078991

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  153. www.sciencedirect.com www.sciencedirect.com
    Assembly of Peripheral Actomyosin Bundles in Epithelial Cells Is Dependent on the CaMKK2/AMPK Pathway
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      RRID:AB_1078991

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  154. elifesciences.org elifesciences.org
    Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome
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      RRID:AB_1078991

      DOI: 10.7554/eLife.38430

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  155. diabetes.diabetesjournals.org diabetes.diabetesjournals.org
    RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes
    1
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      GAPDH

      DOI: 10.2337/db19-0508

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  156. www.embopress.org www.embopress.org
    Adaptive RSK‐EphA2‐GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer
    1
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      GAPDH

      DOI: 10.15252/emmm.201911177

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    embopress.org/doi/abs/10.15252/emmm.201911177
  157. mcb.asm.org mcb.asm.org
    Impact of losing hRpn13 Pru or UCHL5 on proteasome clearance of ubiquitinated proteins and RA190 cytotoxicity
    1
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      anti-GAPDH

      DOI: 10.1128/MCB.00122-20

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  158. www.nature.com www.nature.com
    C9orf72 in myeloid cells suppresses STING-induced inflammation
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      glyceraldehyde-3-phosphate dehydrogenase

      DOI: 10.1038/s41586-020-2625-x

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  159. academic.oup.com academic.oup.com
    Full length RTEL1 is required for the elongation of the single-stranded telomeric overhang by telomerase
    1
    1. scibot 03 Sep 2020
      Anti-GAPDH

      DOI: 10.1093/nar/gkaa503

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  160. Aug 2020
  161. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ankyrin-G mediates targeting of both Na+ and KATP channels to the rat cardiac intercalated disc
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  162. Jan 2020
  163. cancerres.aacrjournals.org cancerres.aacrjournals.org
    HORMAD1 Is a Negative Prognostic Indicator in Lung Adenocarcinoma and Specifies Resistance to Oxidative and Genotoxic Stress
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  164. www.sciencedirect.com www.sciencedirect.com
    Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes
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    ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection
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  166. www.jneurosci.org www.jneurosci.org
    Risperidone ameliorates prefrontal cortex neural atrophy and oxidative/nitrosative stress in brain and peripheral blood of rats with neonatal ventral hippocampus lesion
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  167. www.sciencedirect.com www.sciencedirect.com
    Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments
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    The Retinal Ganglion Cell Transportome Identifies Proteins Transported to Axons and Presynaptic Compartments in the Visual System In Vivo
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      DOI: 10.1016/j.celrep.2019.07.037

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  169. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  172. www.sciencedirect.com www.sciencedirect.com
    Genetic and Functional Dissection of the Role of Individual 5-HT2 Receptors as Entry Receptors for JC Polyomavirus
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      DOI: 10.1016/j.stem.2019.03.017

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  181. Nov 2018
  182. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  183. www.sciencedirect.com www.sciencedirect.com
    Retinal structure and function in monkeys with fetal alcohol exposure
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  184. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  185. www.sciencedirect.com www.sciencedirect.com
    mTORC1 Promotes Metabolic Reprogramming by the Suppression of GSK3-Dependent Foxk1 Phosphorylation
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    Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells
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    c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling
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    The Amaryllidaceae Alkaloid Haemanthamine Binds the Eukaryotic Ribosome to Repress Cancer Cell Growth
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    As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid
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    Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling
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  191. Nov 2017
  192. www.eneuro.org www.eneuro.org
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    Activity-Dependent Gating of Parvalbumin Interneuron Function by the Perineuronal Net Protein Brevican
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    MLL/WDR5 Complex Regulates Kif2A Localization to Ensure Chromosome Congression and Proper Spindle Assembly during Mitosis
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  197. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activation of Ras-ERK Signaling and GSK-3 by Amyloid Precursor Protein and Amyloid Beta Facilitates Neurodegeneration in Alzheimer’s Disease
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    Endothelin-1 promotes hypertrophic remodelling of cardiac myocytes by activating sustained signalling and transcription downstream of endothelin type A receptors
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  199. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The topology, structure and PE interaction of LITAF underpin a Charcot-Marie-Tooth disease type 1C
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  200. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Agenesis of the corpus callosum in Nogo receptor deficient mice
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    onlinelibrary.wiley.com/doi/10.1002/cne.24064/full
  201. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Induction of neural differentiation in rat C6 glioma cells with taxol
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