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Erk inhibitors intercept Erk-mediated negative feedback while imposing cell-cycle arrest and activating p38

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sciencedirect.com/science/article/pii/S2589004226020055
Jun 2026
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Deacylation of SNAP25 protein family isoforms reveals distinct substrate selectivities of α/β hydrolase domain (ABHD) deacylases

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  DOI: 10.64898/2026.01.21.700842
  
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biorxiv.org/content/10.64898/2026.01.21.700842v2
May 2026
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BPS Publications

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  DOI: 10.1111/bph.70469
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.70469
Apr 2026
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HCMV infection depends on EGLN1-mediated mitochondrial activation to increase dNTP pools for viral DNA replication

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ErbB family receptor dimerization dynamics and dysregulation via long-term single-molecule imaging

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Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade

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Jan 2026
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Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo

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sciencedirect.com/science/article/pii/S0092867425014205
Nov 2025
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PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

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pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
Oct 2025
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RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

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TAOK2 controls synaptic plasticity and anxiety via ERK and calcium signaling

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Jul 2025
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Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

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May 2025
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Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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  DOI: 10.1016/j.celrep.2025.115728
  
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sciencedirect.com/science/article/pii/S2211124725004991
Mar 2025
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Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma

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cell.com/cell-metabolism/fulltext/S1550-4131(25)00021-X
Feb 2025
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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sciencedirect.com/science/article/pii/S2211124725001111
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The TSH receptor antibody reactome contributes to retro-orbital inflammation

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/jendso/bvae182
  
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dx.doi.org/10.1210/jendso/bvae182
Dec 2024
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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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Aug 2024
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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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Jul 2024
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Cancer-associated endocrine cells participate in pancreatic carcinogenesis

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52.53.155.43/00ed7388bef43fd34d4811e77f0e00ce1748f907/1-s2.0-S0016508524052259-main-html.html
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wang-et-al-2024-lilrb1-hla-g-axis-defines-a-checkpoint-driving-natural-killer-cell-exhaustion-in-tuberculosis-html.html

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ncbi.nlm.nih.gov/pmc/articles/PMC11319715/
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LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis

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embopress.org/doi/10.1038/s44321-024-00106-1
Mar 2024
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PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay

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Dec 2023
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Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis

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Jul 2023
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Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia

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Jun 2023
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MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

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sciencedirect.com/science/article/pii/S030438352300215X
Feb 2023
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Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species

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  DOI: 10.1126/sciadv.add7969
  
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Jan 2023
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SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis

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  DOI: 10.1158/2159-8290.CD-21-1514
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9262862/
Jun 2022
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cd-21-1514-html.html

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52.53.155.43/30b9574de57b2e4ccfd380c8f4f8e4cb5eb75f43/cd-21-1514-html.html
Apr 2022
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A superior loading control for the cellular thermal shift assay

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  DOI: 10.1038/s41598-022-10653-7
  
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Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation

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  DOI: 10.1016/j.molcel.2022.03.026
  
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sciencedirect.com/science/article/pii/S1097276522002647
Jan 2022
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
Dec 2021
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Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

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  DOI: 10.7554/eLife.73430
  
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elifesciences.org/articles/73430
Jul 2021
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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

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  DOI: 10.1016/j.cub.2021.06.030
  
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sciencedirect.com/science/article/pii/S0960982221008253
Jun 2021
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Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

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  DOI: 10.1016/j.isci.2021.102643
  
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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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  DOI: 10.1016/j.ccell.2021.05.002
  
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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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  DOI: 10.1016/j.cell.2021.04.001
  
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Discovery of Covalent MKK4/7 Dual Inhibitor

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  DOI: 10.1016/j.chembiol.2020.08.014
  
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Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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  DOI: 10.1126/sciadv.aaz6699
  
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CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

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Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

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  DOI: 10.7554/eLife.44219
  
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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  DOI: 10.1016/j.ccell.2019.01.020
  
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Nov 2018
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Untitled document

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

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