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In Vitro Inhibition of STAT5 Signaling Limits CD8+ T-cell Exhaustion and Improves Outcomes in Adoptive T-cell Therapy

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1. scibot 08 Oct 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1158/2326-6066.CIR-25-1493
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13635738/
Jul 2026
aacrjournals.org aacrjournals.org

Engineering T Cells with a Tumor-Reactive Chimeric T Cell Receptor Reduces Exhaustion and Promotes Persistence to Elicit Enhanced Antitumor Responses

1
1. scibot 11 Jul 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1158/0008-5472.CAN-25-0777
  
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aacrjournals.org/cancerres/article/86/11/2688/785304/Engineering-T-Cells-with-a-Tumor-Reactive-Chimeric
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Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors

2
1. scibot 06 Jul 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2026.06.006
  
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2. scibot 05 Jul 2026
  
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  RRID: AB_10855034
  
  DOI: 10.1016/j.immuni.2026.06.006
  
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  Curator: @nmaralla
  
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sciencedirect.com/science/article/pii/S1074761326002578
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B cell-derived type I interferon sustains T cell functionality upon strong TCR stimulation during chronic infection

1
1. scibot 06 Jul 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2026.06.003
  
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sciencedirect.com/science/article/pii/S1074761326002542
Jun 2026
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Expansion and mobilization of virus-specific stem-like CD8 T cells in chronic viral infection after treatment with a long-acting IL-7, NT-I7

1
1. scibot 03 Jun 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.celrep.2026.117204
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13222646/
May 2026
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Targeted protein degradation via chimeric antigen receptor (CAR)-mediated antigen endocytosis in T cells

1
1. scibot 22 May 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.hlife.2026.05.003
  
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sciencedirect.com/science/article/pii/S2949928326000313
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Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress

1
1. scibot 01 May 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2026.04.004
  
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sciencedirect.com/science/article/pii/S1074761326001445
Apr 2026
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Inflammaging in aged tissues drives remodeling of the CD8+ T cell compartment

1
1. scibot 24 Apr 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.celrep.2026.117303
  
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sciencedirect.com/science/article/pii/S2211124726003815
Mar 2026
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Synthetic M13 phage engagers expand CAR-T cell antigen recognition to overcome tumor heterogeneity

1
1. scibot 31 Mar 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.tibtech.2026.02.008
  
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sciencedirect.com/science/article/pii/S0167779926000478
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NF-κB-activated fibroblasts orchestrate inflammaging and emergence of pro-inflammatory granzyme K+ T cells

1
1. scibot 31 Mar 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2026.02.016
  
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sciencedirect.com/science/article/pii/S1074761326000865
Feb 2026
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Meningeal blood vessel blockage enhances anti-glioblastoma immunity

1
1. scibot 05 Feb 2026
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.cell.2025.12.045
  
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sciencedirect.com/science/article/pii/S0092867425014941
Dec 2025
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Neurons undergo IFNγ-driven persistent epigenetic shifts and synaptopathy in encephalitis

1
1. scibot 25 Dec 2025
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.neuron.2025.11.006
  
  Resource: (Thermo Fisher Scientific Cat# 12-6502-82, RRID:AB_10855034)
  
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sciencedirect.com/science/article/pii/S0896627325008530
Sep 2025
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CD7 regulates the persistence of terminally exhausted CD8+ T cells during chronic infection

1
1. scibot 23 Sep 2025
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.celrep.2025.116316
  
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sciencedirect.com/science/article/pii/S2211124725010873
www.nature.com www.nature.com

GD2TIF cells as a platform for single-dose and long-term delivery of biologics

1
1. scibot 03 Sep 2025
  
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  RRID:AB_10855034
  
  DOI: 10.1038/s41467-025-63427-w
  
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nature.com/articles/s41467-025-63427-w
Aug 2025
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Multimodal targeting of metastatic renal cell carcinoma via CD70-directed allogeneic CAR-NKT cells

1
1. scibot 30 Aug 2025
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.xcrm.2025.102321
  
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sciencedirect.com/science/article/pii/S2666379125003945
Apr 2025
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Protocol for investigating the impact of transcription regulator deficiency on tumor-specific CD8+ T cell responses via adoptive cell transfer

1
1. scibot 03 Apr 2025
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.xpro.2025.103703
  
  Resource: (Thermo Fisher Scientific Cat# 12-6502-82, RRID:AB_10855034)
  
  Curator: @scibot
  
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sciencedirect.com/science/article/pii/S2666166725001091
Mar 2025
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Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

1
1. scibot 04 Mar 2025
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.celrep.2025.115388
  
  Resource: (Thermo Fisher Scientific Cat# 12-6502-82, RRID:AB_10855034)
  
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sciencedirect.com/science/article/pii/S2211124725001597
Feb 2025
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In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313

1
1. scibot 06 Feb 2025
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2025.01.009
  
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sciencedirect.com/science/article/pii/S1074761325000342
Dec 2024
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Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

1
1. scibot 06 Dec 2024
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.ccell.2024.11.003
  
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sciencedirect.com/science/article/pii/S1535610824004380
Sep 2024
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The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis

1
1. scibot 04 Sep 2024
  
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  AB_10855034
  
  DOI: 10.1016/j.celrep.2024.114690
  
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sciencedirect.com/science/article/pii/S2211124724010416
Aug 2024
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Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition

1
1. scibot 22 Aug 2024
  
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  AB_10855034
  
  DOI: 10.1016/j.celrep.2024.114632
  
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sciencedirect.com/science/article/pii/S2211124724009823
Jul 2024
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Distinct epigenomic landscapes underlie tissue-specific memory T cell differentiation

1
1. scibot 25 Jul 2024
  
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  AB_10855034
  
  DOI: 10.1016/j.immuni.2024.06.014
  
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sciencedirect.com/science/article/pii/S1074761324003200
Mar 2024
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

2
1. scibot 13 Mar 2024
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2024.02.014
  
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2. scibot 13 Mar 2024
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2024.02.014
  
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sciencedirect.com/science/article/pii/S1074761324000906
Feb 2024
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Circulating cancer-specific CD8 T cell frequency is associated with response to PD-1 blockade in Merkel cell carcinoma

2
1. scibot 13 Feb 2024
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.xcrm.2024.101412
  
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2. scibot 13 Feb 2024
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.xcrm.2024.101412
  
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sciencedirect.com/science/article/pii/S2666379124000351
Nov 2023
www.nature.com www.nature.com

Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity

1
1. scibot 25 Nov 2023
  
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  RRID:AB_10855034
  
  DOI: 10.1038/s41586-023-06749-3
  
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nature.com/articles/s41586-023-06749-3
Apr 2023
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Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

1
1. scibot 20 Apr 2023
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.celrep.2023.112186
  
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sciencedirect.com/science/article/pii/S2211124723001973
Feb 2023
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The alarmin interleukin-33 promotes the expansion and preserves the stemness of Tcf-1+ CD8+ T cells in chronic viral infection

1
1. scibot 23 Feb 2023
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2023.01.029
  
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sciencedirect.com/science/article/pii/S1074761323000419
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Graft-versus-host disease is locally maintained in target tissues by resident progenitor-like T cells

1
1. scibot 02 Feb 2023
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2023.01.003
  
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sciencedirect.com/science/article/pii/S1074761323000134
Nov 2022
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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

1
1. scibot 15 Nov 2022
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.immuni.2022.10.020
  
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sciencedirect.com/science/article/pii/S1074761322005611
May 2022
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Functional assessment of the cell-autonomous role of NADase CD38 in regulating CD8+ T cell exhaustion

1
1. scibot 21 May 2022
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.isci.2022.104347
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9117873/
Apr 2022
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Distinct phenotypic states and spatial distribution of CD8+ T cell clonotypes in human brain metastases

1
1. scibot 28 Apr 2022
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.xcrm.2022.100620
  
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sciencedirect.com/science/article/pii/S2666379122001379
Dec 2021
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Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential

1
1. scibot 01 Dec 2021
  
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  RRID:AB_10855034
  
  DOI: 10.1016/j.celrep.2021.110064
  
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sciencedirect.com/science/article/pii/S2211124721015503
Sep 2021
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PD-1+ Tcf1+ CD8+ T cells from established chronic infection can form memory while retaining a stableimprint of persistent antigen exposure

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1. scibot 08 Sep 2021
  
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  DOI: 10.1016/j.celrep.2021.109672
  
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sciencedirect.com/science/article/pii/S2211124721011165
Jul 2021
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Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection

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1. scibot 07 Jul 2021
  
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  DOI: 10.1016/j.immuni.2021.06.007
  
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sciencedirect.com/science/article/pii/S107476132100251X
Jun 2021
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors

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1. scibot 08 Jun 2021
  
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  DOI: 10.1016/j.immuni.2021.05.003
  
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pmc.ncbi.nlm.nih.gov/articles/PMC9273026/
May 2021
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The loss of RNA N6-adenosine methyltransferase Mettl14 in tumor-associated macrophages promotes CD8+ T cell dysfunction and tumor growth

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1. scibot 21 May 2021
  
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  DOI: 10.1016/j.ccell.2021.04.016
  
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cell.com/cancer-cell/fulltext/S1535-6108(21)00224-5
Mar 2021
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Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

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1. scibot 08 Mar 2021
  
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  DOI: 10.1016/j.immuni.2020.11.005
  
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sciencedirect.com/science/article/pii/S1074761320304921
Feb 2021
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Dynamic adoption of anergy by antigen-exhausted CD4+ T cells

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1. scibot 10 Feb 2021
  
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  DOI: 10.1016/j.celrep.2021.108748
  
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cell.com/cell-reports/fulltext/S2211-1247(21)00061-9
Sep 2020
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Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection

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  DOI: 10.1016/j.celrep.2020.108078
  
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sciencedirect.com/science/article/pii/S2211124720310639