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CDK12/13 inhibition overcomes platinum resistance by impairing RNA metabolism

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1. scibot 10 Sep 2026
  
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  DOI: 10.1038/s41392-026-02932-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13538385/
Jul 2026
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ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer

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Jun 2026
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WEE1 kinase inhibition to overcome acquired resistance to targeted therapies in colorectal cancer

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  DOI: 10.1038/s44321-026-00434-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13269805/
Nov 2025
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WDFY2 promotes MRN complex formation required for homologous recombination-mediated DNA repair

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sciencedirect.com/science/article/pii/S2211124725012914
Sep 2024
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Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism

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sciencedirect.com/science/article/pii/S2211383524003733
Jul 2024
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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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ncbi.nlm.nih.gov/pmc/articles/PMC11233922/
Apr 2024
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Telomere dysfunction alters intestinal stem cell dynamics to promote cancer

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Mar 2024
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Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance

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ncbi.nlm.nih.gov/pmc/articles/PMC11209755/
Jan 2024
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Tolerance to colibactin correlates with homologous recombination proficiency and resistance to irinotecan in colorectal cancer cells

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1. scibot 19 Jan 2024
  
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  DOI: 10.1016/j.xcrm.2023.101376
  
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Nov 2023
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Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

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sciencedirect.com/science/article/pii/S2589004223022460
Oct 2023
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Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer

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1. scibot 28 Oct 2023
  
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Sep 2023
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The interplay of TARG1 and PARG protects against genomic instability

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sciencedirect.com/science/article/pii/S2211124723011245
Aug 2023
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Small molecule targeting of transcription-replication conflict for selective chemotherapy

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1. scibot 03 Aug 2023
  
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  DOI: 10.1016/j.chembiol.2023.07.001
  
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Kinase Suppressor of RAS 1 (KSR1) Maintains the Transformed Phenotype of BRAFV600E Mutant Human Melanoma Cells

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1. scibot 01 Aug 2023
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10380721/
Jun 2023
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Suppression of TREX1 Deficiency-Induced Cellular Senescence and Interferonopathies by Inhibition of DNA Damage Response

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1. scibot 27 Jun 2023
  
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  DOI: 10.1016/j.isci.2023.107090
  
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sciencedirect.com/science/article/pii/S2589004223011677
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DHX9-mediated pathway contributes to the malignant phenotype of Myelodysplastic syndromes

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  DOI: 10.1016/j.isci.2023.106962
  
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sciencedirect.com/science/article/pii/S2589004223010398
Apr 2023
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Nuclear ATR lysine-tyrosylation protects against heart failure by activating DNA damage response

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1. scibot 20 Apr 2023
  
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  DOI: 10.1016/j.celrep.2023.112400
  
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sciencedirect.com/science/article/pii/S2211124723004114
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A kinome-wide CRISPR screen identifies CK1α as a target to overcome enzalutamide resistance of prostate cancer

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1. scibot 19 Apr 2023
  
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  DOI: 10.1016/j.xcrm.2023.101015
  
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Adiponectin-mediated promotion of CD44 suppresses diabetic vascular inflammatory effects

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1. scibot 09 Apr 2023
  
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  DOI: 10.1016/j.isci.2023.106428
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10067764/
Mar 2023
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Targeting Mutant Dicer Tumorigenesis in Pleuropulmonary Blastoma via Inhibition of RNA Polymerase I

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  DOI: 10.1016/j.trsl.2023.03.001
  
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sciencedirect.com/science/article/pii/S1931524423000415
Feb 2023
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Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53null Colorectal Cancer Cell Line

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1. scibot 08 Feb 2023
  
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  DOI: 10.3390/ijms24032983
  
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mdpi.com/1422-0067/24/3/2983
Nov 2022
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NEIL3 contributes to the Fanconi anemia/BRCA pathway by promoting the downstream double-strand break repair step

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sciencedirect.com/science/article/pii/S2211124722014656
Sep 2022
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SMN controls neuromuscular junction integrity through U7 snRNP

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1. scibot 21 Sep 2022
  
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  DOI: 10.1016/j.celrep.2022.111393
  
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sciencedirect.com/science/article/pii/S221112472201230X
May 2022
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Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

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sciencedirect.com/science/article/pii/S2211124722005253
Jan 2022
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WASH interacts with Ku to regulate DNA double-stranded break repair

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  DOI: 10.1016/j.isci.2021.103676
  
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sciencedirect.com/science/article/pii/S2589004221016461
Sep 2021
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In situ observation of mitochondrial biogenesis as the early event of apoptosis

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1. scibot 25 Sep 2021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8441175/
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Reading ADP-ribosylation signaling using chemical biology and interaction proteomics

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  DOI: 10.1016/j.molcel.2021.08.037
  
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sciencedirect.com/science/article/pii/S1097276521007176
Aug 2021
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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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  DOI: 10.1016/j.cmet.2021.07.009
  
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Jul 2021
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mTORC1 Couples Nucleotide Synthesis to Nucleotide Demand Resulting in a Targetable Metabolic Vulnerability

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1. scibot 29 Jul 2021
  
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  Histone H2A.X
  
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Jun 2021
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MAP4K1 functions as a tumor promotor and drug mediator for AML via modulation of DNA damage/repair system and MAPK pathway

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  DOI: 10.1016/j.ebiom.2021.103441
  
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An Integrated Analysis of the Response of Colorectal Adenocarcinoma Caco-2 Cells to X-Ray Exposure

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  DOI: 10.3389/fonc.2021.688919
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8209426/
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Bacterial genotoxins induce T cell senescence

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  DOI: 10.1016/j.celrep.2021.109220
  
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sciencedirect.com/science/article/pii/S2211124721005714
May 2021
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Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease

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1. scibot 21 May 2021
  
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  DOI: 10.1016/j.molcel.2021.04.028
  
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sciencedirect.com/science/article/pii/S1097276521003579
Jan 2020
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Small Molecule Inhibitors of KDM5 Histone Demethylases Increase the Radiosensitivity of Breast Cancer Cells Overexpressing JARID1B

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1. scibot 13 Jan 2020
  
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  DOI: 10.3390/molecules24091739
  
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ncbi.nlm.nih.gov/pmc/articles/PMC6540222/
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A PRMT5-RNF168-SMURF2 Axis Controls H2AX Proteostasis

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.celrep.2019.08.031
  
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sciencedirect.com/science/article/pii/S2211124719310654
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JARID1B expression and its function in DNA damage repair are tightly regulated by miRNAs in breast cancer

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Nov 2018
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Untitled document

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1. scibot 05 Nov 2018
  
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Nov 2017
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DNA-PK Promotes the Mitochondrial, Metabolic, and Physical Decline that Occurs During Aging

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1. scibot 08 Nov 2017
  
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