162 Matching Annotations
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    Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy
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    sciencedirect.com/science/article/pii/S2666379125003908
  3. Aug 2025
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    TRIM6 ablation reverses ICB resistance in MSS gastric cancer by unleashing cGAS-STING-dependent antitumor immunity
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    DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps
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    cell.com/cancer-cell/abstract/S1535-6108(25)00320-4
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    Selective Alanine Transporter Utilization is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer
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  7. Jul 2025
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    Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity promoting immunotherapy efficacy
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    The costimulatory molecule ICOS limits memory-like properties and function of exhausted PD-1+CD8+ T cells
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    sciencedirect.com/science/article/pii/S1074761325002481
  10. Jun 2025
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    NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1/PD-L1 pathway
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    Glutamate transporter SLC1A6 promotes resistance to immunotherapy in cancer
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    Efflux of N1-acetylspermidine from hepatoma fosters macrophage-mediated immune suppression to dampen immunotherapeutic efficacy
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  14. May 2025
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    Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer
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    Bone metastases diminish extraosseous response to checkpoint blockade immunotherapy through osteopontin-producing osteoclasts
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  17. Apr 2025
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    KIF26B promotes bladder cancer progression via activating Wnt/β-catenin signaling in a TRAF2-dependent pathway
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    Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma
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    Trabectedin Enhances the Antitumor Effects of IL-12 in Triple-Negative Breast Cancer
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  22. Mar 2025
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    Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy
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    Low-dose irradiation of the gut improves the efficacy of PD-L1 blockade in metastatic cancer patients
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  25. Feb 2025
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    Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma
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    The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8+ T cells in mice
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    Distinct cellular mechanisms underlie chemotherapies and PD-L1 blockade combinations in triple-negative breast cancer
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  29. Jan 2025
  30. 52.53.155.43 52.53.155.43
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  31. Dec 2024
  32. www.science.org www.science.org
    NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1–PD-L1
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    IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages
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    A yeast-based oral therapeutic delivers immune checkpoint inhibitors to reduce intestinal tumor burden
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    Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity
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  36. Nov 2024
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    Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma
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    Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance
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  39. Oct 2024
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    MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation
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    Quiescence and aging of melanocyte stem cells and a novel association with PD-L1
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  42. Sep 2024
  43. www.biorxiv.org www.biorxiv.org
    Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes
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    biorxiv.org/content/10.1101/2024.09.18.613649v1
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    Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell
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    The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
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  46. Aug 2024
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    PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis
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    Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization
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    Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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  51. Jul 2024
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    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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    Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
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    Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
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    Cyclin dependent kinase 9 inhibition reduced programmed death-ligand 1 expression and improved treatment efficacy in hepatocellular carcinoma
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    Original research: Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
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    ncbi.nlm.nih.gov/pmc/articles/PMC11218019/
  57. Jun 2024
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    Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
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    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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  60. May 2024
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    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
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    Lipid-encapsulated mRNAs encoding complex fusion proteins potentiate anti-tumor immune responses
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    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
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  65. Apr 2024
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    Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy
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    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
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  70. Feb 2024
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    Sympathetic Signals Promote Immunosuppressive Neutrophils in Lung Tumors
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    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
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  73. Dec 2023
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    NK cells propagate T cell immunity following in situ tumor vaccination
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    Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes
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    Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12
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    science.org/doi/10.1126/sciimmunol.adf4919
  77. Nov 2023
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    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
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    PD-L1-mediated immune evasion in triple-negative breast cancer is linked to the loss of ZNF652
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  81. Oct 2023
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    Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine
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    Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
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    The Transcription Factor IRF4 Determines the Anti-Tumor Immunity of CD8+ T cells
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    cell.com/iscience/abstract/S2589-0042(23)02164-8
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    Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
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  86. Sep 2023
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    Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control
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  88. Aug 2023
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    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
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    The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
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  91. Jul 2023
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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  93. Jun 2023
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    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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    PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
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    Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression
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    tandfonline.com/doi/abs/10.1080/2162402X.2023.2219164
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    Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression
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  99. May 2023
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    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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  102. Apr 2023
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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
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    cell.com/cell/fulltext/S0092-8674(23)00271-4
  106. Mar 2023
  107. www.science.org www.science.org
    Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy
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    science.org/doi/10.1126/sciimmunol.add8005
  108. Feb 2023
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    XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
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  110. Jan 2023
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    aacrjournals.org/cancerdiscovery/article/12/8/1942/707227/Enhancing-PD-L1-Degradation-by-ITCH-during-MAPK
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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