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NOLC1 suppresses immunochemotherapy by inhibiting p53-mediated ferroptosis in gastric cancer

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1. scibot 04 Sep 2025
  
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  DOI: 10.7554/eLife.103904
  
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elifesciences.org/articles/103904
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Zeaxanthin augments CD8+ effector T cell function and immunotherapy efficacy

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.xcrm.2025.102324
  
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sciencedirect.com/science/article/pii/S2666379125003970
Aug 2025
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Identification and validation of intratumoral microbiome associated with sensitization to immune checkpoint inhibitors

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1. scibot 27 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102306
  
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sciencedirect.com/science/article/pii/S2666379125003799
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An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102310
  
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sciencedirect.com/science/article/pii/S2666379125003830
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A preclinical model for the identification of therapeutically active transgenes in local cancer immunotherapy

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1. scibot 21 Aug 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1080/2162402X.2025.2543620
  
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tandfonline.com/doi/full/10.1080/2162402X.2025.2543620
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Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection

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1. scibot 19 Aug 2025
  
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  DOI: 10.1126/sciadv.adx6587
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12356262/
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Targeting lipid scrambling potentiates ferroptosis and triggers tumor immune rejection

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1. scibot 19 Aug 2025
  
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  DOI: 10.1126/sciadv.adx6587
  
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science.org/doi/10.1126/sciadv.adx6587
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Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.cmet.2025.07.008
  
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sciencedirect.com/science/article/pii/S1550413125003353
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Targeting the MYC oncogene with a selective bi-steric mTORC1 inhibitor elicits tumor regression in MYC-driven cancers

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1. scibot 13 Aug 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.chembiol.2025.07.004
  
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sciencedirect.com/science/article/pii/S2451945625002272
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Computational framework for prioritizing candidate compounds overcoming the resistance of pancancer immunotherapy

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1. scibot 06 Aug 2025
  
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  AB_10949053
  
  DOI: 10.1016/j.xcrm.2025.102276
  
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sciencedirect.com/science/article/pii/S2666379125003490
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T cells Instruct Immune Checkpoint Inhibitor Therapy Resistance in Tumors Responsive to IL-1 and TNFα Inflammation

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1. scibot 05 Aug 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1158/2326-6066.CIR-24-0416
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11790381/
Jul 2025
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BRD9 inhibition overcomes oncolytic virus therapy resistance in glioblastoma

1
1. scibot 31 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.xcrm.2025.102258
  
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sciencedirect.com/science/article/pii/S2666379125003313
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1-s2.0-S1525001625005799-main-html.html

1
1. scibot 29 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.ymthe.2025.07.043
  
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cell.com/molecular-therapy-family/molecular-therapy/abstract/S1525-0016(25)00579-9
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Cancer immunology data engine reveals secreted AOAH as a potential immunotherapy

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1. scibot 29 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.cell.2025.07.004
  
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sciencedirect.com/science/article/pii/S0092867425007937
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Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors

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1. scibot 25 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.ccell.2025.07.002
  
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sciencedirect.com/science/article/pii/S1535610825002739
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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1. scibot 25 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
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RANKL/PD-1 dual blockade demonstrates survival benefit for patients with advanced lung adenocarcinoma harboring KRAS mutations

1
1. scibot 16 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.xcrm.2025.102235
  
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sciencedirect.com/science/article/pii/S2666379125003088
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Combined KRAS inhibition and immune therapy generates durable complete responses in an autochthonous PDAC model

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1. scibot 15 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1158/2159-8290.CD-24-0489
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11858029/
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RORγ Bridges Cancer-Driven Lipid Dysmetabolism and Myeloid Immunosuppression

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1. scibot 08 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1158/2159-8290.CD-24-0199
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12223513/
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Mitochondrial complex IV remodeling in tumor-associated macrophages amplifies interferon signaling and promotes anti-tumor immunity

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1. scibot 01 Jul 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.immuni.2025.06.006
  
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sciencedirect.com/science/article/pii/S1074761325002754
Jun 2025
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Overcoming resistance to immunotherapy by targeting CD38 in human tumor explants

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1. scibot 28 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.xcrm.2025.102210
  
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sciencedirect.com/science/article/pii/S2666379125002836
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Gut microbiota dysbiosis induced by brain tumors modulates the efficacy of immunotherapy

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1. scibot 28 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.celrep.2025.115825
  
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sciencedirect.com/science/article/pii/S2211124725005960
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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis

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1. scibot 28 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.ccell.2025.06.006
  
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sciencedirect.com/science/article/pii/S1535610825002569
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Bispecific targeting of 4-1BB and CCR8 boosts antitumor immunity via Ti-Treg depletion and CD8+ activation

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1. scibot 21 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.isci.2025.112829
  
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sciencedirect.com/science/article/pii/S2589004225010909
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Probiotic-mediated tumor microenvironment reprogramming with protease-sensitive interleukin-15 and photothermal therapy

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1. scibot 18 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.xcrm.2025.102191
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12208336/
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1. scibot 13 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1158/2159-8290.cd-24-1033
  
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2. scibot 11 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1158/2159-8290.cd-24-1033
  
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52.53.155.43/a7ee3b12d468dfb2dd9f5d25a6280eb2adf38466/PDF-html.html
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An organoid co-culture model for probing systemic anti-tumor immunity in lung cancer

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1. scibot 13 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.stem.2025.05.011
  
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sciencedirect.com/science/article/pii/S1934590925001912
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Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models

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1. scibot 13 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.ccell.2025.05.014
  
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sciencedirect.com/science/article/pii/S1535610825002235
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Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1421
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12130801/
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Trametinib potentiates anti-PD-1 efficacy in tumors established from chemotherapy-primed pancreatic cancer cells

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1. scibot 11 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1158/1535-7163.MCT-23-0833
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614707/
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Mutation of SMARCA4 Induces Cancer Cell–Intrinsic Defects in the Enhancer Landscape and Resistance to Immunotherapy

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-2054
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12127800/
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Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115800
  
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sciencedirect.com/science/article/pii/S2211124725005716
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Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer

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1. scibot 11 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1007/s00262-025-04074-4
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12145344/
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Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade

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1. scibot 04 Jun 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.xcrm.2025.102141
  
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sciencedirect.com/science/article/pii/S2666379125002149
May 2025
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Microbiota-derived urocanic acid triggered bytyrosine kinase inhibitors potentiates cancer immunotherapy efficacy

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1. scibot 29 May 2025
  
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  RRID:AB_10949053
  
  DOI: 10.1016/j.chom.2025.04.022
  
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PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma

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Serotonin transporter inhibits antitumor immunity through regulating the intratumoral serotonin axis

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BPS Publications

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Trajectories of macrophage ontogeny and reprogramming in cancer

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Sickle cell disease induces chromatin introversion and ferroptosis in CD8+ T cells to suppress anti-tumor immunity

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Tumor microenvironment-associated oxidative stress impairs SIRT1 secretion to suppress anti-tumor immune response

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Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer

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Optimizing anti-PD-1/PD-L1 therapy efficacy and fecal microbiota transplantation donor selection through gut mycobiome-based enterotype

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Parabacteroides distasonis promotes CXCL9 secretion of tumor-associated macrophages and enhances CD8+T cell activity to trigger anti-tumor immunity against anti-PD-1 treatment in non-small cell lung cancer mice

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Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T Cell Pyrimidine Synthesis

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STING Agonist VB-85247 Induces Durable Antitumor Immune Responses by Intravesical Administration in a Non–Muscle-Invasive Bladder Cancer

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Fluorescence Lifetime Imaging Enables In Vivo Quantification of PD-L1 Expression and Intertumoral Heterogeneity

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Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures

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An iron-rich subset of macrophages promotes tumor growth through a Bach1-Ednrb axis

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Tumor-derived arachidonic acid reprograms neutrophils to promote immune suppression and therapy resistance in triple-negative breast cancer

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Lactylation of LSD1 is an acquired epigenetic vulnerability of BRAFi/MEKi-resistant melanoma

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Translation dysregulation in cancer as a source for targetable antigens

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The local microenvironment suppresses the synergy between irradiation and anti-PD1 therapy in breast-to-brain metastasis

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Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes

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AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity

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PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy

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Interferon-γ-stimulated antigen-presenting cancer-associated fibroblasts hinder neoadjuvant chemoimmunotherapy efficacy in lung cancer

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LTA4H improves the tumor microenvironment and prevents HCC progression via targeting the HNRNPA1/LTBP1/TGF-β axis

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Lymph node macrophages drive immune tolerance and resistance to cancer therapy by induction of the immune-regulatory cytokine IL-33

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IL-17RA signaling provides dual tumor-suppressor function during late-stage colorectal carcinogenesis

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Selective apoptosis of tumor-associated platelets boosts the anti-metastatic potency of PD-1 blockade therapy

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AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity

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Hyperthermic intrathoracic chemotherapy modulates the immune microenvironment of pleural mesothelioma and improves the impact of dual immune checkpoint inhibition

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Activation of IL-2/IL-2R pathway by Hedyotis diffusa polysaccharide improves immunotherapy in colorectal cancer

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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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A microRNA-regulated transcriptional state defines intratumoral CD8+ T cells that respond to immunotherapy

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Cryoablation does not significantly contribute to systemic effector immune responses in poorly immunogenic B16F10 melanoma model

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Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer

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Nanrilkefusp alfa (SOT101), an IL-15 receptor βγ superagonist, as a single agent or with anti-PD-1 in patients with advanced cancers

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Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance

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  DOI: 10.1101/2024.10.28.620093
  
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1-s2.0-S2589004225002172-main-html.html

1
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1-s2.0-S2589004225001919-main-html.html

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Jan 2025
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Age-dependent differences in breast tumor microenvironment: challenges and opportunities for efficacy studies in preclinical models

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Targeting the mevalonate pathway potentiates NUAK1 inhibition-induced immunogenic cell death and antitumor immunity

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Intestinal Akkermansia muciniphila complements the efficacy of PD1 therapy in MAFLD-related hepatocellular carcinoma

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Itaconate transporter SLC13A3 confers immunotherapy resistance via alkylation-mediated stabilization of PD-L1

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PDF-html.html

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Resveratrol amplifies the anti-tumor effect of α-PD-1 by altering the intestinal microbiome and PGD2 content

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Dec 2024
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PDF-html.html

1
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Targeting P4HA1 promotes CD8+ T cell progenitor expansion toward immune memory and systemic anti-tumor immunity

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Spatial Context of Immune Checkpoints as Predictors of Overall Survival in Patients with Resectable Colorectal Cancer Independent of Standard Tumor–Node–Metastasis Stages

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BPS Publications

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N-terminal acetylation of transcription factor LIP induces immune therapy resistance via suppression of PD-L1 expression in non-small cell lung cancer

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Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells

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Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma

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Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

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ACSS2 acts as a lactyl-CoA synthetase and couples KAT2A to function as a lactyltransferase for histone lactylation and tumor immune evasion

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Synergistic anti-tumor effects of oncolytic virus and anti-programmed cell death protein 1 antibody combination therapy: For suppression of lymph node and distant metastasis in a murine melanoma model

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Effects of gut microbiota on immune checkpoint inhibitors in multi-cancer and as microbial biomarkers for predicting therapeutic response

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  DOI: 10.1016/j.medj.2024.10.007
  
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can-24-0880-html.html

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DHDH-mediated D-xylose metabolism induces immune evasion in triple-negative breast cancer

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Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

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Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

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crc-24-0270-html.html

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Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy

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  DOI: 10.1101/2024.09.09.612140
  
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Targeting of CD40 and PD-L1 pathways inhibit progression of oral premalignant lesions in a carcinogen-induced model of oral squamous cell carcinoma

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Sep 2024
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Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer

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Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models

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PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination

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  DOI: 10.1158/2326-6066.CIR-23-0289
  
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H3K9 lactylation in malignant cells facilitates CD8+ T cell dysfunction and poor immunotherapy response

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Type I interferon signaling regulates myeloid and T cell crosstalk in the glioblastoma tumor microenvironment

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Aug 2024
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

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Efficacy of novel allogeneic cancer cells vaccine to treat colorectal cancer

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  DOI: 10.3389/fonc.2024.1427428
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11303197/
Jul 2024
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Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor

1
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  DOI: 10.1016/j.chom.2024.06.010
  
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VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

1
1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

1
1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.medj.2024.06.002
  
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CDK4/6 inhibition sensitizes intracranial tumors to PD-1 blockade in preclinical models of brain metastasis

1
1. scibot 18 Jul 2024
  
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  DOI: 10.1158/1078-0432.CCR-23-0433
  
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PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies

1
1. scibot 17 Jul 2024
  
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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

1
1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101640
  
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Biomineralization-inspired synthesis of autologous cancer vaccines for personalized metallo-immunotherapy

1
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  DOI: 10.1016/j.isci.2024.110189
  
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Jun 2024
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Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity

1
1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114300
  
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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

1
1. scibot 04 Jun 2024
  
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  DOI: 10.1016/j.celrep.2024.114289
  
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May 2024
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

1
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  DOI: 10.1016/j.immuni.2024.04.025
  
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Metabolic regulator LKB1 controls adipose tissue ILC2 PD-1 expression and mitochondrial homeostasis to prevent insulin resistance

1
1. scibot 21 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.024
  
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ALK inhibitors suppress HCC and synergize with anti-PD-1 therapy and ABT-263 in preclinical models

1
1. scibot 10 May 2024
  
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cell.com/iscience/abstract/S2589-0042(24)01022-8
Apr 2024
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LKB1 prevents ILC2 exhaustion to enhance antitumor immunity

1
1. scibot 26 Apr 2024
  
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  DOI: 10.1016/j.celrep.2023.113579
  
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Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1

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1. scibot 24 Apr 2024
  
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  DOI: 10.1126/sciimmunol.adj5097
  
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QDPR deficiency drives immune suppression in pancreatic cancer

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  DOI: 10.1016/j.cmet.2024.03.015
  
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CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer

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  DOI: 10.1016/j.xcrm.2024.101479
  
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Genetic interactions reveal distinct biological and therapeutic implications in breast cancer

1
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  DOI: 10.1016/j.ccell.2024.03.006
  
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Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells

1
1. scibot 02 Apr 2024
  
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  DOI: 10.1016/j.cell.2024.03.011
  
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Hippo-signaling-controlled MHC class I antigen processing and presentation pathway potentiates antitumor immunity

1
1. scibot 27 Mar 2024
  
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  DOI: 10.1016/j.celrep.2024.114003
  
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Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy

2
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A specific enterotype derived from gut microbiome of older individuals enables favorable responses to immune checkpoint blockade therapy

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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

1
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Leishmania braziliensis enhances monocyte responses to promote anti-tumor activity

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  DOI: 10.1016/j.celrep.2024.113932
  
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EZH2 Inhibition Promotes Tumor Immunogenicity in Lung Squamous Cell Carcinomas

2
1. scibot 15 Feb 2024
  
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  RRID:AB_10949053
  
  DOI: 10.1158/2767-9764.CRC-23-0399
  
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  DOI: 10.1158/2767-9764.CRC-23-0399
  
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The XCL1-Mediated DNA Vaccine Targeting Type 1 Conventional Dendritic Cells Combined with Gemcitabine and Anti-PD1 Antibody Induces Potent Antitumor Immunity in a Mouse Lung Cancer Model

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  DOI: 10.3390/ijms25031880
  
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Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5

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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

1
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  RRID:AB_3075399
  
  DOI: 10.1016/j.cmet.2024.01.005
  
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Interrogation of endothelial and mural cells in brain metastasis reveals key immune-regulatory mechanisms

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DNA damage repair profiling of esophageal squamous cell carcinoma uncovers clinically relevant molecular subtypes with distinct prognoses and therapeutic vulnerabilities

1
1. scibot 19 Jan 2024
  
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Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

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  DOI: 10.1016/j.ccell.2023.12.013
  
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A novel translational PET imaging approach to quantifying abscopal immune activation following targeted radiotherapy and checkpoint blockade.

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  DOI: 10.1016/j.ijrobp.2023.12.047
  
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Interferon-stimulated neutrophils as a predictor of immunotherapy response

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  DOI: 10.1016/j.ccell.2023.12.005
  
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A TCF4-dependent gene regulatory network confers resistance to immunotherapy in melanoma

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  DOI: 10.1016/j.cell.2023.11.037
  
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Preventive Treatment with PD-1 Antibody Increases Tissue-Resident Memory T Cells Infiltration and Delays Esophageal Carcinogenesis

1
1. scibot 06 Dec 2023
  
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  DOI: 10.1158/1940-6207.CAPR-23-0196
  
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The tumor-derived cytokine Chi3l1 induces neutrophil extracellular traps that promote T cell exclusion in triple-negative breast cancer

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Engineering irradiated tumor-derived microparticles as personalized vaccines to enhance anti-tumor immunity

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Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1

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capr-23-0196-html.html

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Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity

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E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

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An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2

1
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Enniatin A inhibits the chaperone Hsp90 and unleashes the immune system against triple-negative breast cancer

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Targeting VCP potentiates immune checkpoint therapy for colorectal cancer

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Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response

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Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease

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Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma

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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

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Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy

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Supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation

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Glioblastoma vascular plasticity limits effector T-cell infiltration and is blocked by cAMP activation

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Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

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S-531011, a Novel Anti-Human CCR8 Antibody, Induces Potent Antitumor Responses through Depletion of Tumor-Infiltrating CCR8-Expressing Regulatory T Cells

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Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

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Activating Inducible T cell Co-stimulator (ICOS) yields anti-tumor activity alone and in combination with anti-PD-1 checkpoint blockade

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CRISPR-Cas9 screening identifies an IRF1-SOCS1-mediated negative feedback loop that limits CXCL9 expression and antitumor immunity

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PIIS2211124723009622-html.html

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A CSF-1R-blocking antibody/IL-10 fusion protein increases anti-tumor immunity by effectuating tumor-resident CD8+ T cells

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METTL3 drives NAFLD-related hepatocellular carcinoma and is a therapeutic target for boosting immunotherapy

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Homeostatic PD-1 signaling restrains EOMES-dependent oligoclonal expansion of liver-resident CD8 T cells

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crc-22-0293-html.html

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OncoLoop: A network-based precision cancer medicine framework

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SMYD3 represses tumor-intrinsic interferon response in HPV-negative squamous cell carcinoma of the head and neck

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A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence

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TCR-independent CD137 (4-1BB) signaling promotes CD8+-exhausted T cell proliferation and terminal differentiation

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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

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PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior

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A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer

1
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IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

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Cholesterol efflux pathways hinder KRAS-driven lung tumor progenitor cell expansion

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  DOI: 10.1016/j.stem.2023.05.005
  
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Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity

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CCL19+ dendritic cells potentiate clinical benefit of anti-PD-(L)1 immunotherapy in triple-negative breast cancer

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  DOI: 10.1016/j.medj.2023.04.008
  
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Germline modifiers of the tumor immune microenvironment implicate drivers of cancer risk and immunotherapy response

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  DOI: 10.1038/s41467-023-38271-5
  
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Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma

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Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal

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18F-FMISO PET Imaging Identifies Hypoxia and Immunosuppressive Tumor Microenvironments and Guides Targeted Evofosfamide Therapy in Tumors Refractory to PD-1 and CTLA-4 Inhibition

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Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer

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  DOI: 10.1016/j.chom.2023.04.010
  
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Targeting ULK1 decreases interferon-γ-mediated resistance to immune checkpoint inhibitors

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Lenvatinib or anti-VEGF in combination with anti-PD-1 differentially augments anti-tumor activity in melanoma

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  DOI: 10.1172/jci.insight.157347
  
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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy

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Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

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Identification of fibrocyte cluster in tumors reveals the role in antitumor immunity by PD-L1 blockade

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An optimized IL-12-Fc expands its therapeutic window, achieving strong activity against mouse tumors at tolerable drug doses

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Liposome-Encapsulated Eribulin Shows Enhanced Antitumor Activity over Eribulin for Combination Therapy with Anti–PD-1 Antibody

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  DOI: 10.1158/1535-7163.MCT-22-0475
  
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Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects

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Lacticaseibacillus rhamnosus Probio-M9 enhanced the antitumor response to anti-PD-1 therapy by modulating intestinal metabolites

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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

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  DOI: 10.1016/j.cell.2023.03.007
  
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IFNγ is a central node of cancer immune equilibrium

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Adhesion analysis via a tumor vasculature-like microfluidic device identifies CD8+ T cells with enhanced tumor homing to improve cell therapy

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Feb 2023
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Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

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