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Antibody-Mediated Targeting of Secretory Protein SCUBE3 Suppresses Cancer Progression by Inhibiting Oncogenic Signaling and Inducing Anti-tumor Immunity

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1. scibot 11 Jul 2026
  
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  DOI: 10.1158/0008-5472.CAN-25-0521
  
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aacrjournals.org/cancerres/article/86/5/1252/774876/Antibody-Mediated-Targeting-of-Secretory-Protein
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Targeting cholesterol esterification sensitizes liver cancer to CD8+ T cell attack by impairing metabolic and redox resilience

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1. scibot 07 Jul 2026
  
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  DOI: 10.1016/j.immuni.2026.06.002
  
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sciencedirect.com/science/article/pii/S1074761326002530
Mar 2026
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Immunogenic tumor cell death and T-cell-derived IFN-γ elicit tumoricidal macrophages to potentiate OX40 immunotherapy

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1. scibot 27 Mar 2026
  
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  DOI: 10.1016/j.xcrm.2026.102699
  
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sciencedirect.com/science/article/pii/S2666379126001163
Feb 2026
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CLIM-TIME identifies metastatic microenvironment modulators for T cell therapy response

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1. scibot 12 Feb 2026
  
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  DOI: 10.1016/j.cell.2025.12.042
  
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sciencedirect.com/science/article/pii/S0092867425014916
Jan 2026
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METTL3/CD98-mediated glutamate efflux in CAFs drives CD8+ T cell exhaustion and impedes neoadjuvant immunochemotherapy

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1. scibot 29 Jan 2026
  
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  DOI: 10.1016/j.celrep.2026.116933
  
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sciencedirect.com/science/article/pii/S2211124726000112
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Microbial metabolite FAD mobilizes adipocyte lipid remodeling to enhance cancer immunotherapy efficacy

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1. scibot 22 Jan 2026
  
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  DOI: 10.1016/j.cmet.2025.12.012
  
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sciencedirect.com/science/article/pii/S1550413125005431
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p57 increases immunotherapy efficacy by promoting cGAS-STING-mediated innate sensing in hepatocellular carcinoma

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116769
  
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sciencedirect.com/science/article/pii/S2211124725015414
Dec 2025
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Dysplastic epithelial repair promotes the tissue residence of lymphocytes to inhibit alveolar regeneration post viral infection

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1. scibot 23 Dec 2025
  
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  DOI: 10.1016/j.stem.2025.12.005
  
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sciencedirect.com/science/article/pii/S1934590925004394
Oct 2025
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Distinct T cell functions enable efficient immunoediting and prevent tumor emergence of developing sarcomas

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1. scibot 08 Oct 2025
  
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  DOI: 10.1016/j.ccell.2025.09.005
  
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sciencedirect.com/science/article/pii/S1535610825003976
Aug 2025
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Inhibiting KRAS with CD47 and immune checkpoint overcomes intrinsic resistance to combined KRAS and immune checkpoint inhibitor therapy

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1. scibot 30 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102317
  
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sciencedirect.com/science/article/pii/S2666379125003908
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Tumor-associated Schwann cell remodeling under metabolic stress via lactate sensing orchestrates pancreatic ductal adenocarcinoma development

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.cmet.2025.07.008
  
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sciencedirect.com/science/article/pii/S1550413125003353
Jul 2025
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Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity

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1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102257
  
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sciencedirect.com/science/article/pii/S2666379125003301
Jun 2025
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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.06.006
  
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sciencedirect.com/science/article/pii/S1535610825002569
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EHMT1/2 inhibition promotes regression of therapy-resistant ovarian cancer tumors in a CD8 T cell-dependent manner

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1. scibot 11 Jun 2025
  
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  DOI: 10.1158/1541-7786.MCR-24-0067
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11614706/
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Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115800
  
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sciencedirect.com/science/article/pii/S2211124725005716
May 2025
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Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer

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1. scibot 16 May 2025
  
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  DOI: 10.1016/j.celrep.2025.115676
  
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sciencedirect.com/science/article/pii/S2211124725004474
Apr 2025
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Adenosine Uptake through the Nucleoside Transporter ENT1 Suppresses Antitumor Immunity and T Cell Pyrimidine Synthesis

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1. scibot 17 Apr 2025
  
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  DOI: 10.1158/0008-5472.CAN-24-1875
  
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aacrjournals.org/cancerres/article/85/4/692/751418/Adenosine-Uptake-through-the-Nucleoside
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Targeting the dendritic cell-secreted immunoregulatory cytokine CCL22 alleviates radioresistance

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1. scibot 02 Apr 2025
  
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  DOI: 10.1158/1078-0432.CCR-23-3616
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11444901/
Mar 2025
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AGO2 mediates immunotherapy failure via suppressing tumor IFN-gamma response-dependent CD8+ T cell immunity

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1. scibot 20 Mar 2025
  
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  DOI: 10.1016/j.celrep.2025.115445
  
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sciencedirect.com/science/article/pii/S2211124725002165
Feb 2025
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can-24-1875-html.html

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1. scibot 13 Feb 2025
  
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  DOI: 10.1158/0008-5472.can-24-1875
  
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52.53.155.43/4182fc38f6d84ee454983d471ee248d2b61614bf/can-24-1875-html.html
Dec 2024
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A commonly inherited human PCSK9 germline variant drives breast cancer metastasis via LRP1 receptor

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1. scibot 10 Dec 2024
  
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  DOI: 10.1016/j.cell.2024.11.009
  
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sciencedirect.com/science/article/pii/S0092867424013266
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Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells

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1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115023
  
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sciencedirect.com/science/article/pii/S2211124724013743
Nov 2024
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Probiotics and their metabolite spermidine enhance IFN-γ+CD4+ T cell immunity to inhibit hepatitis B virus

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1. scibot 14 Nov 2024
  
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  DOI: 10.1016/j.xcrm.2024.101822
  
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Sep 2024
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Fusobacterium nucleatum facilitates anti-PD-1 therapy in microsatellite stable colorectal cancer

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1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.019
  
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Glioblastoma induces the recruitment and differentiation of dendritic-like “hybrid” neutrophils from skull bone marrow

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1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.ccell.2024.08.008
  
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sciencedirect.com/science/article/pii/S1535610824003076
Aug 2024
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Malic enzyme 2 maintains metabolic state and anti-tumor immunity of CD8+ T cells

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1. scibot 22 Aug 2024
  
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  DOI: 10.1016/j.molcel.2024.07.021
  
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sciencedirect.com/science/article/pii/S1097276524006191
Jul 2024
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Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer

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1. scibot 25 Jul 2024
  
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  DOI: 10.1126/science.adh4567
  
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science.org/doi/10.1126/science.adh4567
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Preclinical study and phase II trial of adapting low-dose radiotherapy to immunotherapy in small cell lung cancer

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.medj.2024.06.002
  
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sciencedirect.com/science/article/pii/S2666634024002484
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Original research: Second-generation checkpoint inhibitors and Treg depletion synergize with a mouse cancer vaccine in accordance with tumor microenvironment characterization

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1. scibot 04 Jul 2024
  
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  DOI: 10.1136/jitc-2024-008970
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11218019/
May 2024
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Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma

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1. scibot 07 May 2024
  
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  DOI: 10.1016/j.immuni.2024.04.006
  
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sciencedirect.com/science/article/pii/S1074761324002115
Apr 2024
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Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

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1. scibot 18 Apr 2024
  
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  DOI: 10.1016/j.celrep.2024.114094
  
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  DOI: 10.1016/j.celrep.2024.114094
  
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sciencedirect.com/science/article/pii/S2211124724004224
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Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages

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1. scibot 18 Apr 2024
  
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  DOI: 10.1016/j.immuni.2024.03.020
  
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sciencedirect.com/science/article/pii/S1074761324001419
Mar 2024
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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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1. scibot 15 Mar 2024
  
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  DOI: 10.1016/j.cell.2024.02.022
  
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cell.com/cell/fulltext/S0092-8674(24)00224-1
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

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1. scibot 13 Mar 2024
  
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  RRID:AB_1107671
  
  DOI: 10.1016/j.immuni.2024.02.014
  
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2. scibot 13 Mar 2024
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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Elimination of oncogenic KRAS in genetic mouse models eradicates pancreatic cancer by inducing FAS-dependent apoptosis by CD8+ T cells

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Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

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KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells

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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC

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YTHDF2 inhibition potentiates radiotherapy antitumor efficacy

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Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells

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  DOI: 10.1158/2326-6066.CIR-21-0326
  
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Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis

1
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Neutrophil Conversion to a Tumor-Killing Phenotype Underpins Effective Microbial Therapy

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DNA-damaged podocyte-CD8 T cell crosstalk exacerbates kidney injury by altering DNA methylation

1
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Combinatory EHMT and PARP inhibition induces an interferon response and a CD8 T cell-dependent tumor regression in PARP inhibitor-resistant models

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Microglia drive transient insult-induced brain injury by chemotactic recruitment of CD8+ T lymphocytes

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Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

1
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MPS1 inhibition primes immunogenicity of KRAS-LKB1 mutant lung cancer

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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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Tnfrsf4-expressing regulatory T cells promote immune escape of chronic myeloid leukemia stem cells

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  DOI: 10.1172/jci.insight.151797
  
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SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects

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Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses

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CD95/Fas protects triple negative breast cancer from anti-tumor activity of NK cells

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Activating a collaborative innate-adaptive immune response to control metastasis

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Untitled document

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Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma

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  DOI: 10.1016/j.cell.2018.10.038
  
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Untitled document

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Interferon-γ Drives Treg Fragility to Promote Anti-tumor Immunity

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A vaccine inducing solely cytotoxic T lymphocytes fully prevents Zika virus infection and fetal damage

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NAD+ Metabolism Maintains Inducible PD-L1 Expression to Drive Tumor Immune Evasion

1
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  DOI: 10.1016/j.cmet.2020.10.021
  
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Cytotoxic lymphocytes target characteristic biophysical vulnerabilities in cancer

1
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Affinity-Restricted Memory B Cells Dominate Recall Responses to Heterologous Flaviviruses

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Sep 2020
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The Unfolded Protein Response Mediator PERK Governs Myeloid Cell-Driven Immunosuppression in Tumors through Inhibition of STING Signaling

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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

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Blockade of the Phagocytic Receptor MerTK on Tumor-Associated Macrophages Enhances P2X7R-Dependent STING Activation by Tumor-Derived cGAMP

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Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment

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B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer

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Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ

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  DOI: 10.1016/j.immuni.2019.06.017
  
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RIP1 Kinase Drives Macrophage-Mediated Adaptive Immune Tolerance in Pancreatic Cancer

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  DOI: 10.1016/j.ccell.2018.10.006
  
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Untitled document

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  DOI: 10.1016/j.immuni.2019.01.010
  
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Nov 2018
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Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

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Low-Protein Diet Induces IRE1α-Dependent Anticancer Immunosurveillance

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Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction

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The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

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