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Exploiting the polypharmacology of alectinib for synergistic RNA splicing disruption with RBM39 degraders

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1. scibot 09 Jan 2026
  
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  RRID:AB_1079749
  
  DOI: 10.1016/j.celrep.2025.116784
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1079749
  
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  RRID:AB_1079749
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sciencedirect.com/science/article/pii/S2211124725015566
Sep 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

RBM39 degrader invigorates innate immunity to eradicate neuroblastoma despite cancer cell plasticity

1
1. scibot 22 Sep 2025
  
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  RRID:AB_1079749
  
  DOI: 10.1038/s41467-025-63979-x
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1079749
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12443969/
Mar 2024
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Metabolic reprogramming of cancer cells by JMJD6-mediated pre-mRNA splicing associated with therapeutic response to splicing inhibitor

1
1. scibot 17 Mar 2024
  
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  RRID:AB_1079749
  
  DOI: 10.7554/eLife.90993
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1079749
  
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  RRID:AB_1079749
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RRID:AB_1079749

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ncbi.nlm.nih.gov/pmc/articles/PMC10942784/
Nov 2023
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Pharmacological depletion of RNA splicing factor RBM39 by indisulam synergizes with PARP inhibitors in high-grade serous ovarian carcinoma

1
1. scibot 02 Nov 2023
  
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  RRID:AB_1079749
  
  DOI: 10.1016/j.celrep.2023.113307
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1079749
  
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  RRID:AB_1079749
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sciencedirect.com/science/article/pii/S2211124723013190
Jun 2022
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An oncogenic JMJD6-DGAT1 axis tunes the epigenetic regulation of lipid droplet formation in clear cell renal cell carcinoma

1
1. scibot 29 Jun 2022
  
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  RRID:AB_1079749
  
  DOI: 10.1016/j.molcel.2022.06.003
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1079749
  
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sciencedirect.com/science/article/pii/S1097276522005391
Jun 2021
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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

1
1. scibot 25 Jun 2021
  
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  RRID:AB_1079749
  
  DOI: 10.1016/j.cell.2021.05.038
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @scibot
  
  SciCrunch record: RRID:AB_1079749
  
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sciencedirect.com/science/article/pii/S0092867421006905
Jan 2020
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Aryl Sulfonamides Degrade RBM39 and RBM23 by Recruitment to CRL4-DCAF15

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1079749
  
  DOI: 10.1016/j.celrep.2019.09.079
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1079749
  
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  RRID:AB_1079749 RRIDCUR:Validated
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RRIDCUR:Validated

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sciencedirect.com/science/article/pii/S2211124719312835
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Untitled document

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1. scibot 13 Jan 2020
  
  in Public
  
  RRID:AB_1079749
  
  DOI: 10.1016/j.celrep.2019.03.063
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @evieth
  
  SciCrunch record: RRID:AB_1079749
  
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  RRID:AB_1079749 RRIDCUR:Validated
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RRIDCUR:Validated

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ncbi.nlm.nih.gov/pmc/articles/PMC6499400/
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Targeting an RNA-Binding Protein Network in Acute Myeloid Leukemia

1
1. scibot 13 Jan 2020
  
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  RRID:AB_1079749
  
  DOI: 10.1016/j.ccell.2019.01.010
  
  Resource: (Sigma-Aldrich Cat# HPA001591, RRID:AB_1079749)
  
  Curator: @ethanbadger
  
  SciCrunch record: RRID:AB_1079749
  
  What is this?
  
  RRID:AB_1079749 RRIDCUR:Validated
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RRID:AB_1079749

RRIDCUR:Validated

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scibot

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sciencedirect.com/science/article/pii/S1535610819300443