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GD2TIF cells as a platform for single-dose and long-term delivery of biologics

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1. scibot 03 Sep 2025
  
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  DOI: 10.1038/s41467-025-63427-w
  
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nature.com/articles/s41467-025-63427-w
Aug 2025
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Stress-induced glucocorticoids enhance acute inflammation by promoting the differentiation of Th17 cells

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  DOI: 10.1016/j.celrep.2025.116093
  
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sciencedirect.com/science/article/pii/S2211124725008642
Jul 2025
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Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer

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1. scibot 25 Jul 2025
  
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  DOI: 10.1016/j.ccell.2025.06.021
  
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sciencedirect.com/science/article/pii/S1535610825002715
Jun 2025
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De-coupling immune parameters and toxicity associated with IL-12 agonism

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  DOI: 10.1016/j.celrep.2025.115840
  
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sciencedirect.com/science/article/pii/S2211124725006114
May 2025
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A CD4+ T cell-intrinsic complement C5aR2-prostacyclin-IL-1R2 axis orchestrates Th1 cell contraction

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1. scibot 31 May 2025
  
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  DOI: 10.1016/j.immuni.2025.05.003
  
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sciencedirect.com/science/article/pii/S1074761325002225
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Targeting WEE1 in tumor-associated dendritic cells potentiates antitumor immunity via the cGAS/STING pathway

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  DOI: 10.1016/j.celrep.2025.115733
  
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sciencedirect.com/science/article/pii/S2211124725005042
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Glycosylation-driven programs coordinate immunoregulatory and pro-angiogenic functions of myeloid-derived suppressor cells

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  DOI: 10.1016/j.immuni.2025.04.027
  
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sciencedirect.com/science/article/pii/S1074761325001906
Mar 2025
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Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.cell.2025.02.014
  
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sciencedirect.com/science/article/pii/S0092867425001990
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

TMEM41B is an endoplasmic reticulum Ca2+ release channel maintaining naive T cell quiescence and responsiveness

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1. scibot 06 Mar 2025
  
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  DOI: 10.1038/s41421-024-00766-w
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11880246/
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Temporal dynamics of immune cell transcriptomics in brain metastasis progression influenced by gut microbiome dysbiosis

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  DOI: 10.1016/j.celrep.2025.115356
  
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cell.com/cell-reports/abstract/S2211-1247(25)00127-5
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Integrated computational analysis identifies therapeutic targets with dual action in cancer cells and T cells

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1. scibot 04 Mar 2025
  
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  DOI: 10.1016/j.immuni.2025.02.007
  
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sciencedirect.com/science/article/pii/S107476132500072X
Jan 2025
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CAR T cells, CAR NK cells, and CAR macrophages exhibit distinct traits in glioma models but are similarly enhanced when combined with cytokines

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1. scibot 31 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2025.101931
  
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sciencedirect.com/science/article/pii/S2666379125000047
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MFGE8 induces anti-PD-1 therapy resistance by promoting extracellular vesicle sorting of PD-L1

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1. scibot 23 Jan 2025
  
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  DOI: 10.1016/j.xcrm.2024.101922
  
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sciencedirect.com/science/article/pii/S2666379124006931
Dec 2024
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Reciprocal regulation of mTORC1 signaling and ribosomal biosynthesis determines cell cycle progression in activated T cells

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1. scibot 20 Dec 2024
  
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  DOI: 10.1126/scisignal.adi8753
  
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science.org/doi/10.1126/scisignal.adi8753
Nov 2024
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Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.xcrm.2024.101822
  
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sciencedirect.com/science/article/pii/S2666379124005937
Sep 2024
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Induction of immortal-like and functional CAR T cells by defined factors

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1. scibot 27 Sep 2024
  
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  DOI: 10.1084/jem.20232368
  
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pmc.ncbi.nlm.nih.gov/articles/PMC10965394/
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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.005
  
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sciencedirect.com/science/article/pii/S1550413124003322
Aug 2024
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Soluble Tim-3 serves as a tumor prognostic marker and therapeutic target for CD8+ T cell exhaustion and anti-PD-1 resistance

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1. scibot 25 Aug 2024
  
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  DOI: 10.1016/j.xcrm.2024.101686
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11384939/
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Inherent preference for polyunsaturated fatty acids instigates ferroptosis of Treg cells that aggravates high-fat-diet-related colitis

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.celrep.2024.114636
  
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sciencedirect.com/science/article/pii/S2211124724009860
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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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1. scibot 21 Aug 2024
  
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  DOI: 10.1016/j.cmet.2017.10.006
  
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sciencedirect.com/science/article/pii/S1550413117306186
Jul 2024
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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells

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1. scibot 31 Jul 2024
  
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  DOI: 10.1016/j.celrep.2024.114565
  
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sciencedirect.com/science/article/pii/S2211124724008945
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Proteobacteria impair anti-tumor immunity in the omentum by consuming arginine

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1. scibot 18 Jul 2024
  
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  DOI: 10.1016/j.chom.2024.06.003
  
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cell.com/cell-host-microbe/abstract/S1931-3128(24)00197-5
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Pan-cancer mapping of single CD8+ T cell profiles reveals a TCF1:CXCR6 axis regulating CD28 co-stimulation and anti-tumor immunity

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1. scibot 16 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101640
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11293343/
Jun 2024
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A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice

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1. scibot 06 Jun 2024
  
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  DOI: 10.1038/s41590-024-01834-9
  
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nature.com/articles/s41590-024-01834-9
May 2024
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The histone lysine methyltransferase MLL1 regulates the activation and functional specialization of regulatory T cells

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1. scibot 14 May 2024
  
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  DOI: 10.1016/j.celrep.2024.114222
  
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sciencedirect.com/science/article/pii/S2211124724005503
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Chemoradiotherapy-induced ACKR2+ tumor cells drive CD8+ T cell senescence and cervical cancer recurrence

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1. scibot 09 May 2024
  
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  DOI: 10.1016/j.xcrm.2024.101550
  
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sciencedirect.com/science/article/pii/S2666379124002428
Apr 2024
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25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages

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1. scibot 19 Apr 2024
  
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  DOI: 10.1016/j.immuni.2024.03.021
  
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sciencedirect.com/science/article/pii/S1074761324001420
Feb 2024
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The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis

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1. scibot 22 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113824
  
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sciencedirect.com/science/article/pii/S2211124724001529
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RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis

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1. scibot 16 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113786
  
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  DOI: 10.1016/j.celrep.2024.113786
  
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sciencedirect.com/science/article/pii/S2211124724001141
Nov 2023
www.biorxiv.org www.biorxiv.org

Induction of immortal-like and functional CAR-T cells by defined factors

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1. scibot 17 Nov 2023
  
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  DOI: 10.1101/2023.11.06.565785
  
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biorxiv.org/content/10.1101/2023.11.06.565785v1
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One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice

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1. scibot 17 Nov 2023
  
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  DOI: 10.1101/2023.11.06.565713
  
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biorxiv.org/content/10.1101/2023.11.06.565713v1
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An essential role for miR-15/16 in Treg suppression and restriction of proliferation

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1. scibot 02 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113298
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10664750/
Oct 2023
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Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation

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1. scibot 28 Oct 2023
  
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  DOI: 10.1016/j.celrep.2023.113323
  
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sciencedirect.com/science/article/pii/S2211124723013359
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Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma

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1. scibot 13 Oct 2023
  
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  RRID:AB_1107634
  
  DOI: 10.1016/j.ccell.2023.09.011
  
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sciencedirect.com/science/article/pii/S1535610823003276
Sep 2023
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Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control

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1. scibot 01 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113047
  
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Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection

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Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α

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Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation

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The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis

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Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity

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RORψt+CD4+ T cells promote IL-23R-mediated neuronal cell apoptosis in the central nervous system

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Apr 2023
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PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion

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Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis

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Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut

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Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance

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Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity

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Jan 2023
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P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy

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Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell

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Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis

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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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Quantitative Increase in T Regulatory Cells Enhances Bone Remodeling in Osteogenesis Imperfecta

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METTL14-dependent m6A modification controls iNKT cell development and function

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Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment

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Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells

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Neuropilin-1 cooperates with PD-1 in CD8+ T-cells predicting outcomes in melanoma patients treated with anti-PD1

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Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function

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May 2022
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Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate

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Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization

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Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells

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Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis

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Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation

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PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory

1
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Aug 2021
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Delivery of membrane impermeable molecules to primary mouse T lymphocytes

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MicroRNA-10a Negatively Regulates CD4+ T Cell IL-10 Production through Suppression of Blimp1

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NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells

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Untitled document

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Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells

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Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration

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The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity

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Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses

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The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation

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Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β

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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response

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Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells

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Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation

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MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23

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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity

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Niche-Selective Inhibition of Pathogenic Th17 Cells by Targeting Metabolic Redundancy

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A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance

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Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

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Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

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Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

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Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis

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Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity

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Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex

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Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming

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Serine Catabolism Feeds NADH when Respiration Is Impaired

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miR-15/16 Restrain Memory T Cell Differentiation, Cell Cycle, and Survival

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Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease

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PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways

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A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation

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Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis

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Pro-Survival Lipid Sphingosine-1-Phosphate Metabolically Programs T Cells to Limit Anti-tumor Activity

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High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.immuni.2019.01.003
  
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Nov 2018
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Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens

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CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity

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Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells

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1. scibot 05 Nov 2018
  
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Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation

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Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production

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T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation

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Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism

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CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response

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Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation

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1. scibot 08 Nov 2017
  
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