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SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

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1. scibot 03 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116139
  
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sciencedirect.com/science/article/pii/S2211124725009106
Aug 2025
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Lymphoma accelerates T cell and tissue aging

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.ccell.2025.07.023
  
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sciencedirect.com/science/article/pii/S1535610825003290
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Selective Alanine Transporter Utilization is a Therapeutic Vulnerability in ARID1A-Mutant Ovarian Cancer

1
1. scibot 05 Aug 2025
  
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  DOI: 10.1158/0008-5472.CAN-25-0654
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12314749/
Jul 2025
www.cell.com www.cell.com

TIM3+ breast cancer cells license immune evasion during micrometastasis outbreak

1
1. scibot 15 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.015
  
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cell.com/cancer-cell/abstract/S1535-6108(25)00265-X
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Activated T Cells Break Tumor Immunosuppression by Macrophage Reeducation

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1. scibot 08 Jul 2025
  
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  DOI: 10.1158/2159-8290.CD-24-0415
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12223510/
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Augment proteasome inhibitor efficacy activates CD8+ T cell-mediated antitumor immunity in breast cancer

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1. scibot 02 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102211
  
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sciencedirect.com/science/article/pii/S2666379125002848
Jun 2025
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Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models

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1. scibot 13 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.05.014
  
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sciencedirect.com/science/article/pii/S1535610825002235
May 2025
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IL-2 immunotherapy rescues irradiation-induced T cell exhaustion in mouse colon cancer

1
1. scibot 29 May 2025
  
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  DOI: 10.1016/j.isci.2025.112639
  
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PD-1 Blockade Mitigates Surgery-Induced Immunosuppression and Increases the Efficacy of Photodynamic Therapy for Pleural Mesothelioma

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1. scibot 28 May 2025
  
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  DOI: 10.1158/2767-9764.CRC-24-0571
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12099492/
Apr 2025
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A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection

1
1. scibot 24 Apr 2025
  
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  RRID:AB_6533215
  
  DOI: 10.1016/j.cell.2025.03.043
  
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sciencedirect.com/science/article/pii/S0092867425003952
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Pre-existing intratumoral stem-like CD8+ T cells drive radiotherapy-induced tumor immunity

1
1. scibot 15 Apr 2025
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.celrep.2025.115566
  
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sciencedirect.com/science/article/pii/S2211124725003377
52.53.155.43 52.53.155.43

Pre-existing intratumoral stem-like CD8+ T-cells drive radiotherapy-induced tumor control

1
1. scibot 11 Apr 2025
  
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  RRID:AB_10950145
  
  DOI: 10.1101/2024.10.16.618635
  
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52.53.155.43/ecad09cc9eabd42f0fef0391e2d71b5d66664c67/2024.10.16.618635.full-html.html
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Spatial transcriptomics reveals tryptophan metabolism restricting maturation of intratumoral tertiary lymphoid structures

1
1. scibot 05 Apr 2025
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.ccell.2025.03.011
  
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sciencedirect.com/science/article/pii/S1535610825001126
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Cancer-cell-derived cGAMP limits the activity of tumor-associated CD8+ T cells

1
1. scibot 03 Apr 2025
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.celrep.2025.115510
  
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sciencedirect.com/science/article/pii/S2211124725002815
Mar 2025
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Inflammatory cytokines mediate the induction of and awakening from metastatic dormancy

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1. scibot 04 Mar 2025
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.celrep.2025.115388
  
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sciencedirect.com/science/article/pii/S2211124725001597
Jan 2025
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Clonally expanded, targetable, natural killer-like NKG7 T cells seed the aged spinal cord to disrupt myeloid-dependent wound healing

1
1. scibot 14 Jan 2025
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.neuron.2024.12.012
  
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sciencedirect.com/science/article/pii/S0896627324009115
Dec 2024
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Nucleo-cytosolic acetyl-CoA drives tumor immune evasion by regulating PD-L1 in melanoma

1
1. scibot 02 Dec 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.celrep.2024.115015
  
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sciencedirect.com/science/article/pii/S2211124724013664
Sep 2024
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Smyd3-mediated immuno-modulation in HPV-negative head and neck squamous cell carcinoma mouse models

1
1. scibot 17 Sep 2024
  
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  AB_10950145
  
  DOI: 10.1016/j.isci.2024.110854
  
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sciencedirect.com/science/article/pii/S2589004224020790
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

PlexinB1 Inactivation Reprograms Immune Cells in the Tumor Microenvironment, Inhibiting Breast Cancer Growth and Metastatic Dissemination

1
1. scibot 05 Sep 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1158/2326-6066.CIR-23-0289
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11369622/
Aug 2024
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

1
1. scibot 28 Aug 2024
  
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  AB_10950145
  
  DOI: 10.1016/j.devcel.2024.08.003
  
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sciencedirect.com/science/article/pii/S1534580724004866
Jul 2024
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Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance

1
1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.cell.2024.06.012
  
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sciencedirect.com/science/article/pii/S0092867424006524
Jun 2024
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Glycoengineering-based anti-PD-1-iRGD peptide conjugate boosts antitumor efficacy through T cell engagement

1
1. scibot 06 Jun 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.xcrm.2024.101590
  
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sciencedirect.com/science/article/pii/S2666379124002829
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Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity

1
1. scibot 04 Jun 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.celrep.2024.114300
  
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sciencedirect.com/science/article/pii/S2211124724006284
May 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Patients and mice with deficiency in the SNARE protein SYNTAXIN-11 have a secondary B cell defect

1
1. scibot 15 May 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1084/jem.20221122
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11082451/
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Circadian tumor infiltration and function of CD8+ T cells dictate immunotherapy efficacy

1
1. scibot 09 May 2024
  
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  AB_10950145
  
  DOI: 10.1016/j.cell.2024.04.015
  
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sciencedirect.com/science/article/pii/S0092867424004100
Apr 2024
www.nature.com www.nature.com

Targeting branched N-glycans and fucosylation sensitizes ovarian tumors to immune checkpoint blockade

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1. scibot 03 Apr 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1038/s41467-024-47069-y
  
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nature.com/articles/s41467-024-47069-y
Mar 2024
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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

1
1. scibot 15 Mar 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.ccell.2024.02.013
  
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sciencedirect.com/science/article/pii/S1535610824000576
Feb 2024
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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

1
1. scibot 28 Feb 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.molcel.2024.01.024
  
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sciencedirect.com/science/article/pii/S1097276524000911
Jan 2024
52.53.155.43 52.53.155.43

Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

1
1. scibot 10 Jan 2024
  
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  RRID:AB_10950145
  
  DOI: 10.1126/sciimmunol.abq2424
  
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52.53.155.43/93ebbe5a83b6a28b0d01edad42fa81f437079176/sciimmunol.abq2424_sm-html.html
Nov 2023
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PD-L1-mediated immune evasion in triple-negative breast cancer is linked to the loss of ZNF652

1
1. scibot 02 Nov 2023
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.celrep.2023.113343
  
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sciencedirect.com/science/article/pii/S2211124723013554
Oct 2023
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Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses

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1. scibot 27 Oct 2023
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.cmet.2023.09.011
  
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sciencedirect.com/science/article/pii/S1550413123003674
Sep 2023
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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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1. scibot 30 Sep 2023
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.xcrm.2023.101206
  
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sciencedirect.com/science/article/pii/S2666379123003737
Aug 2023
52.53.155.43 52.53.155.43

CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells

2
1. scibot 17 Aug 2023
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.xcrm.2023.101151
  
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2. scibot 11 Aug 2023
  
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  RRID:AB_10950145
  
  DOI: 10.1016/j.xcrm.2023.101151
  
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52.53.155.43/75914c2645b295883453ae6f0848b8ff04ccb7e0/PIIS266637912300304X-html.html
Jun 2023
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Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2

1
1. scibot 28 Jun 2023
  
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  DOI: 10.1016/j.celrep.2023.112693
  
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ZNF451 favors triple-negative breast cancer progression by enhancing SLUG-mediated CCL5 transcriptional expression

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Cancer-cell-derived fumarate suppresses the anti-tumor capacity of CD8+ T cells in the tumor microenvironment

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Fusobacterium nucleatum-derived succinic acid induces tumor resistance to immunotherapy in colorectal cancer

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Accumulation of branched-chain amino acids reprograms glucose metabolism in CD8+ T cells with enhanced effector function and anti-tumor response

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KDM5A Inhibits Antitumor Immune Responses Through Downregulation of the Antigen-Presentation Pathway in Ovarian Cancer

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Intersection of immune and oncometabolic pathways drives cancer hyperprogression during immunotherapy

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Enhancing PD-L1 Degradation by ITCH during MAPK Inhibitor Therapy Suppresses Acquired Resistance

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Oct 2022
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PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

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PD-1/PD-L1 blockade abrogates a dysfunctional innate-adaptive immune axis in critical β-coronavirus disease

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NOTCH induced MDSC recruitment after oHSV virotherapy in CNS cancer models modulates anti-tumor immunotherapy

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Jul 2022
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cir-22-0088-html.html

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Lenalidomide bypasses CD28 co-stimulation to reinstate PD-1 immunotherapy by activating Notch signaling

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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

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Tryptophan-derived microbial metabolites activate the aryl hydrocarbon receptor in tumor-associated macrophages to suppress anti-tumor immunity

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TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures

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Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

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The allergy mediator histamine confers resistanceto immunotherapy in cancer patients via activationof the macrophage histamine receptor H1

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Anti-PD-1/L1 lead-in before MAPK inhibitor combination maximizes antitumor immunity and efficacy

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Untitled document

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Untitled document

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CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment

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Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma

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Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors

1
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Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

1
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Systemic Inflammation Suppresses Lymphoid Tissue Remodeling and B Cell Immunity during Concomitant Local Infection

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Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

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Control of Viral Infection by Natural Killer Cell Inhibitory Receptors

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CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

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ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis

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Robust Iterative Stimulation with Self-Antigens Overcomes CD8+ T Cell Tolerance to Self- and Tumor Antigens

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Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance

1
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Oncolytic Viruses Engineered to Enforce Leptin Expression, Reprogram Tumor-Infiltrating T Cell Metabolism, and Promote Tumor Clearance

1
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A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus

1
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  DOI: 10.1016/j.chom.2018.11.011
  
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  Curator: @evieth
  
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sciencedirect.com/science/article/pii/S1931312818305936
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Untitled document

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  RRID:AB_10950145
  
  DOI: 10.1016/j.cell.2019.03.025
  
  Resource: (Bio X Cell Cat# BE0117, RRID:AB_10950145)
  
  Curator: @ethanbadger
  
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Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

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  DOI: 10.1016/j.ccell.2019.04.003
  
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  Curator: @ethanbadger
  
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  RRID:AB_10950145 RRIDCUR:Validated
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Nov 2018
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Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy

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  Curator: @Jmenke
  
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  RRID:AB_10950145 RRIDCUR:Validated
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Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer

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1. scibot 05 Nov 2018
  
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