345 Matching Annotations
  1. Jun 2021
  2. www.sciencedirect.com www.sciencedirect.com
    Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice
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    1. scibot 26 Jun 2021
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      DOI: 10.1016/j.neurobiolaging.2021.06.012

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    sciencedirect.com/science/article/pii/S0197458021002062
  3. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2‐mediated mechanism
    1
    1. scibot 25 Jun 2021
      RRID:AB_10956588

      DOI: 10.1111/bph.15433

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15433
  4. www.sciencedirect.com www.sciencedirect.com
    The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
    1
    1. scibot 25 Jun 2021
      RRID:AB_10956588

      DOI: 10.1016/j.ccell.2021.06.003

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    sciencedirect.com/science/article/pii/S1535610821002865
  5. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction
    1
    1. scibot 18 Jun 2021
      RRID:AB_10956588

      DOI: 10.1016/j.isci.2021.102544

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    ncbi.nlm.nih.gov/pmc/articles/PMC8184503/
  6. www.sciencedirect.com www.sciencedirect.com
    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
    1
    1. scibot 16 Jun 2021
      RRID:AB_10956588

      DOI: 10.1016/j.neuron.2021.05.020

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    sciencedirect.com/science/article/pii/S0896627321003731
  7. www.sciencedirect.com www.sciencedirect.com
    Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion
    1
    1. scibot 16 Jun 2021
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      DOI: 10.1016/j.cell.2021.05.015

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    sciencedirect.com/science/article/pii/S0092867421006322
  8. www.sciencedirect.com www.sciencedirect.com
    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
    1
    1. scibot 09 Jun 2021
      RRID:AB_10956588

      DOI: 10.1016/j.celrep.2021.109217

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    sciencedirect.com/science/article/pii/S2211124721005684
  9. www.nature.com www.nature.com
    High-throughput screening for natural compound-based autophagy modulators reveals novel chemotherapeutic mode of action for arzanol
    1
    1. scibot 05 Jun 2021
      926–68070

      DOI: 10.1038/s41419-021-03830-5

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    nature.com/articles/s41419-021-03830-5
  10. www.sciencedirect.com www.sciencedirect.com
    Generation of locus-specific degradable tag knock-ins in mouse and human cell lines
    1
    1. scibot 04 Jun 2021
      RRID:AB_10956588

      DOI: 10.1016/j.xpro.2021.100575

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    sciencedirect.com/science/article/pii/S2666166721002823
  11. www.sciencedirect.com www.sciencedirect.com
    Targeted delivery of CRISPR-Cas9 and transgenes enables complex immune cell engineering
    1
    1. scibot 02 Jun 2021
      AB_1095658

      DOI: 10.1016/j.celrep.2021.109207

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    sciencedirect.com/science/article/pii/S2211124721005568
  12. May 2021
  13. www.sciencedirect.com www.sciencedirect.com
    Systematic Functional Analysis of SARS-CoV-2 Proteins Uncovers Viral Innate Immune Antagonists and Remaining Vulnerabilities
    1
    1. scibot 11 May 2021
      RRID:AB_10956588

      DOI: 10.1016/j.celrep.2021.109126

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    sciencedirect.com/science/article/pii/S2211124721004654
  14. www.sciencedirect.com www.sciencedirect.com
    LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
    1
    1. scibot 08 May 2021
      RRID:AB_10956588

      DOI: 10.1016/j.molcel.2020.10.021

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    sciencedirect.com/science/article/pii/S1097276520307280
  15. www.sciencedirect.com www.sciencedirect.com
    Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists
    1
    1. scibot 07 May 2021
      RRID:AB_10956588

      DOI: 10.1016/j.molcel.2020.09.020

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    sciencedirect.com/science/article/pii/S109727652030650X
  16. www.sciencedirect.com www.sciencedirect.com
    Evolving cryo-EM structural approaches for GPCR drug discovery
    1
    1. scibot 06 May 2021
      RRID:AB_10956588

      DOI: 10.1016/j.str.2021.04.008

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    sciencedirect.com/science/article/pii/S0969212621001246
  17. www.sciencedirect.com www.sciencedirect.com
    PIWI proteomics identifies Atari and Pasilla as piRNA biogenesis factors in Aedes mosquitoes
    1
    1. scibot 05 May 2021
      RRID:AB_10956588

      DOI: 10.1016/j.celrep.2021.109073

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    sciencedirect.com/science/article/pii/S2211124721004046
  18. Apr 2021
  19. www.sciencedirect.com www.sciencedirect.com
    The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
    1
    1. scibot 30 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.cmet.2020.11.011

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    sciencedirect.com/science/article/pii/S1550413120306069
  20. www.sciencedirect.com www.sciencedirect.com
    Discovery of Covalent MKK4/7 Dual Inhibitor
    1
    1. scibot 27 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.chembiol.2020.08.014

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    sciencedirect.com/science/article/pii/S2451945620303366
  21. www.sciencedirect.com www.sciencedirect.com
    Neurons Release Serine to Support mRNA Translation in Pancreatic Cancer
    1
    1. scibot 24 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.cell.2020.10.016

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    sciencedirect.com/science/article/pii/S0092867420313222
  22. www.sciencedirect.com www.sciencedirect.com
    A Structural Model of the Endogenous Human BAF Complex Informs Disease Mechanisms
    1
    1. scibot 24 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.cell.2020.09.051

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    sciencedirect.com/science/article/pii/S0092867420312484
  23. www.sciencedirect.com www.sciencedirect.com
    An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells
    1
    1. scibot 24 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.cell.2020.07.001

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    sciencedirect.com/science/article/pii/S0092867420308230
  24. www.cell.com www.cell.com
    IL6/STAT3 Signaling Hijacks Estrogen Receptor α Enhancers to Drive Breast Cancer Metastasis
    1
    1. scibot 20 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.ccell.2020.06.007

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    cell.com/cancer-cell/fulltext/S1535-6108(20)30311-1
  25. www.sciencedirect.com www.sciencedirect.com
    Complex-dependent histone acetyltransferase activity of KAT8 determines its role in transcription and cellular homeostasis
    1
    1. scibot 19 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.molcel.2021.02.012

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    sciencedirect.com/science/article/pii/S1097276521000988
  26. www.sciencedirect.com www.sciencedirect.com
    Huntingtin-mediated axonal transport requires arginine methylation by PRMT6
    1
    1. scibot 14 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.celrep.2021.108980

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    sciencedirect.com/science/article/pii/S2211124721002941
  27. www.cell.com www.cell.com
    Loss of LUC7L2 and U1 snRNP subunits shifts energy metabolism from glycolysis to OXPHOS
    1
    1. scibot 14 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.molcel.2021.02.033

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    cell.com/molecular-cell/fulltext/S1097-2765(21)00143-X
  28. europepmc.org europepmc.org
    http://biorxiv.org/cgi/content/short/2020.11.11.379099
    1
    1. scibot 11 Apr 2021
      RRID:AB_10956588

      DOI: 10.1101/2020.11.11.379099

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    europepmc.org/articles/PMC7668735/
  29. www.sciencedirect.com www.sciencedirect.com
    Argonaute-CLIP delineates versatile, functional RNAi networks in Aedes aegypti, a major vector of human viruses
    1
    1. scibot 07 Apr 2021
      RRID:AB_10956588

      DOI: 10.1016/j.chom.2021.03.004

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    sciencedirect.com/science/article/pii/S1931312821001323
  30. Mar 2021
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    https://biorxiv.org/cgi/content/10.1101/2021.02.23.432450
    1
    1. scibot 10 Mar 2021
      RRID:AB_10956588

      DOI: 10.1101/2021.02.23.432450

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    ncbi.nlm.nih.gov/pmc/articles/PMC7924263/
  32. www.sciencedirect.com www.sciencedirect.com
    Omnitemporal choreographies of all five STIM/Orai and IP3Rs underlie the complexity of mammalian Ca2+ signaling
    1
    1. scibot 03 Mar 2021
      RRID:AB_10956588

      DOI: 10.1016/j.celrep.2021.108760

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    sciencedirect.com/science/article/pii/S2211124721000735
  33. Feb 2021
  34. academic.oup.com academic.oup.com
    A Positive Feedback Loop Between TGFβ and Androgen Receptor Supports Triple-Negative Breast Cancer Anoikis Resistance
    1
    1. scibot 28 Feb 2021
      RRID:AB_10956588

      DOI: 10.1210/endocr/bqaa226

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    academic.oup.com/endo/article/162/2/bqaa226/6027912
  35. www.nature.com www.nature.com
    Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats
    1
    1. scibot 27 Feb 2021
      anti-mouse IRDye 680RD

      DOI: 10.1038/s41467-021-21021-w

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    nature.com/articles/s41467-021-21021-w
  36. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    Adenosine A2A receptor (A2AR) stimulation enhances mitochondrial metabolism and mitigates reactive oxygen species‐mediated mitochondrial injury
    1
    1. scibot 24 Feb 2021
      RRID:AB_10956588

      DOI: 10.1096/fj.201902459R

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    faseb.onlinelibrary.wiley.com/doi/10.1096/fj.201902459R
  37. www.sciencedirect.com www.sciencedirect.com
    Development of a potent and selective chemical probe for the pleiotropic kinase CK2
    1
    1. scibot 01 Feb 2021
      RRID:AB_10956588

      DOI: 10.1016/j.chembiol.2020.12.013

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    sciencedirect.com/science/article/pii/S2451945620305225
  38. Dec 2020
  39. www.sciencedirect.com www.sciencedirect.com
    Opposite Surfaces of the Cdc15 F-BAR Domain Create a Membrane Platform That Coordinates Cytoskeletal and Signaling Components for Cytokinesis
    1
    1. scibot 23 Dec 2020
      RRID:AB_10956588

      DOI: 10.1016/j.celrep.2020.108526

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    sciencedirect.com/science/article/pii/S2211124720315151
  40. www.sciencedirect.com www.sciencedirect.com
    IFI16 knockdown in primary HIV-1 target cells
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    1. scibot 22 Dec 2020
      RRID:AB_10956588

      DOI: 10.1016/j.xpro.2020.100236

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    sciencedirect.com/science/article/pii/S2666166720302239
  41. www.cell.com www.cell.com
    Poison Exon Splicing Regulates a Coordinated Network of SR Protein Expression during Differentiation and Tumorigenesis
    1
    1. scibot 10 Dec 2020
      RRID:AB_10956588

      DOI: 10.1016/j.molcel.2020.10.019

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    cell.com/molecular-cell/abstract/S1097-2765(20)30726-7
  42. Nov 2020
  43. www.frontiersin.org www.frontiersin.org
    Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway
    1
    1. scibot 19 Nov 2020
      RRID:AB_10956588

      DOI: 10.3389/fendo.2020.579161

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    frontiersin.org/article/10.3389/fendo.2020.579161/full
  44. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Enzymatic Activity of CD73 Modulates Invasion of Gliomas via Epithelial–Mesenchymal Transition-Like Reprogramming
    1
    1. scibot 14 Nov 2020
      goat-anti-mouse

      DOI: 10.3390/ph13110378

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    pubmed.ncbi.nlm.nih.gov/33187081/
  45. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Loss of Muscle Carnitine Palmitoyltransferase 2 Prevents Diet-Induced Obesity and Insulin Resistance despite Long-Chain Acylcarnitine Accumulation
    1
    1. scibot 14 Nov 2020
      RRID:AB_10956588

      DOI: 10.1016/j.celrep.2020.108374

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    Identification of ubiquitin Ser57 kinases regulating the oxidative stress response in yeast
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  47. Oct 2020
  48. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heparan sulfate proteoglycan‐mediated dynamin‐dependent transport of neural stem cell exosomes in an in vitro blood‐brain barrier model
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    EB1 Directly Regulates APC-Mediated Actin Nucleation
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  50. Sep 2020
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    Single‐cell RNA sequencing study of retinal immune regulators identified CD47 and CD59a expression in photoreceptors—Implications in subretinal immune regulation
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      DOI: 10.1002/jnr.24618

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    A Family of Argonaute-Interacting Proteins Gates Nuclear RNAi
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    BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
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    Structure-Based Identification and Functional Characterization of a Lipocalin in the Malaria Parasite Plasmodium falciparum
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    Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
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    Impairing committed cholesterol biosynthesis in white matter astrocytes, but not grey matter astrocytes, enhances in vitro myelination
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      DOI: 10.1111/jnc.15113

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    CCDC57 Cooperates with Microtubules and Microcephaly Protein CEP63 and Regulates Centriole Duplication and Mitotic Progression
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    Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells
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    Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19
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    GABAergic neurons in the insular cortex play an important role in cue-morphine reward memory reconsolidation
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    Global Landscape and Dynamics of Parkin and USP30-Dependent Ubiquitylomes in iNeurons during Mitophagic Signaling
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    A Switch in p53 Dynamics Marks Cells That Escape from DSB-Induced Cell Cycle Arrest
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  63. elifesciences.org elifesciences.org
    The orphan receptor GPR88 blunts the signaling of opioid receptors and multiple striatal GPCRs
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      DOI: 10.7554/eLife.50519

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    Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions
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      DOI: 10.7554/eLife.54822

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  66. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    BET, SRC, and BCL2 family inhibitors are synergistic drug combinations with PARP inhibitors in ovarian cancer
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    Protein O-GlcNAc Modification Links Dietary and Gut Microbial Cues to the Differentiation of Enteroendocrine L Cells
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    Fyn Kinase Controls Tau Aggregation In Vivo
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    RBM45 associates with nuclear stress bodies and forms nuclear inclusions during chronic cellular stress and in neurodegenerative diseases
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      DOI: 10.1186/s40478-020-00965-y

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    The Autophagy-Initiating Kinase ULK1 Controls RIPK1-Mediated Cell Death
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    The Alazami Syndrome-Associated Protein LARP7 Guides U6 Small Nuclear RNA Modification and Contributes to Splicing Robustness
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    Chaperone-Mediated Protein Disaggregation Triggers Proteolytic Clearance of Intra-nuclear Protein Inclusions
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    FKBP10 Regulates Protein Translation to Sustain Lung Cancer Growth
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    S-phase-independent silencing establishment in Saccharomyces cerevisiae
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    G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules
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    Quantifying the Central Dogma in the p53 Pathway in Live Single Cells
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      IRDye 680RD Goat anti-Mouse IgG SecondaryAntibody

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    Doa10 is a membrane protein retrotranslocase in ER-associated protein degradation
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    Deletion of 2‐aminoadipic semialdehyde synthase limits metabolite accumulation in cell and mouse models for glutaric aciduria type 1
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    Antibody Validation for Western blot: By the User, for the User
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  80. www.cell.com www.cell.com
    A Genome-wide ER-phagy Screen Highlights Key Roles of Mitochondrial Metabolism and ER-Resident UFMylation
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    Selective PP2A Enhancement through Biased Heterotrimer Stabilization
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  82. Aug 2020
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    Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling
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  84. Jan 2020
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    Oncogenic Biogenesis of pri-miR-17∼92 Reveals Hierarchy and Competition among Polycistronic MicroRNAs
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    The Bromodomain Protein 4 Contributes to the Regulation of Alternative Splicing
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    IFI16 Targets the Transcription Factor Sp1 to Suppress HIV-1 Transcription and Latency Reactivation
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    Activity-Dependent Nucleation of Dynamic Microtubules at Presynaptic Boutons Controls Neurotransmission
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    EGFR-Pak Signaling Selectively Regulates Glutamine Deprivation-Induced Macropinocytosis
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    The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
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    CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons
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    Astrocyte‐specific transcriptome analysis using the ALDH1L1 bacTRAP mouse reveals novel biomarkers of astrogliosis in response to neurotoxicity
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    Activation of GSK3β induced by recall of cocaine reward memories is dependent on GluN2A/B NMDA receptor signaling
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    Properties of Individual Hippocampal Synapses Influencing NMDA-Receptor Activation by Spontaneous Neurotransmission
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    A CEP104-CSPP1 Complex Is Required for Formation of Primary Cilia Competent in Hedgehog Signaling
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    Recurrent SMARCB1 Mutations Reveal a Nucleosome Acidic Patch Interaction Site That Potentiates mSWI/SNF Complex Chromatin Remodeling
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    Small-Molecule and CRISPR Screening Converge to Reveal Receptor Tyrosine Kinase Dependencies in Pediatric Rhabdoid Tumors
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    Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7
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    Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss
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    53BP1 Enforces Distinct Pre- and Post-resection Blocks on Homologous Recombination
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    Mutual Zonated Interactions of Wnt and Hh Signaling Are Orchestrating the Metabolism of the Adult Liver in Mice and Human
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    A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering
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    A Genome-wide CRISPR Screen Identifies ZCCHC14 as a Host Factor Required for Hepatitis B Surface Antigen Production
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    Neuroprotective activity of leukemia inhibitory factor is relayed through myeloid zinc finger-1 in a rat model of stroke
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    Small-Molecule Inhibition of the UNC-Src Interaction Impairs Dynamic Src Localization in Cells
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    SLC19A1 Is an Importer of the Immunotransmitter cGAMP
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    Superior efficacy of cotreatment with BET protein inhibitor and BCL2 or MCL1 inhibitor against AML blast progenitor cells
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    TEX264 Is an Endoplasmic Reticulum-Resident ATG8-Interacting Protein Critical for ER Remodeling during Nutrient Stress
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    Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion
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    Proteomics, Post-translational Modifications, and Integrative Analyses Reveal Molecular Heterogeneity within Medulloblastoma Subgroups
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