356 Matching Annotations
  1. Jun 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Development of a PCSK9-targeted nanoparticle vaccine to effectively decrease the hypercholesterolemia
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    sciencedirect.com/science/article/pii/S2666379124003185
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    Tirzepatide modulates the regulation of adipocyte nutrient metabolism through long-acting activation of the GIP receptor
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    sciencedirect.com/science/article/pii/S1550413124001864
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    A designed ankyrin-repeat protein that targets Parkinson’s disease-associated LRRK2
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    sciencedirect.com/science/article/pii/S0021925824019707
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    Inhibition of NLRP3 inflammasome alleviates cognitive deficits in a mouse model of anti-NMDAR encephalitis induced by active immunization
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    sciencedirect.com/science/article/pii/S1567576924008944
  6. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    De novo TLK1 and MDM1 mutations in a patient with a neurodevelopmental disorder and immunodeficiency
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    ncbi.nlm.nih.gov/pmc/articles/PMC11166698/
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    SARM1 regulates pro-inflammatory cytokine expression in human monocytes by NADase-dependent and -independent mechanisms
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    sciencedirect.com/science/article/pii/S2589004224011623
  8. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Alpha-synuclein aggregates are phosphatase resistant
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    ncbi.nlm.nih.gov/pmc/articles/PMC11141014/
  9. May 2024
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    Pain hypersensitivity is dependent on autophagy protein Beclin 1 in males but not females
    1
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    sciencedirect.com/science/article/pii/S2211124724006211
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
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    sciencedirect.com/science/article/pii/S1097276524003939
  12. www.cell.com www.cell.com
    SIN-3 transcriptional coregulator maintains mitochondrial homeostasis and polyamine flux
    1
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    cell.com/iscience/abstract/S2589-0042(24)01011-3
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    Intratumoral delivery of the chitin-derived C100 adjuvant promotes robust STING, IFNAR, and CD8+ T cell-dependent anti-tumor immunity
    1
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  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Analysis of tumor-associated AXIN1 missense mutations identifies variants that activate β-catenin signaling
    1
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      DOI: 10.1158/0008-5472.CAN-23-2268

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  15. www.biorxiv.org www.biorxiv.org
    Identification of novel and distinct FGF23 signaling in a Klotho-dependent and -independent manner
    1
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    biorxiv.org/content/10.1101/2024.01.18.576116v1
  16. www.mdpi.com www.mdpi.com
    Laryngeal Cancer Cells Metabolize 25-Hydroxyvitamin D3 and Respond to 24R,25-dihydroxyvitamin D3 via a Mechanism Dependent on Estrogen Receptor Levels
    1
    1. scibot 03 May 2024
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      DOI: 10.3390/cancers16091635

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  17. iubmb.onlinelibrary.wiley.com iubmb.onlinelibrary.wiley.com
    BAG3 regulates cilia homeostasis of glioblastoma via its WW domain
    1
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      DOI: 10.1002/biof.2060

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    iubmb.onlinelibrary.wiley.com/doi/10.1002/biof.2060
  18. Apr 2024
  19. www.sciencedirect.com www.sciencedirect.com
    Proximity proteomics reveals UCH-L1 as an essential regulator of NLRP3-mediated IL-1β production in human macrophages and microglia
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    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.celrep.2024.114152

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      DOI: 10.1016/j.celrep.2024.114152

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    sciencedirect.com/science/article/pii/S2211124724004807
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    Thbs1 regulates skeletal muscle mass in a TGFβ-Smad2/3-ATF4-dependent manner
    1
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      DOI: 10.1016/j.celrep.2024.114149

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    sciencedirect.com/science/article/pii/S2211124724004777
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    The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
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      DOI: 10.1016/j.bbadis.2024.167193

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    sciencedirect.com/science/article/pii/S0925443924001820
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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
    1
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      DOI: 10.1016/j.devcel.2024.03.032

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    sciencedirect.com/science/article/pii/S1534580724002004
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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      DOI: 10.1016/j.celrep.2024.114114

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    sciencedirect.com/science/article/pii/S221112472400442X
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    Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors
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    sciencedirect.com/science/article/pii/S245194562400120X
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    Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
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    nature.com/articles/s41598-024-59013-7
  26. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
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    ncbi.nlm.nih.gov/pmc/articles/PMC10993987/
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    sciencedirect.com/science/article/pii/S1097276524002259
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    Human brain small extracellular vesicles contain selectively packaged, full-length mRNA
    1
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    sciencedirect.com/science/article/pii/S2211124724003899
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    sciencedirect.com/science/article/pii/S2211124724003528
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
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    Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain
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      DOI: 10.1016/j.devcel.2024.03.021

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    sciencedirect.com/science/article/pii/S1534580724001898
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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      DOI: 10.1016/j.isci.2024.109487

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    ncbi.nlm.nih.gov/pmc/articles/PMC10973142/
  33. Mar 2024
  34. www.biorxiv.org www.biorxiv.org
    Prostaglandin D2 synthase controls Schwann cells metabolism
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      DOI: 10.1101/2024.02.29.582775

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    biorxiv.org/content/10.1101/2024.02.29.582775v1
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
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      DOI: 10.1158/2767-9764.CRC-23-0513

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    ncbi.nlm.nih.gov/pmc/articles/PMC10946310/
  36. www.sciencedirect.com www.sciencedirect.com
    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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      DOI: 10.1016/j.celrep.2024.113965

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    sciencedirect.com/science/article/pii/S2211124724002936
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    sciencedirect.com/science/article/pii/S2211124724001165
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5
    1
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      DOI: 10.1371/journal.pone.0298820

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    ncbi.nlm.nih.gov/pmc/articles/PMC10919853/
  39. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
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      DOI: 10.1038/s41392-024-01768-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10904759/
  40. Feb 2024
  41. www.sciencedirect.com www.sciencedirect.com
    PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
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    sciencedirect.com/science/article/pii/S2211124724001591
  42. 52.53.155.43 52.53.155.43
    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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      DOI: 10.1210/endocr/bqae018

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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA
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    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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  46. journals.physiology.org journals.physiology.org
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    Glia trigger endocytic clearance of axonal proteins to promote rodent myelination
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  53. Dec 2023
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    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
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    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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    Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly
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    Recruitment of FBXO22 for Targeted Degradation of NSD2
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
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    Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
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    Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller
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    Unbiased discovery of natural sequence variants that influence fungal virulence
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    Blocking oligomerization is the most viable strategy to inhibit STING
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  71. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection
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  75. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    Palbociclib releases the latent differentiation capacity of neuroblastoma cells
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    The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes
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    Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain
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    Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores
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    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
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    SOD1G93A Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism
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  83. Aug 2023
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    Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
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    A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis
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    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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  88. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
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    Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
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    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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    Development of a human iPSC-derived placental barrier-on-chip model
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer
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  97. Jun 2023
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    Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
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  104. May 2023
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    General trends in the effects of VX-661 and VX-445 on the plasma membrane expression of clinical CFTR variants
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  106. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling
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  112. Apr 2023
  113. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    Proteomic discovery of chemical probes that perturb protein complexes in human cells
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    ATG5 provides host protection acting as a switch in the atg8ylation cascade between autophagy and secretion
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    UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Role of parvalbumin in fatigue-induced changes in force and cytosolic calcium transients in intact single mouse myofibers
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  119. Mar 2023
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    Behavioral circatidal rhythms require Bmal1 in Parhyale hawaiensis
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    Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
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    Hippo pathway and Bonus control developmental cell fate decisions in the Drosophila eye
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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  125. www.biorxiv.org www.biorxiv.org
    Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models
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    Inhibition of monoamine oxidase-a increases respiration in isolated mouse cortical mitochondria
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  127. Feb 2023
  128. www.embopress.org www.embopress.org
    Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis
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    Structural basis for Parkinson’s disease-linked LRRK2’s binding to microtubules
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  142. Nov 2022
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    Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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  166. May 2022
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    AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
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    Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts
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  171. Apr 2022
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    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
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  175. Mar 2022
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward
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    Subtractive CRISPR screen identifies the ATG16L1/vacuolar ATPase axis as required for non-canonical LC3 lipidation
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    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens
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    A strategy to assess the cellular activity of E3 ligase components against neo-substrates using electrophilic probes
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    A photo-cross-linking GlcNAc analog enables covalent capture of N-linked glycoprotein-binding partners on the cell surface
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  224. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival
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      DOI: 10.7554/eLife.45248

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    BAG3 is a negative regulator of ciliogenesis in glioblastoma and triple-negative breast cancer cells
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  226. www.sciencedirect.com www.sciencedirect.com
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    Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition
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    Mechano-dependent signaling by Latrophilin/CIRL quenches cAMP in proprioceptive neurons
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      DOI: 10.7554/eLife.28360

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