36 Matching Annotations
  1. May 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Novel therapeutic strategies targeting bypass pathways and mitochondrial dysfunction to combat resistance to RET inhibitors in NSCLC
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    1. scibot 21 May 2024
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      DOI: 10.1016/j.bbadis.2024.167249

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    sciencedirect.com/science/article/pii/S0925443924002382
  3. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contrasting consequences of podocyte IGF1R inhibition
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    1. scibot 09 May 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11068853/
  4. Apr 2024
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Burdock miR8175 in diet improves insulin resistance induced by obesity in mice through food absorption
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    ncbi.nlm.nih.gov/pmc/articles/PMC11039404/
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Growth hormone promotes the reconstruction of injured axons in the hypothalamo-neurohypophyseal system
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    1. scibot 24 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC11034602/
  7. Mar 2024
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Thyroid cancers exhibit oncogene-enhanced macropinocytosis that is restrained by IGF1R and promotes albumin-drug-conjugate response
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    1. scibot 03 Mar 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10527034/
  9. Oct 2023
  10. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint
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    1. scibot 14 Oct 2023
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    ncbi.nlm.nih.gov/pmc/articles/PMC10562782/
  11. Sep 2023
  12. www.sciencedirect.com www.sciencedirect.com
    Signaling-induced systematic repression of miRNAs uncovers cancer vulnerabilities and targeted therapy sensitivity
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    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.xcrm.2023.101200

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    sciencedirect.com/science/article/pii/S2666379123003671
  13. Aug 2023
  14. 52.53.155.43 52.53.155.43
    L858R emerges as a potential biomarker predicting response of lung cancer models to anti-EGFR antibodies: Comparison of osimertinib vs. cetuximab
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    1. scibot 11 Aug 2023
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  16. Jul 2023
  17. 52.53.155.43 52.53.155.43
    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    1. scibot 18 Jul 2023
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  18. www.cell.com www.cell.com
    Fetal manipulation of maternal metabolism is a critical function of the imprinted Igf2 gene
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    1. scibot 13 Jul 2023
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    cell.com/cell-metabolism/fulltext/S1550-4131(23)00217-6
  19. May 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Kinetics of RTK activation determine ERK reactivation and resistance to dual BRAF/MEK inhibition in melanoma
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    1. scibot 31 May 2023
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  21. Feb 2023
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells
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    1. scibot 17 Feb 2023
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      DOI: 10.1126/scisignal.abj5879

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    ncbi.nlm.nih.gov/pmc/articles/PMC9528501/
  23. www.sciencedirect.com www.sciencedirect.com
    PTEN phosphatase inhibits metastasis by negatively regulating the Entpd5/IGF1R pathway through ATF6
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    1. scibot 17 Feb 2023
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      DOI: 10.1016/j.isci.2023.106070

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    sciencedirect.com/science/article/pii/S2589004223001475
  24. Dec 2022
  25. www.sciencedirect.com www.sciencedirect.com
    Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis
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    1. scibot 24 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111834

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    sciencedirect.com/science/article/pii/S2211124722017260
  26. Nov 2022
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice
    1
    1. scibot 19 Nov 2022
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      DOI: 10.1158/2767-9764.crc-22-0256

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    ncbi.nlm.nih.gov/pmc/articles/PMC9648418/
  28. Oct 2022
  29. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance
    1
    1. scibot 26 Oct 2022
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      DOI: 10.1016/j.isci.2022.105233

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    ncbi.nlm.nih.gov/pmc/articles/PMC9579486/
  30. Apr 2022
  31. academic.oup.com academic.oup.com
    Insights into Ferroptosis: Targeting Glycolysis to Treat Graves’ Orbitopathy
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    1. scibot 28 Apr 2022
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      DOI: 10.1210/clinem/dgac163

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    academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgac163/6550655
  32. Oct 2021
  33. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    BPS Publications
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    1. scibot 20 Oct 2021
      RRID:AB_10950969

      DOI: 10.1111/bph.15616

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15616
  34. Aug 2021
  35. www.sciencedirect.com www.sciencedirect.com
    Isthmin-1 is an adipokine that promotes glucose uptake and improves glucose tolerance and hepatic steatosis
    1
    1. scibot 04 Aug 2021
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      DOI: 10.1016/j.cmet.2021.07.010

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    sciencedirect.com/science/article/pii/S1550413121003260
  36. Jul 2021
  37. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Identification of candidates for driver oncogenes in scirrhous‐type gastric cancer cell lines
    1
    1. scibot 29 Jul 2021
      IGF1R

      DOI: 10.1111/cas.14111

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    onlinelibrary.wiley.com/doi/full/10.1111/cas.14111
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 27 Jul 2021
      AB_10950969

      DOI: 10.1210/en.2017-00693

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    ncbi.nlm.nih.gov/pmc/articles/PMC5761602/
  39. May 2021
  40. www.sciencedirect.com www.sciencedirect.com
    The E3 ligase TRAF4 Promotes IGF Signaling by Mediating Atypical Ubiquitination of IRS-1
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      anti-IGF-1 Receptor β-subunit (D23H3)

      DOI: 10.1016/j.jbc.2021.100739

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    sciencedirect.com/science/article/pii/S0021925821005287
  41. Mar 2021
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    α-Synuclein plasma membrane localization correlates with cellular phosphatidylinositol polyphosphate levels
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    1. scibot 09 Mar 2021
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      DOI: 10.7554/eLife.61951

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    ncbi.nlm.nih.gov/pmc/articles/PMC7929559/
  43. Feb 2021
  44. biosignaling.biomedcentral.com biosignaling.biomedcentral.com
    L-plastin Ser5 phosphorylation is modulated by the PI3K/SGK pathway and promotes breast cancer cell invasiveness
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    1. scibot 25 Feb 2021
      RRID:AB_10950969

      DOI: 10.1186/s12964-021-00710-5

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    biosignaling.biomedcentral.com/articles/10.1186/s12964-021-00710-5
  45. Jan 2021
  46. onlinelibrary.wiley.com onlinelibrary.wiley.com
    TC10, a Rho family GTPase, is required for efficient axon regeneration in a neuron‐autonomous manner
    1
    1. scibot 08 Jan 2021
      RRID:AB_10949773

      DOI: 10.1111/jnc.15235

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15235
  47. Oct 2020
  48. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma
    1
    1. scibot 27 Oct 2020
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      DOI: 10.1016/j.celrep.2020.108293

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    pubmed.ncbi.nlm.nih.gov/33086062/
  49. Sep 2020
  50. dev.biologists.org dev.biologists.org
    Vessel-derived angiocrine IGF-1 promotes Meckel's cartilage proliferation to drive jaw growth during embryogenesis
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    1. scibot 09 Sep 2020
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      DOI: 10.1242/dev.190488

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    dev.biologists.org/content/147/11/dev190488
  51. Jan 2020
  52. www.nature.com www.nature.com
    eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
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      DOI: 10.1038/s41467-019-13086-5

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    nature.com/articles/s41467-019-13086-5
  53. Nov 2018
  54. www.sciencedirect.com www.sciencedirect.com
    A Loss of Epigenetic Control Can Promote Cell Death through Reversing the Balance of Pathways in a Signaling Network
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    1. scibot 05 Nov 2018
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S1097276518306853
  55. www.sciencedirect.com www.sciencedirect.com
    Overcoming Resistance to Dual Innate Immune and MEK Inhibition Downstream of KRAS
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    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1535610818303696
  56. elifesciences.org elifesciences.org
    Untitled document
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    elifesciences.org/articles/32893
  57. www.sciencedirect.com www.sciencedirect.com
    Microenvironment-Mediated Mechanisms of Resistance to HER2 Inhibitors Differ between HER2+ Breast Cancer Subtypes
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    sciencedirect.com/science/article/pii/S2405471218300541
  58. academic.oup.com academic.oup.com
    Untitled document
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      AB_10950969

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    academic.oup.com/endo/article/159/1/285/4259053
  59. Nov 2017
  60. www.sciencedirect.com www.sciencedirect.com
    The Ubiquitin Ligase CHIP Integrates Proteostasis and Aging by Regulation of Insulin Receptor Turnover
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      Curator: @gabimpine

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    sciencedirect.com/science/article/pii/S0092867417304154