89 Matching Annotations
  1. Apr 2024
  2. www.sciencedirect.com www.sciencedirect.com
    25-Hydroxycholesterol regulates lysosome AMP kinase activation and metabolic reprogramming to educate immunosuppressive macrophages
    1
    1. scibot 19 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.021

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    sciencedirect.com/science/article/pii/S1074761324001420
  3. Feb 2024
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    The CD27/CD70 pathway negatively regulates visceral adipose tissue-resident Th2 cells and controls metabolic homeostasis
    1
    1. scibot 22 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113824

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    sciencedirect.com/science/article/pii/S2211124724001529
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    RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis
    2
    1. scibot 16 Feb 2024
      RRID:AB_1107634

      DOI: 10.1016/j.celrep.2024.113786

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    2. scibot 16 Feb 2024
      RRID:AB_1107634

      DOI: 10.1016/j.celrep.2024.113786

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    sciencedirect.com/science/article/pii/S2211124724001141
  6. Nov 2023
  7. www.biorxiv.org www.biorxiv.org
    Induction of immortal-like and functional CAR-T cells by defined factors
    1
    1. scibot 17 Nov 2023
      RRID:AB_1107634

      DOI: 10.1101/2023.11.06.565785

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    biorxiv.org/content/10.1101/2023.11.06.565785v1
  8. www.biorxiv.org www.biorxiv.org
    One infusion of engineered long-lasting and multifunctional T cells cures asthma in mice
    1
    1. scibot 17 Nov 2023
      RRID:AB_1107634

      DOI: 10.1101/2023.11.06.565713

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    biorxiv.org/content/10.1101/2023.11.06.565713v1
  9. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    An essential role for miR-15/16 in Treg suppression and restriction of proliferation
    1
    1. scibot 02 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113298

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    ncbi.nlm.nih.gov/pmc/articles/PMC10664750/
  10. Oct 2023
  11. www.sciencedirect.com www.sciencedirect.com
    Kruppel-like factor 2+ CD4 T cells avert microbiota-induced intestinal inflammation
    1
    1. scibot 28 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113323

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    sciencedirect.com/science/article/pii/S2211124723013359
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    Progenitor-like exhausted SPRY1+CD8+ T cells potentiate responsiveness to neoadjuvant PD-1 blockade in esophageal squamous cell carcinoma
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.ccell.2023.09.011

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    sciencedirect.com/science/article/pii/S1535610823003276
  13. Sep 2023
  14. www.sciencedirect.com www.sciencedirect.com
    Molecular, metabolic, and functional CD4 T cell paralysis in the lymph node impedes tumor control
    1
    1. scibot 01 Sep 2023
      RRID:AB_1107634

      DOI: 10.1016/j.celrep.2023.113047

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    sciencedirect.com/science/article/pii/S2211124723010586
  15. Aug 2023
  16. www.sciencedirect.com www.sciencedirect.com
    Loss of CD4+ T cell-intrinsic arginase 1 accelerates Th1 response kinetics and reduces lung pathology during influenza infection
    1
    1. scibot 12 Aug 2023
      RRID:AB_1107634

      DOI: 10.1016/j.immuni.2023.07.014

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    sciencedirect.com/science/article/pii/S1074761323003278
  17. Jul 2023
  18. www.sciencedirect.com www.sciencedirect.com
    Tumor aerobic glycolysis confers immune evasion through modulating sensitivity to T cell-mediated bystander killing via TNF-α
    1
    1. scibot 28 Jul 2023
      RRID:AB_1107634

      DOI: 10.1016/j.cmet.2023.07.001

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    sciencedirect.com/science/article/abs/pii/S1550413123002516
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    Graded expression of the chemokine receptor CX3CR1 marks differentiation states of human and murine T cells and enables cross-species interpretation
    1
    1. scibot 27 Jul 2023
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      DOI: 10.1016/j.immuni.2023.06.025

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    sciencedirect.com/science/article/pii/S1074761323002820
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    The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis
    1
    1. scibot 27 Jul 2023
      RRID:AB_1107634

      DOI: 10.1016/j.celrep.2023.112877

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    sciencedirect.com/science/article/pii/S2211124723008884
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    Vaccine-boosted CAR T crosstalk with host immunity to reject tumors with antigen heterogeneity
    1
    1. scibot 07 Jul 2023
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      DOI: 10.1016/j.cell.2023.06.002

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    sciencedirect.com/science/article/pii/S0092867423006426
  22. Jun 2023
  23. 52.53.155.43 52.53.155.43
    RORψt+CD4+ T cells promote IL-23R-mediated neuronal cell apoptosis in the central nervous system
    1
    1. scibot 01 Jun 2023
      RRID:AB_1107634

      DOI: 10.1101/2023.04.17.537133

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    52.53.155.43/333ed306ab43198840b04e278f040205d2c57b40/2023.04.17.537133v1.full-html.html
  24. Apr 2023
  25. www.sciencedirect.com www.sciencedirect.com
    PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell progenitor differentiation and elicit terminal CD8+ T cell exhaustion
    1
    1. scibot 29 Apr 2023
      RRID:AB_1107634

      DOI: 10.1016/j.celrep.2023.112436

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    sciencedirect.com/science/article/pii/S2211124723004473
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    Restraint of IFN-γ expression through a distal silencer CNS–28 for tissue homeostasis
    1
    1. scibot 12 Apr 2023
      RRID:AB_1107634

      DOI: 10.1016/j.immuni.2023.03.006

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    sciencedirect.com/science/article/pii/S1074761323001267
  27. Mar 2023
  28. www.sciencedirect.com www.sciencedirect.com
    Endoplasmic reticulum stress in the intestinal epithelium initiates purine metabolite synthesis and promotes Th17 cell differentiation in the gut
    2
    1. scibot 16 Mar 2023
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      DOI: 10.1016/j.immuni.2023.02.018

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    2. scibot 16 Mar 2023
      RRID:AB_1

      DOI: 10.1016/j.immuni.2023.02.018

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    sciencedirect.com/science/article/pii/S1074761323000924
  29. www.sciencedirect.com www.sciencedirect.com
    Tissue-resident Lachnospiraceae family bacteria protect against colorectal carcinogenesis by promoting tumor immune surveillance
    1
    1. scibot 10 Mar 2023
      RRID:AB_1107634

      DOI: 10.1016/j.chom.2023.01.013

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    sciencedirect.com/science/article/pii/S1931312823000380
  30. Feb 2023
  31. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity
    1
    1. scibot 01 Feb 2023
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      DOI: 10.1016/j.isci.2023.105954

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    ncbi.nlm.nih.gov/pmc/articles/PMC9883195/
  32. Jan 2023
  33. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    P2RX7 enhances tumor control by CD8+ T cells in adoptive cell therapy
    1
    1. scibot 06 Jan 2023
      RRID:AB_1107634

      DOI: 10.1158/2326-6066.CIR-21-0691

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    ncbi.nlm.nih.gov/pmc/articles/PMC9250641/
  34. Nov 2022
  35. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multiomics analysis couples mRNA turnover and translational control of glutamine metabolism to the differentiation of the activated CD4+ T cell
    1
    1. scibot 17 Nov 2022
      RRID:AB_1107634

      DOI: 10.1038/s41598-022-24132-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC9669047/
  36. www.researchsquare.com www.researchsquare.com
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    1
    1. scibot 11 Nov 2022
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      DOI: 10.21203/rs.3.rs-658360/v1

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    researchsquare.com/article/rs-1715073/v1
  37. Sep 2022
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Glucose promotes regulatory T cell differentiation to maintain intestinal homeostasis
    1
    1. scibot 21 Sep 2022
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      DOI: 10.1016/j.isci.2022.105004

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    ncbi.nlm.nih.gov/pmc/articles/PMC9460814/
  39. www.sciencedirect.com www.sciencedirect.com
    Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity
    1
    1. scibot 13 Sep 2022
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      DOI: 10.1016/j.xcrm.2022.100744

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    sciencedirect.com/science/article/pii/S2666379122002932
  40. Aug 2022
  41. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Quantitative Increase in T Regulatory Cells Enhances Bone Remodeling in Osteogenesis Imperfecta
    1
    1. scibot 27 Aug 2022
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      DOI: 10.1016/j.isci.2022.104818

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    ncbi.nlm.nih.gov/pmc/articles/PMC9400089/
  42. www.sciencedirect.com www.sciencedirect.com
    METTL14-dependent m6A modification controls iNKT cell development and function
    1
    1. scibot 06 Aug 2022
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      DOI: 10.1016/j.celrep.2022.111156

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    sciencedirect.com/science/article/pii/S2211124722009652
  43. www.sciencedirect.com www.sciencedirect.com
    Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
    1
    1. scibot 02 Aug 2022
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      DOI: 10.1016/j.immuni.2022.07.001

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    sciencedirect.com/science/article/pii/S107476132200334X
  44. Jul 2022
  45. www.sciencedirect.com www.sciencedirect.com
    Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells
    1
    1. scibot 13 Jul 2022
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      DOI: 10.1016/j.cmet.2022.06.008

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    sciencedirect.com/science/article/pii/S1550413122002285
  46. Jun 2022
  47. www.sciencedirect.com www.sciencedirect.com
    Neuropilin-1 cooperates with PD-1 in CD8+ T-cells predicting outcomes in melanoma patients treated with anti-PD1
    1
    1. scibot 17 Jun 2022
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      DOI: 10.1016/j.isci.2022.104353

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    sciencedirect.com/science/article/pii/S2589004222006241
  48. aacrjournals.org aacrjournals.org
    Carbon monoxide activates PERK-regulated autophagy to induce immunometabolic reprogramming and boost anti-tumor T cell function
    1
    1. scibot 01 Jun 2022
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      DOI: 10.1158/0008-5472.CAN-21-3155

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    aacrjournals.org/cancerres/article/82/10/1969/696318/Carbon-Monoxide-Activates-PERK-Regulated-Autophagy
  49. May 2022
  50. www.sciencedirect.com www.sciencedirect.com
    Localization of a TORC1-eIF4F translation complex during CD8+ T cell activation drives divergent cell fate
    1
    1. scibot 25 May 2022
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      DOI: 10.1016/j.molcel.2022.04.016

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    sciencedirect.com/science/article/pii/S1097276522003276
  51. Jan 2022
  52. www.nature.com www.nature.com
    Adenosine 2A receptor and TIM3 suppress cytolytic killing of tumor cells via cytoskeletal polarization
    1
    1. scibot 15 Jan 2022
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      DOI: 10.1038/s42003-021-02972-8

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    nature.com/articles/s42003-021-02972-8
  53. Dec 2021
  54. www.sciencedirect.com www.sciencedirect.com
    Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells
    1
    1. scibot 21 Dec 2021
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      DOI: 10.1016/j.immuni.2021.11.017

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    sciencedirect.com/science/article/pii/S1074761321005094
  55. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation
    1
    1. scibot 08 Dec 2021
      RRID:AB_1107634

      DOI: 10.7554/eLife.70978

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    ncbi.nlm.nih.gov/pmc/articles/PMC8639145/
  56. Nov 2021
  57. www.sciencedirect.com www.sciencedirect.com
    Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade
    1
    1. scibot 24 Nov 2021
      RRID:AB_1107634

      DOI: 10.1016/j.celrep.2021.110021

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    sciencedirect.com/science/article/pii/S2211124721015035
  58. www.sciencedirect.com www.sciencedirect.com
    Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis
    1
    1. scibot 03 Nov 2021
      RRID:AB_1107634

      DOI: 10.1016/j.celrep.2021.109911

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    sciencedirect.com/science/article/pii/S221112472101384X
  59. Oct 2021
  60. www.sciencedirect.com www.sciencedirect.com
    Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation
    1
    1. scibot 13 Oct 2021
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      DOI: 10.1016/j.immuni.2021.09.018

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    PI3Kδ coordinates transcriptional, chromatin, and metabolic changes to promote effector CD8+ T cells at the expense of central memory
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  62. Aug 2021
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    Delivery of membrane impermeable molecules to primary mouse T lymphocytes
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    MicroRNA-10a Negatively Regulates CD4+ T Cell IL-10 Production through Suppression of Blimp1
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    NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells
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  68. Jul 2021
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    Natural Genetic Variation Reveals Key Features of Epigenetic and Transcriptional Memory in Virus-Specific CD8 T Cells
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  70. Jun 2021
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    Toll-like receptor 2 induces pathogenicity in Th17 cells and reveals a role for IPCEF in regulating Th17 cell migration
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    The glutathione peroxidase Gpx4 prevents lipid peroxidation and ferroptosis to sustain Treg cell activation and suppression of antitumor immunity
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  73. May 2021
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    Glycolytic ATP fuels phosphoinositide 3-kinase signaling to support effector T helper 17 cell responses
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    The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation
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    Sensing of ATP via the Purinergic Receptor P2RX7 Promotes CD8+ Trm Cell Generation by Enhancing Their Sensitivity to the Cytokine TGF-β
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    Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
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  78. Apr 2021
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    Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells
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    MicroRNA-221 and -222 modulate intestinal inflammatory Th17 cell response as negative feedback regulators downstream of interleukin-23
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    Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity
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    A distal Foxp3 enhancer enables interleukin-2 dependent thymic Treg cell lineage commitment for robust immune tolerance
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  85. Mar 2021
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    Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity
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    Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity
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  90. Dec 2020
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    Ribosome-Targeting Antibiotics Impair T Cell Effector Function and Ameliorate Autoimmunity by Blocking Mitochondrial Protein Synthesis
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    Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity
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    Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex
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    Methionine Metabolism Shapes T Helper Cell Responses through Regulation of Epigenetic Reprogramming
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    Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease
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    PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways
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    A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation
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    Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adoptive Transfer Experimental Autoimmune Encephalomyelitis
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    High Glucose Intake Exacerbates Autoimmunity through Reactive-Oxygen-Species-Mediated TGF-β Cytokine Activation
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      DOI: 10.1016/j.immuni.2018.12.020

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  110. www.sciencedirect.com www.sciencedirect.com
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    1. scibot 13 Jan 2020
      RRID:AB_1107634

      DOI: 10.1016/j.immuni.2019.01.003

      Resource: (Bio X Cell Cat# BE0001-1, RRID:AB_1107634)

      Curator: @ethanbadger

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    sciencedirect.com/science/article/pii/S1074761319300032
  111. Nov 2018
  112. www.sciencedirect.com www.sciencedirect.com
    Protein Barcodes Enable High-Dimensional Single-Cell CRISPR Screens
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    1. scibot 05 Nov 2018
      RRID:AB_1107634

      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S0092867418312340
  113. www-sciencedirect-com.ezproxy.is.ed.ac.uk www-sciencedirect-com.ezproxy.is.ed.ac.uk
    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
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    1. scibot 05 Nov 2018
      RRID:AB_1107634

      Curator: @Jmenke

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  114. www.sciencedirect.com www.sciencedirect.com
    Blimp-1 Functions as a Molecular Switch to Prevent Inflammatory Activity in Foxp3+RORγt+ Regulatory T Cells
    1
    1. scibot 05 Nov 2018
      RRID:AB_1107634

      Curator: @evieth

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  115. elifesciences.org elifesciences.org
    Glutathione de novo synthesis but not recycling process coordinates with glutamine catabolism to control redox homeostasis and directs murine T cell differentiation
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    1. scibot 05 Nov 2018
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  116. www.sciencedirect.com www.sciencedirect.com
    Iron Drives T Helper Cell Pathogenicity by Promoting RNA-Binding Protein PCBP1-Mediated Proinflammatory Cytokine Production
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    T Cell Receptor-Regulated TGF-β Type I Receptor Expression Determines T Cell Quiescence and Activation
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    1. scibot 05 Nov 2018
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    Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism
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      RRID:AB_1107634

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    CD38-NAD+Axis Regulates Immunotherapeutic Anti-Tumor T Cell Response
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  120. Nov 2017
  121. www.sciencedirect.com www.sciencedirect.com
    Catch and Release of Cytokines Mediated by Tumor Phosphatidylserine Converts Transient Exposure into Long-Lived Inflammation
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    1. scibot 08 Nov 2017
      AB_1107634

      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S1097276517303283