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Jan 2026
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MITA/STING-driven CD38 induction in Siglec-Flow macrophages promotes regulatory T cell survival and non-small cell lung cancer progression

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1. scibot 13 Jan 2026
  
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Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

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1. scibot 09 Jan 2026
  
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Dec 2025
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Potentiating immunotherapy in “immune-cold” solid tumors through orchestrating T cell immunity via tumor-specific genetic engineering

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1. scibot 17 Dec 2025
  
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  DOI: 10.1016/j.xcrm.2025.102510
  
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sciencedirect.com:5037/science/article/pii/S266637912500583X
Oct 2025
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Glucocorticoids unleash immune-dependent melanoma control through inhibition of the GARP/TGF-β axis

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1. scibot 25 Oct 2025
  
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  DOI: 10.1158/2159-8290.CD-24-1224
  
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pmc.ncbi.nlm.nih.gov/articles/PMC7618275/
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TET2-mutant clonal hematopoiesis enhances macrophage antigen presentation and improves immune checkpoint therapy in solid tumors

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1. scibot 18 Oct 2025
  
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Sep 2025
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Bifidobacteria-derived exopolysaccharide promotes anti-tumor immunity

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  DOI: 10.1016/j.celrep.2025.116223
  
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Jun 2025
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Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity

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1. scibot 11 Jun 2025
  
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Fc-optimized anti-CTLA-4 antibodies increase tumor-associated high endothelial venules and sensitize refractory tumors to PD-1 blockade

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1. scibot 04 Jun 2025
  
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sciencedirect.com/science/article/pii/S2666379125002149
May 2025
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Somatic hypermutation unlocks antibody specificities beyond the primary repertoire

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1. scibot 17 May 2025
  
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  DOI: 10.1016/j.immuni.2025.04.014
  
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Feb 2025
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Hyperthermic intrathoracic chemotherapy modulates the immune microenvironment of pleural mesothelioma and improves the impact of dual immune checkpoint inhibition

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1. scibot 20 Feb 2025
  
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aacrjournals.org/cancerimmunolres/article/13/2/185/751253/Hyperthermic-Intrathoracic-Chemotherapy-Modulates
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Activation of IL-2/IL-2R pathway by Hedyotis diffusa polysaccharide improves immunotherapy in colorectal cancer

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1. scibot 20 Feb 2025
  
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  DOI: 10.1016/j.ijbiomac.2025.141013
  
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sciencedirect.com/science/article/pii/S0141813025015624
Dec 2024
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Stochastic modeling of single-cell gene expression adaptation reveals non-genomic contribution to evolution of tumor subclones

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1. scibot 19 Dec 2024
  
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  DOI: 10.1016/j.cels.2024.11.013
  
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Botensilimab, an Fc-Enhanced Anti–CTLA-4 Antibody, Is Effective against Tumors Poorly Responsive to Conventional Immunotherapy

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1. scibot 11 Dec 2024
  
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  DOI: 10.1158/2159-8290.CD-24-0190
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11609826/
Aug 2024
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Fc-enhanced anti-CTLA-4, anti-PD-1, doxorubicin, and ultrasound-mediated BBB opening: A novel combinatorial immunotherapy regimen for gliomas

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1. scibot 22 Aug 2024
  
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  DOI: 10.1093/neuonc/noae135
  
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Jun 2024
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Glucagon-like peptide 1 receptor is a T cell-negative costimulatory molecule

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1. scibot 05 Jun 2024
  
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  DOI: 10.1016/j.cmet.2024.05.001
  
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May 2024
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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

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1. scibot 24 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.025
  
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Mar 2024
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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.ccell.2024.02.013
  
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Feb 2024
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Lactate modulates RNA splicing to promote CTLA-4 expression in tumor-infiltrating regulatory T cells

2
1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.019
  
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  DOI: 10.1016/j.immuni.2024.01.019
  
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Dec 2023
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NK cells propagate T cell immunity following in situ tumor vaccination

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1. scibot 17 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113556
  
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Oct 2023
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Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer

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1. scibot 01 Oct 2023
  
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Jul 2023
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A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence

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1. scibot 21 Jul 2023
  
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May 2023
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Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal

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1. scibot 05 May 2023
  
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  DOI: 10.1016/j.stem.2023.04.005
  
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Apr 2023
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Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma

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1. scibot 12 Apr 2023
  
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Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment

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1. scibot 07 Apr 2023
  
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  DOI: 10.1016/j.cell.2023.03.011
  
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cell.com/cell/fulltext/S0092-8674(23)00271-4
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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

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  DOI: 10.1016/j.cell.2023.03.007
  
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A neutrophil response linked to tumor control in immunotherapy

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  DOI: 10.1016/j.cell.2023.02.032
  
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Mar 2023
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IFNγ is a central node of cancer immune equilibrium

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  DOI: 10.1016/j.celrep.2023.112219
  
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Jan 2023
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The loss of epithelial Smad4 drives immune evasion via CXCL1 while displaying vulnerability to combinatorial immunotherapy in gastric cancer

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1. scibot 28 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111878
  
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MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

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1. scibot 19 Jan 2023
  
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

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1. scibot 07 Jan 2023
  
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  DOI: 10.1158/2159-8290.CD-21-0003
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9401506/
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Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1

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1. scibot 07 Jan 2023
  
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  DOI: 10.1158/2159-8290.CD-21-0900
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9262841/
Dec 2022
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Hyaluronan driven by epithelial aPKC deficiency remodels the microenvironment and creates a vulnerability in mesenchymal colorectal cancer

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1. scibot 17 Dec 2022
  
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  DOI: 10.1016/j.ccell.2022.11.016
  
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IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer

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1. scibot 17 Dec 2022
  
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  DOI: 10.1016/j.ccell.2022.11.014
  
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Depletion of conventional type-1 dendritic cells in established tumors suppresses immunotherapy efficacy

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1. scibot 03 Dec 2022
  
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  DOI: 10.1158/0008-5472.CAN-22-1046
  
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aacrjournals.org/cancerres/article/82/23/4373/710691/Depletion-of-Conventional-Type-1-Dendritic-Cells
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can-22-1046-html.html

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52.53.155.43/31121aea6deac1c0e5bfa6acfce4eeee5d0658c1/can-22-1046-html.html
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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

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A novel selective inhibitor JBI-589 targets PAD4-mediated neutrophil migration to suppress tumor progression

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Sep 2022
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Mutant-IDH inhibits Interferon-TET2 signaling to promote immunoevasion and tumor maintenance in cholangiocarcinoma

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Jun 2022
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cd-21-0900-html.html

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Flow cytometry analysis of endothelial cells and subsets of exhausted CD8+ T cells in murine tumor models

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Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy

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The allergy mediator histamine confers resistanceto immunotherapy in cancer patients via activationof the macrophage histamine receptor H1

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Simultaneously Combined Cancer Cell- and CTLA4-Targeted NIR-PIT Causes a Synergistic Treatment Effect in Syngeneic Mouse Models

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Myeloid antigen-presenting cell niches sustain antitumor T cells and license PD-1 blockade via CD28 costimulation

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Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity

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Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma

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Untitled document

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Untitled document

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Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING

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Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity

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Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade

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Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

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  InVivoPlus anti-mouse CTLA-4 (CD152) Anti-CTLA-4 Mouse Monoclonal Antibody
  
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DNA Sensing in Mismatch Repair-Deficient Tumor Cells Is Essential for Anti-tumor Immunity

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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses

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Restricting Glycolysis Preserves T Cell Effector Functions and Augments Checkpoint Therapy

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B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer

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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

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Untitled document

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Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

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High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy

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IKZF1 Enhances Immune Infiltrate Recruitment in Solid Tumors and Susceptibility to Immunotherapy

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Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens

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Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity

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Antibody Tumor Targeting Is Enhanced by CD27 Agonists through Myeloid Recruitment

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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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1. scibot 05 Nov 2018
  
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