191 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    Chromatin context-dependent regulation and epigenetic manipulation of prime editing
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    1. scibot 12 Apr 2024
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      DOI: 10.1016/j.cell.2024.03.020

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    sciencedirect.com/science/article/pii/S0092867424003118
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    A noncoding regulatory variant in IKZF1 increases acute lymphoblastic leukemia risk in Hispanic/Latino children
    1
    1. scibot 12 Apr 2024
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      DOI: 10.1016/j.xgen.2024.100526

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    sciencedirect.com/science/article/pii/S2666979X24000685
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    KCNJ2 inhibition mitigates mechanical injury in a human brain organoid model of traumatic brain injury
    1
    1. scibot 05 Apr 2024
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      DOI: 10.1016/j.stem.2024.03.004

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    sciencedirect.com/science/article/pii/S1934590924000857
  5. Mar 2024
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    Histone H3.1 is a chromatin-embedded redox sensor triggered by tumor cells developing adaptive phenotypic plasticity and multidrug resistance
    1
    1. scibot 19 Mar 2024
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      DOI: 10.1016/j.celrep.2024.113897

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    sciencedirect.com/science/article/pii/S2211124724002250
  7. Feb 2024
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    Alternative mRNA splicing events and regulators in epidermal differentiation
    2
    1. scibot 27 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113814

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    2. scibot 27 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113814

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    sciencedirect.com/science/article/pii/S2211124724001426
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Search for Chromosomal Instability aiding Variants (CIVa) reveal naturally occurring kinetochore gene variants that perturb chromosome segregation
    1
    1. scibot 18 Feb 2024
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      DOI: 10.1016/j.isci.2024.109007

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    ncbi.nlm.nih.gov/pmc/articles/PMC10867425/
  10. Jan 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Downregulation of the kidney glucagon receptor, essential for renal function and systemic homeostasis, contributes to chronic kidney disease
    1
    1. scibot 19 Jan 2024
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      DOI: 10.1016/j.cmet.2023.12.024

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    sciencedirect.com/science/article/pii/S1550413123004758
  12. Dec 2023
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    The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases
    1
    1. scibot 20 Dec 2023
      RRID:AB_10953628

      DOI: 10.1016/j.celrep.2023.113581

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    sciencedirect.com/science/article/pii/S2211124723015930
  14. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquiton—An inducible, linkage-specific polyubiquitylation tool
    1
    1. scibot 16 Dec 2023
      RRID:AB_10953628

      DOI: 10.1016/j.molcel.2023.11.016

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    ncbi.nlm.nih.gov/pmc/articles/PMC10804999/
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Genome-wide screen reveals Rab12 GTPase as a critical activator of Parkinson’s disease-linked LRRK2 kinase
    1
    1. scibot 15 Dec 2023
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      DOI: 10.7554/eLife.87098

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    ncbi.nlm.nih.gov/pmc/articles/PMC10708890/
  16. Nov 2023
  17. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Light activates Ube3a, an Angelman syndrome-associated gene, by mediating the chromatin structures during postnatal development of mouse retina
    1
    1. scibot 25 Nov 2023
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      DOI: 10.1111/jnc.16018

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16018
  18. www.sciencedirect.com www.sciencedirect.com
    Replicative stress in gastroesophageal premalignancy is associated with chromosomal instability and sensitivity to DNA damage response inhibitors
    1
    1. scibot 04 Nov 2023
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      DOI: 10.1016/j.isci.2023.108169

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    sciencedirect.com/science/article/pii/S2589004223022460
  19. Oct 2023
  20. www.sciencedirect.com www.sciencedirect.com
    Contribution of radixin and ezrin to the maintenance of hepatocytes' excretory function in health and disease
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.heliyon.2023.e21009

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    sciencedirect.com/science/article/pii/S2405844023082178
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    Blocking of ebolavirus spread through intercellular connections by an MPER-specific antibody depends on BST2/tetherin
    2
    1. scibot 21 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113254

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    2. scibot 21 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113254

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    sciencedirect.com/science/article/pii/S2211124723012664
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Ubiquitination of the protocadherin-γA3 variable cytoplasmic domain modulates cell-cell interaction
    1
    1. scibot 05 Oct 2023
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      DOI: 10.3389/fcell.2023.1261048

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    ncbi.nlm.nih.gov/pmc/articles/PMC10544333/
  23. Sep 2023
  24. www.sciencedirect.com www.sciencedirect.com
    Myeloid BAF60a deficiency alters metabolic homeostasis and exacerbates atherosclerosis
    1
    1. scibot 30 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113171

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    sciencedirect.com/science/article/pii/S221112472301183X
  25. Aug 2023
  26. www.sciencedirect.com www.sciencedirect.com
    A Zpr1 co-chaperone mediates folding of eukaryotic translation elongation factor 1A via a GTPase cycle
    1
    1. scibot 23 Aug 2023
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      DOI: 10.1016/j.molcel.2023.07.028

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    sciencedirect.com/science/article/abs/pii/S1097276523006019
  27. 52.53.155.43 52.53.155.43
    ASCL1 is activated downstream of the ROR2/CREB signaling pathway to support lineage plasticity in prostate cancer
    2
    1. scibot 18 Aug 2023
      RRID:AB_10953628

      DOI: 10.1016/j.celrep.2023.112937

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    2. scibot 10 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112937

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    52.53.155.43/5c44b570825d260ed49e3beddaa9d47779a57883/PIIS2211124723009488-html.html
  28. 52.53.155.43 52.53.155.43
    Journal of Neurochemistry - 2023 - Kamte-html.html
    1
    1. scibot 16 Aug 2023
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      DOI: 10.1111/jnc.15914

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    52.53.155.43/8cb485a49ceb78e16481f91948fc91a6dba16017/Journal of Neurochemistry - 2023 - Kamte-html.html
  29. Jul 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A defective mechanosensing pathway affects fibroblast-to-myofibroblast transition in the old male mouse heart
    1
    1. scibot 29 Jul 2023
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      DOI: 10.1016/j.isci.2023.107283

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    ncbi.nlm.nih.gov/pmc/articles/PMC10372839/
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    FOXA2 controls the anti-oxidant response in FH-deficient cells
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    1. scibot 07 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112751

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    sciencedirect.com/science/article/pii/S2211124723007623
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    The C-terminus of Sudan ebolavirus VP40 contains a functionally important CXnC motif, a target for redox modifications
    1
    1. scibot 01 Jul 2023
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      DOI: 10.1016/j.str.2023.06.004

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    sciencedirect.com/science/article/abs/pii/S0969212623002009
  33. Jun 2023
  34. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells
    1
    1. scibot 22 Jun 2023
      RRID: AB_1095362

      DOI: 10.1152/ajpendo.00109.2019

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    ncbi.nlm.nih.gov/pmc/articles/PMC6962504/
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    Dynamic interplay between IL-1 and WNT pathways in regulating dermal adipocyte lineage cells during skin development and wound regeneration
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112647

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    sciencedirect.com/science/article/pii/S2211124723006587
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
    1
    1. scibot 02 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112579

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    sciencedirect.com/science/article/pii/S2211124723005909
  37. 52.53.155.43 52.53.155.43
    BPS Publications
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    1. scibot 01 Jun 2023
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      DOI: 10.1111/bph.16145

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    52.53.155.43/7a1276d45430138c9432ff25359932d8ef5aed01/British J Pharmacology - 2023 - Mazzotta - BQ788 Reveals Glial ETBR Modulation of Neuronal Cholinergic and Nitrergic-html.html
  38. www.mdpi.com www.mdpi.com
    Inducible Knockout of 14-3-3β Attenuates Proliferation and Spheroid Formation in a Human Glioblastoma Cell Line U87MG
    1
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      DOI: 10.3390/brainsci13060868

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    mdpi.com/2076-3425/13/6/868
  39. May 2023
  40. 52.53.155.43 52.53.155.43
    BPS Publications
    2
    1. scibot 25 May 2023
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      DOI: 10.1111/bph.16145

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      DOI: 10.1111/bph.16145

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    52.53.155.43/7a1276d45430138c9432ff25359932d8ef5aed01/British J Pharmacology - 2023 - Mazzotta - BQ788 Reveals Glial ETBR Modulation of Neuronal Cholinergic and Nitrergic-html.html
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    Metamorphic proteins at the basis of human autophagy initiation and lipid transfer
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    1. scibot 20 May 2023
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      DOI: 10.1016/j.molcel.2023.04.026

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    sciencedirect.com/science/article/pii/S1097276523003210
  42. www.mdpi.com www.mdpi.com
    The RhoA-ROCK1/ROCK2 Pathway Exacerbates Inflammatory Signaling in Immortalized and Primary Microglia
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    1. scibot 18 May 2023
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      DOI: 10.3390/cells12101367

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    mdpi.com/2073-4409/12/10/1367
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Nrl:CreERT2 mouse model to induce mosaic gene expression in rod photoreceptors
    1
    1. scibot 11 May 2023
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      DOI: 10.3389/fnmol.2023.1161127

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    ncbi.nlm.nih.gov/pmc/articles/PMC10166802/
  44. journals.physiology.org journals.physiology.org
    Sex-specific Phenotypes in the Aging Mouse Heart and Consequences for Chronic Fibrosis
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    1. scibot 05 May 2023
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      DOI: 10.1152/ajpheart.00078.2022

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    journals.physiology.org/doi/full/10.1152/ajpheart.00078.2022
  45. journals.physiology.org journals.physiology.org
    Sex-specific phenotypes in the aging mouse heart and consequences for chronic fibrosis
    1
    1. scibot 05 May 2023
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      DOI: 10.1152/ajpheart.00078.2022

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    journals.physiology.org/doi/10.1152/ajpheart.00078.2022
  46. Apr 2023
  47. www.sciencedirect.com www.sciencedirect.com
    A tubule-sheet continuum model for the mechanism of nuclear envelope assembly
    1
    1. scibot 26 Apr 2023
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      DOI: 10.1016/j.devcel.2023.04.003

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    sciencedirect.com/science/article/pii/S1534580723001569
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    Histone phosphorylation integrates the hepatic glucagon-PKA-CREB gluconeogenesis program in response to fasting
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    1. scibot 06 Apr 2023
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      DOI: 10.1016/j.molcel.2023.02.007

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    sciencedirect.com/science/article/pii/S1097276523001028
  49. Mar 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Neofunctionalisation of ciliary BBS proteins to nuclear roles is likely a frequent innovation across eukaryotes
    1
    1. scibot 30 Mar 2023
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      DOI: 10.1016/j.isci.2023.106410

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    H3K27me3 Demethylases Maintain the Transcriptional and Epigenomic Landscape of the Intestinal Epithelium
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  52. Feb 2023
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    Mutations in Parkinsonism-linked endocytic proteins synaptojanin1 and auxilin have synergistic effects on dopaminergic axonal pathology
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    Recycling of modified H2A-H2B provides short-term memory of chromatin states
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    CRISPR screening reveals a dependency on ribosome recycling for efficient SARS-CoV-2 programmed ribosomal frameshifting and viral replication
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  56. Jan 2023
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    Protein folding stress potentiates NLRP1 and CARD8 inflammasome activation
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    The NLRP1 and CARD8 inflammasomes detect reductive stress
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    Zinc-finger protein Zpr1 is a bespoke chaperone essential for eEF1A biogenesis
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    Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice
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  61. Dec 2022
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    KMT2D deficiency drives lung squamous cell carcinoma and hypersensitivity to RTK-RAS inhibition
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  63. Nov 2022
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    TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo
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    Targeted degradation of PCNA outperforms stoichiometric inhibition to result in programed cell death
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  66. Oct 2022
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    Selenium modulates cancer cell response to pharmacologic ascorbate
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    A human iPSC-array-based GWAS identifies a virus susceptibility locus in the NDUFA4 gene and functional variants
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    Validation of a non-oncogene encoded vulnerability to exportin 1 inhibition in pediatric renal tumors
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    Confined migration induces heterochromatin formation and alters chromatin accessibility
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    Sex differences in brain tumor glutamine metabolism reveal sex-specific vulnerabilities to treatment
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    Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells
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    Sonic hedgehog is not a limb morphogen but acts as a trigger to specify all digits in mice
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    MASTL is enriched in cancerous and pluripotent stem cells and influences OCT1/OCT4 levels
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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    Selective endocytosis of Ca2+-permeable AMPARs by the Alzheimer’s disease risk factor CALM bidirectionally controls synaptic plasticity
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  81. May 2022
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    Aldh2 is a lineage-specific metabolic gatekeeper in melanocyte stem cells
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    Translational Strategies for Repotrectinib in Neuroblastoma
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    miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence
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    A presynaptic phosphosignaling hub for lasting homeostatic plasticity
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    Canonical Wnt Signaling Induces Focal Adhesion and Integrin Beta-1 Endocytosis
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  88. Mar 2022
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    BMI-1 regulates DNA end resection and homologous recombination repair
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    Linkage reprogramming by tailor-made E3s reveals polyubiquitin chain requirements in DNA-damage bypass
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    Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
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    Interleukin-6 mimics insulin-dependent cellular distribution of some cytoskeletal proteins and Glut4 transporter without effect on glucose uptake in 3T3-L1 adipocytes
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    Small disulfide loops in peptide hormones mediate self-aggregation and secretory granule sorting
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    Heat shock induces premature transcript termination and reconfigures the human transcriptome
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    Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis
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    Brain-derived autophagosome profiling reveals the engulfment of nucleoid-enriched mitochondrial fragments by basal autophagy in neurons
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    miR-376a-3p and miR-376b-3p overexpression in Hutchinson-Gilford progeria fibroblasts inhibits cell proliferation and induces premature senescence
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    H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity
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    Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation
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    The Systemic Administration of the Histamine H1 Receptor Antagonist/Inverse Agonist Chlorpheniramine to Pregnant Rats Impairs the Development of Nigro-Striatal Dopaminergic Neurons
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    Mitochondrial metabolism is a key regulator of the fibro-inflammatory and adipogenic stromal subpopulations in white adipose tissue
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    Reciprocal communication between astrocytes and endothelial cells is required for astrocytic glutamate transporter 1 (GLT-1) expression
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    Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma
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  151. Apr 2021
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  156. Mar 2021
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    Urokinase-type plasminogen activator promotes N-cadherin-mediated synaptic recovery in the ischemic brain - Ariel Diaz, Paola Merino, Patrick McCann, Manuel A Yepes, Laura G Quiceno, Enrique Torre, Amelia Tomkins, Xiaodong Zhang, Chadwick M Hales, Frank C Tong, Manuel Yepes, 2021
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    The histone demethylase KDM5 is required for synaptic structure and function at the Drosophila neuromuscular junction
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  165. Jan 2021
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    CB1 receptor signaling modulates amygdalar plasticity during context-cocaine memory reconsolidation to promote subsequent cocaine seeking
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    Generation of induced pluripotent stem cell lines deficient for Cadherin 13 (UKWMPi002-A-1/B/C) Bassociated with neurodevelopmental disorders using CRISPR/Cas9
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  169. Dec 2020
  170. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The ribosomal RNA m5C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans
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    Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions
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    Evaluation of [ 18 F]F-DPA as a target for TSPO in head and neck cancer under normal conditions and after radiotherapy
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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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    Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis
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    Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription
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    Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races
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    PRL3-DDX21 Transcriptional Control of Endolysosomal Genes Restricts Melanocyte Stem Cell Differentiation
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    Differentiation Drives Widespread Rewiring of the Neural Stem Cell Chaperone Network
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    GSK3 Inhibits Macropinocytosis and Lysosomal Activity through the Wnt Destruction Complex Machinery
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    A Model of Differential Mammary Growth Initiation by Stat3 and Asymmetric Integrin-α6 Inheritance
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    Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells
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    CtBP1-Mediated Membrane Fission Contributes to Effective Recycling of Synaptic Vesicles
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    A Conserved PDZ-Binding Motif in aPKC Interacts with Par-3 and Mediates Cortical Polarity
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    Lipopolysaccharide activates microglia via neuraminidase 1 desialylation of Toll‐like Receptor 4
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    Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling
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    The exocyst complex regulates insulin-stimulated glucose uptake of skeletal muscle cells | American Journal of Physiology-Endocrinology and Metabolism
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    Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells
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    Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
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    Reduction of Global H3K27me3 Enhances HER2/ErbB2 Targeted Therapy
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    PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism
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    Marine bacterial extracts as a new rich source of drugs against Alzheimer's disease
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    Inhibition of Glucose Transporters and Glutaminase Synergistically Impairs Tumor Cell Growth
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    Autoinhibition Mechanism of the Ubiquitin-Conjugating Enzyme UBE2S by Autoubiquitination
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    Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription
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    Oligodendrocytes Support Neuronal Glutamatergic Transmission via Expression of Glutamine Synthetase
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    The RNA-Binding ATPase, Armitage, Couples piRNA Amplification in Nuage to Phased piRNA Production on Mitochondria
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    mTORC1-Regulated and HUWE1-Mediated WIPI2 Degradation Controls Autophagy Flux
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    An Endothelial-to-Adipocyte Extracellular Vesicle Axis Governed by Metabolic State
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    Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy
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    CARM1 Is Essential for Myeloid Leukemogenesis but Dispensable for Normal Hematopoiesis
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    A Role for Hypocretin/Orexin in Metabolic and Sleep Abnormalities in a Mouse Model of Non-metastatic Breast Cancer
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    Phase Separation of FUS Is Suppressed by Its Nuclear Import Receptor and Arginine Methylation
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    The Histamine H1 Receptor Participates in the Increased Dorsal Telencephalic Neurogenesis in Embryos from Diabetic Rats.
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    17β-Estradiol Directly Lowers Mitochondrial Membrane Microviscosity and Improves Bioenergetic Function in Skeletal Muscle
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    Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response
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    The RNA Surveillance Factor UPF1 Represses Myogenesis via Its E3 Ubiquitin Ligase Activity
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    Transient acidosis while retrieving a fear-related memory enhances its lability
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    Multivalent Small-Molecule Pan-RAS Inhibitors
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