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  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
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    1. scibot 04 Jul 2024
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      DOI: 10.1136/jitc-2024-008970

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    ncbi.nlm.nih.gov/pmc/articles/PMC11218019/
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Stabilizing Tumor-Resident Mast Cells Restores T-Cell Infiltration and Sensitizes Sarcomas to PD-L1 Inhibition
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    1. scibot 07 Jun 2024
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      DOI: 10.1158/1078-0432.CCR-24-0246

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    2. scibot 07 Jun 2024
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      DOI: 10.1158/1078-0432.CCR-24-0246

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    ncbi.nlm.nih.gov/pmc/articles/PMC11145177/
  5. www.sciencedirect.com www.sciencedirect.com
    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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    1. scibot 06 Jun 2024
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      DOI: 10.1016/j.xcrm.2024.101592

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    sciencedirect.com/science/article/pii/S2666379124002842
  6. May 2024
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    Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite
    2
    1. scibot 31 May 2024
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      DOI: 10.1016/j.ccell.2024.05.006

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    2. scibot 31 May 2024
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      DOI: 10.1016/j.ccell.2024.05.006

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    sciencedirect.com/science/article/pii/S1535610824001697
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    ARID1A suppresses R-loop-mediated STING-type I interferon pathway activation of anti-tumor immunity
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    1. scibot 21 May 2024
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      DOI: 10.1016/j.cell.2024.04.025

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    sciencedirect.com/science/article/pii/S0092867424004513
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Lipid-encapsulated mRNAs encoding complex fusion proteins potentiate anti-tumor immune responses
    1
    1. scibot 17 May 2024
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      DOI: 10.1158/0008-5472.CAN-23-2875

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    ncbi.nlm.nih.gov/pmc/articles/PMC11094416/
  10. www.sciencedirect.com www.sciencedirect.com
    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
    1
    1. scibot 17 May 2024
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      DOI: 10.1016/j.ccell.2024.04.011

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    sciencedirect.com/science/article/pii/S1535610824001351
  11. Apr 2024
  12. www.sciencedirect.com www.sciencedirect.com
    Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy
    1
    1. scibot 24 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114141

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    sciencedirect.com/science/article/pii/S2211124724004698
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    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
    1
    1. scibot 12 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101479

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    sciencedirect.com/science/article/pii/S2666379124001253
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
    1
    1. scibot 11 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114088

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    sciencedirect.com/science/article/pii/S2211124724004169
  15. www.nature.com www.nature.com
    Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade
    1
    1. scibot 03 Apr 2024
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      DOI: 10.1038/s41467-024-47069-y

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    nature.com/articles/s41467-024-47069-y
  16. Feb 2024
  17. www.biorxiv.org www.biorxiv.org
    Sympathetic Signals Promote Immunosuppressive Neutrophils in Lung Tumors
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1101/2024.02.15.580434

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    biorxiv.org/content/10.1101/2024.02.15.580434v1
  18. www.sciencedirect.com www.sciencedirect.com
    Cell-intrinsic PD-L1 ablation sustains effector CD8+ T cell responses and promotes antitumor T cell therapy
    1
    1. scibot 02 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113712

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    sciencedirect.com/science/article/pii/S2211124724000408
  19. Dec 2023
  20. www.sciencedirect.com www.sciencedirect.com
    NK cells propagate T cell immunity following in situ tumor vaccination
    1
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113556

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    sciencedirect.com/science/article/pii/S2211124723015681
  21. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Helicobacter pylori CagA promotes immune evasion of gastric cancer by upregulating PD-L1 level in exosomes
    1
    1. scibot 06 Dec 2023
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      DOI: 10.1016/j.isci.2023.108414

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    ncbi.nlm.nih.gov/pmc/articles/PMC10692710/
  22. www.science.org www.science.org
    Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12
    1
    1. scibot 02 Dec 2023
      RRID:AB_10949073

      DOI: 10.1126/sciimmunol.adf4919

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    science.org/doi/10.1126/sciimmunol.adf4919
  23. Nov 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Anti-tumor effect of PD-L1-targeting antagonistic aptamer-ASO delivery system with dual inhibitory function in immunotherapy
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.chembiol.2023.10.010

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    sciencedirect.com/science/article/pii/S2451945623003719
  25. www.sciencedirect.com www.sciencedirect.com
    A SOX9-B7x axis safeguards dedifferentiated tumor cells from immune surveillance to drive breast cancer progression
    1
    1. scibot 17 Nov 2023
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      DOI: 10.1016/j.devcel.2023.10.010

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    sciencedirect.com/science/article/pii/S1534580723005518
  26. www.sciencedirect.com www.sciencedirect.com
    PD-L1-mediated immune evasion in triple-negative breast cancer is linked to the loss of ZNF652
    1
    1. scibot 02 Nov 2023
      RRID:AB_10949073

      DOI: 10.1016/j.celrep.2023.113343

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    sciencedirect.com/science/article/pii/S2211124723013554
  27. Oct 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine
    1
    1. scibot 14 Oct 2023
      RRID:AB_10949073

      DOI: 10.1016/j.xcrm.2023.101229

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    sciencedirect.com/science/article/pii/S2666379123004068
  29. www.sciencedirect.com www.sciencedirect.com
    Genetic and pharmaceutical targeting of HIF1α allows combo-immunotherapy to boost graft vs. leukemia without exacerbation graft vs. host disease
    1
    1. scibot 13 Oct 2023
      RRID:AB_10949073

      DOI: 10.1016/j.xcrm.2023.101236

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    sciencedirect.com/science/article/pii/S2666379123004135
  30. www.cell.com www.cell.com
    The Transcription Factor IRF4 Determines the Anti-Tumor Immunity of CD8+ T cells
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.isci.2023.108087

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    cell.com/iscience/abstract/S2589-0042(23)02164-8
  31. www.sciencedirect.com www.sciencedirect.com
    Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113224

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    sciencedirect.com/science/article/pii/S2211124723012366
  32. Sep 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control
    1
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      DOI: 10.1016/j.celrep.2023.113047

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    sciencedirect.com/science/article/pii/S2211124723010586
  34. Aug 2023
  35. 52.53.155.43 52.53.155.43
    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
    2
    1. scibot 12 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101145

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    2. scibot 10 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101145

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    52.53.155.43/9f1a09025b86686c62561e67323b0c82e4153e7b/PIIS2666379123002987-html.html
  36. www.sciencedirect.com www.sciencedirect.com
    The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
    1
    1. scibot 03 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112905

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    sciencedirect.com/science/article/pii/S2211124723009166
  37. Jul 2023
  38. www.sciencedirect.com www.sciencedirect.com
    Enhanced bypass of PD-L1 translation reduces the therapeutic response to mTOR kinase inhibitors
    2
    1. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112764

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    2. scibot 08 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112764

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    sciencedirect.com/science/article/pii/S2211124723007751
  39. Jun 2023
  40. 52.53.155.43 52.53.155.43
    TOPK mediates immune evasion of Renal Cell Carcinoma via upregulating the expression of PD-L1
    1
    1. scibot 30 Jun 2023
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      DOI: 10.1016/j.isci.2023.107185

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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.immuni.2023.05.008

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    sciencedirect.com/science/article/pii/S107476132300225X
  42. www.sciencedirect.com www.sciencedirect.com
    PD-L1/PD-1 checkpoint pathway regulates hippocampal neuronal excitability and learning and memory behavior
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      DOI: 10.1016/j.neuron.2023.05.022

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    sciencedirect.com/science/article/pii/S0896627323003951
  43. www.tandfonline.com www.tandfonline.com
    Decreased melanoma CSF-1 secretion by Cannabigerol treatment reprograms regulatory myeloid cells and reduces tumor progression
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      DOI: 10.1080/2162402X.2023.2219164

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    tandfonline.com/doi/abs/10.1080/2162402X.2023.2219164
  44. www.sciencedirect.com www.sciencedirect.com
    Intravenous heterologous prime-boost vaccination activates innate and adaptive immunity to promote tumor regression
    1
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      DOI: 10.1016/j.celrep.2023.112599

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    sciencedirect.com/science/article/pii/S2211124723006101
  45. May 2023
  46. www.sciencedirect.com www.sciencedirect.com
    Proteomics of immune cells from liver tumors reveals immunotherapy targets
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      DOI: 10.1016/j.xgen.2023.100331

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    sciencedirect.com/science/article/pii/S2666979X2300099X
  47. www.sciencedirect.com www.sciencedirect.com
    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    1. scibot 26 May 2023
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      DOI: 10.1016/j.ccell.2023.04.018

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    sciencedirect.com/science/article/pii/S1535610823001629
  48. Apr 2023
  49. www.sciencedirect.com www.sciencedirect.com
    Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis
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      DOI: 10.1016/j.ccell.2023.03.002

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    sciencedirect.com/science/article/pii/S1535610823000508
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    ER-localized JmjC domain-containing protein JMJD8 targets STING to promote immune evasion and tumor growth in breast cancer
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    1. scibot 13 Apr 2023
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      DOI: 10.1016/j.devcel.2023.03.015

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    Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
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  52. Mar 2023
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    Fc glycoengineering of a PD-L1 antibody harnesses Fcγ receptors for increased antitumor efficacy
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  54. Feb 2023
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    XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections
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  56. Jan 2023
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    The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer
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    Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance
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    Immune checkpoint therapy-elicited sialylation of IgG antibodies impairs antitumorigenic type I interferon responses in hepatocellular carcinoma
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  62. Dec 2022
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    Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer
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  64. Nov 2022
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    The transcription factor IRF2 drives interferon-mediated CD8+ T cell exhaustion to restrict anti-tumor immunity
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  68. Oct 2022
  69. www.cell.com www.cell.com
    Systemic vaccination induces CD8+ T cells and remodels the tumor microenvironment
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    The primordial differentiation of tumor-specific memory CD8+ T cells as bona fide responders to PD-1/PD-L1 blockade in draining lymph nodes
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  71. Sep 2022
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    Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
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  73. Aug 2022
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  75. Jun 2022
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    Proinflammatory signaling in islet β cells propagates invasion of pathogenic immune cells in autoimmune diabetes
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    Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity
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    The SETDB1–TRIM28 complex suppresses antitumor immunity
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  79. May 2022
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    Tumor-induced erythroid precursor-differentiated myeloid cells mediate immunosuppression and curtail anti-PD-1/PD-L1 treatment efficacy
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    WEE1 inhibition enhances the antitumor immune response to PD-L1 blockade by the concomitant activation of STING and STAT1 pathways in SCLC
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  82. Apr 2022
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    The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade
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    Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
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  85. Mar 2022
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    CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4
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  87. Feb 2022
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    Preclinical Pharmacokinetics and Dosimetry of an 89Zr Labelled Anti-PDL1 in an Orthotopic Lung Cancer Murine Model
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    Albendazole reduces hepatic inflammation and endoplasmic reticulum-stress in a mouse model of chronic Echinococcus multilocularis infection
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  93. Dec 2021
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  95. Nov 2021
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  97. Sep 2021
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  99. Aug 2021
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    Novel oncolytic adenovirus expressing enhanced cross-hybrid IgGA Fc PD-L1 inhibitor activates multiple immune effector populations leading to enhanced tumor killing in vitro, in vivo and with patient-derived tumor organoids
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  104. Jul 2021
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    Discovery of Small Molecules for the Reversal of T Cell Exhaustion
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    Soluble PD-L1 generated by endogenous retroelement exaptation is a receptor antagonist
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    Checkpoint Blockade Immunotherapy Induces Dynamic Changes in PD-1−CD8+ Tumor-Infiltrating T Cells
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    Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells
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      Anti-mouse PD-L1 (B7-H1) clone 10F.9G2

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    Transforming growth factor-β-regulated mTOR activity preserves cellular metabolism to maintain long-term T cell responses in chronic infection
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  110. May 2021
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    Role of nuclear localization in the regulation and function of T-bet and Eomes in exhausted CD8 T cells
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  112. mct.aacrjournals.org mct.aacrjournals.org
    Recombinant Orthopoxvirus Primes Colon Cancer for Checkpoint Inhibitor and Cross-Primes T Cells for Antitumor and Antiviral Immunity
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  113. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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  114. www.sciencedirect.com www.sciencedirect.com
    Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity
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      DOI: 10.1016/j.molcel.2020.10.015

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    Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
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  116. Apr 2021
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
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    HSP90 Inhibition Enhances Cancer Immunotherapy by Modulating the Surface Expression of Multiple Immune Checkpoint Proteins
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    Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance
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    CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10
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    Stanniocalcin 1 is a phagocytosis checkpoint driving tumor immune resistance
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  122. Feb 2021
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    DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity
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    Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade
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  125. Dec 2020
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    A Two-Step Process of Effector Programming Governs CD4+ T Cell Fate Determination Induced by Antigenic Activation in the Steady State
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  127. Oct 2020
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    PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction
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  129. Sep 2020
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    Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies
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  131. www.sciencedirect.com www.sciencedirect.com
    CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization
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  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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  133. www.cell.com www.cell.com
    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
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    The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling
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    Lymph Node Stromal Cells Generate Antigen-Specific Regulatory T Cells and Control Autoreactive T and B Cell Responses
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    Isotype Switching Converts Anti-CD40 Antagonism to Agonism to Elicit Potent Antitumor Activity
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    Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
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    PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells
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      Anti-mouse PDL-1 (10F.9G2)

      DOI: 10.1016/j.immuni.2018.05.006

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  139. Jan 2020
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    Clonally Expanded T Cells Reveal Immunogenicity of Rhabdoid Tumors
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    PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
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    PD-1 Signaling Promotes Control of Chronic Viral Infection by Restricting Type-I-Interferon-Mediated Tissue Damage
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    Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens
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      DOI: 10.1016/j.celrep.2019.08.038

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    The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality
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    IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-Dependent Anti-inflammatory Properties
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  146. www.cell.com www.cell.com
    Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
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  147. Nov 2018
  148. www-sciencedirect-com.ezproxy.is.ed.ac.uk www-sciencedirect-com.ezproxy.is.ed.ac.uk
    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
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  149. www.sciencedirect.com www.sciencedirect.com
    Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy
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    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
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    Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity
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    High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease
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  154. www.sciencedirect.com www.sciencedirect.com
    Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

      Resource used:

      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1535610817304713
  155. www.sciencedirect.com www.sciencedirect.com
    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
    1
    1. scibot 05 Nov 2018
      RRID:AB_10949073

      Resource used:

      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073
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    sciencedirect.com/science/article/pii/S1074761317304806
  156. Nov 2017
  157. www.sciencedirect.com www.sciencedirect.com
    Tumor Interferon Signaling Regulates a Multigenic Resistance Program to Immune Checkpoint Blockade
    1
    1. scibot 08 Nov 2017
      BE0101

      Curator: @Jmenke

      Resource used:

      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S009286741631594X
  158. www.sciencedirect.com www.sciencedirect.com
    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
    1
    1. scibot 08 Nov 2017
      Anti-mouse PD-L1BioXCellCat# BE0101

      Curator: @Jmenke

      Resource used:

      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

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      RRID:AB_10949073 RRIDCUR:Missing
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    sciencedirect.com/science/article/pii/S1535610817302982
  159. www.sciencedirect.com www.sciencedirect.com
    Systemic Immunity Is Required for Effective Cancer Immunotherapy
    1
    1. scibot 08 Nov 2017
      AB_10949073

      Curator: @Zeljana_Babic

      Resource used:

      (Bio X Cell Cat# BE0101, RRID:AB_10949073)

      SciCrunch record: RRID:AB_10949073

      Alternate resolvers: SciCrunch xml N2T identifiers.org

      What is this?

      RRID:AB_10949073 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S009286741631738X