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    MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells
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  3. Jun 2024
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    The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress
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  5. May 2024
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    Ubiquitin-mediated regulation of APE2 protein abundance
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    Improved detection of DNA replication fork-associated proteins
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  8. Apr 2024
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    The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia
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  10. Mar 2024
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization
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  13. Feb 2024
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    p53 promotes antiviral innate immunity by driving hexosamine metabolism
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  15. Jan 2024
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    Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors
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    A quantitative model for virus uncoating predicts influenza A infectivity
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  18. Nov 2023
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    RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks
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    FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation
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  21. Oct 2023
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    MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction
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    PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly
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  24. Sep 2023
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    TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation
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    Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection
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  27. Jul 2023
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    Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production
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  29. Jun 2023
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    Identification of XAF1 as an endogenous AKT inhibitor
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    TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2
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  32. Apr 2023
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    Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING
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    PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1
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  35. Mar 2023
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    Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination
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  37. Feb 2023
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    Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1
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  39. Aug 2022
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    Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop
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    The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
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  42. Jul 2022
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    Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy
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  44. Mar 2022
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    Delicate regulation of IL-1β-mediated inflammation by cyclophilin A
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  46. Feb 2022
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    E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression
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  48. Dec 2021
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    Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
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  50. Sep 2021
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    The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation
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  52. Aug 2021
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    O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity
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    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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    ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6127031/
  55. Jul 2021
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  57. Jun 2021
  58. www.cell.com www.cell.com
    Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity
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    cell.com/molecular-cell/fulltext/S1097-2765(21)00451-2
  59. Sep 2020
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    TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation
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    Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome
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  62. Jan 2020
  63. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains
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    onlinelibrary.wiley.com/doi/full/10.1111/jnc.14796
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    Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages
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    Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology
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    sciencedirect.com/science/article/pii/S0896627319308839
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    A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.celrep.2019.08.031

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    sciencedirect.com/science/article/pii/S2211124719310654
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    Untitled document
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      DOI: 10.1016/j.immuni.2019.01.014

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    sciencedirect.com/science/article/pii/S1074761319300378
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    NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25
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      DOI: 10.1016/j.chom.2019.02.013

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    sciencedirect.com/science/article/pii/S193131281930109X
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    Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State
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      DOI: 10.1016/j.molcel.2018.10.033

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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276518308931
  70. Nov 2018
  71. www.ncbi.nlm.nih.govhttp: www.ncbi.nlm.nih.govhttp:
    Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage
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      Curator: @evieth

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    ncbi.nlm.nih.govhttp://europepmc.org/articles/PMC6127031/