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    Pericancerous cross-presentation to cytotoxic T lymphocytes impairs immunotherapeutic efficacy in hepatocellular carcinoma
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    1. scibot 21 Nov 2024
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  3. Nov 2024
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    Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance
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  5. Oct 2024
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    MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation
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    Quiescence and aging of melanocyte stem cells and a novel association with PD-L1
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  8. Sep 2024
  9. www.biorxiv.org www.biorxiv.org
    Beta cell extracellular vesicle PD-L1 as a novel regulator of CD8+ T cell activity and biomarker during the evolution of Type 1 Diabetes
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    Dietary vitamin B3 supplementation induces the antitumor immunity against liver cancer via biased GPR109A signaling in myeloid cell
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    The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
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  12. Aug 2024
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    PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis
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    sciencedirect.com/science/article/pii/S1074761324003765
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    Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization
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    Aerobic glycolysis but not GLS1-dependent glutamine metabolism is critical for anti-tumor immunity and response to checkpoint inhibition
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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  17. Jul 2024
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    Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer
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    Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
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    Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity
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    Cyclin dependent kinase 9 inhibition reduced programmed death-ligand 1 expression and improved treatment efficacy in hepatocellular carcinoma
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    Original research: Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
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  23. Jun 2024
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
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    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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  26. May 2024
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    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
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    Lipid-encapsulated mRNAs encoding complex fusion proteins potentiate anti-tumor immune responses
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    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
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  31. Apr 2024
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    Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy
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    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
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      DOI: 10.1038/s41467-024-47069-y

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  36. Feb 2024
  37. www.biorxiv.org www.biorxiv.org
    Sympathetic Signals Promote Immunosuppressive Neutrophils in Lung Tumors
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      DOI: 10.1101/2024.02.15.580434

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    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
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    sciencedirect.com/science/article/pii/S2211124724000408
  39. Dec 2023
  40. www.sciencedirect.com www.sciencedirect.com
    NK cells propagate T cell immunity following in situ tumor vaccination
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  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes
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    ncbi.nlm.nih.gov/pmc/articles/PMC10692710/
  42. www.science.org www.science.org
    Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12
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      DOI: 10.1126/sciimmunol.adf4919

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    science.org/doi/10.1126/sciimmunol.adf4919
  43. Nov 2023
  44. www.sciencedirect.com www.sciencedirect.com
    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
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      DOI: 10.1016/j.chembiol.2023.10.010

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    sciencedirect.com/science/article/pii/S2451945623003719
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    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
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      DOI: 10.1016/j.devcel.2023.10.010

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    sciencedirect.com/science/article/pii/S1534580723005518
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    PD-L1-mediated immune evasion in triple-negative breast cancer is linked to the loss of ZNF652
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      DOI: 10.1016/j.celrep.2023.113343

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  47. Oct 2023
  48. www.sciencedirect.com www.sciencedirect.com
    Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine
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      DOI: 10.1016/j.xcrm.2023.101229

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    sciencedirect.com/science/article/pii/S2666379123004068
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    Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
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      DOI: 10.1016/j.xcrm.2023.101236

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    sciencedirect.com/science/article/pii/S2666379123004135
  50. www.cell.com www.cell.com
    The Transcription Factor IRF4 Determines the Anti-Tumor Immunity of CD8+ T cells
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      DOI: 10.1016/j.isci.2023.108087

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    cell.com/iscience/abstract/S2589-0042(23)02164-8
  51. www.sciencedirect.com www.sciencedirect.com
    Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
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  52. Sep 2023
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    Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control
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  54. Aug 2023
  55. 52.53.155.43 52.53.155.43
    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
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    The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
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  57. Jul 2023
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    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
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  59. Jun 2023
  60. 52.53.155.43 52.53.155.43
    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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    PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
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    Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression
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    Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression
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  65. May 2023
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    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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  68. Apr 2023
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    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
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  72. Mar 2023
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    Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy
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  74. Feb 2023
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    XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
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  76. Jan 2023
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors
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    Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy
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    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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  82. Dec 2022
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    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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  84. Nov 2022
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    Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
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    The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
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    Tumor-intrinsic SIRPA promotes sensitivity to checkpoint inhibition immunotherapy in melanoma
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  88. Oct 2022
  89. www.cell.com www.cell.com
    Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment
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    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
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  91. Sep 2022
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    Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
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  93. Aug 2022
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    Fasting renders immunotherapy effective against low-immunogenic breast cancer while reducing side effects
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  95. Jun 2022
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    Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes
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    Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity
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    The SETDB1–TRIM28 complex suppresses antitumor immunity
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  99. May 2022
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    Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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  102. Apr 2022
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
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  105. Mar 2022
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    Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model
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  124. Jul 2021
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    Discovery of Small Molecules for the Reversal of T Cell Exhaustion
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    Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
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  130. May 2021
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    Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
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    Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity
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    Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
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  136. Apr 2021
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
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  142. Feb 2021
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    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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    CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization
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    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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    Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
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    Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity
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      DOI: 10.1016/j.ccell.2020.03.016

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @ethanbadger

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1535610820301562
  158. www.sciencedirect.com www.sciencedirect.com
    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
    1
    1. scibot 04 Sep 2020
      Anti-mouse PDL-1 (10F.9G2)

      DOI: 10.1016/j.immuni.2018.05.006

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @Naa003

      SciCrunch record: RRID:AB_10949073

      Curator comments: InVivoMab anti-mouse PD-L1 (B7-H1) antibody Bio X Cell Cat# BE0101

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      RRIDCUR:Missing RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761318302425
  159. Jan 2020
  160. www.sciencedirect.com www.sciencedirect.com
    Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949073

      DOI: 10.1016/j.ccell.2019.10.008

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @ethanbadger

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1535610819304829
  161. www.sciencedirect.com www.sciencedirect.com
    PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949073

      DOI: 10.1016/j.immuni.2019.11.003

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @ethanbadger

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761319304613
  162. www.sciencedirect.com www.sciencedirect.com
    PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949073

      DOI: 10.1016/j.celrep.2019.10.092

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @ethanbadger

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719314147
  163. www.sciencedirect.com www.sciencedirect.com
    Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949073

      DOI: 10.1016/j.celrep.2019.08.038

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @ethanbadger

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2211124719310782
  164. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949073

      DOI: 10.1016/j.immuni.2019.08.013

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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      RRID:AB_10949073 RRIDCUR:Validated
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    pmc.ncbi.nlm.nih.gov/articles/PMC6903704/
  165. www.sciencedirect.com www.sciencedirect.com
    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949073

      DOI: 10.1016/j.cmet.2019.01.006

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @Naa003

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1550413119300063
  166. www.cell.com www.cell.com
    Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
    1
    1. scibot 13 Jan 2020
      RRID:AB_10949073

      DOI: 10.1016/j.cell.2019.02.016

      Resource: (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      Curator: @ethanbadger

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      RRID:AB_10949073 RRIDCUR:Validated
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    cell.com/cell/fulltext/S0092-8674(19)30165-5
  167. Nov 2018
  168. www-sciencedirect-com.ezproxy.is.ed.ac.uk www-sciencedirect-com.ezproxy.is.ed.ac.uk
    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

      Curator: @Jmenke

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073 RRIDCUR:Validated
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    www-sciencedirect-com.ezproxy.is.ed.ac.uk/science/article/pii/S107476131830342X
  169. www.sciencedirect.com www.sciencedirect.com
    Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

      Curator: @Jmenke

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S0092867418311796
  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

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    ncbi.nlm.nih.gov/pmc/articles/PMC6775781/
  171. www.sciencedirect.com www.sciencedirect.com
    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761317304235
  172. www.sciencedirect.com www.sciencedirect.com
    Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S153561081830223X
  173. www.sciencedirect.com www.sciencedirect.com
    High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761318300323
  174. www.sciencedirect.com www.sciencedirect.com
    Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1535610817304713
  175. www.sciencedirect.com www.sciencedirect.com
    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761317304806
  176. Nov 2017
  177. www.sciencedirect.com www.sciencedirect.com
    Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
    1
    1. scibot 08 Nov 2017
      BE0101

      Curator: @Jmenke

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S009286741631594X
  178. www.sciencedirect.com www.sciencedirect.com
    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
    1
    1. scibot 08 Nov 2017
      Anti-mouse PD-L1BioXCellCat# BE0101

      Curator: @Jmenke

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1535610817302982
  179. www.sciencedirect.com www.sciencedirect.com
    Systemic Immunity Is Required for Effective Cancer Immunotherapy
    1
    1. scibot 08 Nov 2017
      AB_10949073

      Curator: @Zeljana_Babic

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      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

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      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S009286741631738X