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Fc‐Dependent Targeting of the GAS6–MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21

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1. scibot 22 Oct 2026
  
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  DOI: 10.1002/advs.78290
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13669479/
Sep 2026
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Fast tumor accumulation and payload release of c-Met targeting aptamer-drug conjugate enables robust anti-tumor efficacy

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  DOI: 10.1016/j.xcrm.2026.103005
  
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sciencedirect.com/science/article/pii/S2666379126004222
Aug 2026
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Brain assembloids reveal efficacy and off target effects in high grade glioma brain cancer

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1. scibot 20 Aug 2026
  
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  DOI: 10.1016/j.isci.2026.117247
  
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sciencedirect.com/science/article/pii/S2589004226026258
Jul 2026
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Amphiregulin-mediated EGFR activation drives both intrinsic and acquired resistance to KRAS G12C inhibitors in KRAS G12C–mutant non-small cell lung cancer

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1. scibot 07 Jul 2026
  
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  DOI: 10.1038/s41388-026-03877-8
  
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nature.com/articles/s41388-026-03877-8
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MEN1-related Neuroendocrine Tumors show c-MET Overexpression

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1. scibot 01 Jul 2026
  
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  DOI: 10.1210/jendso/bvaf147
  
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academic.oup.com/jes/article/9/10/bvaf147/8249684
Mar 2026
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Immunological effects of amivantamab in EGFR or MET-expressing non-small cell lung cancer

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1. scibot 27 Mar 2026
  
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  DOI: 10.1007/s00262-026-04369-0
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13013883/
Feb 2026
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The Prolyl Isomerase PIN1 Impacts Fibroblast Differentiation States and Crosstalk in Pancreatic Cancer

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1. scibot 19 Feb 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-3437
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12912258/
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Targeting CAFs-Mediated Stromal Signaling in a Patient-Derived Organotypic Colorectal Tumor Model

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1. scibot 04 Feb 2026
  
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  DOI: 10.1158/1535-7163.MCT-24-0756
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12316546/
Jan 2026
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A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC

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1. scibot 30 Jan 2026
  
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  DOI: 10.1007/s13402-025-01152-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12847129/
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Mitigating tumor heterogeneity in lung Cancer: A dual-targeted NIR-II imaging strategy for accurate tumor localization and intraoperative navigation

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1. scibot 05 Jan 2026
  
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  DOI: 10.1016/j.canlet.2026.218241
  
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sciencedirect.com/science/article/pii/S0304383526000042
Nov 2025
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YAP/TAZ transcriptional co-activators create therapeutic vulnerability to verteporfin in EGFR mutant glioblastoma

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1. scibot 08 Nov 2025
  
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  DOI: 10.1158/1078-0432.CCR-20-0018
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8440125/
Oct 2025
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Plakophilin 3 drives acinar cell transformation and promotes cancer initiation and progression in pancreas

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1. scibot 30 Oct 2025
  
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  DOI: 10.1016/j.celrep.2025.116487
  
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sciencedirect.com/science/article/pii/S2211124725012586
Jul 2025
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Therapeutic targeting of syndecan-1 axis overcomes acquired resistance to KRAS-targeted therapy in gastrointestinal cancers

1
1. scibot 29 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102253
  
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sciencedirect.com/science/article/pii/S266637912500326X
Apr 2025
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PDF-html.html

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1. scibot 19 Apr 2025
  
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  DOI: 10.1158/1535-7163.mct-24-0756
  
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52.53.155.43/a9bdac937b5d56e963502c7a9aeebc7cca17a770/PDF-html.html
Jan 2025
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The potential of lazertinib and amivantamab combination therapy as a treatment strategy for uncommon EGFR-mutated NSCLC

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1. scibot 28 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2025.101929
  
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sciencedirect.com/science/article/pii/S2666379125000023
Dec 2024
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MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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1. scibot 11 Dec 2024
  
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  DOI: 10.4103/NRR.NRR-D-23-01471
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11624886/
Sep 2024
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Anti-HDGF antibody targets EGFR tyrosine kinase inhibitor-tolerant cells in NSCLC patient-derived xenografts

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1. scibot 05 Sep 2024
  
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  DOI: 10.1158/2767-9764.CRC-24-0020
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11370239/
Mar 2024
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Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion

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1. scibot 28 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.114002
  
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sciencedirect.com/science/article/pii/S2211124724003309
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Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis

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1. scibot 26 Mar 2024
  
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  DOI: 10.1038/s41388-024-03008-1
  
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nature.com/articles/s41388-024-03008-1
Jan 2024
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Cholinergic signaling via muscarinic M1 receptor confers resistance to docetaxel in prostate cancer

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1. scibot 23 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101388
  
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sciencedirect.com/science/article/pii/S2666379123006171
Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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1. scibot 18 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
Jun 2023
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Phosphoproteomics guides effective low-dose drug combinations against pancreatic ductal adenocarcinoma

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1. scibot 03 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112581
  
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sciencedirect.com/science/article/pii/S2211124723005922
Apr 2023
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Single targeting of MET in EGFR-mutated and MET-amplified non-small cell lung cancer

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1. scibot 18 Apr 2023
  
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  DOI: 10.1038/s41416-023-02264-4
  
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nature.com/articles/s41416-023-02264-4
Feb 2023
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VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer

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1. scibot 04 Feb 2023
  
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  DOI: 10.1016/j.ebiom.2023.104451
  
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sciencedirect.com/science/article/pii/S2352396423000166
Jan 2023
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EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

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1. scibot 11 Jan 2023
  
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  DOI: 10.7554/eLife.79432
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9829410/
Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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1. scibot 24 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111834
  
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sciencedirect.com/science/article/pii/S2211124722017260
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Immunological profiles of human oligodendrogliomas define two distinct molecular subtypes

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1. scibot 17 Dec 2022
  
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  DOI: 10.1016/j.ebiom.2022.104410
  
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sciencedirect.com/science/article/pii/S2352396422005928
Nov 2022
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B cell linker protein (BLNK) is a regulator of Met receptor signaling and trafficking in non-small cell lung cancer

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1. scibot 18 Nov 2022
  
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  DOI: 10.1016/j.isci.2022.105419
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9646953/
Aug 2022
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Combination of type I and type II MET tyrosine kinase inhibitors as therapeutic approach to prevent resistance

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1. scibot 04 Aug 2022
  
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  DOI: 10.1158/1535-7163.MCT-21-0344
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8828669/
Jul 2022
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Efficacy of Combined Use of Everolimus and Second-Generation Pan-EGRF Inhibitors in KRAS Mutant Non-Small Cell Lung Cancer Cell Lines

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1. scibot 31 Jul 2022
  
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  DOI: 10.3390/ijms23147774
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9317664/
Jun 2022
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Single-cell transcriptomes underscore genetically distinct tumor characteristics and microenvironment for hereditary kidney cancers.

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  DOI: 10.1016/j.isci.2022.104463
  
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sciencedirect.com/science/article/pii/S2589004222007349
Apr 2022
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Cholesterol suppresses GOLM1-dependent selective autophagy of RTKs in hepatocellular carcinoma

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1. scibot 21 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110712
  
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sciencedirect.com/science/article/pii/S2211124722004739
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Loss of KMT5C Promotes EGFR Inhibitor Resistance in NSCLC via LINC01510-Mediated Upregulation of MET

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1. scibot 16 Apr 2022
  
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  DOI: 10.1158/0008-5472.CAN-20-0821
  
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aacrjournals.org/cancerres/article/82/8/1534/694341/Loss-of-KMT5C-Promotes-EGFR-Inhibitor-Resistance
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Intraoperative MET-receptor targeted fluorescent imaging and spectroscopy for lymph node detection in papillary thyroid cancer: novel diagnostic tools for more selective central lymph node compartment dissection

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1. scibot 08 Apr 2022
  
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  DOI: 10.1007/s00259-022-05763-3
  
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Nov 2021
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Targeting glioblastoma signaling and metabolism with a re-purposed brain-penetrant drug

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  DOI: 10.1016/j.celrep.2021.109957
  
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Oct 2021
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A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling

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1. scibot 23 Oct 2021
  
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  DOI: 10.7554/eLife.70885
  
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pmc.ncbi.nlm.nih.gov/articles/PMC8516413/
Jul 2021
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Identification of candidates for driver oncogenes in scirrhous‐type gastric cancer cell lines

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1. scibot 29 Jul 2021
  
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  DOI: 10.1111/cas.14111
  
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onlinelibrary.wiley.com/doi/full/10.1111/cas.14111
Jun 2021
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Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction

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  DOI: 10.1016/j.isci.2021.102544
  
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May 2021
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Targeting pan-ETS factors inhibits melanoma progression

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  DOI: 10.1158/0008-5472.CAN-19-1668
  
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Feb 2021
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Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signaling

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  DOI: 10.1016/j.celrep.2021.108765
  
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Oct 2020
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Receptor-Driven ERK Pulses Reconfigure MAPK Signaling and Enable Persistence of Drug-Adapted BRAF-Mutant Melanoma Cells

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1. scibot 31 Oct 2020
  
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  DOI: 10.1016/j.cels.2020.10.002
  
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Sep 2020
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Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

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  DOI: 10.1016/j.ccell.2019.12.012
  
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cell.com/cancer-cell/abstract/S1535-6108(19)30582-3
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A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells

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Defining and Targeting Adaptations to Oncogenic KRASG12C Inhibition Using Quantitative Temporal Proteomics

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  DOI: 10.1016/j.celrep.2020.03.021
  
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Glioblastoma Cell Resistance to EGFR and MET Inhibition Can Be Overcome via Blockade of FGFR-SPRY2 Bypass Signaling

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Inhibition of Tumor VEGFR2 Induces Serine 897 EphA2-Dependent Tumor Cell Invasion and Metastasis in NSCLC

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Jan 2020
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TRPML1 Promotes Protein Homeostasis in Melanoma Cells by Negatively Regulating MAPK and mTORC1 Signaling

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  DOI: 10.1016/j.celrep.2019.07.086
  
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Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction

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  DOI: 10.1016/j.celrep.2019.07.050
  
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LECT2, a Ligand for Tie1, Plays a Crucial Role in Liver Fibrogenesis

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  RRID:AB_10858224
  
  DOI: 10.1016/j.cell.2019.07.021
  
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Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors

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  DOI: 10.1016/j.celrep.2019.07.021
  
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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets

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  DOI: 10.1016/j.chembiol.2019.06.003
  
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c-Met and PD-L1 on Circulating Exosomes as Diagnostic and Prognostic Markers for Pancreatic Cancer

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  DOI: 10.3390/ijms20133305
  
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Untitled document

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  DOI: 10.1016/j.celrep.2018.12.013
  
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sciencedirect.com/science/article/pii/S2211124718319247
Nov 2018
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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

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sciencedirect.com/science/article/pii/S2451945617303549