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Sep 2025
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Vitamin D Binding Protein, a Ligand of Integrin beta 1, Motivates Both Tumor Cells and Schwann Cells to Promote Perineural Invasion in Pancreatic Ductal Adenocarcinoma

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1. scibot 18 Sep 2025
  
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  DOI: 10.1002/advs.202511726
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/advs.202511726
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The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level

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1. scibot 12 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116249
  
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sciencedirect.com/science/article/pii/S2211124725010204
Aug 2025
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Kinome reprogramming of G2/M kinases and repression of MYCN contribute to superior efficacy of lorlatinib in ALK-driven neuroblastoma

1
1. scibot 07 Aug 2025
  
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  RRID:AB_10891442
  
  DOI: 10.1158/1535-7163.MCT-24-0684
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12322148/
Jul 2025
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Chemotherapy awakens dormant cancer cells in lung by inducing neutrophil extracellular traps

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1. scibot 03 Jul 2025
  
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  RRID:AB_10891442
  
  DOI: 10.1016/j.ccell.2025.06.007
  
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sciencedirect.com/science/article/pii/S1535610825002570
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The immune response against cancer is modulated by stromal cell fibronectin

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1. scibot 01 Jul 2025
  
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  DOI: 10.1016/j.neo.2025.101196
  
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sciencedirect.com/science/article/pii/S1476558625000764
Jun 2025
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Dynamic decoding of VEGF signaling and coordinated control of multiple phenotypes by the Src-TEM4-YAP pathway

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1. scibot 21 Jun 2025
  
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  RRID:AB_10891442
  
  DOI: 10.1016/j.cels.2025.101321
  
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sciencedirect.com/science/article/pii/S2405471225001541
May 2025
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Focal Adhesion Kinase Orchestrates GLUT4 Translocation and Glucose Uptake via Cytoskeletal Turnover in Primary Adipocytes

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1. scibot 24 May 2025
  
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  DOI: 10.1096/fj.202402764RR
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12093284/
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CRB2 Depletion Induces YAP Signaling and Disrupts Mechanosensing in Podocytes

1
1. scibot 20 May 2025
  
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  RRID:AB_10891442
  
  DOI: 10.1152/ajprenal.00318.2024
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12076484/
Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

1
1. scibot 28 Feb 2025
  
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  DOI: 10.1016/j.ccell.2025.02.001
  
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sciencedirect.com/science/article/pii/S1535610825000534
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Clioquinol inhibits angiogenesis by promoting VEGFR2 degradation and synergizes with AKT inhibition to suppress triple-negative breast cancer vascularization

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1. scibot 04 Feb 2025
  
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  DOI: 10.1007/s10456-024-09965-1
  
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link.springer.com/article/10.1007/s10456-024-09965-1
Sep 2024
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Mcam stabilizes a luminal progenitor-like breast cancer cell state via Ck2 control and Src/Akt/Stat3 attenuation

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1. scibot 18 Sep 2024
  
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  DOI: 10.1038/s41523-024-00687-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11401886/
Jul 2024
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Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation

1
1. scibot 20 Jul 2024
  
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  DOI: 10.1038/s41540-024-00400-1
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11252164/
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The extracellular matrix integrates mitochondrial homeostasis

1
1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.cell.2024.05.057
  
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sciencedirect.com/science/article/pii/S009286742400638X
Jun 2024
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FAK regulates tension transmission to the nucleus and endothelial transcriptome independent of kinase activity

1
1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114297
  
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sciencedirect.com/science/article/pii/S2211124724006259
May 2024
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A proteomics approach to isolating neuropilin-dependent α5 integrin trafficking pathways: neuropilin 1 and 2 co-traffic α5 integrin through endosomal p120RasGAP to promote polarised fibronectin fibrillogenesis in endothelial cells

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1. scibot 30 May 2024
  
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  DOI: 10.1038/s42003-024-06320-4
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11126613/
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Alarmin S100A8 imparts chemoresistance of esophageal cancer by reprogramming cancer-associated fibroblasts

1
1. scibot 23 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101576
  
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sciencedirect.com/science/article/pii/S2666379124002684
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Repurposing homoharringtonine for thyroid cancer treatment through TIMP1/FAK/PI3K/AKT signaling pathway

1
1. scibot 23 May 2024
  
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  RRID:AB_10891442
  
  DOI: 10.1016/j.isci.2024.109829
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11103377/
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ATG9B regulates bacterial internalization via actin rearrangement

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1. scibot 05 May 2024
  
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  RRID:AB_10891442
  
  DOI: 10.1016/j.isci.2024.109623
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11066431/
Apr 2024
aacrjournals.org aacrjournals.org

Sarcoma cells secrete hypoxia-modified collagen VI to weaken the lung endothelial barrier and promote metastasis

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1. scibot 19 Apr 2024
  
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  RRID:AB_10891442
  
  DOI: 10.1158/0008-5472.CAN-23-0910
  
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aacrjournals.org/cancerres/article/84/7/977/742043/Sarcoma-Cells-Secrete-Hypoxia-Modified-Collagen-VI
Mar 2024
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IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF

2
1. scibot 28 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113989
  
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2. scibot 28 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.113989
  
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sciencedirect.com/science/article/pii/S2211124724003176
Jan 2024
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Mechanosensitive hormone signaling promotes mammary progenitor expansion and breast cancer risk

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1. scibot 11 Jan 2024
  
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  DOI: 10.1016/j.stem.2023.12.002
  
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sciencedirect.com/science/article/pii/S1934590923004320
Dec 2023
www.biorxiv.org www.biorxiv.org

Together, Neuropilin 1 and Neuropilin 2 direct α5 integrin trafficking through GTPase-activating-protein p120RasGAP in endothelial cells to promote fibronectin fibrillogenesis

1
1. scibot 02 Dec 2023
  
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  RRID:AB_10891442
  
  DOI: 10.1101/2023.11.28.568967
  
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biorxiv.org/content/10.1101/2023.11.28.568967v1
Nov 2023
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Brain metastasis-associated fibroblasts secrete fucosylated PVR/CD155 that induces breast cancer invasion

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1. scibot 28 Nov 2023
  
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  RRID:AB_10891442
  
  DOI: 10.1016/j.celrep.2023.113463
  
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sciencedirect.com/science/article/pii/S2211124723014754
Oct 2023
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High-throughput chemogenetic drug screening reveals PKC-RhoA/PKN as a targetable signaling vulnerability in GNAQ-driven uveal melanoma

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.xcrm.2023.101244
  
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sciencedirect.com/science/article/pii/S2666379123004214
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Collagen 1-mediated CXCL1 secretion in tumor cells activates fibroblasts to promote radioresistance of esophageal cancer

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1. scibot 27 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113270
  
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sciencedirect.com/science/article/pii/S2211124723012822
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Mechanochemical coupling of MGF mediates periodontal regeneration

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1. scibot 09 Oct 2023
  
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  DOI: 10.1002/btm2.10603
  
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aiche.onlinelibrary.wiley.com/doi/10.1002/btm2.10603
Aug 2023
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CdGAP is a talin-binding protein and a target of TGF-β signaling that promotes HER2-positive breast cancer growth and metastasis

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1. scibot 10 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112936
  
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sciencedirect.com/science/article/pii/S2211124723009476
Jul 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IGF1R inhibition enhances the therapeutic effects of Gq/11 inhibition in metastatic uveal melanoma progression

1
1. scibot 06 Jul 2023
  
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  DOI: 10.1158/1535-7163.MCT-22-0147
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9812929/
Jun 2023
52.53.155.43 52.53.155.43

Macrophage-derived cathepsin S remodels the extracellular matrix to promote liver fibrogenesis

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1. scibot 16 Jun 2023
  
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  DOI: 10.1053/j.gastro.2023.05.039
  
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52.53.155.43/6547da8aa0b8d7e491fdd14880a12803f28db0ef/1-s2.0-S0016508523008120-main-html.html
Apr 2023
aacrjournals.org aacrjournals.org

CD142 Identifies Neoplastic Desmoid Tumor Cells, Uncovering Interactions Between Neoplastic and Stromal Cells That Drive Proliferation

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1. scibot 28 Apr 2023
  
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  DOI: 10.1158/2767-9764.CRC-22-0403
  
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aacrjournals.org/cancerrescommun/article/3/4/697/726086/CD142-Identifies-Neoplastic-Desmoid-Tumor-Cells
Mar 2023
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FAK-mediated phosphorylation at Y464 regulates p85β nuclear translocation to promote tumorigenesis of ccRCC by repressing RB1 expression

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1. scibot 02 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112188
  
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sciencedirect.com/science/article/pii/S2211124723001997
Feb 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells

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1. scibot 17 Feb 2023
  
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  DOI: 10.1126/scisignal.abj5879
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
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GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis

1
1. scibot 17 Feb 2023
  
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  RRID:AB_10891442
  
  DOI: 10.1016/j.devcel.2023.01.006
  
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The mechanosensitive TRPV2 calcium channel promotes human melanoma invasiveness and metastatic potential

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GSNOR deficiency promotes tumor growth via FAK1 S-nitrosylation

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A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration

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CRABP2 is associated with thyroid cancer recurrence and promotes invasion via the integrin/FAK/AKT pathway

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Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin

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The Cancermuts software package for the prioritization of missense cancer variants: a case study of AMBRA1 in melanoma

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Competition for endothelial cell polarity drives vascular morphogenesis in the mouse retina

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Methionine oxidation activates pyruvate kinase M2 to promote pancreatic cancer metastasis

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Protrudin regulates FAK activation, endothelial cell migration and angiogenesis

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Angiopoietin-2-induced lymphatic endothelial cell migration drives lymphangiogenesis via the β1 integrin-RhoA-formin axis

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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis

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Deciphering cell signaling networks with massively multiplexed biosensor barcoding

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Senescent immune cells release grancalcin to promote skeletal aging

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Retraction fibers produced by fibronectin-integrin α5β1 interaction promote motility of brain tumor cells

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Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR Signaling

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Induction of cyclophilin A by influenza A virus infection facilitates group A Streptococcus coinfection

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Loss of Ambra1 promotes melanoma growth and invasion

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Gain-of-function hot spot mutant p53R248Q regulation of integrin/FAK/ERK signaling in esophageal squamous cell carcinoma

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  phospho-FAK
  
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Matrix Rigidity Controls Epithelial-Mesenchymal Plasticity and Tumor Metastasis via a Mechanoresponsive EPHA2/LYN Complex

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Collagen-rich omentum is a premetastatic niche for integrin α2-mediated peritoneal metastasis

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Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling

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Targeting the Tie2–α v β 3 integrin axis with bi-specific reagents for the inhibition of angiogenesis

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Secreted Pyruvate Kinase M2 Promotes Lung Cancer Metastasis through Activating the Integrin Beta1/FAK Signaling Pathway

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OVA66 promotes tumour angiogenesis and progression through enhancing autocrine VEGF-VEGFR2 signalling

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Novel role for CRK adaptor proteins as essential components of SRC/FAK signaling for epithelial‐mesenchymal transition and colorectal cancer aggressiveness

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Divergent Polypharmacology-Driven Cellular Activity of Structurally Similar Multi-Kinase Inhibitors through Cumulative Effects on Individual Targets

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Untitled document

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Untitled document

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Insulinlike Growth Factor–Binding Protein-1 Improves Vascular Endothelial Repair in Male Mice in the Setting of Insulin Resistance

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Nov 2017
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Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma

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