231 Matching Annotations
  1. Last 7 days
  2. www.sciencedirect.com www.sciencedirect.com
    Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response
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    1. scibot 17 Nov 2024
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      DOI: 10.1016/j.medj.2024.10.007

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  3. Nov 2024
  4. 52.53.155.43 52.53.155.43
    can-24-0880-html.html
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    DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer
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    1. scibot 11 Nov 2024
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    sciencedirect.com/science/article/pii/S2666634024004100
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    Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy
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    1. scibot 11 Nov 2024
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    sciencedirect.com/science/article/pii/S1535610824003969
  7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
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    1. scibot 08 Nov 2024
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      DOI: 10.1158/0008-5472.CAN-24-0134

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    pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
  8. 52.53.155.43 52.53.155.43
    crc-24-0270-html.html
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  9. Oct 2024
  10. www.biorxiv.org www.biorxiv.org
    Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
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    1. scibot 02 Oct 2024
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      DOI: 10.1101/2024.09.09.612140

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    biorxiv.org/content/10.1101/2024.09.09.612140v1
  11. aacrjournals.org aacrjournals.org
    Targeting of CD40 and PD-L1 pathways inhibit progression of oral premalignant lesions in a carcinogen-induced model of oral squamous cell carcinoma
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    1. scibot 02 Oct 2024
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      DOI: 10.1158/1940-6207.CAPR-20-0418

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    aacrjournals.org/cancerpreventionresearch/article/14/3/313/47829/Targeting-of-CD40-and-PD-L1-Pathways-Inhibits
  12. Sep 2024
  13. www.sciencedirect.com www.sciencedirect.com
    Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer
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    sciencedirect.com/science/article/pii/S1535610824003180
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    Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models
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    1. scibot 17 Sep 2024
      AB_10949053

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    sciencedirect.com/science/article/pii/S2589004224020790
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination
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    1. scibot 05 Sep 2024
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      DOI: 10.1158/2326-6066.CIR-23-0289

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    ncbi.nlm.nih.gov/pmc/articles/PMC11369622/
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    H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response
    1
    1. scibot 04 Sep 2024
      AB_10949053

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    sciencedirect.com/science/article/pii/S2211124724010374
  17. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Type I interferon signaling regulates myeloid and T cell crosstalk in the glioblastoma tumor microenvironment
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    1. scibot 04 Sep 2024
      AB_10949053

      DOI: 10.1016/j.isci.2024.110810

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    pmc.ncbi.nlm.nih.gov/articles/PMC11404196/
  18. Aug 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression
    1
    1. scibot 28 Aug 2024
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    sciencedirect.com/science/article/pii/S1534580724004866
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Efficacy of novel allogeneic cancer cells vaccine to treat colorectal cancer
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    1. scibot 21 Aug 2024
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      DOI: 10.3389/fonc.2024.1427428

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  21. Jul 2024
  22. www.cell.com www.cell.com
    Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor
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    1. scibot 30 Jul 2024
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      DOI: 10.1016/j.chom.2024.06.010

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    cell.com/cell-host-microbe/abstract/S1931-3128(24)00228-2
  23. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    1. scibot 27 Jul 2024
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      DOI: 10.1016/j.isci.2024.110285

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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
    1
    1. scibot 19 Jul 2024
      AB_10949053

      DOI: 10.1016/j.medj.2024.06.002

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    sciencedirect.com/science/article/pii/S2666634024002484
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CDK4/6 inhibition sensitizes intracranial tumors to PD-1 blockade in preclinical models of brain metastasis
    1
    1. scibot 18 Jul 2024
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      DOI: 10.1158/1078-0432.CCR-23-0433

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    PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies
    1
    1. scibot 17 Jul 2024
      AB_10949053

      DOI: 10.1016/j.xcrm.2024.101649

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    sciencedirect.com/science/article/pii/S266637912400363X
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
    1
    1. scibot 16 Jul 2024
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      DOI: 10.1016/j.xcrm.2024.101640

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    ncbi.nlm.nih.gov/pmc/articles/PMC11293343/
  28. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy
    1
    1. scibot 14 Jul 2024
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      DOI: 10.1016/j.isci.2024.110189

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    ncbi.nlm.nih.gov/pmc/articles/PMC11233966/
  29. Jun 2024
  30. www.sciencedirect.com www.sciencedirect.com
    Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114300

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    sciencedirect.com/science/article/pii/S2211124724006284
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114289

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    ncbi.nlm.nih.gov/pmc/articles/PMC11315447/
  32. May 2024
  33. www.sciencedirect.com www.sciencedirect.com
    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death
    1
    1. scibot 24 May 2024
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      DOI: 10.1016/j.immuni.2024.04.025

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    sciencedirect.com/science/article/pii/S1074761324002309
  34. www.sciencedirect.com www.sciencedirect.com
    Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance
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    1. scibot 21 May 2024
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      DOI: 10.1016/j.immuni.2024.04.024

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    sciencedirect.com/science/article/pii/S1074761324002292
  35. www.cell.com www.cell.com
    ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models
    1
    1. scibot 10 May 2024
      RRID:AB_10949053

      DOI: 10.1016/j.isci.2024.109800

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    cell.com/iscience/abstract/S2589-0042(24)01022-8
  36. Apr 2024
  37. www.sciencedirect.com www.sciencedirect.com
    LKB1 prevents ILC2 exhaustion to enhance antitumor immunity
    1
    1. scibot 26 Apr 2024
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      DOI: 10.1016/j.celrep.2023.113579

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    sciencedirect.com/science/article/pii/S2211124723015917
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 24 Apr 2024
      RRID:AB_10949053

      DOI: 10.1126/sciimmunol.adj5097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
  39. www.sciencedirect.com www.sciencedirect.com
    QDPR deficiency drives immune suppression in pancreatic cancer
    1
    1. scibot 23 Apr 2024
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      DOI: 10.1016/j.cmet.2024.03.015

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    sciencedirect.com/science/article/pii/S1550413124001190
  40. www.sciencedirect.com www.sciencedirect.com
    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
    1
    1. scibot 12 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101479

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    sciencedirect.com/science/article/pii/S2666379124001253
  41. www.sciencedirect.com www.sciencedirect.com
    Genetic interactions reveal distinct biological and therapeutic implications in breast cancer
    1
    1. scibot 09 Apr 2024
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      DOI: 10.1016/j.ccell.2024.03.006

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    sciencedirect.com/science/article/pii/S1535610824000916
  42. www.sciencedirect.com www.sciencedirect.com
    Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells
    1
    1. scibot 02 Apr 2024
      BioxcellCat# be0146

      DOI: 10.1016/j.cell.2024.03.011

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    sciencedirect.com/science/article/pii/S0092867424003039
  43. Mar 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity
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      DOI: 10.1016/j.celrep.2024.114003

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    sciencedirect.com/science/article/pii/S2211124724003310
  45. www.sciencedirect.com www.sciencedirect.com
    Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
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      DOI: 10.1016/j.ccell.2024.03.001

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      DOI: 10.1016/j.ccell.2024.03.001

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    sciencedirect.com/science/article/pii/S1535610824000801
  46. www.sciencedirect.com www.sciencedirect.com
    A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy
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    1. scibot 21 Mar 2024
      RRID:AB_10949053

      DOI: 10.1016/j.chom.2024.03.002

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    sciencedirect.com/science/article/pii/S1931312824000751
  47. www.sciencedirect.com www.sciencedirect.com
    Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers
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    1. scibot 15 Mar 2024
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      DOI: 10.1016/j.ccell.2024.02.013

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    sciencedirect.com/science/article/pii/S1535610824000576
  48. www.sciencedirect.com www.sciencedirect.com
    Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity
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    1. scibot 08 Mar 2024
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2024.113932

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    sciencedirect.com/science/article/pii/S2211124724002602
  49. Feb 2024
  50. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas
    2
    1. scibot 15 Feb 2024
      RRID:AB_10949053

      DOI: 10.1158/2767-9764.CRC-23-0399

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  51. www.mdpi.com www.mdpi.com
    The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor Immunity in a Mouse Lung Cancer Model
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      DOI: 10.3390/ijms25031880

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  52. www.sciencedirect.com www.sciencedirect.com
    Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5
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      DOI: 10.1016/j.cmet.2024.01.012

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  53. www.sciencedirect.com www.sciencedirect.com
    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  54. Jan 2024
  55. www.sciencedirect.com www.sciencedirect.com
    Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms
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      DOI: 10.1016/j.ccell.2023.12.018

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  56. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities
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  57. www.sciencedirect.com www.sciencedirect.com
    Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer
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    A novel translational PET imaging approach to quantifying abscopal immune activation following targeted radiotherapy and checkpoint blockade.
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      DOI: 10.1016/j.ijrobp.2023.12.047

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  59. www.sciencedirect.com www.sciencedirect.com
    Interferon-stimulated neutrophils as a predictor of immunotherapy response
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  60. www.sciencedirect.com www.sciencedirect.com
    A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma
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  61. Dec 2023
  62. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Preventive Treatment with PD-1 Antibody Increases Tissue-Resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis
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      DOI: 10.1158/1940-6207.CAPR-23-0196

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  63. www.sciencedirect.com www.sciencedirect.com
    The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer
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  64. www.sciencedirect.com www.sciencedirect.com
    Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity
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  65. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
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  66. 52.53.155.43 52.53.155.43
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  67. Nov 2023
  68. link.springer.com link.springer.com
    Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity
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      DOI: 10.1038/s41586-023-06749-3

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  69. www.sciencedirect.com www.sciencedirect.com
    E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC
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    An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2
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    Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer
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  72. Oct 2023
  73. www.sciencedirect.com www.sciencedirect.com
    Targeting VCP potentiates immune checkpoint therapy for colorectal cancer
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    Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response
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    Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
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    Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy
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    Supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation
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    Glioblastoma vascular plasticity limits effector T-cell infiltration and is blocked by cAMP activation
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      DOI: 10.1158/2326-6066.CIR-22-0872

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    Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer
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  82. Sep 2023
  83. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells
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  84. www.sciencedirect.com www.sciencedirect.com
    Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy
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  85. Aug 2023
  86. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade
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  87. www.sciencedirect.com www.sciencedirect.com
    CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity
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  88. 52.53.155.43 52.53.155.43
    PIIS2211124723009622-html.html
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  89. www.sciencedirect.com www.sciencedirect.com
    A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells
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    METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy
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  91. 52.53.155.43 52.53.155.43
    Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells
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  92. 52.53.155.43 52.53.155.43
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  93. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    OncoLoop: A network-based precision cancer medicine framework
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  94. Jul 2023
  95. www.sciencedirect.com www.sciencedirect.com
    SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck
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    A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence
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  97. www.sciencedirect.com www.sciencedirect.com
    TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation
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  98. Jun 2023
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    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
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    PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
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  101. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer
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  102. www.sciencedirect.com www.sciencedirect.com
    IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy
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    Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion
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  104. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
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  105. May 2023
  106. www.sciencedirect.com www.sciencedirect.com
    CCL19+ dendritic cells potentiate clinical benefit of anti-PD-(L)1 immunotherapy in triple-negative breast cancer
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  107. www.nature.com www.nature.com
    Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response
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  108. www.sciencedirect.com www.sciencedirect.com
    Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
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  109. www.sciencedirect.com www.sciencedirect.com
    Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal
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  110. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition
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    Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer
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  112. Apr 2023
  113. aacrjournals.org aacrjournals.org
    Targeting ULK1 decreases interferon-γ-mediated resistance to immune checkpoint inhibitors
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  114. insight.jci.org insight.jci.org
    Lenvatinib or anti-VEGF in combination with anti-PD-1 differentially augments anti-tumor activity in melanoma
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  115. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy
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  116. www.sciencedirect.com www.sciencedirect.com
    Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response
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    Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade
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    An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses
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  119. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody
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  120. www.sciencedirect.com www.sciencedirect.com
    Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects
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    Lacticaseibacillus rhamnosus Probio-M9 enhanced the antitumor response to anti-PD-1 therapy by modulating intestinal metabolites
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    T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
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  123. Mar 2023
  124. www.sciencedirect.com www.sciencedirect.com
    IFNγ is a central node of cancer immune equilibrium
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    Adhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T cells with enhanced tumor homing to improve cell therapy
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  126. Feb 2023
  127. www.sciencedirect.com www.sciencedirect.com
    Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer
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  128. www.embopress.org www.embopress.org
    Pericyte stem cells induce Ly6G+ cell accumulation and immunotherapy resistance in pancreatic cancer
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  129. Jan 2023
  130. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Impact of mouse model tumor implantation site on acquired resistance to anti-PD-1 immune checkpoint therapy
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  131. www.sciencedirect.com www.sciencedirect.com
    S-adenosylmethionine blocks tumorigenesis and with immune checkpoint inhibitor enhances anti-cancer efficacy against BRAF mutant and wildtype melanomas
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    MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
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  133. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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  134. Dec 2022
  135. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  136. www.sciencedirect.com www.sciencedirect.com
    IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
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  137. www.sciencedirect.com www.sciencedirect.com
    Cancer cell-derived type I interferons instruct tumor monocyte polarization
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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The CIt protocol: a blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells.
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  139. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
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  140. Nov 2022
  141. aacrjournals.org aacrjournals.org
    A novel selective inhibitor JBI-589 targets PAD4-mediated neutrophil migration to suppress tumor progression
    1
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      RRID:AB_10949053

      DOI: 10.1158/0008-5472.CAN-21-4045

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    aacrjournals.org/cancerres/article/82/19/3561/709408/A-Novel-Selective-Inhibitor-JBI-589-Targets-PAD4
  142. aacrjournals.org aacrjournals.org
    Phototherapy with cancer-specific nanoporphyrin potentiates immunotherapy in bladder cancer
    1
    1. scibot 22 Nov 2022
      RRID:AB_10949053

      DOI: 10.1158/1078-0432.CCR-22-1362

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    aacrjournals.org/clincancerres/article/28/21/4820/709840/Phototherapy-with-Cancer-Specific-Nanoporphyrin
  143. www.sciencedirect.com www.sciencedirect.com
    Cardiac myosin-specific autoimmune T cells contribute to immune-checkpoint-inhibitor-associated myocarditis
    1
    1. scibot 10 Nov 2022
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2022.111611

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    sciencedirect.com/science/article/pii/S2211124722014802
  144. www.sciencedirect.com www.sciencedirect.com
    Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection
    1
    1. scibot 05 Nov 2022
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2022.111478

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    sciencedirect.com/science/article/pii/S2211124722013286
  145. jitc.bmj.com jitc.bmj.com
    Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation
    1
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      RRID:AB_10949053

      DOI: 10.1136/jitc-2022-004874

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  146. Oct 2022
  147. 52.53.155.43 52.53.155.43
    ccr-22-1362 (1)-html.html
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      DOI: 10.1158/1078-0432.ccr-22-1362

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  148. www.sciencedirect.com www.sciencedirect.com
    Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy
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      RRID:AB_10949053

      DOI: 10.1016/j.immuni.2022.09.014

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  149. www.sciencedirect.com www.sciencedirect.com
    Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy
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      RRID:AB_10949053

      DOI: 10.1016/j.cmet.2022.09.021

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  150. www.sciencedirect.com www.sciencedirect.com
    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
    1
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      RRID:AB_10949053

      DOI: 10.1016/j.cell.2022.09.020

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  151. Sep 2022
  152. www.sciencedirect.com www.sciencedirect.com
    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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    1. scibot 24 Sep 2022
      RRID:AB_10949053

      DOI: 10.1016/j.ccell.2022.08.016

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    sciencedirect.com/science/article/pii/S1535610822003804
  153. www.sciencedirect.com www.sciencedirect.com
    Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1
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      DOI: 10.1016/j.cmet.2022.08.016

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  154. www.sciencedirect.com www.sciencedirect.com
    Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
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      DOI: 10.1016/j.xcrm.2022.100744

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  155. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PTP1B is an intracellular checkpoint that limits T cell and CAR T cell anti-tumor immunity
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      RRID:AB_10949053

      DOI: 10.1158/2159-8290.CD-21-0694

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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma
    1
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      DOI: 10.1158/2159-8290.CD-21-1077

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  157. Aug 2022
  158. www.sciencedirect.com www.sciencedirect.com
    Tumor targeted 4-1BB agonist antibody-albumin fusions with high-affinity to FcRn induce anti-tumor immunity without toxicity
    1
    1. scibot 30 Aug 2022
      RRID:AB_10949053

      DOI: 10.1016/j.isci.2022.104958

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    sciencedirect.com/science/article/pii/S2589004222012305
  159. www.sciencedirect.com www.sciencedirect.com
    Aerobic glycolysis promotes tumor immune evasion by hexokinase2-mediated phosphorylation of IκBα
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      RRID:AB_10949053

      DOI: 10.1016/j.cmet.2022.08.002

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  160. www.sciencedirect.com www.sciencedirect.com
    Stromal remodeling regulates dendritic cell abundance and activity in the tumor microenvironment
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      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2022.111201

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    sciencedirect.com/science/article/pii/S221112472201018X
  161. www.sciencedirect.com www.sciencedirect.com
    Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
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      RRID:AB_10949053

      DOI: 10.1016/j.immuni.2022.07.001

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  162. Jul 2022
  163. www.sciencedirect.com www.sciencedirect.com
    Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer
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      RRID:AB_10949053

      DOI: 10.1016/j.ccell.2022.06.011

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  164. Jun 2022
  165. 52.53.155.43 52.53.155.43
    cd-21-1022-html.html
    3
    1. scibot 30 Jun 2022
      AB_10949053

      DOI: 10.1158/2159-8290.CD-21-1022

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      AB_10949053

      DOI: 10.1158/2159-8290.cd-21-1022

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      AB_10949053

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  166. www.sciencedirect.com www.sciencedirect.com
    Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling
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      RRID:AB_10949053

      DOI: 10.1016/j.chembiol.2022.05.012

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    sciencedirect.com/science/article/pii/S2451945622002045
  167. www.sciencedirect.com www.sciencedirect.com
    Flow cytometry analysis of endothelial cells and subsets of exhausted CD8+ T cells in murine tumor models
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    1. scibot 09 Jun 2022
      RRID:AB_10949053

      DOI: 10.1016/j.xpro.2022.101444

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    sciencedirect.com/science/article/pii/S2666166722003240
  168. www.sciencedirect.com www.sciencedirect.com
    PGE2-EP2/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment
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      DOI: 10.1016/j.celrep.2022.110914

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    sciencedirect.com/science/article/pii/S221112472200691X
  169. www.sciencedirect.com www.sciencedirect.com
    Exercise-induced engagement of the IL-15/IL-15Rα axis promotes anti-tumor immunity in pancreatic cancer
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      RRID:AB_10949053

      DOI: 10.1016/j.ccell.2022.05.006

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    sciencedirect.com/science/article/pii/S1535610822002173
  170. May 2022
  171. www.sciencedirect.com www.sciencedirect.com
    Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity
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      RRID:AB_10949053

      DOI: 10.1016/j.ccell.2022.04.004

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    sciencedirect.com/science/article/pii/S1535610822001660
  172. www.cell.com www.cell.com
    Glutaminase inhibition impairs CD8 T cell activation in STK11-/Lkb1-deficient lung cancer
    1
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      RRID:AB_10949053

      DOI: 10.1016/j.cmet.2022.04.003

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    cell.com/cell-metabolism/fulltext/S1550-4131(22)00130-9
  173. Apr 2022
  174. www.sciencedirect.com www.sciencedirect.com
    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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      RRID:AB_10949053

      DOI: 10.1016/j.immuni.2022.03.007

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    sciencedirect.com/science/article/pii/S1074761322001303
  175. Mar 2022
  176. www.sciencedirect.com www.sciencedirect.com
    PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade
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      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2022.110582

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    sciencedirect.com/science/article/pii/S2211124722003266
  177. www.sciencedirect.com www.sciencedirect.com
    AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1+ CD8 T cells
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      RRID:AB_10949053

      DOI: 10.1016/j.xcrm.2022.100554

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    sciencedirect.com/science/article/pii/S266637912200060X
  178. www.sciencedirect.com www.sciencedirect.com
    The microbial metabolite trimethylamine N-oxide promotes antitumor immunity in triple-negative breast cancer
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    sciencedirect.com/science/article/pii/S1550413122000547
  179. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Heterogeneity of tyrosine-based melanin anabolism regulates pulmonary and cerebral organotropic colonization microenvironment of melanoma cells
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      RRID:AB_2894808

      DOI: 10.7150/thno.69198

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    ncbi.nlm.nih.gov/pmc/articles/PMC8899568/
  180. www.sciencedirect.com www.sciencedirect.com
    Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity
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      DOI: 10.1016/j.xcrm.2022.100534

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    sciencedirect.com/science/article/pii/S2666379122000349
  181. Feb 2022
  182. www.sciencedirect.com www.sciencedirect.com
    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
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  183. Jan 2022
  184. www.sciencedirect.com www.sciencedirect.com
    Magnesium sensing via LFA-1 regulates CD8+ T cell effector function
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      DOI: 10.1016/j.cell.2021.12.039

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    sciencedirect.com/science/article/pii/S0092867421015610
  185. www.sciencedirect.com www.sciencedirect.com
    MEK inhibition overcomes chemoimmunotherapy resistance by inducing CXCL10 in cancer cells
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      DOI: 10.1016/j.ccell.2021.12.009

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  186. Dec 2021
  187. www.nature.com www.nature.com
    Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance
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      DOI: 10.1038/s41467-021-27349-7

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    nature.com/articles/s41467-021-27349-7
  188. www.sciencedirect.com www.sciencedirect.com
    The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota
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      DOI: 10.1016/j.xcrm.2021.100464

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  189. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting myeloid-derived suppressor cells to attenuate vasculogenic mimicry and synergistically enhance the anti-tumor effect of PD-1 inhibitor
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      DOI: 10.1016/j.isci.2021.103392

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  190. Nov 2021
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    Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation
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    LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency
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  193. Oct 2021
  194. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Microbiota triggers STING-type I IFN-dependent monocyte reprogramming of the tumor microenvironment
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  195. Sep 2021
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    Original research: CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell
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      DOI: 10.1136/jitc-2021-003100

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    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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    Effects of exercise and anti-PD-1 on the tumour microenvironment
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  199. Aug 2021
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    Dysregulation of ILC3s unleashes progression and immunotherapy resistance in colon cancer
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    NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
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    NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines
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    Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
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  206. Jul 2021
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    Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
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    Oncolytic Newcastle disease virus expressing a checkpoint inhibitor as a radioenhancing agent for murine melanoma
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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    Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma
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    Lipopolysaccharide-mediated chronic inflammation promotes tobacco carcinogen-induced lung cancer and determines the efficacy of immunotherapy
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  212. Jun 2021
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    Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
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    Immune checkpoint blockade reprograms systemic immune landscape and tumor microenvironment in obesity-associated breast cancer
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    Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment
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    Protocol to establish a lung adenocarcinoma immunotherapy allograft mouse model with FACS and immunofluorescence-based analysis of tumor response
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    Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity
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  218. May 2021
  219. aacrjournals.org aacrjournals.org
    A MyD88/IL-1R axis regulates PD-1 expression on tumor-associated macrophages and sustains their immunosuppressive function in melanoma
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    aacrjournals.org/cancerres/article/81/9/2358/670580/A-MyD88-IL1R-Axis-Regulates-PD-1-Expression-on
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    BMI1 Inhibition Eliminates Residual Cancer Stem Cells after PD1 Blockade and Activates Antitumor Immunity to Prevent Metastasis and Relapse
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    Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation
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      DOI: 10.1016/j.molcel.2021.01.010

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    Eomes-Dependent Loss of the Co-activating Receptor CD226 Restrains CD8+ T Cell Anti-tumor Functions and Limits the Efficacy of Cancer Immunotherapy
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    Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
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    Pharmacological Wnt ligand inhibition overcomes key tumor-mediated resistance pathways to anti-PD-1 immunotherapy
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  226. Apr 2021
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    Metabolic-Pathway-Based Subtyping of Triple-Negative Breast Cancer Reveals Potential Therapeutic Targets
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    Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells
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    CD36-mediated ferroptosis dampens intratumoral CD8+ T cell effector function and impairs their antitumor ability
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    Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer
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      InVivoPlus anti-mouse PD-1 (CD279)

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  231. Mar 2021
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    PD-1 suppresses the maintenance of cell couples between cytotoxic T cells and target tumor cells within the tumor
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    Integrin αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer
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  234. Feb 2021
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    Profiling of patients with glioma reveals the dominant immunosuppressive axis is refractory to immune function restoration
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      DOI: 10.1172/jci.insight.134386

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  236. Jan 2021
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    Targeting Phosphatidylserine Enhances the Anti-tumor Response to Tumor-Directed Radiation Therapy in a Preclinical Model of Melanoma
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  238. Sep 2020
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    Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance
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    Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer
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    sciencedirect.com/science/article/pii/S1535610820300970
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    FOXD3 Regulates VISTA Expression in Melanoma
    1
    1. scibot 23 Sep 2020
      RRID:AB_10949053

      DOI: 10.1016/j.celrep.2019.12.036

      Resource: (Bio X Cell Cat# BE0146, RRID:AB_10949053)

      Curator: @ethanbadger

      SciCrunch record: RRID:AB_10949053

      What is this?
      RRID:AB_10949053 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719316936