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  1. Last 7 days
  2. www.cell.com www.cell.com
    MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating USP18/VDAC2 pathway
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    1. scibot 22 Aug 2024
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      DOI: 10.1016/j.isci.2024.110483

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    cell.com/iscience/abstract/S2589-0042(24)01708-5
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    TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation
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    1. scibot 22 Aug 2024
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    sciencedirect.com/science/article/pii/S2211124724009549
  4. Aug 2024
  5. www.sciencedirect.com www.sciencedirect.com
    Glycometabolic reprogramming-induced XRCC1 lactylation confers therapeutic resistance in ALDH1A3-overexpressing glioblastoma
    1
    1. scibot 19 Aug 2024
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      DOI: 10.1016/j.cmet.2024.07.011

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    sciencedirect.com/science/article/pii/S1550413124002821
  6. May 2024
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    mTORC1-CTLH E3 ligase regulates the degradation of HMG-CoA synthase 1 through the Pro/N-degron pathway
    1
    1. scibot 24 May 2024
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    sciencedirect.com/science/article/pii/S1097276524003939
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    Upregulation of neuronal ER-phagy improves organismal fitness and alleviates APP toxicity
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    1. scibot 21 May 2024
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      DOI: 10.1016/j.celrep.2024.114255

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    sciencedirect.com/science/article/pii/S2211124724005837
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    An ATP13A1-assisted topogenesis pathway for folding multi-spanning membrane proteins
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    1. scibot 09 May 2024
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    sciencedirect.com/science/article/pii/S1097276524003253
  10. Apr 2024
  11. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Dimethyl fumarate covalently modifies Cys673 of NLRP3 to exert anti-inflammatory effects
    1
    1. scibot 10 Apr 2024
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    ncbi.nlm.nih.gov/pmc/articles/PMC10995871/
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    TMC7 functions as a suppressor of Piezo2 in primary sensory neurons blunting peripheral mechanotransduction
    1
    1. scibot 04 Apr 2024
      RRID:AB_11042321

      DOI: 10.1016/j.celrep.2024.114014

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    sciencedirect.com/science/article/pii/S2211124724003425
  13. Feb 2024
  14. 52.53.155.43 52.53.155.43
    AURKA enhances the glycolysis and development of ovarian endometriosis through ERβ
    1
    1. scibot 28 Feb 2024
      AB_11042321

      DOI: 10.1210/endocr/bqae018

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    52.53.155.43/763b9f4f88af8a11d49032bb21ea7f98fd438708/bqae018-html.html
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CREB3L4 promotes hepatocellular carcinoma progression and decreases sorafenib chemosensitivity by promoting RHEB-mTORC1 signaling pathway
    1
    1. scibot 03 Feb 2024
      RRID:AB_11042321

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    ncbi.nlm.nih.gov/pmc/articles/PMC10831937/
  16. Jan 2024
  17. www.sciencedirect.com www.sciencedirect.com
    Nucleoporin Seh1 controls murine neocortical development via transcriptional repression of p21 in neural stem cells
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    1. scibot 25 Jan 2024
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      DOI: 10.1016/j.devcel.2024.01.002

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    sciencedirect.com/science/article/pii/S1534580724000029
  18. www.cell.com www.cell.com
    p53-responsive CMBL reprograms glucose metabolism and suppresses cancer development by destabilizing phosphofructokinase PFKP
    1
    1. scibot 25 Jan 2024
      RRID:AB_11042321

      DOI: 10.1016/j.celrep.2023.113426

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    cell.com/cell-reports/abstract/S2211-1247(23)01438-9
  19. www.sciencedirect.com www.sciencedirect.com
    OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB
    1
    1. scibot 11 Jan 2024
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      DOI: 10.1016/j.molcel.2023.11.042

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    sciencedirect.com/science/article/pii/S1097276523010195
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    Proteogenomic characterization of small cell lung cancer identifies biological insights and subtype-specific therapeutic strategies
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    1. scibot 05 Jan 2024
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      DOI: 10.1016/j.cell.2023.12.004

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    sciencedirect.com/science/article/pii/S0092867423013351
  21. Nov 2023
  22. 52.53.155.43 52.53.155.43
    JUN mediates Glucocorticoid Resistance by stabilizing HIF1a in T-Cell Acute Lymphoblastic Leukemia
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    52.53.155.43/6be56724144b1726399953666c182a50bbffb46a/1-s2.0-S2589004223023192-main-html.html
  23. www.embopress.org www.embopress.org
    MST2 methylation by PRMT5 inhibits Hippo signaling and promotes pancreatic cancer progression
    1
    1. scibot 03 Nov 2023
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      DOI: 10.15252/embj.2023114558

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    embopress.org/doi/full/10.15252/embj.2023114558
  24. Oct 2023
  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Phosphorylated YBX2 is stabilized to promote glycolysis in brown adipocytes
    1
    1. scibot 20 Oct 2023
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      DOI: 10.1016/j.isci.2023.108091

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    ncbi.nlm.nih.gov/pmc/articles/PMC10583057/
  26. Sep 2023
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CHIP protects against septic acute kidney injury by inhibiting NLRP3-mediated pyroptosis
    1
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      DOI: 10.1016/j.isci.2023.107762

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    ncbi.nlm.nih.gov/pmc/articles/PMC10492219/
  28. www.sciencedirect.com www.sciencedirect.com
    Deciphering the functional landscape of phosphosites with deep neural network
    1
    1. scibot 07 Sep 2023
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      DOI: 10.1016/j.celrep.2023.113048

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    sciencedirect.com/science/article/pii/S2211124723010598
  29. Aug 2023
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    PRMT4 Facilitates White Adipose Tissue Browning and Thermogenesis by Methylating PPARγ
    1
    1. scibot 02 Aug 2023
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      DOI: 10.2337/db22-1016

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    ncbi.nlm.nih.gov/pmc/articles/PMC10382653/
  31. Jul 2023
  32. www.sciencedirect.com www.sciencedirect.com
    The degradation of TGR5 mediated by Smurf1 contributes to diabetic nephropathy
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.celrep.2023.112851

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    sciencedirect.com/science/article/pii/S2211124723008628
  33. Jun 2023
  34. www.sciencedirect.com www.sciencedirect.com
    QKI shuttles internal m7G-modified transcripts into stress granules and modulates mRNA metabolism
    1
    1. scibot 28 Jun 2023
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      DOI: 10.1016/j.cell.2023.05.047

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    sciencedirect.com/science/article/pii/S0092867423005986
  35. www.sciencedirect.com www.sciencedirect.com
    Dephosphorylation of Six2Y129 protects tyrosine hydroxylase-positive cells in SNpc by regulating TEA domain 1 expression
    1
    1. scibot 23 Jun 2023
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      DOI: 10.1016/j.isci.2023.107049

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    sciencedirect.com/science/article/pii/S2589004223011264
  36. www.sciencedirect.com www.sciencedirect.com
    Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity
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      DOI: 10.1016/j.cell.2023.05.039

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    sciencedirect.com/science/article/pii/S0092867423005913
  37. www.sciencedirect.com www.sciencedirect.com
    Non-canonical role of UCKL1 on ferroptosis defence in colorectal cancer
    1
    1. scibot 21 Jun 2023
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      DOI: 10.1016/j.ebiom.2023.104650

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    sciencedirect.com/science/article/pii/S2352396423002153
  38. aacrjournals.org aacrjournals.org
    MYC/glutamine dependency is a therapeutic vulnerability in pancreatic cancer with deoxycytidine kinase inactivation-induced gemcitabine resistance
    1
    1. scibot 10 Jun 2023
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      DOI: 10.1158/1541-7786.MCR-22-0554

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    aacrjournals.org/mcr/article/21/5/444/726027/MYC-Glutamine-Dependency-Is-a-Therapeutic
  39. aacrjournals.org aacrjournals.org
    USP10 regulates ZEB1 ubiquitination and protein stability to inhibit ZEB1-mediated colorectal cancer metastasis
    1
    1. scibot 10 Jun 2023
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      DOI: 10.1158/1541-7786.MCR-22-0552

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    aacrjournals.org/mcr/article/21/6/578/726510/USP10-Regulates-ZEB1-Ubiquitination-and-Protein
  40. www.sciencedirect.com www.sciencedirect.com
    Host genetics highlights IFN-γ-dependent Toxoplasma genes encoding secreted and non-secreted virulence factors in in vivo CRISPR screens
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    1. scibot 03 Jun 2023
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      DOI: 10.1016/j.celrep.2023.112592

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    sciencedirect.com/science/article/pii/S2211124723006034
  41. www.sciencedirect.com www.sciencedirect.com
    Methionine restriction promotes cGAS activation and chromatin untethering through demethylation to enhance antitumor immunity
    1
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      DOI: 10.1016/j.ccell.2023.05.005

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    sciencedirect.com/science/article/pii/S1535610823001733
  42. May 2023
  43. www.sciencedirect.com www.sciencedirect.com
    Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation
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    1. scibot 25 May 2023
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      DOI: 10.1016/j.isci.2023.106852

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    sciencedirect.com/science/article/pii/S258900422300929X
  44. Apr 2023
  45. www.sciencedirect.com www.sciencedirect.com
    RNA Pol II preferentially regulates ribosomal protein expression by trapping disassociated subunits
    1
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      DOI: 10.1016/j.molcel.2023.02.028

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    sciencedirect.com/science/article/pii/S1097276523001557
  46. www.sciencedirect.com www.sciencedirect.com
    Coronavirus Subverts ER-phagy by Hijacking FAM134B and ATL3 into p62 Condensates to Facilitate Viral Replication
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      DOI: 10.1016/j.celrep.2023.112286

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    sciencedirect.com/science/article/pii/S2211124723002978
  47. Mar 2023
  48. www.sciencedirect.com www.sciencedirect.com
    STING activation in platelets aggravates septic thrombosis by enhancing platelet activation and granule secretion
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      DOI: 10.1016/j.immuni.2023.02.015

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    sciencedirect.com/science/article/pii/S1074761323000894
  49. www.sciencedirect.com www.sciencedirect.com
    PPT1 Regulation Of HSP90α Depalmitoylation Participates In The Pathogenesis Of Hyperandrogenism
    1
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      DOI: 10.1016/j.isci.2023.106131

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    sciencedirect.com/science/article/pii/S2589004223002080
  50. Dec 2022
  51. www.sciencedirect.com www.sciencedirect.com
    Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis
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    1. scibot 24 Dec 2022
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      DOI: 10.1016/j.celrep.2022.111850

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    sciencedirect.com/science/article/pii/S2211124722017429
  52. Aug 2022
  53. www.sciencedirect.com www.sciencedirect.com
    S-palmitoylation of PCSK9 induces sorafenib resistance in liver cancer by activating the PI3K/AKT pathway
    1
    1. scibot 17 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111194

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    sciencedirect.com/science/article/pii/S2211124722010117
  54. www.sciencedirect.com www.sciencedirect.com
    TMUB1 is an endoplasmic reticulum-resident escortase that promotes the p97-mediated extraction of membrane proteins for degradation
    1
    1. scibot 12 Aug 2022
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      DOI: 10.1016/j.molcel.2022.07.006

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    sciencedirect.com/science/article/pii/S1097276522006633
  55. Apr 2022
  56. www.sciencedirect.com www.sciencedirect.com
    Brown adipose tissue involution associated with progressive restriction in progenitor competence
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      DOI: 10.1016/j.celrep.2022.110575

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    sciencedirect.com/science/article/pii/S2211124722003199
  57. www.sciencedirect.com www.sciencedirect.com
    Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis
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    1. scibot 07 Apr 2022
      RRID:AB_11042321

      DOI: 10.1016/j.molcel.2022.03.016

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  58. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy
    1
    1. scibot 05 Apr 2022
      RRID:AB_11042321

      DOI: 10.1016/j.isci.2022.104085

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    ncbi.nlm.nih.gov/pmc/articles/PMC8971941/
  59. Mar 2022
  60. www.sciencedirect.com www.sciencedirect.com
    Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells
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    1. scibot 26 Mar 2022
      RRID:AB_11042321

      DOI: 10.1016/j.molcel.2022.02.033

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    sciencedirect.com/science/article/pii/S1097276522002076
  61. www.sciencedirect.com www.sciencedirect.com
    Intestinal Tuft-2 cells exert antimicrobial immunity via sensing bacterial metabolite N-undecanoylglycine
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    1. scibot 26 Mar 2022
      RRID:AB_11042321

      DOI: 10.1016/j.immuni.2022.03.001

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    sciencedirect.com/science/article/pii/S1074761322001248
  62. www.sciencedirect.com www.sciencedirect.com
    Lipid flippase dysfunction as a therapeutic target for endosomal anomalies in Alzheimer’s disease
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    1. scibot 02 Mar 2022
      RRID:AB_11042321

      DOI: 10.1016/j.isci.2022.103869

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    sciencedirect.com/science/article/pii/S2589004222001390
  63. Oct 2021
  64. www.sciencedirect.com www.sciencedirect.com
    Glycogen accumulation and phase separation drives liver tumor initiation
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    1. scibot 22 Oct 2021
      RRID:AB_11042321

      DOI: 10.1016/j.cell.2021.10.001

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    sciencedirect.com/science/article/pii/S0092867421011752
  65. www.sciencedirect.com www.sciencedirect.com
    RetroCHMP3 blocks budding of enveloped viruses without blocking cytokinesis
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      RRID:AB_11042321

      DOI: 10.1016/j.cell.2021.09.008

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  66. Sep 2021
  67. www.nature.com www.nature.com
    Pantoprazole ameliorates liver fibrosis and suppresses hepatic stellate cell activation in bile duct ligation rats by promoting YAP degradation
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    1. scibot 24 Sep 2021
      51064‐2‐AP

      DOI: 10.1038/s41401-021-00754-w

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    nature.com/articles/s41401-021-00754-w
  68. Aug 2021
  69. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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      DOI: 10.1016/j.cell.2018.11.004

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    sciencedirect.com/science/article/pii/S0092867418314636
  70. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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      RRID:AB_11042321

      DOI: 10.1111/bph.15490

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    bpspubs.onlinelibrary.wiley.com/doi/10.1111/bph.15490
  71. Jul 2021
  72. www.sciencedirect.com www.sciencedirect.com
    EGY3 mediates chloroplastic ROS homeostasis and promotes retrograde signaling in response to salt stress in Arabidopsis
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    1. scibot 14 Jul 2021
      RRID:AB_11042321

      DOI: 10.1016/j.celrep.2021.109384

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    sciencedirect.com/science/article/pii/S2211124721007828
  73. Jun 2021
  74. www.sciencedirect.com www.sciencedirect.com
    Bacterial RF3 senses chaperone function in co-translational folding
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      RRID:AB_11042321

      DOI: 10.1016/j.molcel.2021.05.016

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    sciencedirect.com/science/article/pii/S1097276521004007
  75. May 2021
  76. www.sciencedirect.com www.sciencedirect.com
    UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9ORF72 animal model
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    1. scibot 15 May 2021
      RRID:AB_11042321

      DOI: 10.1016/j.neuron.2021.04.023

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  77. www.sciencedirect.com www.sciencedirect.com
    Dcaf11 activates Zscan4-mediated alternative telomere lengthening in early embryos and embryonic stem cells
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    1. scibot 09 May 2021
      RRID:AB_11042321

      DOI: 10.1016/j.stem.2020.11.018

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    sciencedirect.com/science/article/pii/S1934590920305828
  78. www.sciencedirect.com www.sciencedirect.com
    RNF126-Mediated Reubiquitination Is Required for Proteasomal Degradation of p97-Extracted Membrane Proteins
    1
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      RRID:AB_11042321

      DOI: 10.1016/j.molcel.2020.06.023

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    sciencedirect.com/science/article/pii/S1097276520304251
  79. Apr 2021
  80. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival
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    1. scibot 10 Apr 2021
      RRID:AB_11042321

      DOI: 10.3389/fimmu.2021.633796

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    ncbi.nlm.nih.gov/pmc/articles/PMC8027073/
  81. Nov 2020
  82. www.sciencedirect.com www.sciencedirect.com
    PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval
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      RRID:AB_11042321

      DOI: 10.1016/j.celrep.2020.108312

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    sciencedirect.com/science/article/pii/S2211124720313012
  83. Jan 2020
  84. www.sciencedirect.com www.sciencedirect.com
    Type-I-IFN-Stimulated Gene TRIM5γ Inhibits HBV Replication by Promoting HBx Degradation
    1
    1. scibot 13 Jan 2020
      RRID:AB_11042321

      DOI: 10.1016/j.celrep.2019.11.041

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    sciencedirect.com/science/article/pii/S2211124719315232
  85. www.sciencedirect.com www.sciencedirect.com
    Structural Basis for a Species-Specific Determinant of an SIV Vif Protein toward Hominid APOBEC3G Antagonism
    1
    1. scibot 13 Jan 2020
      RRID:AB_11042321

      DOI: 10.1016/j.chom.2019.10.014

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    sciencedirect.com/science/article/pii/S1931312819305384
  86. www.sciencedirect.com www.sciencedirect.com
    Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination
    1
    1. scibot 13 Jan 2020
      RRID:AB_11042321

      DOI: 10.1016/j.neuron.2019.02.018

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    sciencedirect.com/science/article/pii/S0896627319301539
  87. www.sciencedirect.com www.sciencedirect.com
    FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis
    1
    1. scibot 12 Jan 2020
      RRID:AB_11042321

      DOI: 10.1016/j.devcel.2018.12.021

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    sciencedirect.com/science/article/pii/S1534580718311171