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    The IRE1α-XBP1 arm of the unfolded protein response is a host factor activated in SARS-CoV-2 infection
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    sciencedirect.com/science/article/pii/S0925443924001820
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    Sustained ERK signaling promotes G2 cell cycle exit and primes cells for whole-genome duplication
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    sciencedirect.com/science/article/pii/S1534580724002004
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    Endothelial cell expression of a STING gain-of-function mutation initiates pulmonary lymphocytic infiltration
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  5. Apr 2024
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    Heterogeneity of tethered agonist signaling in adhesion G protein-coupled receptors
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    Longitudinal markers of cerebral amyloid angiopathy and related inflammation in rTg-DI rats
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    XTX301, a Tumor-Activated Interleukin-12 Has the Potential to Widen the Therapeutic Index of IL12 Treatment for Solid Tumors as Evidenced by Preclinical Studies
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    An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains
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    sciencedirect.com/science/article/pii/S1097276524002259
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    Human brain small extracellular vesicles contain selectively packaged, full-length mRNA
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    sciencedirect.com/science/article/pii/S2211124724003899
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    A rewiring of DNA replication mediated by MRE11 exonuclease underlies primed-to-naive cell de-differentiation
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    sciencedirect.com/science/article/pii/S2211124724003528
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    Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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    sciencedirect.com/science/article/pii/S2666379124001666
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    Temporal dynamics and stoichiometry in human Notch signaling from Notch synaptic complex formation to nuclear entry of the Notch intracellular domain
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    Defects of renal tubular homeostasis and cystogenesis in the Pkhd1-knockout
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  15. Mar 2024
  16. www.biorxiv.org www.biorxiv.org
    Prostaglandin D2 synthase controls Schwann cells metabolism
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    Targeting Tryptophan Catabolism in Ovarian Cancer to Attenuate Macrophage Infiltration and PD-L1 Expression
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    Interaction between host G3BP and viral nucleocapsid protein regulates SARS-CoV-2 replication and pathogenicity
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    HDAC5 enhances IRF3 activation and is targeted for degradation by protein C6 from orthopoxviruses including Monkeypox virus and Variola virus
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    The dispensability of 14-3-3 proteins for the regulation of human cardiac sodium channel Nav1.5
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    Contactin-associated protein-like 2 (CNTNAP2) mutations impair the essential α-secretase cleavages, leading to autism-like phenotypes
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  22. Feb 2024
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    PRMT1 acts as a suppressor of MHC-I and anti-tumor immunity
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    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
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    Evolutionary analysis identifies a Golgi pathway and correlates lineage-specific factors with endomembrane organelle emergence in apicomplexans
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    SEPN1-related myopathy depends on the oxidoreductase ERO1A and is druggable with the chemical chaperone TUDCA
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    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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  28. journals.physiology.org journals.physiology.org
    The iron chelator and OXPHOS inhibitor VLX600 induces mitophagy and an autophagy-dependent type of cell death in glioblastoma cells
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    SLAM-ITseq identifies that Nrf2 induces liver regeneration through the pentose phosphate pathway
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  30. 52.53.155.43 52.53.155.43
    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    Glia trigger endocytic clearance of axonal proteins to promote rodent myelination
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  32. Jan 2024
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    EXO1 protects BRCA1-deficient cells against toxic DNA lesions
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    sciencedirect.com/science/article/pii/S1097276523010857
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    METTL17 is an Fe-S cluster checkpoint for mitochondrial translation
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  35. Dec 2023
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression
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    ncbi.nlm.nih.gov/pmc/articles/PMC10740391/
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    Potential therapeutic implications of histidine catabolism by the gut microbiota in NAFLD patients with morbid obesity
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    Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth
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    sciencedirect.com/science/article/pii/S245194562300421X
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    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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  40. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
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      DOI: 10.7554/eLife.87098

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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide
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      DOI: 10.7554/eLife.80944

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    ncbi.nlm.nih.gov/pmc/articles/PMC10691799/
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    Calmodulin regulates protease versus co-chaperone activity of a metacaspase
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  43. Nov 2023
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    Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly
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    Recruitment of FBXO22 for Targeted Degradation of NSD2
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    Effects of hepatic mitochondrial pyruvate carrier deficiency on de novo lipogenesis and gluconeogenesis in mice
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    STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts
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    Single-cell transcriptomics identifies a WNT7A-FZD5 signaling axis that maintains fallopian tube stem cells in patient-derived organoids
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    Visualizing the chaperone-mediated folding trajectory of the G protein β5 β-propeller
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    Unbiased discovery of natural sequence variants that influence fungal virulence
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    Blocking oligomerization is the most viable strategy to inhibit STING
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  53. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PCDH12 loss results in premature neuronal differentiation and impeded migration in a cortical organoid model
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    Iron acquisition by a commensal bacterium modifies host nutritional immunity during Salmonella infection
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  57. Sep 2023
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    Essential role of the amino-terminal region of Drosha for the Microprocessor function
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    Palbociclib releases the latent differentiation capacity of neuroblastoma cells
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    The Polycomb repressive complex 2 deposits H3K27me3 and represses transposable elements in a broad range of eukaryotes
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    Fusion crystallization reveals the behavior of both the 1TEL crystallization chaperone and the TNK1 UBA domain
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    Viral sensing by epithelial cells involves PKR- and caspase-3-dependent generation of gasdermin E pores
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    Crizotinib has Preclinical Efficacy in Philadelphia-negative Myeloproliferative Neoplasms
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    SOD1G93A Astrocyte-Derived Extracellular Vesicles Induce Motor Neuron Death by a miRNA-155-5p-Mediated Mechanism
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  65. Aug 2023
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    Comprehensive single-cell genome analysis at nucleotide resolution using the PTA Analysis Toolbox
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    A dynamic actin cytoskeleton is required to prevent constitutive VDAC-dependent MAPK signalling and aberrant lipid homeostasis
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    A peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms
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  70. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Tomatidine targets ATF4-dependent signaling and induces ferroptosis to limit pancreatic cancer progression
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    Art2 mediates selective endocytosis of methionine transporters during adaptation to sphingolipid depletion
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  72. Jul 2023
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    Loss of STING in parkin mutant flies suppresses muscle defects and mitochondria damage
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    Hexokinase 2-mediated gene expression via histone lactylation is required for hepatic stellate cell activation and liver fibrosis
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    Phage anti-CBASS protein simultaneously sequesters cyclic trinucleotides and dinucleotides
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    Development of a human iPSC-derived placental barrier-on-chip model
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    The kinesin Kif21b binds myosin Va and mediates changes in actin dynamics underlying homeostatic synaptic downscaling
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    ATF6-mediated signaling contributes to PARP Inhibitor Resistance in Ovarian Cancer
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  79. Jun 2023
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    Clonal evolution in tyrosine kinase inhibitor-resistance: lessons from in vitro-models
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    Non-muscle MYH10/myosin IIB recruits ESCRT-III to participate in autophagosome closure to maintain neuronal homeostasis
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    SRSF10 regulates proliferation of neural progenitor cells and affects neurogenesis in developing mouse neocortex
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    Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification
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    Hypomorphism of a Novel Long ERα Isoform Causes Severe Reproductive Dysfunctions in Female Mice
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    Btbd11 supports cell-type-specific synaptic function
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  86. May 2023
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    General trends in the effects of VX-661 and VX-445 on the plasma membrane expression of clinical CFTR variants
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    Methylated histones on mitotic chromosomes promote Topoisomerase IIα function for high fidelity chromosome segregation.
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    HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways
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    MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells
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    Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone Signaling
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  94. Apr 2023
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    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    Role of parvalbumin in fatigue-induced changes in force and cytosolic calcium transients in intact single mouse myofibers
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  102. 52.53.155.43 52.53.155.43
    Behavioral circatidal rhythms require Bmal1 in Parhyale hawaiensis
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    Chemoproteomics-enabled discovery of a covalent molecular glue degrader targeting NF-κB
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    Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state
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    Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models
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    IDH2 and TET2 mutations synergize to modulate T Follicular Helper cell functional interactionwith the AITL microenvironment
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    Epidermal stratification requires retromer-mediated desmoglein-1 recycling
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    Systematic analysis of the MAPK signaling network reveals MAP3K-driven control of cell fate
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    Structural basis for product specificities of MLL family methyltransferases
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    Insulin and serine metabolism as sex-specific hallmarks of Alzheimer’s disease in the human hippocampus
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    DPY30 acts as an ASH2L-specific stabilizer to stimulate the enzyme activity of MLL family methyltransferases on different substrates
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    Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer
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  144. Jun 2022
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    Parkinson’s disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes
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    MacroH2As regulate enhancer-promoter contacts affecting enhancer activity and sensitivity to inflammatory cytokines
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  148. May 2022
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    The E3 ubiquitin ligase RNF216/TRIAD3 is a key coordinator of the hypothalamic-pituitary-gonadal axis
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    AURKA and PLK1 inhibition selectively and synergistically block cell cycle progression in diffuse midline glioma
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    Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
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    Proteolytic pan-RAS cleavage leads to tumor regression in patient-derived pancreatic cancer xenografts
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  153. Apr 2022
  154. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of substrates of palmitoyl protein thioesterase 1 highlights roles of depalmitoylation in disulfide bond formation and synaptic function
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    Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C
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    ADAM17 regulates p75NTR–mediated fibrinolysis and nerve remyelination
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  157. Mar 2022
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    Kinase domain autophosphorylation rewires the activity and substrate specificity of CK1 enzymes
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    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
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    Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host antiviral defense
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    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness
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    Recurrent evolution of an inhibitor of ESCRT-dependent virus budding and LINE-1 retrotransposition in primates
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    YAP regulates an SGK1/mTORC1/SREBP-dependent lipogenic program to support proliferation and tissue growth
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    An Inducible CRISPR/Cas9 Screen Identifies DTX2 as a Transcriptional Regulator of Human Telomerase
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  168. Jan 2022
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    Circadian Transcription Factor NPAS2 and the NAD+-Dependent Deacetylase SIRT1 Interact in the Mouse Nucleus Accumbens and Regulate Reward
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    PEGylated talazoparib enhances therapeutic window of its combination with temozolomide in Ewing sarcoma
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  175. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  177. Dec 2021
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    Assessing kinetics and recruitment of DNA repair factors using high content screens
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    Substratum stiffness regulates Erk signaling dynamics through receptor-level control
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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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    Frontotemporal Lobar Dementia Mutant Tau Impairs Axonal Transport through a Protein Phosphatase 1γ-Dependent Mechanism
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    A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction
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    An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens
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    Endogenous piRNA-guided slicing triggers responder and trailer piRNA production from viral RNA in Aedes aegypti mosquitoes
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    Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival
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    Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition
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    USP49 potently stabilizes APOBEC3G protein by removing ubiquitin and inhibits HIV-1 replication
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      IRDye 680RD Goat anti-Mouse IgG (H + L), 0.5 mg Antibody

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    The Ebola Virus Nucleoprotein Recruits the Host PP2A-B56 Phosphatase to Activate Transcriptional Support Activity of VP30
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    Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes
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    The conserved MASRPF motif in the Attractin homolog, Distracted, is required for association with Drosophila E3-ligase Mgrn1
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  224. Jun 2021
  225. www.sciencedirect.com www.sciencedirect.com
    Age-related neuroinflammation and pathology in the locus coeruleus and hippocampus: beta-adrenergic antagonists exacerbate impairment of learning and memory in aged mice
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    1. scibot 26 Jun 2021
      926-68070

      DOI: 10.1016/j.neurobiolaging.2021.06.012

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    sciencedirect.com/science/article/pii/S0197458021002062
  226. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
    Activation of nuclear receptor PXR induces atherogenic lipids and PCSK9 through SREBP2‐mediated mechanism
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      DOI: 10.1111/bph.15433

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15433
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    The AML microenvironment catalyzes a stepwise evolution to gilteritinib resistance
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      DOI: 10.1016/j.ccell.2021.06.003

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    sciencedirect.com/science/article/pii/S1535610821002865
  228. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction
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      RRID:AB_10956588

      DOI: 10.1016/j.isci.2021.102544

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    ncbi.nlm.nih.gov/pmc/articles/PMC8184503/
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    C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation
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      DOI: 10.1016/j.neuron.2021.05.020

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    sciencedirect.com/science/article/pii/S0896627321003731
  230. www.sciencedirect.com www.sciencedirect.com
    Budding epithelial morphogenesis driven by cell-matrix versus cell-cell adhesion
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      DOI: 10.1016/j.cell.2021.05.015

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    sciencedirect.com/science/article/pii/S0092867421006322
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    A role for the ribosome-associated complex in activation of the IRE1 branch of UPR
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      DOI: 10.1016/j.celrep.2021.109217

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    sciencedirect.com/science/article/pii/S2211124721005684