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Structural basis of regulated N-glycosylation at the secretory translocon

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1. scibot 25 Nov 2025
  
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  DOI: 10.1038/s41586-025-09756-8
  
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nature.com/articles/s41586-025-09756-8
Nov 2025
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System analysis links SMARCD3 regulons to growth signaling and MEK inhibitor response in everolimus-resistant ER+ breast cancer cells

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sciencedirect.com/science/article/pii/S2666379125004987
Jul 2025
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SOS1 Inhibition Enhances the Efficacy of KRASG12C Inhibitors and Delays Resistance in Lung Adenocarcinoma

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pmc.ncbi.nlm.nih.gov/articles/PMC11695159/
Jun 2025
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Redundancy of the OST catalytic subunit facilitates therapeutic targeting of N-glycosylation

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sciencedirect.com/science/article/pii/S2451945625001667
Mar 2025
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CDK4 selective inhibition improves preclinical anti-tumor efficacy and safety

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sciencedirect.com/science/article/pii/S1535610825000583
Feb 2025
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The roles of Growth Hormone dependent JAK-STAT5 and Lyn kinase signalling in determining lifespan and cancer incidence

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  DOI: 10.1210/endocr/bqae136
  
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Disrupting AGR2/IGF1 paracrine and reciprocal signaling for pancreatic cancer therapy

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  DOI: 10.1016/j.xcrm.2024.101927
  
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sciencedirect.com/science/article/pii/S2666379124006980
May 2024
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Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC

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sciencedirect.com/science/article/pii/S0925443924002382
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Contrasting consequences of podocyte IGF1R inhibition

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ncbi.nlm.nih.gov/pmc/articles/PMC11068853/
Apr 2024
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Burdock miR8175 in diet improves insulin resistance induced by obesity in mice through food absorption

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ncbi.nlm.nih.gov/pmc/articles/PMC11039404/
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Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system

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1. scibot 24 Apr 2024
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11034602/
Mar 2024
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Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response

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1. scibot 03 Mar 2024
  
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  DOI: 10.1158/1078-0432.CCR-22-2976
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10527034/
Oct 2023
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A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint

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1. scibot 14 Oct 2023
  
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  DOI: 10.1016/j.isci.2023.107919
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10562782/
Sep 2023
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Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.xcrm.2023.101200
  
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sciencedirect.com/science/article/pii/S2666379123003671
Aug 2023
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L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab

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  DOI: 10.1016/j.xcrm.2023.101142
  
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  DOI: 10.1016/j.xcrm.2023.101142
  
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52.53.155.43/bb31ad2b14838f5cede2aca897c595e2febf2f88/PIIS2666379123002951-html.html
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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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1. scibot 11 Aug 2023
  
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  DOI: 10.1016/j.molcel.2023.07.015
  
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sciencedirect.com/science/article/pii/S1097276523005580
Jul 2023
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PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate

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1. scibot 18 Jul 2023
  
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  DOI: 10.1101/2023.05.18.541123
  
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52.53.155.43/47cafcf0b0c101b9655865f446b83a64cc86d1a1/2023.05.18.541123v1.full-html.html
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Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene

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1. scibot 13 Jul 2023
  
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  DOI: 10.1016/j.cmet.2023.06.007
  
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cell.com/cell-metabolism/fulltext/S1550-4131(23)00217-6
May 2023
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Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma

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  DOI: 10.1016/j.celrep.2023.112570
  
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sciencedirect.com/science/article/pii/S2211124723005818
Feb 2023
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IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells

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  DOI: 10.1126/scisignal.abj5879
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
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PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6

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sciencedirect.com/science/article/pii/S2589004223001475
Dec 2022
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Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis

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1. scibot 24 Dec 2022
  
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sciencedirect.com/science/article/pii/S2211124722017260
Nov 2022
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A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice

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  DOI: 10.1158/2767-9764.crc-22-0256
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
Oct 2022
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The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance

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1. scibot 26 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105233
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9579486/
Apr 2022
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Insights into Ferroptosis: Targeting Glycolysis to Treat Graves’ Orbitopathy

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1. scibot 28 Apr 2022
  
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  DOI: 10.1210/clinem/dgac163
  
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academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac163/6550655
Oct 2021
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BPS Publications

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  DOI: 10.1111/bph.15616
  
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bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15616
Aug 2021
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Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis

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  DOI: 10.1016/j.cmet.2021.07.010
  
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sciencedirect.com/science/article/pii/S1550413121003260
Jul 2021
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Identification of candidates for driver oncogenes in scirrhous‐type gastric cancer cell lines

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1. scibot 29 Jul 2021
  
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  IGF1R
  
  DOI: 10.1111/cas.14111
  
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onlinelibrary.wiley.com/doi/full/10.1111/cas.14111
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Untitled document

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  DOI: 10.1210/en.2017-00693
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5761602/
May 2021
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The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1

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  anti-IGF-1 Receptor β-subunit (D23H3)
  
  DOI: 10.1016/j.jbc.2021.100739
  
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sciencedirect.com/science/article/pii/S0021925821005287
Mar 2021
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α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels

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1. scibot 09 Mar 2021
  
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  DOI: 10.7554/eLife.61951
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7929559/
Feb 2021
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L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness

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1. scibot 25 Feb 2021
  
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  DOI: 10.1186/s12964-021-00710-5
  
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biosignaling.biomedcentral.com/articles/10.1186/s12964-021-00710-5
Jan 2021
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TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron‐autonomous manner

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1. scibot 08 Jan 2021
  
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  RRID:AB_10949773
  
  DOI: 10.1111/jnc.15235
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15235
Oct 2020
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Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma

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1. scibot 27 Oct 2020
  
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  DOI: 10.1016/j.celrep.2020.108293
  
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pubmed.ncbi.nlm.nih.gov/33086062/
Sep 2020
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Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis

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  DOI: 10.1242/dev.190488
  
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Jan 2020
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eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

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  DOI: 10.1038/s41467-019-13086-5
  
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Nov 2018
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A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network

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Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS

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Untitled document

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Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes

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Untitled document

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Nov 2017
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The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover

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