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Human GBP4 promotes TRIM21-BIP-dependent autophagy to restrict M. tuberculosis infection by preventing SORT1-mediated progranulin degradation

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1. scibot 27 Jul 2026
  
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  DOI: 10.1016/j.celrep.2026.117739
  
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Jul 2026
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KRAS-mediated CCDC6 degradation drives xCT upregulation and ferroptosis evasion

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A Peptide-Based PROTAC Degrader of BRCA2 Sensitizes Metastatic Castration-Resistant Prostate Cancer to PARP Inhibition

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-24-4096
  
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aacrjournals.org/cancerres/article/85/18/3490/764450/A-Peptide-Based-PROTAC-Degrader-of-BRCA2
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Cytosolic EZH2-IMPDH2 complexes regulate melanoma progression and metastasis via GTP

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Jun 2026
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SARS-CoV-2 ORF3a blocks lysosomal cholesterol egress by disrupting VPS39-regulated NPC2 trafficking and BMP metabolism

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May 2026
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Activating an interleukin 4-FLT3-STAT6 axis in multipotent progenitors restores lymphopoiesis in inflammation and aging

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1. scibot 30 May 2026
  
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Apr 2026
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Genetically encoded manipulation of ATP/ADP ratio in human cells uncovers proteomic and physiological signatures of energy stress

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Mar 2026
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Blood-brain barrier-penetrative lipid nanoparticles enable systemic delivery of TRIM11 mRNA to disaggregate Tau in Alzheimer’s disease models

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Mitochondrial control of glycerolipid synthesis by a PEP shuttle

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1. scibot 20 Mar 2026
  
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Stepwise selection of Tof11/12 and GmRVE1 facilitates soybean adaptation to high-latitude regions

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1. scibot 03 Mar 2026
  
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Feb 2026
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MEDAG functions as an A-kinase-anchoring protein in adipocytes

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1. scibot 26 Feb 2026
  
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The serotonin receptor 2b (5-HT2B) modulates heart remodeling following myocardial infarction via regulation of Hippo pathway

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1. scibot 20 Feb 2026
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12915196/
Jan 2026
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Targeting TCF21-TCF3 heterodimer in tumor-associated pericytes attenuates hematogenous metastasis by restoring pericyte gatekeeper function

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  DOI: 10.1016/j.xcrm.2025.102569
  
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Uncovering genetic interactions in the DNA repair network in response to endogenous damage and ionizing radiation

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  DOI: 10.1016/j.celrep.2025.116850
  
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Ubiquitination-directed cytosolic DNA degradation governs cGAS-STING-mediated immune response to DNA damage

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  DOI: 10.1016/j.ccell.2025.12.013
  
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Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer

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  DOI: 10.1016/j.xcrm.2025.102534
  
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Dec 2025
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Mitochondrial VHL rewires cell metabolism in hypoxia

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.cmet.2025.11.013
  
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NEXN targeting MYOCD by facilitating EMT-related β-catenin nuclear translocation modulates the metastasis of hepatocellular carcinoma

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1. scibot 19 Dec 2025
  
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  DOI: 10.1016/j.isci.2025.114054
  
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Nov 2025
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drner-et-al-2025-fluorescent-protein-and-peptide-tags-alter-condensate-formation-and-dynamics-in-vivo-and-in-vitro-html.html

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1. scibot 25 Nov 2025
  
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54.241.53.176/afde91798d5f8bba27c3d251abe3a407e39b1790/drner-et-al-2025-fluorescent-protein-and-peptide-tags-alter-condensate-formation-and-dynamics-in-vivo-and-in-vitro-html.html
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UMP functions as an endogenous regulator of NR4A1 to control gastric cancer progression

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1. scibot 22 Nov 2025
  
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1-s2.0-S2589004225023156-main-html.html

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Oct 2025
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CRISPR-Cas9 screening reveals G2E3 as a novel ubiquitin-linked factor controlling autophagosome-lysosome fusion and cancer cell progression

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Sep 2025
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14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity and toxicity

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1. scibot 27 Sep 2025
  
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A covalent inhibitor targeting Cys16 on RhoA in colorectal cancer

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Jul 2025
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PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth

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1-s2.0-S2589004225013288-main-html.html

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Jun 2025
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kong-et-al-adipose-tissue-secreted-spz5-promotes-distal-tumor-progression-via-toll-6-mediated-hh-pathway-activation-in-html.html

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Adipose tissue-secreted Spz5 promotes distal tumor progression via Toll-6-mediated Hh pathway activation in Drosophila

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PRPS activity tunes redox homeostasis in Myc-driven lymphoma

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May 2025
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TOP1 Mutations and Cross-Resistance to Antibody–Drug Conjugates in Patients with Metastatic Breast Cancer

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  DOI: 10.1158/1078-0432.CCR-24-2771
  
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A postsynaptic GPR158-PLCXD2 complex controls spine apparatus abundance and dendritic spine maturation

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Apr 2025
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Cytosolic cytochrome c represses ferroptosis

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  DOI: 10.1016/j.cmet.2025.03.014
  
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Mar 2025
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Lactylation orchestrates ubiquitin-independent degradation of cGAS and promotes tumor growth

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  DOI: 10.1016/j.celrep.2025.115441
  
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cell.com/cell-reports/fulltext/S2211-1247(25)00212-8
Feb 2025
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A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair

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Isolation and Characterization of Antibodies Against Vascular Cell Adhesion Molecule-1 Reveals Putative Role for Ig-like Domains 2 and 3 in Cell-to-Cell Interaction

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Nov 2024
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Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

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Global isonicotinylome analysis identified SMAD3 isonicotinylation promotes liver cancer cell epithelial–mesenchymal transition and invasion

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Ngfr+ cholinergic projection from SI/nBM to mPFC selectively regulates temporal order recognition memory

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APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

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Jul 2024
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Autocrine glutamate signaling drives cell competition in Drosophila

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Chimeric antigen receptor-induced antigen loss protects CD5.CART cells from fratricide without compromising on-target cytotoxicity

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May 2024
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Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors

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A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death

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BPS Publications

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Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma

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Jan 2024
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MIIP downregulation drives colorectal cancer progression through inducing peri-cancerous adipose tissue browning

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Type 2 cytokine signaling in macrophages protects from cellular senescence and organismal aging

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Discovery of galectin-8 as an LILRB4 ligand driving M-MDSCs defines a class of antibodies to fight solid tumors

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circGlis3 promotes β-cell dysfunction by inhibiting hnRNPF nuclear translocation and encoding Glis3-348aa protein

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FK506 bypasses the effect of erythroferrone in cancer cachexia skeletal muscle atrophy

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NEMO reshapes the α-Synuclein aggregate interface and acts as an autophagy adapter by co-condensation with p62

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Mitoguardin 1 and 2 promote granulosa cell proliferation by activating AKT and regulating the Hippo-YAP1 signaling pathway

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CD36 maintains lipid homeostasis via selective uptake of monounsaturated fatty acids during matrix detachment and tumor progression

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Zmym4 is required for early cranial gene expression and craniofacial cartilage formation

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Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion

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Aug 2023
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Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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Optineurin tunes outside-in signaling to regulate lysosome biogenesis and phagocytic clearance in the retina

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Dual role of the adhesion G-protein coupled receptor ADRGE5/CD97 in glioblastoma invasion and proliferation

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Jul 2023
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NEMO reshapes the protein aggregate interface and promotes aggrephagy by co-condensation with p62

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Jun 2023
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Secreted Akkermansia muciniphila threonyl-tRNA synthetase functions to monitor and modulate immune homeostasis

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May 2023
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Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response

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Exercise-derived peptide protects against pathological cardiac remodeling

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APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size

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Mar 2023
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Mitoguardin2 is Associated with Hyperandrogenism and Regulates Steroidogenesis in Human Ovarian Granulosa Cells

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VE-822 upregulates the deubiquitinase OTUD1 to stabilize FHL1 to inhibit the progression of lung adenocarcinoma

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Single substitution in H3.3G34 alters DNMT3A recruitment to cause progressive neurodegeneration

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The tetraspan LHFPL5 is critical to establish maximal force sensitivity of the mechanotransduction channel of cochlear hair cells

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RNF138 inhibits late inflammatory gene transcription through degradation of SMARCC1 of the SWI/SNF complex

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Targeted pseudouridylation: An approach for suppressing nonsense mutations in disease genes

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Cytosolic DNA sensing by cGAS/STING promotes TRPV2-mediated Ca2+ release to protect stressed replication forks

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Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy

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Disrupting Circadian Rhythm via the PER1–HK2 Axis Reverses Trastuzumab Resistance in Gastric Cancer

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Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates

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RSPO2 promotes progression of ovarian cancer through dual receptor-mediated FAK/Src signaling activation

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Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death

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OTUB2 exerts tumor-suppressive roles via STAT1-mediated CALML3 activation and increased phosphatidylserine synthesis

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The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines

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STAT6 in mitochondrial outer membrane impairs mitochondrial fusion by inhibiting MFN2 dimerization

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Imatinib and methazolamide ameliorate COVID-19-induced metabolic complications via elevating ACE2 enzymatic activity and inhibiting viral entry

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Amino acid starvation-induced LDLR trafficking accelerates lipoprotein endocytosis and LDL clearance

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AMPK-PERK axis represses oxidative metabolism and enhances apoptotic priming of mitochondria in acute myeloid leukemia

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YAP regulates alveolar epithelial cell differentiation and AGER via NFIB/KLF5/NKX2-1

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Shigella OspC3 suppresses murine cytosolic LPS sensing

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Dominant-negative ATF5 rapidly depletes survivin in tumor cells

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EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure

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Functional Genomics Identifies Metabolic Vulnerabilities in Pancreatic Cancer

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Neuronal Inactivity Co-opts LTP Machinery to Drive Potassium Channel Splicing and Homeostatic Spike Widening

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Systematic characterization of mutations altering protein degradation in human cancers

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Evasion of type-I interferon by SARS-CoV-2

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AMPK-mediated phosphorylation on 53BP1 promotes c-NHEJ

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Impact of WIN site inhibitor on the WDR5 interactome

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Evasion of type-I interferon by SARS-CoV-2

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FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster

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Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

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TRIM32/USP11 Balances ARID1A Stability and the Oncogenic/Tumor-Suppressive Status of Squamous Cell Carcinoma

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Cell Cycle Inhibitor Whi5 Records Environmental Information to Coordinate Growth and Division in Yeast

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MitoRibo-Tag Mice Provide a Tool for In Vivo Studies of Mitoribosome Composition

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EHD1 impairs decidualization by regulating the Wnt4/β-catenin signaling pathway in recurrent implantation failure

1
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Heat Shock Factor 1 Is a Direct Antagonist of AMP-Activated Protein Kinase

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N-WASP Control of LPAR1 Trafficking Establishes Response to Self-Generated LPA Gradients to Promote Pancreatic Cancer Cell Metastasis

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Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus

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Ca2+-Stimulated AMPK-Dependent Phosphorylation of Exo1 Protects Stressed Replication Forks from Aberrant Resection

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  DOI: 10.1016/j.molcel.2019.04.003
  
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IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration

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Untitled document

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  DOI: 10.1016/j.devcel.2019.03.011
  
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Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination

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Autophagy Regulates the Liver Clock and Glucose Metabolism by Degrading CRY1

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Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1

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Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma

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