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Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade

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1. scibot 24 Apr 2026
  
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  DOI: 10.1172/JCI185220
  
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jci.org/articles/view/185220
Jan 2026
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Multimodal supramolecular targeting chimeras enable spatiotemporally resolved protein degradation in vivo

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.007
  
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sciencedirect.com/science/article/pii/S0092867425014205
Nov 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PTEN Oxidation Promotes Constitutive PI3K Signaling and Inducible Macropinocytosis in Pancreatic Cancer

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1. scibot 15 Nov 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-4501
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12614194/
Oct 2025
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RAF-independent MEK mutations drive refractory histiocytic neoplasms but respond to ERK inhibition

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1. scibot 28 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.014
  
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sciencedirect.com/science/article/pii/S1535610825004064
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TAOK2 controls synaptic plasticity and anxiety via ERK and calcium signaling

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1. scibot 22 Oct 2025
  
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  DOI: 10.1016/j.isci.2025.113712
  
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sciencedirect.com/science/article/pii/S258900422501973X
Jul 2025
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Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

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1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102253
  
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sciencedirect.com/science/article/pii/S266637912500326X
May 2025
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Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.chembiol.2025.04.008
  
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sciencedirect.com/science/article/pii/S245194562500131X
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An integrated proteomics approach identifies phosphorylation sites on viral and host proteins that regulate West Nile virus infection

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115728
  
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sciencedirect.com/science/article/pii/S2211124725004991
Mar 2025
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Realigned transsulfuration drives BRAF-V600E-targeted therapy resistance in melanoma

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1. scibot 07 Mar 2025
  
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  DOI: 10.1016/j.cmet.2025.01.021
  
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cell.com/cell-metabolism/fulltext/S1550-4131(25)00021-X
Feb 2025
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Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

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1. scibot 25 Feb 2025
  
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  DOI: 10.1016/j.celrep.2025.115340
  
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sciencedirect.com/science/article/pii/S2211124725001111
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The TSH receptor antibody reactome contributes to retro-orbital inflammation

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1. scibot 20 Feb 2025
  
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  DOI: 10.1210/jendso/bvae182
  
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dx.doi.org/10.1210/jendso/bvae182
Dec 2024
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Biased signaling by mutant EGFR underlies dependence on PKCα in lung adenocarcinoma

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1. scibot 05 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115026
  
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sciencedirect.com/science/article/pii/S2211124724013779
Aug 2024
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In vivo vulnerabilities to GPX4 and HDAC inhibitors in drug-persistent versus drug-resistant BRAFV600E lung adenocarcinoma

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1. scibot 18 Aug 2024
  
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  DOI: 10.1016/j.xcrm.2024.101663
  
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sciencedirect.com/science/article/pii/S266637912400377X
Jul 2024
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Cancer-associated endocrine cells participate in pancreatic carcinogenesis

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1. scibot 25 Jul 2024
  
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  DOI: 10.1053/j.gastro.2024.07.016
  
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52.53.155.43/00ed7388bef43fd34d4811e77f0e00ce1748f907/1-s2.0-S0016508524052259-main-html.html
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wang-et-al-2024-lilrb1-hla-g-axis-defines-a-checkpoint-driving-natural-killer-cell-exhaustion-in-tuberculosis-html.html

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1. scibot 23 Jul 2024
  
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  DOI: 10.1038/s44321-024-00106-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11319715/
www.embopress.org www.embopress.org

LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis

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1. scibot 23 Jul 2024
  
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  DOI: 10.1038/s44321-024-00106-1
  
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embopress.org/doi/10.1038/s44321-024-00106-1
Mar 2024
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PDGFRα+ITGA11+ fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay

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1. scibot 01 Mar 2024
  
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  DOI: 10.1016/j.ccell.2024.02.002
  
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2. scibot 01 Mar 2024
  
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  DOI: 10.1016/j.ccell.2024.02.002
  
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sciencedirect.com/science/article/pii/S1535610824000461
Dec 2023
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Wildtype C-Raf gene dosage and dimerization drive prostate cancer metastasis

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1. scibot 02 Dec 2023
  
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  DOI: 10.1016/j.isci.2023.108480
  
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sciencedirect.com/science/article/pii/S2589004223025579
Jul 2023
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Sox10 escalates vascular inflammation by mediating vascular smooth muscle cell transdifferentiation and pyroptosis in neointimal hyperplasia

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1. scibot 27 Jul 2023
  
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  DOI: 10.1016/j.celrep.2023.112869
  
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sciencedirect.com/science/article/pii/S221112472300880X
Jun 2023
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MEK inhibitor and anti-EGFR antibody overcome sotorasib resistance signals and enhance its antitumor effect in colorectal cancer cells

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1. scibot 21 Jun 2023
  
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  DOI: 10.1016/j.canlet.2023.216264
  
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sciencedirect.com/science/article/pii/S030438352300215X
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Scaffold coupling: ERK activation by trans-phosphorylation across different scaffold protein species

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1. scibot 17 Feb 2023
  
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  DOI: 10.1126/sciadv.add7969
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9931222/
Jan 2023
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SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis

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1. scibot 07 Jan 2023
  
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  DOI: 10.1158/2159-8290.CD-21-1514
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9262862/
Jun 2022
52.53.155.43 52.53.155.43

cd-21-1514-html.html

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1. scibot 30 Jun 2022
  
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  DOI: 10.1158/2159-8290.CD-21-1514
  
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2. scibot 25 Jun 2022
  
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  DOI: 10.1158/2159-8290.cd-21-1514
  
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  DOI: 10.1158/2159-8290.cd-21-1514
  
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52.53.155.43/30b9574de57b2e4ccfd380c8f4f8e4cb5eb75f43/cd-21-1514-html.html
Apr 2022
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A superior loading control for the cellular thermal shift assay

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1. scibot 29 Apr 2022
  
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  DOI: 10.1038/s41598-022-10653-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9035151/
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Lyso-PAF, a biologically inactive phospholipid, contributes to RAF1 activation

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  DOI: 10.1016/j.molcel.2022.03.026
  
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sciencedirect.com/science/article/pii/S1097276522002647
Jan 2022
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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1. scibot 05 Jan 2022
  
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  DOI: 10.1016/j.ccell.2019.04.011
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8717880/
Dec 2021
elifesciences.org elifesciences.org

Experiments from unfinished Registered Reports in the Reproducibility Project: Cancer Biology

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1. scibot 11 Dec 2021
  
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  DOI: 10.7554/eLife.73430
  
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elifesciences.org/articles/73430
Jul 2021
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The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

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  DOI: 10.1016/j.cub.2021.06.030
  
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sciencedirect.com/science/article/pii/S0960982221008253
Jun 2021
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Flightless I is a catabolic factor of chondrocytes that promotes hypertrophy and cartilage degeneration in osteoarthritis

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1. scibot 18 Jun 2021
  
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  DOI: 10.1016/j.isci.2021.102643
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8187833/
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Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma

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  DOI: 10.1016/j.ccell.2021.05.002
  
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sciencedirect.com/science/article/pii/S1535610821002683
May 2021
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LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome

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  DOI: 10.1016/j.cell.2021.04.001
  
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cell.com/cell/fulltext/S0092-8674(21)00436-0
Apr 2021
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Discovery of Covalent MKK4/7 Dual Inhibitor

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1. scibot 27 Apr 2021
  
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  DOI: 10.1016/j.chembiol.2020.08.014
  
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sciencedirect.com/science/article/pii/S2451945620303366
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Genome-wide kinetic properties of transcriptional bursting in mouse embryonic stem cells

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1. scibot 17 Sep 2020
  
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  RRID:AB_10829473
  
  DOI: 10.1126/sciadv.aaz6699
  
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  RRID:AB_10829473 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7299619/
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CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing’s sarcoma

1
1. scibot 03 Sep 2020
  
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  anti-MEK1/2
  
  DOI: 10.1038/s41589-019-0424-1
  
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Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons

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  DOI: 10.7554/eLife.44219
  
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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

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  DOI: 10.1016/j.ccell.2019.01.020
  
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Nov 2018
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Untitled document

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Phosphatidylinositol-5-Phosphate 4-Kinases Regulate Cellular Lipid Metabolism By Facilitating Autophagy

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Listeria Adhesion Protein Induces Intestinal Epithelial Barrier Dysfunction for Bacterial Translocation

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Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

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KRAS Dimerization Impacts MEK Inhibitor Sensitivity and Oncogenic Activity of Mutant KRAS

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