180 Matching Annotations
  1. Last 7 days
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    Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity
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    1. scibot 20 Nov 2024
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      DOI: 10.1016/j.celrep.2024.114855

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    sciencedirect.com/science/article/pii/S2211124724012063
  3. Nov 2024
  4. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma
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    1. scibot 08 Nov 2024
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    pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
  5. journals.plos.org journals.plos.org
    Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate
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    1. scibot 07 Nov 2024
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      DOI: 10.1371/journal.ppat.1012566

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    journals.plos.org/plospathogens/article
  6. Oct 2024
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    Stress triggers irritable bowel syndrome with diarrhea through a spermidine-mediated decline in type I interferon
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    1. scibot 04 Oct 2024
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    sciencedirect.com/science/article/pii/S1550413124003668
  8. www.biorxiv.org www.biorxiv.org
    Hematopoietic Tet2 inactivation enhances the response to checkpoint blockade immunotherapy
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    1. scibot 02 Oct 2024
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      DOI: 10.1101/2024.09.09.612140

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    biorxiv.org/content/10.1101/2024.09.09.612140v1
  9. Sep 2024
  10. www.sciencedirect.com www.sciencedirect.com
    A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies
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    1. scibot 27 Sep 2024
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    sciencedirect.com/science/article/pii/S2666379124004774
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    SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation
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    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S1550413124003322
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    Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow
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    1. scibot 10 Sep 2024
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    sciencedirect.com/science/article/pii/S1535610824003076
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    The transcription regulator ID3 maintains tumor-specific memory CD8+ T cells in draining lymph nodes during tumorigenesis
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    1. scibot 04 Sep 2024
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    sciencedirect.com/science/article/pii/S2211124724010416
  14. Aug 2024
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    Uncovering therapeutic targets for macrophage-mediated T cell suppression and PD-L1 therapy sensitization
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    1. scibot 27 Aug 2024
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    sciencedirect.com/science/article/pii/S2666379124004191
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    Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells
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    1. scibot 22 Aug 2024
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    LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
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    1. scibot 20 Aug 2024
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      DOI: 10.1016/j.cell.2024.07.016

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    sciencedirect.com/science/article/pii/S0092867424007761
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    The cytokine Meteorin-like inhibits anti-tumor CD8+ T cell responses by disrupting mitochondrial function
    1
    1. scibot 19 Aug 2024
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      DOI: 10.1016/j.immuni.2024.07.003

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    sciencedirect.com/science/article/pii/S1074761324003522
  19. Jul 2024
  20. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway
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    1. scibot 27 Jul 2024
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      DOI: 10.1016/j.isci.2024.110285

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    ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
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    Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance
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    1. scibot 18 Jul 2024
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  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
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      DOI: 10.1136/jitc-2024-008970

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    ncbi.nlm.nih.gov/pmc/articles/PMC11218019/
  23. Jun 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity
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    1. scibot 21 Jun 2024
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    sciencedirect.com/science/article/pii/S1074761324002759
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    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
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    1. scibot 06 Jun 2024
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      DOI: 10.1016/j.xcrm.2024.101592

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    sciencedirect.com/science/article/pii/S2666379124002842
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    Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114300

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    sciencedirect.com/science/article/pii/S2211124724006284
  27. May 2024
  28. www.sciencedirect.com www.sciencedirect.com
    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
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    1. scibot 17 May 2024
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      DOI: 10.1016/j.ccell.2024.04.011

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    sciencedirect.com/science/article/pii/S1535610824001351
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    Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma
    1
    1. scibot 07 May 2024
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      DOI: 10.1016/j.immuni.2024.04.006

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    sciencedirect.com/science/article/pii/S1074761324002115
  30. Apr 2024
  31. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
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    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101528

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    sciencedirect.com/science/article/pii/S2666379124001976
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 24 Apr 2024
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      DOI: 10.1126/sciimmunol.adj5097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
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    sciencedirect.com/science/article/pii/S1074761324001419
  34. www.sciencedirect.com www.sciencedirect.com
    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
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    sciencedirect.com/science/article/pii/S2666379124001253
  35. Mar 2024
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation
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    1. scibot 27 Mar 2024
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      DOI: 10.1016/j.isci.2024.109439

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    ncbi.nlm.nih.gov/pmc/articles/PMC10957412/
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    Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
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    sciencedirect.com/science/article/pii/S1535610824000801
  38. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer
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    1. scibot 03 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101397

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    ncbi.nlm.nih.gov/pmc/articles/PMC10897543/
  39. Feb 2024
  40. www.sciencedirect.com www.sciencedirect.com
    IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment
    1
    1. scibot 29 Feb 2024
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    sciencedirect.com/science/article/pii/S2211124724001633
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    RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis
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      DOI: 10.1016/j.celrep.2024.113786

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  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections
    1
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      DOI: 10.1016/j.celrep.2023.113448

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    ncbi.nlm.nih.gov/pmc/articles/PMC10841667/
  43. Jan 2024
  44. www.sciencedirect.com www.sciencedirect.com
    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
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      DOI: 10.1016/j.devcel.2023.07.025

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      DOI: 10.1016/j.devcel.2023.07.025

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    sciencedirect.com/science/article/pii/S1534580723003945
  45. Dec 2023
  46. www.sciencedirect.com www.sciencedirect.com
    NK cells propagate T cell immunity following in situ tumor vaccination
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      DOI: 10.1016/j.celrep.2023.113556

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    sciencedirect.com/science/article/pii/S2211124723015681
  47. www.science.org www.science.org
    Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12
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    1. scibot 02 Dec 2023
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      DOI: 10.1126/sciimmunol.adf4919

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    science.org/doi/10.1126/sciimmunol.adf4919
  48. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 01 Dec 2023
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      DOI: 10.1126/sciimmunol.adj5097

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    science.org/doi/10.1126/sciimmunol.adj5097
  49. Nov 2023
  50. www.sciencedirect.com www.sciencedirect.com
    Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses
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      DOI: 10.1016/j.isci.2023.108348

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    sciencedirect.com/science/article/pii/S2589004223024252
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    CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis
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      DOI: 10.1016/j.celrep.2023.113345

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    sciencedirect.com/science/article/pii/S2211124723013578
  52. Oct 2023
  53. www.sciencedirect.com www.sciencedirect.com
    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
    1
    1. scibot 27 Oct 2023
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    CCR5 promotes the migration of CD8+ T cells to the leishmanial lesions
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    Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response
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    Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
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    Supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation
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    Glioblastoma vascular plasticity limits effector T-cell infiltration and is blocked by cAMP activation
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    Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer
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  61. Sep 2023
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    Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma
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  63. Aug 2023
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    CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells
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    Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC
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    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
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    The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
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    A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence
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    A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity
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    Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma
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  72. Jun 2023
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    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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  75. May 2023
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    Engineer a double team of short-lived and glucose-sensing bacteria for cancer eradication
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  78. Apr 2023
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    Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma
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    Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
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    Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance
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  82. Mar 2023
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    DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation
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    ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery
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    IFNγ is a central node of cancer immune equilibrium
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  86. Feb 2023
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    IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
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  88. Jan 2023
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    SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy
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    Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages
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    Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4+ Th1 Responses and Potential Use as a Cancer Vaccine
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    Microbiota-dependent and -independent postnatal development of salivary immunity
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
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  94. Dec 2022
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    IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
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    Across-cancer immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis
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    Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection
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  99. Nov 2022
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    Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
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    Endogenous metabolism in endothelial and immune cells generates most of the tissue vitamin B3 (nicotinamide)
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    Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells
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      RRID:AB_1107636

      DOI: 10.1016/j.celrep.2022.111594

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  103. Oct 2022
  104. www.sciencedirect.com www.sciencedirect.com
    GM-CSF+ Tc17 cells are required to bolster vaccine immunity against lethal fungal pneumonia without causing overt pathology
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      DOI: 10.1016/j.celrep.2022.111543

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  105. Sep 2022
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    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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      DOI: 10.1016/j.ccell.2022.08.016

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    Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
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    Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD
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  109. Jun 2022
  110. 52.53.155.43 52.53.155.43
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      DOI: 10.1158/2159-8290.CD-21-1022

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    Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity
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    Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity
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  113. May 2022
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    Topical therapy for regression and melanoma prevention of congenital giant nevi
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      RRID:AB_1107636

      DOI: 10.1016/j.cell.2022.04.025

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    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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  116. Apr 2022
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    Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
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  118. Mar 2022
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    Tumor-derived Jagged1 promotes cancer progression through immune evasion
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      DOI: 10.1016/j.celrep.2022.110492

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  120. Feb 2022
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    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
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  122. Dec 2021
  123. elifesciences.org elifesciences.org
    IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells
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      RRID:AB_1107636

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  124. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
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  125. www.sciencedirect.com www.sciencedirect.com
    Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer
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  126. Nov 2021
  127. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
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      RRID:AB_1107636

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  128. www.sciencedirect.com www.sciencedirect.com
    Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade
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  129. Oct 2021
  130. www.sciencedirect.com www.sciencedirect.com
    Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
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  131. Sep 2021
  132. www.sciencedirect.com www.sciencedirect.com
    A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells
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      RRID:AB_1107636

      DOI: 10.1016/j.immuni.2021.08.029

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  133. www.sciencedirect.com www.sciencedirect.com
    Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma
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      DOI: 10.1016/j.immuni.2021.08.019

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    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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      DOI: 10.1016/j.xcrm.2021.100399

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    Activating a collaborative innate-adaptive immune response to control metastasis
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      DOI: 10.1016/j.ccell.2021.08.005

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  136. Aug 2021
  137. www.sciencedirect.com www.sciencedirect.com
    Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy
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      DOI: 10.1016/j.immuni.2021.07.005

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  138. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection
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  139. www.ebiomedicine.com www.ebiomedicine.com
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    ebiomedicine.com/article/S2352-3964(17)30188-3/abstract
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    CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter
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  141. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  142. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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  143. Jul 2021
  144. www.sciencedirect.com www.sciencedirect.com
    Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection
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      DOI: 10.1016/j.immuni.2018.10.009

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    Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
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    Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis
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  148. www.sciencedirect.com www.sciencedirect.com
    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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  149. www.sciencedirect.com www.sciencedirect.com
    A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant
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  150. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma
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    ncbi.nlm.nih.gov/pmc/articles/PMC8267546/
  151. Jun 2021
  152. www.sciencedirect.com www.sciencedirect.com
    Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
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    Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function
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  154. May 2021
  155. www.sciencedirect.com www.sciencedirect.com
    Pre-clinical evaluation of a whole-parasite vaccine to control human babesiosis
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    Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis
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  171. Dec 2020
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    CD8+ T Cell Functional Exhaustion Overrides Pregnancy-Induced Fetal Antigen Alloimmunization
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    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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    Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection
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    The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
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    Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies
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    The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.immuni.2019.04.001

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      DOI: 10.1016/j.chom.2019.02.004

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      DOI: 10.1016/j.immuni.2019.04.009

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    Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection
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      DOI: 10.1016/j.chom.2019.03.003

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      DOI: 10.1016/j.immuni.2019.01.010

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  207. Nov 2018
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    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
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    1. scibot 05 Nov 2018
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  209. www.sciencedirect.com www.sciencedirect.com
    Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy
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    LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance
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    Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response
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    Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer
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    Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells
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    Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection
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  217. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
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      Curator: @evieth

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  218. www.sciencedirect.com www.sciencedirect.com
    White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection
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    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
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  220. Nov 2017
  221. www.sciencedirect.com www.sciencedirect.com
    The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression
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    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
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    1. scibot 08 Nov 2017
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      AB_1107636

      Curator: @ifroman

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