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Jul 2025
www.science.org www.science.org

Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling

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  DOI: 10.1126/science.adm9805
  
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science.org/doi/10.1126/science.adm9805
Jun 2025
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EZH2 loss during metabolic stress drives restoration of MHC class I machinery in melanoma

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sciencedirect.com/science/article/pii/S2589004225010119
May 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

mTOR inhibition in Q175 Huntington’s disease model mice facilitates neuronal autophagy and mutant huntingtin clearance

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  DOI: 10.7554/eLife.104979
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12092004/
Mar 2025
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Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid

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mdpi.com/2072-6694/16/19/3367
Feb 2025
52.53.155.43 52.53.155.43

1-s2.0-S2589004225002901-main-html.html

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52.53.155.43/ad050befce46ee469606c03d2c9e736a6b526b04/1-s2.0-S2589004225002901-main-html.html
Nov 2024
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Opposing roles for AMPK in regulating distinct mitophagy pathways

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sciencedirect.com/science/article/pii/S1097276524008657
Oct 2024
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Hydroxyproline metabolism enhances IFN-γ-induced PD-L1 expression and inhibits autophagic flux

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  DOI: 10.1016/j.chembiol.2023.06.016
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11426993/
Sep 2024
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The ULK1 effector BAG2 regulates autophagy initiation by modulating AMBRA1 localization

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sciencedirect.com/science/article/pii/S2211124724010404
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Activating mTOR mutations are detrimental in nutrient-poor conditions

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  DOI: 10.1158/0008-5472.CAN-22-0121
  
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aacrjournals.org/cancerres/article/82/18/3263/709030/Activating-mTOR-Mutations-Are-Detrimental-in
Dec 2023
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MORG1 limits mTORC1 signaling by inhibiting Rag GTPases

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sciencedirect.com/science/article/pii/S1097276523009681
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Nutrient-regulated control of lysosome function by signaling lipid conversion

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  DOI: 10.1016/j.cell.2023.09.027
  
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sciencedirect.com/science/article/pii/S0092867423010814
Aug 2023
52.53.155.43 52.53.155.43

PIIS2589004223017029-html.html

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  DOI: 10.1016/j.isci.2023.107625
  
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52.53.155.43/258d74bd1c79cf4d725c254c0f9188b69c056c90/PIIS2589004223017029-html.html
Jun 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Restored autophagy is protective against PAK3-induced cardiac dysfunction

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  DOI: 10.1016/j.isci.2023.106970
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10265534/
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Dysregulation of mitochondrial translation caused by CBFB deficiency cooperates with mutant PIK3CA and is a vulnerability in breast cancer

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  DOI: 10.1158/0008-5472.CAN-22-2525
  
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aacrjournals.org/cancerres/article/83/8/1280/725099/Dysregulation-of-Mitochondrial-Translation-Caused
May 2023
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Metamorphic proteins at the basis of human autophagy initiation and lipid transfer

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  DOI: 10.1016/j.molcel.2023.04.026
  
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sciencedirect.com/science/article/pii/S1097276523003210
academic.oup.com academic.oup.com

Whole-body and forearm muscle protein metabolism in patients with acromegaly before and after treatment

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1. scibot 06 May 2023
  
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  DOI: 10.1210/clinem/dgad190
  
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academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgad190/7111800
Apr 2023
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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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  DOI: 10.1016/j.celrep.2023.112316
  
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sciencedirect.com/science/article/pii/S2211124723003273
Feb 2023
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An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation

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  DOI: 10.1016/j.chembiol.2023.01.003
  
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sciencedirect.com/science/article/pii/S2451945623000260
Dec 2022
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USP32-regulated LAMTOR1 ubiquitination impacts mTORC1 activation and autophagy induction

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1. scibot 08 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111653
  
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sciencedirect.com/science/article/pii/S2211124722015248
Oct 2022
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Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival

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  DOI: 10.1016/j.celrep.2022.111435
  
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sciencedirect.com/science/article/pii/S2211124722012761
Aug 2022
52.53.155.43 52.53.155.43

can-22-0121-html.html

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  DOI: 10.1158/0008-5472.can-22-0121
  
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52.53.155.43/e39c6cee634d068d1d0118b99a8c3dfd324cbcce/can-22-0121-html.html
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Mitochondrial hyperfusion via metabolic sensing of regulatory amino acids

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  DOI: 10.1016/j.celrep.2022.111198
  
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sciencedirect.com/science/article/pii/S2211124722010154
Mar 2022
febs.onlinelibrary.wiley.com febs.onlinelibrary.wiley.com

DRAM-4 and DRAM-5 are compensatory regulators of autophagy and cell survival in nutrient-deprived conditions

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  DOI: 10.1111/febs.16365
  
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febs.onlinelibrary.wiley.com/doi/10.1111/febs.16365
Feb 2022
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An AMPKα2-specific phospho-switch controls lysosomal targeting for activation

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sciencedirect.com/science/article/pii/S2211124722000869
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A feature of maternal sleep apnea during gestation causes autism-relevant neuronal and behavioral phenotypes in offspring

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  DOI: 10.1371/journal.pbio.3001502
  
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journals.plos.org/plosbiology/article
Aug 2021
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Untitled document

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  DOI: 10.1016/j.celrep.2018.07.101
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6298213/
Jul 2021
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Untitled document

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ncbi.nlm.nih.gov/pmc/articles/PMC6331339/
Jun 2021
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High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol

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  DOI: 10.1038/s41419-021-03830-5
  
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nature.com/articles/s41419-021-03830-5
May 2021
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Cell size homeostasis is maintained by CDK4-dependent activation of p38 MAPK

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  DOI: 10.1016/j.devcel.2021.04.030
  
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sciencedirect.com/science/article/pii/S1534580721003993
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Akt-mTOR hypoactivity in bipolar disorder gives rise to cognitive impairments associated with altered neuronal structure and function

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  DOI: 10.1016/j.neuron.2021.03.008
  
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sciencedirect.com/science/article/pii/S0896627321001562
Apr 2021
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Pharmacological Targeting of Vacuolar H+-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer

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  DOI: 10.1016/j.chembiol.2020.06.011
  
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sciencedirect.com/science/article/pii/S2451945620302348
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Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer

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  DOI: 10.1016/j.cell.2020.10.016
  
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sciencedirect.com/science/article/pii/S0092867420313222
Mar 2021
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Amino acids-Rab1A-mTORC1 signaling controls whole-body glucose homeostasis

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  DOI: 10.1016/j.celrep.2021.108830
  
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sciencedirect.com/science/article/pii/S2211124721001443
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Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy

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  DOI: 10.1016/j.cell.2020.11.018
  
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sciencedirect.com/science/article/pii/S009286742031535X
Sep 2020
elifesciences.org elifesciences.org

Inhibition of striatonigral autophagy as a link between cannabinoid intoxication and impairment of motor coordination

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1. scibot 26 Sep 2020
  
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  DOI: 10.7554/eLife.56811
  
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elifesciences.org/articles/56811
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Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System

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  DOI: 10.1016/j.chembiol.2020.06.013
  
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H63D variant of the homeostatic iron regulator (HFE) gene alters α‐synuclein expression, aggregation, and toxicity

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  DOI: 10.1111/jnc.15107
  
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Glycolysis-Independent Glucose Metabolism Distinguishes TE from ICM Fate during Mammalian Embryogenesis

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Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

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IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

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Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling

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Leucine Signals to mTORC1 via Its Metabolite Acetyl-Coenzyme A

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Untitled document

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Systematic Functional Annotation of Somatic Mutations in Cancer

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Untitled document

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

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LARP1 functions as a molecular switch for mTORC1-mediated translation of an essential class of mRNAs

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Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator

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Dynamics of mTORC1 activation in response to amino acids

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