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Mar 2026
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4-octyl itaconate inhibits cytokine-mediated inflammation via alkylation of TYK2 and JAK1

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  DOI: 10.1016/j.celrep.2026.117179
  
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sciencedirect.com/science/article/pii/S2211124726002573
Feb 2026
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IFNγ-induced memory in human macrophages is sustained by the durability of cytokine signaling itself

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  DOI: 10.1084/jem.20250976
  
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dx.doi.org/10.1084/jem.20250976
Dec 2025
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Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex

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  DOI: 10.1158/2159-8290.CD-25-0271
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12670082/
Nov 2025
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Therapeutic stress triggers tumor STAT1 acetylation to disarm immunotherapy

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Sep 2025
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Ubiquitination-activated TAB–TAK1–IKK–NF-κB axis modulates gene expression for cell survival in the lysosomal damage response

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  DOI: 10.7554/eLife.106901
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12459955/
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PDE7A inhibition suppresses triple-negative breast cancer by attenuating de novo pyrimidine biosynthesis

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Aug 2025
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Overcoming ovarian cancer resistance and evasion to CAR-T cell therapy by harnessing allogeneic CAR-NKT cells

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  DOI: 10.1016/j.medj.2025.100804
  
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Jul 2025
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Interferon-driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer

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Jun 2025
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Combining Apatinib and Oxaliplatin Remodels the Immunosuppressive Tumor Microenvironment and Sensitizes Desert-Type Gastric Cancer to Immunotherapy

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1. scibot 11 Jun 2025
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12127801/
Apr 2025
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Epigenomic regulation of stemness contributes to the low immunogenicity of the most mutated human cancer

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sciencedirect.com/science/article/pii/S2211124725003328
Mar 2025
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52.53.155.43/dee9a06bd4d5f7e409990fffe7937b86e5d2a784/PDF-html.html
Feb 2025
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Tumor cell–intrinsic Piezo2 drives radioresistance by impairing CD8+ T cell stemness maintenance

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  DOI: 10.1084/jem.20231486
  
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Interferon-a potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment

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1. scibot 14 Feb 2025
  
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  DOI: 10.1158/2159-8290.CD-21-1022
  
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aacrjournals.org/cancerdiscovery/article/12/7/1718/705192/IFN-Potentiates-Anti-PD-1-Efficacy-by-Remodeling
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TGF-β antagonizes IFN-γ-mediated adaptive immune evasion via activation of the AKT-Smad3-SHP1 axis in lung adenocarcinoma

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aacrjournals.org/cancerres/article/83/13/2262/727433/TGF-Antagonizes-IFN-Mediated-Adaptive-Immune
Jan 2025
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Pan-inhibition of super-enhancer-driven oncogenic transcription by next-generation synthetic ecteinascidins yields potent anti-cancer activity

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1. scibot 15 Jan 2025
  
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  DOI: 10.1038/s41467-024-55667-z
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11711318/
Dec 2024
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Macrophages are activated toward phagocytic lymphoma cell clearance by pentose phosphate pathway inhibition

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  DOI: 10.1016/j.xcrm.2024.101830
  
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Aug 2024
jbiomedsci.biomedcentral.com jbiomedsci.biomedcentral.com

Proteasome inhibitors restore the STAT1 pathway and enhance the expression of MHC class I on human colon cancer cells

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jbiomedsci.biomedcentral.com/articles/10.1186/s12929-021-00769-9
Jul 2024
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The canonical antiviral protein oligoadenylate synthetase 1 elicits antibacterial functions by enhancing IRF1 translation

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  DOI: 10.1016/j.immuni.2024.06.003
  
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sciencedirect.com/science/article/pii/S1074761324003091
Jun 2024
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Dynamic control of gene expression by ISGF3 and IRF1 during IFNβ and IFNγ signaling

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  DOI: 10.1038/s44318-024-00092-7
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11148166/
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Opposing tumor-cell-intrinsic and -extrinsic roles of the IRF1 transcription factor in antitumor immunity

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  DOI: 10.1016/j.celrep.2024.114289
  
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IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

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sciencedirect.com/science/article/pii/S2211124721002059
Mar 2024
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SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions

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Type I gamma phosphatidylinositol phosphate 5-kinase i5 controls cell sensitivity to interferon

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Feb 2024
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Dietary elaidic acid boosts tumoral antigen presentation and cancer immunity via ACSL5

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sciencedirect.com/science/article/pii/S1550413124000123
Nov 2023
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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

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  DOI: 10.1126/science.adh5021
  
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  DOI: 10.1126/science.adh5021
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10617673/
Oct 2023
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The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation

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  DOI: 10.1126/science.adh5021
  
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High NEK2 expression in myeloid progenitors suppresses T cell immunity in multiple myeloma

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High-throughput identification of Toxoplasma gondii effector proteins that target host cell transcription

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  DOI: 10.1016/j.chom.2023.09.003
  
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sciencedirect.com/science/article/pii/S1931312823003700
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Endocrine Therapy Synergizes with SMAC Mimetics to Potentiate Antigen Presentation and Tumor Regression in Hormone Receptor–Positive Breast Cancer

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  DOI: 10.1158/0008-5472.CAN-23-1711
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10543960/
Jul 2023
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MEF2A suppresses stress responses that trigger DDX41-dependent IFN production

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  DOI: 10.1016/j.celrep.2023.112805
  
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sciencedirect.com/science/article/pii/S2211124723008161
Jun 2023
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NLRP12-PANoptosome activates PANoptosis and pathology in response to heme and PAMPs

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  DOI: 10.1016/j.cell.2023.05.005
  
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sciencedirect.com/science/article/pii/S009286742300524X
May 2023
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Comparative Analysis of Six IRF Family Members in Alveolar Epithelial Cell-Intrinsic Antiviral Responses

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1. scibot 06 May 2023
  
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  DOI: 10.3390/cells10102600
  
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mdpi.com/2073-4409/10/10/2600/htm
Apr 2023
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MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

1
1. scibot 12 Apr 2023
  
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Targeting USP2 regulation of VPRBP-mediated degradation of p53 and PD-L1 for cancer therapy

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Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria

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Manganese enhances DNA- or RNA-mediated innate immune response by inducing phosphorylation of TANK-binding kinase 1

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Cancer genes disfavoring T cell immunity identified via integrated systems approach

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cd-21-1022-html.html

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EMT alterations in the solute carrier landscape uncover SLC22A10/A15 imposed vulnerabilities in pancreatic cancer

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CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4

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JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction

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Poxviruses and paramyxoviruses use a conserved mechanism of STAT1 antagonism to inhibit interferon signaling

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Overexpression screen of interferon-stimulated genes identifies RARRES3 as a restrictor of Toxoplasma gondii infection

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Channeling macrophage polarization by rocaglates increases macrophage resistance to Mycobacterium tuberculosis

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Reshaping of the Dendritic Cell Chromatin Landscape and Interferon Pathways during HIV Infection

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A genome‐wide screen identifies IRF2 as a key regulator of caspase‐4 in human cells

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  rabbit monoclonal anti‐IRF1
  
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A comprehensive analysis of coregulator recruitment, androgen receptor function and gene expression in prostate cancer

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A PGE2-MEF2A axis enables context-dependent control of inflammatory gene expression

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Interferon-γ induces tumor resistance to anti-PD-1 immunotherapy by promoting YAP phase separation

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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

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IRF1 governs the differential interferon-stimulated gene responses in human monocytes and macrophages by regulating chromatin accessibility

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Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

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Activation of Clustered IFNγ Target Genes Drives Cohesin-Controlled Transcriptional Memory

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Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

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Jan 2020
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Decreased levels of constitutive proteasomes in experimental autoimmune encephalomyelitis may be caused by a combination of subunit displacement and reduced Nfe2l1 expression

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An Evolutionarily Conserved Function of Polycomb Silences the MHC Class I Antigen Presentation Pathway and Enables Immune Evasion in Cancer

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The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

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Differential Activation of the Transcription Factor IRF1 Underlies the Distinct Immune Responses Elicited by Type I and III Interferons

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Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

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IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners

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Untitled document

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The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons

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An Antiviral Branch of the IL-1 Signaling Pathway Restricts Immune-Evasive Virus Replication

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IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

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