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Opposing functions of gut immunomodulatory metabolites on CAR-T therapy

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1. scibot 01 Oct 2026
  
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  DOI: 10.1016/j.cell.2026.09.004
  
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sciencedirect.com/science/article/pii/S0092867426010731
Sep 2026
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Cyclin E-CDK2 regulates cancer cell transcriptional program and response to immunotherapy through BRD4

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1. scibot 04 Sep 2026
  
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  DOI: 10.1016/j.molcel.2026.08.007
  
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sciencedirect.com/science/article/pii/S109727652600554X
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

ADA2-Functionalized OMVs Remodel the Tumor Microenvironment in Pancreatic Cancer

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1. scibot 01 Sep 2026
  
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  DOI: 10.3390/pharmaceutics18080920
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13516308/
Aug 2026
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CCR7+ activated dendritic cells are essential for spontaneous and immunotherapy-driven anti-tumor immunity

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1. scibot 07 Aug 2026
  
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  DOI: 10.1016/j.immuni.2026.07.002
  
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sciencedirect.com/science/article/pii/S1074761326002785
Jun 2026
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A radiopharmaceutical enhances CAR T cells against radio-sensitive and radio-resistant neuroblastoma by tumor sensitization and TME remodeling

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1. scibot 25 Jun 2026
  
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sciencedirect.com/science/article/pii/S2666379126003010
Apr 2026
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Nerves Stimulate Cross-talk Between Gastric Cancer and Group 3 Innate Lymphoid Cells to Enhance Immunosuppression

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1. scibot 17 Apr 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-3092
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13080324/
Mar 2026
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Myofibroblast programming blocks differentiation of TLS-organizing fibroblastic reticular cells in pancreatic cancer

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.03.004
  
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sciencedirect.com/science/article/pii/S153561082600156X
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Vascular STING activation facilitates NK cell anti-tumor immunity in small cell lung cancer

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1. scibot 06 Mar 2026
  
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  DOI: 10.1016/j.ccell.2026.02.008
  
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sciencedirect.com/science/article/pii/S1535610826001066
Feb 2026
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Chemotherapy triggers immune evasion by fostering LEPR+ Kupffer cell differentiation in liver metastases

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1. scibot 13 Feb 2026
  
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  DOI: 10.1016/j.ccell.2026.01.010
  
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sciencedirect.com/science/article/pii/S1535610826000498
Jan 2026
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Innate lymphoid cells activated by the cytokine TL1A link colitis to emergency granulopoiesis and the recruitment of tumor-promoting neutrophils

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1. scibot 23 Jan 2026
  
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  DOI: 10.1016/j.immuni.2025.12.008
  
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sciencedirect.com/science/article/pii/S1074761325005643
Nov 2025
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MYC and p53 Alterations Cooperate through VEGF Signaling to Repress Cytotoxic T Cell and Immunotherapy Responses in Prostate Cancer

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1. scibot 24 Nov 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-2532
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12471896/
Oct 2025
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Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

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1. scibot 25 Oct 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618275/
Sep 2025
aacrjournals.org aacrjournals.org

Tumor-Associated NK Cells Regulate Distinct CD8+ T-cell Differentiation Program in Cancer and Contribute to Resistance against Immune Checkpoint Blockers

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1. scibot 09 Sep 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1232
  
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aacrjournals.org/cancerdiscovery/article/15/9/1835/764367/Tumor-associated-NK-Cells-Regulate-Distinct-CD8-T
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Lrrk2 G2019S mutation incites increased cell-intrinsic neutrophil effector functions and intestinal inflammation in a model of infectious colitis

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1. scibot 06 Sep 2025
  
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  DOI: 10.1038/s41531-025-01077-x
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12397289/
Aug 2025
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Lipid nanoparticles as a tool to dissect dendritic cell maturation pathways

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116150
  
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sciencedirect.com/science/article/pii/S2211124725009210
May 2025
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PINK1 deficiency rewires early immune responses in a mouse model of Parkinson’s disease triggered by intestinal infection

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1. scibot 28 May 2025
  
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  DOI: 10.1038/s41531-025-00945-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12098848/
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Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115679
  
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sciencedirect.com/science/article/pii/S2211124725004504
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Role of Forkhead Box P3 in Interferon γ-mediated PD-L1 Expression and Bladder Cancer Epithelial-to-Mesenchymal Transition

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1. scibot 28 Aug 2024
  
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  DOI: 10.1158/2767-9764.CRC-23-0493
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11345674/
Apr 2024
www.nature.com www.nature.com

Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

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1. scibot 03 Apr 2024
  
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  DOI: 10.1038/s41467-024-47069-y
  
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nature.com/articles/s41467-024-47069-y
Dec 2023
www.cell.com www.cell.com

Aged intestinal stem cells propagate cell-intrinsic sources of inflammaging in mice

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1. scibot 19 Dec 2023
  
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  DOI: 10.1016/j.devcel.2023.11.013
  
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cell.com/developmental-cell/fulltext/S1534-5807(23)00611-1
Nov 2023
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Aurora A kinase inhibition induces accumulation of SCLC tumor cells in mitosis with restored interferon signaling to increase response to PD-L1

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1. scibot 22 Nov 2023
  
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  DOI: 10.1016/j.xcrm.2023.101282
  
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sciencedirect.com/science/article/pii/S2666379123004767
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PTIR1 acts as an isoform of DDX58 and promotes tumor immune resistance through activation of UCHL5

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113388
  
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sciencedirect.com/science/article/pii/S2211124723014006
Oct 2023
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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1. scibot 13 Oct 2023
  
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  DOI: 10.1016/j.ccell.2023.09.001
  
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sciencedirect.com/science/article/pii/S1535610823003185
Sep 2023
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Interferon-g-dependent interactions between tissue-intrinsic γδ T cells and tissue-infiltrating CD8 T cells limit acute contact dermatitis

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1. scibot 29 Sep 2023
  
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  DOI: 10.1016/j.jaci.2023.07.015
  
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sciencedirect.com/science/article/pii/S0091674923009818
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

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1. scibot 12 Aug 2023
  
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  DOI: 10.1136/jitc-2022-006457
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10414095/
Jun 2023
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Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia

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1. scibot 23 Jun 2023
  
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  DOI: 10.1016/j.cmet.2023.05.008
  
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sciencedirect.com/science/article/pii/S1550413123001857
Jan 2023
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Neutrophil-activating therapy for the treatment of cancer

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1. scibot 27 Jan 2023
  
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  DOI: 10.1016/j.ccell.2023.01.002
  
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sciencedirect.com/science/article/pii/S1535610823000028
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Protocol to assess the antitumor efficacy of an immunotherapeutic peptide in syngeneic orthotopic glioma mouse models

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1. scibot 21 Jan 2023
  
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  DOI: 10.1016/j.xpro.2023.102049
  
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sciencedirect.com/science/article/pii/S2666166723000072
Nov 2022
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The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity

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1. scibot 15 Nov 2022
  
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  DOI: 10.1016/j.immuni.2022.10.020
  
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sciencedirect.com/science/article/pii/S1074761322005611
Sep 2022
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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

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1. scibot 24 Sep 2022
  
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  DOI: 10.1016/j.ccell.2022.08.016
  
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sciencedirect.com/science/article/pii/S1535610822003804
Aug 2022
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During early stages of cancer, neutrophils initiate anti-tumor immune responses in tumor-draining lymph nodes

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1. scibot 17 Aug 2022
  
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  DOI: 10.1016/j.celrep.2022.111171
  
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sciencedirect.com/science/article/pii/S2211124722009846
May 2022
www.cell.com www.cell.com

Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer

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1. scibot 05 May 2022
  
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  DOI: 10.1016/j.cmet.2022.04.003
  
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cell.com/cell-metabolism/fulltext/S1550-4131(22)00130-9
Feb 2022
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

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1. scibot 23 Feb 2022
  
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  DOI: 10.1016/j.celrep.2022.110420
  
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pubmed.ncbi.nlm.nih.gov/35196494/
Jan 2022
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Magnesium sensing via LFA-1 regulates CD8+ T cell effector function

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1. scibot 26 Jan 2022
  
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  RRID:AB_10897097
  
  DOI: 10.1016/j.cell.2021.12.039
  
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sciencedirect.com/science/article/pii/S0092867421015610
Nov 2021
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Mitochondrial respiration contributes to the interferon gamma response in antigen-presenting cells

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1. scibot 24 Nov 2021
  
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  DOI: 10.7554/eLife.65109
  
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elifesciences.org/articles/65109
Aug 2021
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The CD155/TIGIT axis promotes and maintains immune evasion in neoantigen-expressing pancreatic cancer

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1. scibot 15 Aug 2021
  
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  DOI: 10.1016/j.ccell.2021.07.007
  
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sciencedirect.com/science/article/pii/S1535610821003846
Jul 2021
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Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist

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1. scibot 31 Jul 2021
  
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  DOI: 10.7554/eLife.50256
  
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elifesciences.org/articles/50256
May 2021
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Molecular tracking devices quantify antigen distribution and archiving in the murine lymph node

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1. scibot 19 May 2021
  
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  DOI: 10.7554/eLife.62781
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8116055/
Feb 2021
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PD-L1 Reverse Signaling in Dermal Dendritic Cells Promotes Dendritic Cell Migration Required for Skin Immunity

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1. scibot 27 Feb 2021
  
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  DOI: 10.1016/j.celrep.2020.108258
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7688291/
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Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade

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1. scibot 24 Feb 2021
  
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  DOI: 10.1016/j.ccell.2020.11.005
  
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cell.com/cancer-cell/abstract/S1535-6108(20)30597-3
Jan 2020
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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.11.003
  
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sciencedirect.com/science/article/pii/S1074761319304613
Nov 2018
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Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1550413118301177
Nov 2017
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Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade

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1. scibot 08 Nov 2017
  
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