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Endogenous fine-mapping and prioritization of functional regulatory elements in complex genetic loci

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.xgen.2025.100982
  
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cell.com/cell-genomics/abstract/S2666-979X(25)00238-1
Aug 2025
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Extrachromosomal DNA biogenesis is dependent on DNA looping and religation by YY1-Lig3-PARylation complex

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sciencedirect.com/science/article/pii/S1097276525006082
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Mutations in MLL3 promote breast cancer progression via HIF1α-dependent intratumoral recruitment and differentiation of regulatory T cells

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.008
  
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sciencedirect.com/science/article/pii/S1074761325003176
Jul 2025
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Epigenome profiling identifies H3K27me3 regulation of extracellular matrix composition in human corticogenesis

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.neuron.2025.06.016
  
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sciencedirect.com/science/article/pii/S089662732500474X
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A STAT3/integrin axis accelerates pancreatic cancer initiation and progression

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1. scibot 23 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.116010
  
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sciencedirect.com/science/article/pii/S2211124725007818
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Light-induced epigenetic modifications in the hypothalamus during avian embryonic development enhance phenotypic plasticity

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1. scibot 16 Jul 2025
  
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  DOI: 10.3389/fcell.2025.1573705
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12241980/
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High fructose promotes MYCN-amplified neuroblastoma progression through NgBR-ACSS2-mediated biosynthesis of acetyl-CoA

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1. scibot 08 Jul 2025
  
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  DOI: 10.1016/j.celrep.2025.115947
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00718-1
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Histone Deacetylase Inhibitors Target DNA Replication Regulators and Replication Stress in Ewing Sarcoma Cells

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  DOI: 10.1158/2767-9764.CRC-25-0058
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12202856/
Jun 2025
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Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.029
  
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  DOI: 10.1158/0008-5472.can-24-3904
  
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52.53.155.43/39661a60067369c81e4f8c30deffb29c14ec6c80/PDF-html.html
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1. scibot 12 Jun 2025
  
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52.53.155.43/6f95ee3860ed32eb2fc3447b03e264cd8239544f/PDF-html.html
May 2025
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De novo assembly of nuclear stress bodies rearranges and enhances NFIL3 to restrain acute inflammatory responses

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1. scibot 29 May 2025
  
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  DOI: 10.1016/j.cell.2025.05.003
  
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sciencedirect.com/science/article/pii/S0092867425005148
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Chromatin modification abnormalities by CHD7 and KMT2C loss promote medulloblastoma progression

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1. scibot 20 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115673
  
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sciencedirect.com/science/article/pii/S2211124725004449
Apr 2025
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Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia

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1. scibot 19 Apr 2025
  
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  DOI: 10.1101/2025.03.19.643917
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11957141/
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Epigenomic regulation of stemness contributes to the low immunogenicity of the most mutated human cancer

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.celrep.2025.115561
  
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sciencedirect.com/science/article/pii/S2211124725003328
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Hypoxia-induced phase separation of ZHX2 alters chromatin looping to drive cancer metastasis

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1. scibot 05 Apr 2025
  
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  DOI: 10.1016/j.molcel.2025.03.009
  
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sciencedirect.com/science/article/pii/S1097276525002023
Mar 2025
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PI3Kβ functions as a protein kinase to promote cellular protein O-GlcNAcylation and acetyl-CoA production for tumor growth

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.molcel.2025.02.024
  
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sciencedirect.com/science/article/pii/S1097276525001868
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Antagonistic roles for MITF and TFE3 in melanoma plasticity

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1. scibot 29 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115474
  
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sciencedirect.com/science/article/pii/S2211124725002451
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1-s2.0-S2589004225003827-main-html.html

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1. scibot 04 Mar 2025
  
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  AB_10949503
  
  DOI: 10.1016/j.isci.2025.112122
  
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52.53.155.43/9971826d61a2d36f2abda36396d24ddec628d233/1-s2.0-S2589004225003827-main-html.html
Feb 2025
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Fusion oncoproteins and cooperating mutations define disease phenotypes in NUP98-rearranged leukemia

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1. scibot 27 Feb 2025
  
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  DOI: 10.1101/2025.01.21.25320683
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11838931/
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Reactive Oxygen species dependent increase in H3K27 acetylation by intermittent hypoxia is regulated by H3S28 phosphorylation

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1. scibot 06 Feb 2025
  
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  DOI: 10.1101/2024.09.09.612097
  
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52.53.155.43/f05ab403f134b3e958e2f7b12bdc7f45adf9ceaf/2024.09.09.612097v1.full-html.html
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Molecular signature of primate astrocytes reveals pathways and regulatory changes contributing to human brain evolution

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  DOI: 10.1016/j.stem.2024.12.011
  
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Jan 2025
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Allelic transcriptomic profiling identifies the role of PRD-like homeobox genes in human embryonic-cleavage-stage arrest

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1. scibot 14 Jan 2025
  
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  DOI: 10.1016/j.devcel.2024.12.031
  
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Efficacy of CBP/p300 Dual Inhibitors against De-repression of KREMEN2 in cBAF-Deficient Cancers

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1. scibot 08 Jan 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0484
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11701801/
Dec 2024
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Acute MeCP2 loss in adult mice reveals transcriptional and chromatin changes that precede neurological dysfunction and inform pathogenesis

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1. scibot 17 Dec 2024
  
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  DOI: 10.1016/j.neuron.2024.11.006
  
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RNA binding protein ZCCHC24 promotes tumorigenicity in triple-negative breast cancer

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1. scibot 11 Dec 2024
  
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  DOI: 10.1038/s44319-024-00282-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11624195/
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BMP suppresses Wnt signaling via the Bcl11b-regulated NuRD complex to maintain intestinal stem cells

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  DOI: 10.1038/s44318-024-00276-1
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11612440/
Sep 2024
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TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases

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  DOI: 10.1016/j.celrep.2019.05.061
  
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sciencedirect.com/science/article/pii/S2211124719306904
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Promoter DNA methylation and transcription factor condensation are linked to transcriptional memory in mammalian cells

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Aug 2024
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FRA1 controls acinar cell plasticity during murine KrasG12D-induced pancreatic acinar to ductal metaplasia

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1. scibot 23 Aug 2024
  
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  DOI: 10.1016/j.devcel.2024.07.021
  
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Feedforward cysteine regulation maintains melanoma differentiation state and limits metastatic spread

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114484
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11316253/
Jul 2024
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Acetyl-CoA metabolism maintains histone acetylation for syncytialization of human placental trophoblast stem cells

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1. scibot 31 Jul 2024
  
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  DOI: 10.1016/j.stem.2024.07.003
  
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Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer

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1. scibot 25 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.06.012
  
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IRF4 requires ARID1A to establish plasma cell identity in multiple myeloma

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1. scibot 24 Jul 2024
  
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  DOI: 10.1016/j.ccell.2024.05.026
  
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Alphaherpesvirus manipulates retinoic acid metabolism for optimal replication

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1. scibot 14 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110144
  
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Jun 2024
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CRISPR activation screens identify the SWI/SNF ATPases as suppressors of ferroptosis

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Inhibition of HDAC activity directly reprograms murine embryonic stem cells to trophoblast stem cells

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Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng

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Epigenetic activation of SOX11 is associated with recurrence and progression of ductal carcinoma in situ to invasive breast cancer

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Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in DSRCTs

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Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor

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Identification of WNK1 as a therapeutic target to suppress IgH/MYC expression in multiple myeloma

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The Drosophila Hippo pathway transcription factor Scalloped and its co-factors alter each other’s chromatin binding dynamics and transcription in vivo

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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

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SP6 controls human cytotrophoblast fate decisions and trophoblast stem cell establishment by targeting MSX2 regulatory elements

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Class I HDAC inhibitors enhance antitumor efficacy and persistence of CAR-T cells by activation of the Wnt pathway

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Transcription elongation defects link oncogenic SF3B1 mutations to targetable alterations in chromatin landscape

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Hepatic Snai1 and Snai2 promote liver regeneration and suppress liver fibrosis in mice

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Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability

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Canonical Wnt signaling directs the generation of functional human PSC-derived atrioventricular canal cardiomyocytes in bioprinted cardiac tissues

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Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a

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Lactic acid induces transcriptional repression of macrophage inflammatory response via histone acetylation

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H2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in pediatric high-grade glioma cells

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Lysine acetyltransferase 6A maintains CD4+ T cell response via epigenetic reprogramming of glucose metabolism in autoimmunity

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IL-15-dependent immune crosstalk between natural killer cells and dendritic cells in HIV-1 elite controllers

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Chronic hypoxia stabilizes 3βHSD1 via autophagy suppression

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Mof plays distinct roles in hepatic lipid metabolism under healthy or non-alcoholic fatty liver conditions

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KDM6B drives epigenetic reprogramming associated with lymphoid stromal cell early commitment and immune properties

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PIIS0092867423009650-html.html

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Discordant interactions between YAP1 and polycomb group protein SCML2 determine cell fate

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

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NFYC-37 promotes tumor growth by activating the mevalonate pathway in bladder cancer

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Mammalian SWI/SNF chromatin remodeling complexes promote tyrosine kinase inhibitor resistance in EGFR-mutant lung cancer

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Ketolysis drives CD8+ T cell effector function through effects on histone acetylation

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A p53/LINC00324 positive feedback loop suppresses tumor growth by counteracting SET-mediated transcriptional repression

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Single-cell dissection of Merkel cell carcinoma heterogeneity unveils transcriptomic plasticity and therapeutic vulnerabilities

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Neuroprotective protein ADNP-dependent histone remodeling complex promotes T helper 2 immune cell differentiation

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Complex regulation of Eomes levels mediated through distinct functional features of the Meteor long non-coding RNA locus

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(A) Elevated expression of histone deacetylase HDAC8 suppresses arginine-proline metabolism in necrotizing enterocolitis

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Quantitative control of Ets1 dosage by a multi-enhancer hub promotes Th1 cell differentiation and protects from allergic inflammation

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Depletion of CUL4B in macrophages ameliorates diabetic kidney disease via miR-194-5p/ITGA9 axis

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DNA-initiated epigenetic cascades driven by C9orf72 hexanucleotide repeat

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Novel enhancers conferring compensatory transcriptional regulation of Nkx2-5 in heart development

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MYC activation impairs cell-intrinsic IFNγ signaling and confers resistance to anti-PD1/PD-L1 therapy in lung cancer

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Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation

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D-2-hydroxyglutarate dehydrogenase governs adult neural stem cell activation and promotes histone acetylation via ATP-citrate lyase

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Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1

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Cancer stem cells, not bulk tumor cells, determine mechanisms of resistance to SMO inhibitors

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Single-cell profiling of lncRNAs in human germ cells and molecular analysis reveals transcriptional regulation of LNC1845 on LHX8

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PPARγ and C/EBPα response to acute cold stress in brown adipose tissue

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Recruitment of TRIM33 to cell-context specific PML nuclear bodies regulates nodal signaling in mESCs

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ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury

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Dual Acting Peptides Target EZH2 and AR: a New Paradigm for Effective Treatment of Castration-Resistant Prostate Cancer

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BAF complex maintains glioma stem cells in pediatric H3K27M-glioma

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Targeting the MITF/APAF-1 axis as salvage therapy for MAPK inhibitors in resistant melanoma

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Selective advantage of epigenetically disrupted cancer cells via phenotypic inertia

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Reversible epigenetic alterations regulate class I HLA loss in prostate cancer

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Aug 2022
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ccr-21-3603-html.html

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RPA1 controls chromatin architecture and maintains lipid metabolic homeostasis

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Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

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Cancer Stem Cells, not Bulk Tumor Cells, Determine Mechanisms of Resistance to SMO Inhibitors

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May 2022
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H3-K27M-mutant nucleosomes interact with MLL1 to shape the glioma epigenetic landscape

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KSHV episome tethering sites on host chromosomes and regulation of latency-lytic switch by CHD4

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The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

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Lactate rewires lipid metabolism and sustains a metabolic-epigenetic axis in prostate cancer

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PTIP governs NAD+ metabolism by regulating CD38 expression to drive macrophage inflammation

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Interferons reshape the 3D conformation and accessibility of macrophage chromatin

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Pharmacological preconditioning by TERT inhibitor BIBR1532 confers neuronal ischemic tolerance through TERT-mediated transcriptional reprogramming

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Aug 2021
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Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements

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Jul 2021
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Untitled document

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May 2021
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Glutamine Metabolism Controls Chondrocyte Identity and Function

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  RRID:AB_10949503
  
  DOI: 10.1016/j.devcel.2020.05.001
  
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Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas

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1. scibot 20 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.07.008
  
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The bone microenvironment increases phenotypic plasticity of ER+ breast cancer cells

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1. scibot 20 Apr 2021
  
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  DOI: 10.1016/j.devcel.2021.03.008
  
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SETD5-Coordinated Chromatin Reprogramming Regulates Adaptive Resistance to Targeted Pancreatic Cancer Therapy

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1. scibot 17 Apr 2021
  
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  DOI: 10.1016/j.ccell.2020.04.014
  
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Dual targeting of the epigenome via FACT complex and histone deacetylase is a potent treatment strategy for DIPG

1
1. scibot 14 Apr 2021
  
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  DOI: 10.1016/j.celrep.2021.108994
  
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Feb 2021
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Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants

1
1. scibot 25 Feb 2021
  
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  DOI: 10.1016/j.stem.2021.01.016
  
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sciencedirect.com/science/article/pii/S1934590921000163
Jan 2021
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Targeted brachyury degradation disrupts a highly specific autoregulatory program controlling chordoma cell identity

1
1. scibot 20 Jan 2021
  
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  DOI: 10.1016/j.xcrm.2020.100188
  
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Nov 2020
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Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling

1
1. scibot 07 Nov 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.celrep.2020.108333
  
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Oct 2020
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Modulating Androgen Receptor-Driven Transcription in Prostate Cancer with Selective CDK9 Inhibitors

1
1. scibot 27 Oct 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.chembiol.2020.10.001
  
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Sep 2020
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Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells

1
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  DOI: 10.1016/j.molcel.2020.03.010
  
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Diverse nucleosome Site-Selectivity among histone deacetylase complexes

1
1. scibot 16 Sep 2020
  
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  RRID:AB_10949503
  
  DOI: 10.7554/eLife.57663
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7316510/
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Tuning Transcription Factor Availability through Acetylation-Mediated Genomic Redistribution

1
1. scibot 15 Sep 2020
  
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  RRID:AB_2616015
  
  DOI: 10.1016/j.molcel.2020.05.025
  
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NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma

1
1. scibot 08 Sep 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.celrep.2020.107782
  
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Chromatin Hyperacetylation Impacts Chromosome Folding by Forming a Nuclear Subcompartment

1
1. scibot 08 Sep 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.molcel.2020.03.018
  
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Jan 2020
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One-Carbon Metabolism Supports S-Adenosylmethionine and Histone Methylation to Drive Inflammatory Macrophages

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.molcel.2019.06.039
  
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Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10949887
  
  DOI: 10.1016/j.cell.2019.08.013
  
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Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.cell.2019.07.048
  
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A Functional Link between Nuclear RNA Decay and Transcriptional Control Mediated by the Polycomb Repressive Complex 2

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.celrep.2019.10.011
  
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p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.celrep.2019.07.027
  
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The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.immuni.2018.12.018
  
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LRH1-driven transcription factor circuitry for hepatocyte identity: Super-enhancer cistromic analysis

1
1. scibot 13 Jan 2020
  
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  RRID:AB_10949503
  
  DOI: 10.1016/j.ebiom.2018.12.056
  
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sciencedirect.com/science/article/pii/S2352396418306339
Nov 2018
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Mutant NPM1 Maintains the Leukemic State through HOX Expression

1
1. scibot 05 Nov 2018
  
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SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

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1. scibot 05 Nov 2018
  
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A Somatically Acquired Enhancer of the Androgen Receptor Is a Noncoding Driver in Advanced Prostate Cancer

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S0092867418306494

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