165 Matching Annotations
  1. Last 7 days
  2. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Original research: Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization
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    1. scibot 04 Jul 2024
      RRID:AB_1107636

      DOI: 10.1136/jitc-2024-008970

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    ncbi.nlm.nih.gov/pmc/articles/PMC11218019/
  3. Jun 2024
  4. www.sciencedirect.com www.sciencedirect.com
    Fasting reshapes tissue-specific niches to improve NK cell-mediated anti-tumor immunity
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    1. scibot 21 Jun 2024
      RRID:AB_1107636

      DOI: 10.1016/j.immuni.2024.05.021

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    sciencedirect.com/science/article/pii/S1074761324002759
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    A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML
    1
    1. scibot 06 Jun 2024
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      DOI: 10.1016/j.xcrm.2024.101592

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    sciencedirect.com/science/article/pii/S2666379124002842
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    Blockage of L2HGDH-mediated S-2HG catabolism orchestrates macrophage polarization to elicit antitumor immunity
    1
    1. scibot 04 Jun 2024
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      DOI: 10.1016/j.celrep.2024.114300

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    sciencedirect.com/science/article/pii/S2211124724006284
  7. May 2024
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    Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy
    1
    1. scibot 17 May 2024
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      DOI: 10.1016/j.ccell.2024.04.011

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    sciencedirect.com/science/article/pii/S1535610824001351
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    Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma
    1
    1. scibot 07 May 2024
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      DOI: 10.1016/j.immuni.2024.04.006

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    sciencedirect.com/science/article/pii/S1074761324002115
  10. Apr 2024
  11. www.sciencedirect.com www.sciencedirect.com
    Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity
    1
    1. scibot 30 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101528

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    sciencedirect.com/science/article/pii/S2666379124001976
  12. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cancer immunotherapy via synergistic co-activation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 24 Apr 2024
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      DOI: 10.1126/sciimmunol.adj5097

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    ncbi.nlm.nih.gov/pmc/articles/PMC11034815/
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    Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages
    1
    1. scibot 18 Apr 2024
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      DOI: 10.1016/j.immuni.2024.03.020

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    sciencedirect.com/science/article/pii/S1074761324001419
  14. www.sciencedirect.com www.sciencedirect.com
    CXCL9/10-engineered dendritic cells promote T cell activation and enhance immune checkpoint blockade for lung cancer
    1
    1. scibot 12 Apr 2024
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      DOI: 10.1016/j.xcrm.2024.101479

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    sciencedirect.com/science/article/pii/S2666379124001253
  15. Mar 2024
  16. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A tetravalent nanovaccine that inhibits growth of HPV-associated head and neck carcinoma via dendritic and T cell activation
    1
    1. scibot 27 Mar 2024
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      DOI: 10.1016/j.isci.2024.109439

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    ncbi.nlm.nih.gov/pmc/articles/PMC10957412/
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    Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy
    2
    1. scibot 22 Mar 2024
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      DOI: 10.1016/j.ccell.2024.03.001

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    2. scibot 22 Mar 2024
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      DOI: 10.1016/j.ccell.2024.03.001

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    sciencedirect.com/science/article/pii/S1535610824000801
  18. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Multimodal immune phenotyping reveals microbial-T cell interactions that shape pancreatic cancer
    1
    1. scibot 03 Mar 2024
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      DOI: 10.1016/j.xcrm.2024.101397

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    ncbi.nlm.nih.gov/pmc/articles/PMC10897543/
  19. Feb 2024
  20. www.sciencedirect.com www.sciencedirect.com
    IL-37 dampens immunosuppressive functions of MDSCs via metabolic reprogramming in the tumor microenvironment
    1
    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113835

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    sciencedirect.com/science/article/pii/S2211124724001633
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    RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis
    2
    1. scibot 16 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113786

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      DOI: 10.1016/j.celrep.2024.113786

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    sciencedirect.com/science/article/pii/S2211124724001141
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    T cell-specific P2RX7 favors lung parenchymal CD4+ T cell accumulation in response to severe lung infections
    1
    1. scibot 11 Feb 2024
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      DOI: 10.1016/j.celrep.2023.113448

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    ncbi.nlm.nih.gov/pmc/articles/PMC10841667/
  23. Jan 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells
    2
    1. scibot 04 Jan 2024
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      DOI: 10.1016/j.devcel.2023.07.025

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      DOI: 10.1016/j.devcel.2023.07.025

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    sciencedirect.com/science/article/pii/S1534580723003945
  25. Dec 2023
  26. www.sciencedirect.com www.sciencedirect.com
    NK cells propagate T cell immunity following in situ tumor vaccination
    1
    1. scibot 17 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113556

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    sciencedirect.com/science/article/pii/S2211124723015681
  27. www.science.org www.science.org
    Noncanonical MAVS signaling restrains dendritic cell–driven antitumor immunity by inhibiting IL-12
    1
    1. scibot 02 Dec 2023
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      DOI: 10.1126/sciimmunol.adf4919

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    science.org/doi/10.1126/sciimmunol.adf4919
  28. www.science.org www.science.org
    Cancer immunotherapy via synergistic coactivation of myeloid receptors CD40 and Dectin-1
    1
    1. scibot 01 Dec 2023
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      DOI: 10.1126/sciimmunol.adj5097

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    science.org/doi/10.1126/sciimmunol.adj5097
  29. Nov 2023
  30. www.sciencedirect.com www.sciencedirect.com
    Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses
    1
    1. scibot 18 Nov 2023
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      DOI: 10.1016/j.isci.2023.108348

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    sciencedirect.com/science/article/pii/S2589004223024252
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    CD115+ monocytes protect microbially experienced mice against E. coli-induced sepsis
    1
    1. scibot 03 Nov 2023
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      DOI: 10.1016/j.celrep.2023.113345

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    sciencedirect.com/science/article/pii/S2211124723013578
  32. Oct 2023
  33. www.sciencedirect.com www.sciencedirect.com
    Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses
    1
    1. scibot 27 Oct 2023
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      DOI: 10.1016/j.cmet.2023.09.011

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    sciencedirect.com/science/article/pii/S1550413123003674
  34. www.biorxiv.org www.biorxiv.org
    CCR5 promotes the migration of CD8+ T cells to the leishmanial lesions
    1
    1. scibot 24 Oct 2023
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      DOI: 10.1101/2023.10.10.561700

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    biorxiv.org/content/10.1101/2023.10.10.561700v1
  35. www.sciencedirect.com www.sciencedirect.com
    Intermittent fasting induced ketogenesis inhibits mouse epithelial ovarian cancer by promoting antitumor T cell response
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.isci.2023.107839

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    sciencedirect.com/science/article/pii/S2589004223019168
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    Oncolytic virus M1 functions as a bifunctional checkpoint inhibitor to enhance the antitumor activity of DC vaccine
    1
    1. scibot 14 Oct 2023
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      DOI: 10.1016/j.xcrm.2023.101229

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    sciencedirect.com/science/article/pii/S2666379123004068
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    TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.ccell.2023.09.001

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    sciencedirect.com/science/article/pii/S1535610823003185
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    Supplementation with a high-glucose drink stimulates anti-tumor immune responses to glioblastoma via gut microbiota modulation
    1
    1. scibot 13 Oct 2023
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      DOI: 10.1016/j.celrep.2023.113220

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    sciencedirect.com/science/article/pii/S2211124723012329
  39. dx.doi.org dx.doi.org
    Glioblastoma vascular plasticity limits effector T-cell infiltration and is blocked by cAMP activation
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    1. scibot 06 Oct 2023
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      DOI: 10.1158/2326-6066.CIR-22-0872

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    dx.doi.org/10.1158/2326-6066.CIR-22-0872
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    Endothelial cells are a key target of IFN-g during response to combined PD-1/CTLA-4 ICB treatment in a mouse model of bladder cancer
    1
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      DOI: 10.1016/j.isci.2023.107937

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  41. Sep 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Adenosine A2A receptor is a tumor suppressor of NASH-associated hepatocellular carcinoma
    1
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    ncbi.nlm.nih.gov/pmc/articles/PMC10518627/
  43. Aug 2023
  44. 52.53.155.43 52.53.155.43
    CD39 inhibition and VISTA blockade may overcome radiotherapy resistance by targeting exhausted CD8+ T cells and immunosuppressive myeloid cells
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      DOI: 10.1016/j.xcrm.2023.101151

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      DOI: 10.1016/j.xcrm.2023.101151

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    52.53.155.43/75914c2645b295883453ae6f0848b8ff04ccb7e0/PIIS266637912300304X-html.html
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    Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC
    1
    1. scibot 16 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101150

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  46. 52.53.155.43 52.53.155.43
    Membrane-localized neoantigens predict the efficacy of cancer immunotherapy
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    1. scibot 12 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101145

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    2. scibot 10 Aug 2023
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      DOI: 10.1016/j.xcrm.2023.101145

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    52.53.155.43/9f1a09025b86686c62561e67323b0c82e4153e7b/PIIS2666379123002987-html.html
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    The pseudokinase Trib1 regulates the transition of exhausted T cells to a KLR+ CD8+ effector state, and its deletion improves checkpoint blockade
    1
    1. scibot 03 Aug 2023
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      DOI: 10.1016/j.celrep.2023.112905

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    sciencedirect.com/science/article/pii/S2211124723009166
  48. Jul 2023
  49. www.sciencedirect.com www.sciencedirect.com
    A surgically optimized intraoperative poly(I:C)-releasing hydrogel prevents cancer recurrence
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    1. scibot 21 Jul 2023
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      DOI: 10.1016/j.xcrm.2023.101113

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    sciencedirect.com/science/article/pii/S2666379123002410
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    A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity
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    Tumor-specific CD4 T cells instruct monocyte fate in pancreatic ductal adenocarcinoma
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  52. Jun 2023
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    Coupled deglycosylation-ubiquitination cascade in regulating PD-1 degradation by MDM2
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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  55. May 2023
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    Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity
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    Engineer a double team of short-lived and glucose-sensing bacteria for cancer eradication
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  58. Apr 2023
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    Synergistic effects of combined immunotherapy strategies in a model of multifocal hepatocellular carcinoma
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    Dietary tryptophan metabolite released by intratumoral Lactobacillus reuteri facilitates immune checkpoint inhibitor treatment
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    Targeting protein tyrosine phosphatases for CDK6-induced immunotherapy resistance
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  62. Mar 2023
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    DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation
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    ILC3s restrict the dissemination of intestinal bacteria to safeguard liver regeneration after surgery
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    IFNγ is a central node of cancer immune equilibrium
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  66. Feb 2023
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    IL-18BP mediates the balance between protective and pathological immune responses to Toxoplasma gondii
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  68. Jan 2023
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    SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy
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    Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8+ T cells and reprogramming macrophages
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    Identification of Immunogenic MHC Class II Human HER3 Peptides that Mediate Anti-HER3 CD4+ Th1 Responses and Potential Use as a Cancer Vaccine
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    Microbiota-dependent and -independent postnatal development of salivary immunity
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    Immunoediting instructs tumor metabolic reprogramming to support immune evasion
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  74. Dec 2022
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    IL-5-producing CD4+ T cells and eosinophils cooperate to enhance response to immune checkpoint blockade in breast cancer
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    Across-cancer immune responses induced by nanovaccines or microvaccines to prevent different cancers and cancer metastasis
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    Spatial transcriptomics demonstrates the role of CD4 T cells in effector CD8 T cell differentiation during chronic viral infection
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  79. Nov 2022
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    Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop
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    Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells
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  83. Oct 2022
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    GM-CSF+ Tc17 cells are required to bolster vaccine immunity against lethal fungal pneumonia without causing overt pathology
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  85. Sep 2022
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    Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses
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    Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity
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    Platelets control liver tumor growth through P2Y12-dependent CD40L release in NAFLD
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    Optimal target saturation of ligand-blocking anti-GITR antibody IBI37G5 dictates FcγR-independent GITR agonism and antitumor activity
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    Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity
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  93. May 2022
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    Topical therapy for regression and melanoma prevention of congenital giant nevi
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    Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
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  96. Apr 2022
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    Type 1 conventional dendritic cells maintain and guide the differentiation of precursors of exhausted T cells in distinct cellular niches
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  98. Mar 2022
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    Tumor-derived Jagged1 promotes cancer progression through immune evasion
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  100. Feb 2022
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    Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
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  102. Dec 2021
  103. elifesciences.org elifesciences.org
    IL-2/JES6-1 mAb complexes dramatically increase sensitivity to LPS through IFN-γ production by CD25+Foxp3- T cells
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    A dysbiotic gut microbiome suppresses antibody mediated-protection against Vibrio cholerae
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  106. Nov 2021
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    CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells
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    Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade
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    Enteric pathogens induce tissue tolerance and prevent neuronal loss from subsequent infections
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  111. Sep 2021
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    A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells
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    Resident memory CD8+ T cells in regional lymph nodes mediate immunity to metastatic melanoma
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    Effector T cell responses unleashed by regulatory T cell ablation exacerbate oral squamous cell carcinoma
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  116. Aug 2021
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    Environmental enteric dysfunction induces regulatory T cells that inhibit local CD4+ T cell responses and impair oral vaccine efficacy
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    Identification of a Locus in Mice that Regulates the Collateral Damage and Lethality of Virus Infection
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    CXCL10+ peripheral activation niches couple preferred sites of Th1 entry with optimal APC encounter
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  123. Jul 2021
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    Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection
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    Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma
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    Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis
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    PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity
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    A safe and effective mucosal RSV vaccine in mice consisting of RSV phosphoprotein and flagellin variant
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    Endogenous Retrovirus Envelope as a Tumor-Associated Immunotherapeutic Target in Murine Osteosarcoma
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  131. Jun 2021
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    Pharmacologic modulation of RNA splicing enhances anti-tumor immunity
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    Lactate dehydrogenase A-dependent aerobic glycolysis promotes natural killer cell anti-viral and anti-tumor function
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  134. May 2021
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    A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage
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    Production of the Cytokine VEGF-A by CD4+ T and Myeloid Cells Disrupts the Corneal Nerve Landscape and Promotes Herpes Stromal Keratitis
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  140. Apr 2021
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    NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion
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    Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells
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    Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis
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    A unified atlas of CD8 T cell dysfunctional states in cancer and infection
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    Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity
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    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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  147. Mar 2021
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    Early innate and adaptive immune perturbations determine long-term severity of chronic virus and Mycobacterium tuberculosis coinfection
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  149. Feb 2021
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    Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses
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  151. Dec 2020
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    Divergent Role for STAT5 in the Adaptive Responses of Natural Killer Cells
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  153. Nov 2020
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    Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade
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  155. Sep 2020
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    Coordinated Viral Control by Cytotoxic Lymphocytes Ensures Optimal Adaptive NK Cell Responses
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    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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    Th1-Th2 Cross-Regulation Controls Early Leishmania Infection in the Skin by Modulating the Size of the Permissive Monocytic Host Cell Reservoir
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    Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma
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    Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection
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    Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment
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    B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer
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    CDK7 Inhibition Potentiates Genome Instability Triggering Anti-tumor Immunity in Small Cell Lung Cancer
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    Antibody Conditioning Enables MHC-Mismatched Hematopoietic Stem Cell Transplants and Organ Graft Tolerance
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    The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction
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    RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer
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    Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies
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    The Chemoattractant Receptor Ebi2 Drives Intranodal Naive CD4+ T Cell Peripheralization to Promote Effective Adaptive Immunity
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    Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection
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    CD8+ T Cell Priming in Established Chronic Viral Infection Preferentially Directs Differentiation of Memory-like Cells for Sustained Immunity
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    Complement C5a Fosters Squamous Carcinogenesis and Limits T Cell Response to Chemotherapy
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    LC3-Associated Phagocytosis in Myeloid Cells Promotes Tumor Immune Tolerance
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    Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response
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    Aerobic Glycolysis Controls Myeloid-Derived Suppressor Cells and Tumor Immunity via a Specific CEBPB Isoform in Triple-Negative Breast Cancer
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    Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells
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    Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection
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      RRID:AB_1107636 RRIDCUR:Validated
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    ncbi.nlm.nih.gov/pmc/articles/PMC5720393/
  198. www.sciencedirect.com www.sciencedirect.com
    White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection
    1
    1. scibot 05 Nov 2018
      RRID:AB_1107636

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      (Bio X Cell Cat# BE0003-1, RRID:AB_1107636)

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      RRID:AB_1107636
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    sciencedirect.com/science/article/pii/S1074761317304867
  199. www.sciencedirect.com www.sciencedirect.com
    Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction
    1
    1. scibot 05 Nov 2018
      RRID:AB_1107636

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      (Bio X Cell Cat# BE0003-1, RRID:AB_1107636)

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      RRID:AB_1107636
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    sciencedirect.com/science/article/pii/S1074761317304806
  200. Nov 2017
  201. www.sciencedirect.com www.sciencedirect.com
    The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression
    1
    1. scibot 08 Nov 2017
      RRID:AB_1107636

      Curator: @Jmenke

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      RRID:AB_1107636 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1074761317303278
  202. www.sciencedirect.com www.sciencedirect.com
    Macrophage Polarization Contributes to Glioblastoma Eradication by Combination Immunovirotherapy and Immune Checkpoint Blockade
    1
    1. scibot 08 Nov 2017
      RRID:AB_1107636

      Curator: @Jmenke

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      (Bio X Cell Cat# BE0003-1, RRID:AB_1107636)

      SciCrunch record: RRID:AB_1107636

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      RRID:AB_1107636 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S1535610817302982
  203. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    1. scibot 08 Nov 2017
      AB_1107636

      Curator: @ifroman

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      (Bio X Cell Cat# BE0003-1, RRID:AB_1107636)

      SciCrunch record: RRID:AB_1107636

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      RRID:AB_1107636 RRIDCUR:Validated
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    sciencedirect.com/science/article/pii/S2352396417301883