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Scap stabilizes PKM2 to promote glycolysis and enhance anti-fungal immunity in macrophages

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1. scibot 17 Mar 2026
  
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  DOI: 10.1016/j.celrep.2026.117106
  
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sciencedirect.com/science/article/pii/S2211124726001841
Oct 2025
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A cancer-specific antigen drives histone acetylation by stabilizing the acetyltransferases

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sciencedirect.com/science/article/pii/S2211124725011799
Jul 2025
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Glucose restriction shapes pre-metastatic innate immune landscapes in the lung through exosomal TRAIL

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sciencedirect.com/science/article/pii/S0092867425007287
Apr 2025
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KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway

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Mar 2025
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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response

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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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Feb 2025
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E3 ligase SYVN1-mediated polyubiquitination of CPSF6 promotes alternative polyadenylation and antivirus effects of macrophages

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Dec 2024
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The Cullin3-Rbx1-KLHL9 E3 ubiquitin ligase complex ubiquitinates Rheb and supports amino acid-induced mTORC1 activation

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1. scibot 21 Dec 2024
  
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sciencedirect.com/science/article/pii/S2211124724014529
Nov 2024
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Inhibition of cathepsin L ameliorates inflammation through the A20/NF-κB pathway in endotoxin-induced acute lung injury

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Regulatory mechanisms of strigolactone perception in rice

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USP7 deubiquitinates KRAS and promotes non-small cell lung cancer

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sciencedirect.com/science/article/pii/S2211124724012683
Oct 2024
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Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon

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1. scibot 04 Oct 2024
  
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sciencedirect.com/science/article/pii/S1550413124003668
Aug 2024
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The deubiquitinase BAP1 and E3 ligase UBE3C sequentially target IRF3 to activate and resolve the antiviral innate immune response

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1. scibot 20 Aug 2024
  
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Jul 2024
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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

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sciencedirect.com/science/article/pii/S2211124724008945
Jun 2024
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The HRD1-SEL1L ubiquitin ligase regulates stress granule homeostasis in couple with distinctive signaling branches of ER stress

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1. scibot 21 Jun 2024
  
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sciencedirect.com/science/article/pii/S2589004224014214
May 2024
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Ubiquitin-mediated regulation of APE2 protein abundance

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1. scibot 07 May 2024
  
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sciencedirect.com/science/article/pii/S0021925824018386
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Improved detection of DNA replication fork-associated proteins

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sciencedirect.com/science/article/pii/S2211124724005060
Apr 2024
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The crosstalk between macrophages and cancer cells potentiates pancreatic cancer cachexia

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Mar 2024
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Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH

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Aging-induced tRNAGlu-derived fragment impairs glutamate biosynthesis by targeting mitochondrial translation-dependent cristae organization

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Feb 2024
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p53 promotes antiviral innate immunity by driving hexosamine metabolism

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Jan 2024
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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

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A quantitative model for virus uncoating predicts influenza A infectivity

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Nov 2023
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RNF14-dependent atypical ubiquitylation promotes translation-coupled resolution of RNA-protein crosslinks

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FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation

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Oct 2023
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MLKL regulates Cx43 ubiquitinational degradation and mediates neuronal necroptosis in ipsilateral thalamus after focal cortical infarction

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  DOI: 10.1186/s13041-023-01064-4
  
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PAICS ubiquitination recruits UBAP2 to trigger phase separation for purinosome assembly

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Sep 2023
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TMEM127 suppresses tumor development by promoting RET ubiquitination, positioning, and degradation

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Systematic profiling of dominant ubiquitin variants reveals key functional nodes contributing to evolutionary selection

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Jul 2023
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Constitutively active autophagy in macrophages dampens inflammation through metabolic and post-transcriptional regulation of cytokine production

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Jun 2023
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Identification of XAF1 as an endogenous AKT inhibitor

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TRIM21 is a druggable target for the treatment of metastatic colorectal cancer through ubiquitination and activation of MST2

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1. scibot 24 Jun 2023
  
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  DOI: 10.1016/j.chembiol.2023.05.009
  
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Apr 2023
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Glutamylation of an HIV-1 protein inhibits the immune response by hijacking STING

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  DOI: 10.1016/j.celrep.2023.112442
  
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PPDPF suppresses the development of hepatocellular carcinoma through TRIM21-mediated ubiquitination of RIPK1

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  DOI: 10.1016/j.celrep.2023.112340
  
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Arginine shortage induces replication stress and confers genotoxic resistance by inhibiting histone H4 translation and promoting PCNA ubiquitination

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Hypoxic postconditioning restores mitophagy against transient global cerebral ischemia via Parkin-induced posttranslational modification of TBK1

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Phosphorylation of BRCA1 by ATM upon double-strand breaks impacts ATM function in end-resection: A potential feedback loop

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The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways

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Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy

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Delicate regulation of IL-1β-mediated inflammation by cyclophilin A

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E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression

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Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

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The protein arginine methyltransferase PRMT1 promotes TBK1 activation through asymmetric arginine methylation

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O-GlcNAc Transferase Links Glucose Metabolism to MAVS-Mediated Antiviral Innate Immunity

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

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TNFAIP3 Interacting Protein 3 Overexpression Suppresses Nonalcoholic Steatohepatitis by Blocking TAK1 Activation

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Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome

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Shank3 regulates striatal synaptic abundance of Cyld, a deubiquitinase specific for Lys63‐linked polyubiquitin chains

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Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

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Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology

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A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis

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NLRP12 Regulates Anti-viral RIG-I Activation via Interaction with TRIM25

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Iruka Eliminates Dysfunctional Argonaute by Selective Ubiquitination of Its Empty State

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Non-canonical Activation of the DNA Sensing Adaptor STING by ATM and IFI16 Mediates NF-κB Signaling after Nuclear DNA Damage

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