153 Matching Annotations
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    The polySUMOylation axis promotes nucleolar release of Tof2 for mitotic exit
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    1. scibot 16 Jul 2024
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    Genome-wide quantification of RNA flow across subcellular compartments reveals determinants of the mammalian transcript life cycle
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    cell.com/molecular-cell/abstract/S1097-2765(24)00511-2
  4. Jun 2024
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    Time-resolved fate mapping identifies the intestinal upper crypt zone as an origin of Lgr5+ crypt base columnar cells
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    sciencedirect.com/science/article/pii/S0092867424004914
  6. Apr 2024
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    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
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    sciencedirect.com/science/article/pii/S1934590924000857
  8. Mar 2024
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    RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors
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    ncbi.nlm.nih.gov/pmc/articles/PMC10959120/
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    FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis
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    sciencedirect.com/science/article/pii/S1097276524001801
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    Control of meiotic entry by dual inhibition of a key mitotic transcription factor
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      DOI: 10.7554/eLife.90425

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  12. Feb 2024
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    C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line
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    sciencedirect.com/science/article/pii/S1097276524000509
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    Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel
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    ncbi.nlm.nih.gov/pmc/articles/PMC10839966/
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    Glia trigger endocytic clearance of axonal proteins to promote rodent myelination
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    sciencedirect.com/science/article/pii/S1534580724000285
  16. Jan 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
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      DOI: 10.1016/j.cmet.2023.12.013

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    sciencedirect.com/science/article/pii/S1550413123004643
  18. Dec 2023
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone Deacetylase Inhibitors Prevent Cytokine-Induced β Cell Dysfunction Through Restoration of Stromal Interaction Molecule 1 Expression and Activation of Store-Operated Calcium Entry
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    ncbi.nlm.nih.gov/pmc/articles/PMC10723426/
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    Intranasal murine pneumonia virus-vectored SARS-CoV-2 vaccine induces mucosal and serum antibodies in macaques
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    sciencedirect.com/science/article/pii/S2589004223025671
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
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    sciencedirect.com/science/article/pii/S2211124723015930
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    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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      DOI: 10.7554/eLife.87098

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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  23. Nov 2023
  24. www.biorxiv.org www.biorxiv.org
    Recruitment of FBXO22 for Targeted Degradation of NSD2
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      DOI: 10.1101/2023.11.01.564830

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    biorxiv.org/content/10.1101/2023.11.01.564830v1
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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    sciencedirect.com/science/article/pii/S2589004223022733
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    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
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    sciencedirect.com/science/article/pii/S2589004223022460
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    APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release
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    sciencedirect.com/science/article/pii/S2211124723012640
  28. Sep 2023
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    Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis
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    Generation of three induced pluripotent stem cell lines from patients with glycogen storage disease type III
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    sciencedirect.com/science/article/pii/S1873506123002003
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    Damaged mitochondria recruit the effector NEMO to activate NF-κB signaling
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    sciencedirect.com/science/article/pii/S109727652300641X
  32. Aug 2023
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    The C9ORF72 repeat expansion alters neurodevelopment
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    sciencedirect.com/science/article/pii/S2211124723009944
  34. Jul 2023
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
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    ncbi.nlm.nih.gov/pmc/articles/PMC10372839/
  36. Jun 2023
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    SINE RNA of the imprinted miRNA clusters mediates constitutive type III interferon expression and antiviral protection in hemochorial placentas
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    sciencedirect.com/science/article/pii/S1931312823002111
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
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    sciencedirect.com/science/article/pii/S2211124723006587
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    The CD73 immune checkpoint promotes tumor cell metabolic fitness
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      DOI: 10.7554/eLife.84508

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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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    sciencedirect.com/science/article/pii/S2211124723005909
  41. May 2023
  42. 52.53.155.43 52.53.155.43
    Towards discovering a novel family of peptides targeting neuroinflammatory states of brain microglia and astrocytes
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      DOI: 10.1111/jnc.15840

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    52.53.155.43/f5f75eab55b9307d9956132a39d0556ca522d7fd/Journal of Neurochemistry - 2023 - Koss - Towards discovering a novel family of peptides targeting neuroinflammatory states-html.html
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    The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
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      DOI: 10.3390/cells12101367

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    mdpi.com/2073-4409/12/10/1367
  44. www.biorxiv.org www.biorxiv.org
    APOE traffics to astrocyte lipid droplets and modulates triglyceride saturation and droplet size
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      DOI: 10.1101/2023.04.28.538740

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    biorxiv.org/content/10.1101/2023.04.28.538740v1
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    Regulatory imbalance between LRRK2 kinase, PPM1H phosphatase, and ARF6 GTPase disrupts the axonal transport of autophagosomes
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      DOI: 10.1016/j.celrep.2023.112448

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    sciencedirect.com/science/article/pii/S221112472300459X
  46. Apr 2023
  47. www.sciencedirect.com www.sciencedirect.com
    Salmonella invasion of a cell is self-limiting due to effector-driven activation of N-WASP
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      DOI: 10.1016/j.isci.2023.106643

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    sciencedirect.com/science/article/pii/S2589004223007204
  48. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cell culture systems for isolation of SARS-CoV-2 clinical isolates and generation of recombinant virus
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      DOI: 10.1016/j.isci.2023.106634

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    ncbi.nlm.nih.gov/pmc/articles/PMC10083141/
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    C9ORF72 suppresses JAK-STAT mediated inflammation
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      DOI: 10.1016/j.isci.2023.106579

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    sciencedirect.com/science/article/pii/S2589004223006569
  50. Mar 2023
  51. www.sciencedirect.com www.sciencedirect.com
    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
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      DOI: 10.1016/j.isci.2023.106410

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    sciencedirect.com/science/article/pii/S258900422300487X
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    Angiotensin Deficient FVB/N Mice are Normotensive
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      DOI: 10.1111/bph.16051

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.16051
  53. Feb 2023
  54. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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  56. Jan 2023
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    The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy
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  58. Dec 2022
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    Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT
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    Intranasal pediatric parainfluenza virus-vectored SARS-CoV-2 vaccine is protective in macaques
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    Phenotypic screening identifies hydroxypyridone anti-fungals as novel medicines for the prevention of hypertrophic scars
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  65. Aug 2022
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    Mfsd2b and Spns2 are essential for maintenance of blood vessels during development and in anaphylactic shock
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    A ROS-dependent mechanism promotes CDK2 phosphorylation to drive progression through S phase
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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  72. Apr 2022
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    Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections
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  75. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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  77. Feb 2022
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    Neuroplastin genetically interacts with Cadherin 23 and the encoded isoform Np55 is sufficient for cochlear hair cell function and hearing
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    Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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    Phospholipid nanoparticles: Therapeutic potentials against atherosclerosis via reducing cholesterol crystals and inhibiting inflammation
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  85. Oct 2021
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    Marker-free lineage tracing reveals an environment-instructed clonogenic hierarchy in pancreatic cancer
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    Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability
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    SHANK3 conformation regulates direct actin binding and crosstalk with Rap1 signaling
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    Genetic basis for an evolutionary shift from ancestral preaxial to postaxial limb polarity in non-urodele vertebrates
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  90. Sep 2021
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  93. Aug 2021
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    Role of hypothalamic MAPK/ERK signaling and central action of FGF1 in diabetes remission
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    Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
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    Continuous clonal labeling reveals uniform progenitor potential in the adult exocrine pancreas
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    Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration
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    Modulation of LIN28B/Let-7 signaling by propranolol contributes to infantile hemangioma involution
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    Dysregulated oxalate metabolism is a driver and therapeutic target in atherosclerosis
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    Modulation of LIN28B/Let-7 Signaling by Propranolol Contributes to Infantile Hemangioma Involution | Arteriosclerosis, Thrombosis, and Vascular Biology
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  104. Jul 2021
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    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
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    The RAB3-RIM Pathway Is Essential for the Release of Neuromodulators
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    The cellular prion protein promotes olfactory sensory neuron survival and axon targeting during adult neurogenesis
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  109. www.sciencedirect.com www.sciencedirect.com
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    A Single Mechanism of Biogenesis, Initiated and Directed by PIWI Proteins, Explains piRNA Production in Most Animals
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  111. Jun 2021
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    NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir
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  114. May 2021
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    NADPH Oxidase 5 and Melatonin: Involvement in Ram Sperm Capacitation
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    α-Synuclein mutation impairs processing of endomembrane compartments and promotes exocytosis and seeding of α-synuclein pathology
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    Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension
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    Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases
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    Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease
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  121. Apr 2021
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    K27-Linked Diubiquitin Inhibits UCHL3 via an Unusual Kinetic Trap
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    Conversion of the death inhibitor ARC to a killer activates pancreatic β cell death in diabetes
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  124. Mar 2021
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    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
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      IRDye 680RD donkey anti-rabbit

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    Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
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    In vivo reconstitution finds multivalent RNA–RNA interactions as drivers of mesh-like condensates
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    Optic nerve regeneration screen identifies multiple genes restricting adult neural repair
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  129. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types
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    MAT2A inhibition blocks the growth of MTAP-deleted cancer cells by reducing PRMT5-dependent mRNA splicing and inducing DNA damage
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    Colorectal Cancer Cells Enter a Diapause-like DTP State to Survive Chemotherapy
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  132. Feb 2021
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    Deficiency of Meis1, a transcriptional regulator, in mice and worms: neurochemical and behavioral characterizations with implications in the restless legs syndrome
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    Cone-shaped HIV-1 capsids are transported through intact nuclear pores
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  135. Jan 2021
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    MDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial Cells
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    TGF-β1 increases permeability of ciliated airway epithelia via redistribution of claudin 3 from tight junction into cell nuclei
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  138. Nov 2020
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    An epilepsy‐associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model
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    Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells
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  141. Oct 2020
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    EB1 Directly Regulates APC-Mediated Actin Nucleation
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  143. Sep 2020
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    SynGAP Splice Variants Display Heterogeneous Spatio‐Temporal Expression And Subcellular Distribution In The Developing Mammalian Brain
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    PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
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    Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage
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    High-Throughput Screens of PAM-Flexible Cas9 Variants for Gene Knockout and Transcriptional Modulation
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    A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance
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    Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
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    A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance
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    Tuba8 Drives Differentiation of Cortical Radial Glia into Apical Intermediate Progenitors by Tuning Modifications of Tubulin C Termini
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    Does Melatonin Exert Its Effect on Ram Sperm Capacitation Through Nitric Oxide Synthase Regulation?
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      DOI: 10.3390/ijms21062093

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    No evidence for Ago2 translocation from the host erythrocyte into the <i>Plasmodium</i> parasite
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      DOI: 10.12688/wellcomeopenres.15852.1

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    Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
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    Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans
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    Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
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    Oncogenic properties and signaling basis of the PAX8‐GLIS3 fusion gene
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  158. Jan 2020
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    Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
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    Quantitative Multiplexed ChIP Reveals Global Alterations that Shape Promoter Bivalency in Ground State Embryonic Stem Cells
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    Agrin-Lrp4-Ror2 signaling regulates adult hippocampal neurogenesis in mice
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    Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase
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    Properties of Individual Hippocampal Synapses Influencing NMDA-Receptor Activation by Spontaneous Neurotransmission
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    Comprehensive Proteomics Analysis of Stressed Human Islets Identifies GDF15 as a Target for Type 1 Diabetes Intervention
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    Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
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    Disease-Causing Mutations in SF3B1 Alter Splicing by Disrupting Interaction with SUGP1
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    The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons
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    The Pseudo Natural Product Myokinasib Is a Myosin Light Chain Kinase 1 Inhibitor with Unprecedented Chemotype
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    Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
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    Metazoan evolution of glutamate receptors reveals unreported phylogenetic groups and divergent lineage-specific events
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    An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
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    The Ciliary Machinery Is Repurposed for T Cell Immune Synapse Trafficking of LCK
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    Selective deletion of glutamine synthetase in the mouse cerebral cortex induces glial dysfunction and vascular impairment that precede epilepsy and neurodegeneration
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    CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
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    Cancer Lipid Metabolism Confers Antiangiogenic Drug Resistance
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    Transient and Permanent Reconfiguration of Chromatin and Transcription Factor Occupancy Drive Reprogramming
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    A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance
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    Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response
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    An Approach to Spatiotemporally Resolve Protein Interaction Networks in Living Cells
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    The novel SH3 domain protein Dlish/CG10933 mediates fat signaling in Drosophila by binding and regulating Dachs
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