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Local delivery of IL-15 and anti-PD-L1 nanobody by in vitro-transcribed circILNb elicits superior antitumor immunity in cold tumors

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1. scibot 11 Oct 2025
  
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  DOI: 10.1016/j.xcrm.2025.102413
  
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sciencedirect.com/science/article/pii/S2666379125004860
Aug 2025
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Inhibition of tumor cell macropinocytosis driver DHODH reverses immunosuppression and overcomes anti-PD1 resistance

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.013
  
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sciencedirect.com/science/article/pii/S107476132500322X
Jul 2025
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Coupling IL-2 with IL-10 to mitigate toxicity and enhance antitumor immunity

1
1. scibot 31 Jul 2025
  
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  DOI: 10.1016/j.xcrm.2025.102257
  
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Jun 2025
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A CXCR4 partial agonist improves immunotherapy by targeting immunosuppressive neutrophils and cancer-driven granulopoiesis

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1. scibot 28 Jun 2025
  
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  DOI: 10.1016/j.ccell.2025.06.006
  
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pdf-html.html

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1. scibot 12 Jun 2025
  
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  DOI: 10.1158/2326-6066.cir-24-0797
  
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52.53.155.43/714962b4df611138463d94a4796d134a4c0f1b27/pdf-html.html
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NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1/PD-L1 pathway

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1126/sciimmunol.adl2967
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12099074/
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Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism

1
1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.chom.2025.05.015
  
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sciencedirect.com/science/article/pii/S1931312825001982
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Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity

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1. scibot 11 Jun 2025
  
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  DOI: 10.1016/j.celrep.2025.115800
  
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sciencedirect.com/science/article/pii/S2211124725005716
May 2025
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Interferon-γ and IL-27 positively regulate type 1 regulatory T cell development during adaptive tolerance

1
1. scibot 18 May 2025
  
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  DOI: 10.1016/j.isci.2025.112308
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12018090/
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Maternal natural killer cells drive neuroimmune disorders in offspring through aberrant secretion of extracellular granzyme B

1
1. scibot 18 May 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.immuni.2025.04.028
  
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sciencedirect.com/science/article/pii/S1074761325001918
Apr 2025
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ULBP2 Promotes Tumor Progression by Suppressing NKG2D-Mediated Anti-Tumor Immunity

1
1. scibot 19 Apr 2025
  
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  RRID:AB_1107737
  
  DOI: 10.3390/ijms26072950
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11988498/
Mar 2025
52.53.155.43 52.53.155.43

PDF-html.html

1
1. scibot 14 Mar 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1101/2025.03.05.639198
  
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52.53.155.43/6a1077851a93128037200ab8bc35f1d4060f0db6/PDF-html.html
Feb 2025
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AKR1D1 suppresses liver cancer progression by promoting bile acid metabolism-mediated NK cell cytotoxicity

1
1. scibot 27 Feb 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.cmet.2025.01.011
  
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An epitope-directed mRNA vaccine inhibits tumor metastasis through the blockade of MICA/B α1/2 shedding

1
1. scibot 25 Feb 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.xcrm.2025.101981
  
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sciencedirect.com/science/article/pii/S2666379125000540
aacrjournals.org aacrjournals.org

Cryoablation does not significantly contribute to systemic effector immune responses in poorly immunogenic B16F10 melanoma model

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1. scibot 13 Feb 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1158/1078-0432.CCR-24-0371
  
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aacrjournals.org/clincancerres/article/30/18/4190/747463/Cryoablation-Does-Not-Significantly-Contribute-to
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Nanoparticle delivery of innate immune agonists combined with senescence-inducing agents promotes T cell control of pancreatic cancer

1
1. scibot 13 Feb 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1126/scitranslmed.adj9366
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11811823/
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Nanrilkefusp alfa (SOT101), an IL-15 receptor βγ superagonist, as a single agent or with anti-PD-1 in patients with advanced cancers

1
1. scibot 11 Feb 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.xcrm.2025.101967
  
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sciencedirect.com/science/article/pii/S2666379125000400
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Platelets tune fear memory in mice

1
1. scibot 04 Feb 2025
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.celrep.2025.115261
  
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sciencedirect.com/science/article/pii/S2211124725000324
Dec 2024
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NK cells restrain cytotoxic CD8+ T cells in the submandibular gland via PD-1–PD-L1

1
1. scibot 29 Dec 2024
  
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  RRID:AB_1107737
  
  DOI: 10.1126/sciimmunol.adl2967
  
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science.org/doi/10.1126/sciimmunol.adl2967
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Flt3L enhances clonal diversification and selective expansion of intratumoral CD8+ T cells while differentiating into effector-like cells

1
1. scibot 02 Dec 2024
  
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  DOI: 10.1016/j.celrep.2024.115023
  
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sciencedirect.com/science/article/pii/S2211124724013743
Nov 2024
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Tumor stage-driven disruption of NK cell maturation in human and murine tumors

1
1. scibot 26 Nov 2024
  
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  DOI: 10.1016/j.isci.2024.111233
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11585790/
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Targeting the aminopeptidase ERAP enhances antitumor immunity by disrupting the NKG2A-HLA-E inhibitory checkpoint

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1. scibot 24 Nov 2024
  
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  DOI: 10.1016/j.immuni.2024.10.013
  
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Tissue-colonizing disseminated tumor cells secrete prostaglandin E2 to promote NK cell dysfunction and evade anti-metastatic immunity

1
1. scibot 20 Nov 2024
  
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  DOI: 10.1016/j.celrep.2024.114855
  
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Targeting the immune privilege of tumor-initiating cells to enhance cancer immunotherapy

1
1. scibot 11 Nov 2024
  
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  DOI: 10.1016/j.ccell.2024.10.008
  
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pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Targeting Catechol-O-Methyltransferase Induces Mitochondrial Dysfunction and Enhances the Efficacy of Radiotherapy in Glioma

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1. scibot 08 Nov 2024
  
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  RRID:AB_1107737
  
  DOI: 10.1158/0008-5472.CAN-24-0134
  
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pmc.ncbi.nlm.nih.gov/articles/PMC11532787/
Sep 2024
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A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies

1
1. scibot 27 Sep 2024
  
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  DOI: 10.1016/j.xcrm.2024.101747
  
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Microbiota regulates neonatal disease tolerance to virus-evoked necrotizing enterocolitis by shaping the STAT1-NLRC5 axis in the intestinal epithelium

1
1. scibot 25 Sep 2024
  
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  DOI: 10.1016/j.chom.2024.08.013
  
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sciencedirect.com/science/article/pii/S1931312824003202
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Opposing Functions of Interferon Coordinate Adaptive and Innate Immune Responses to Cancer Immune Checkpoint Blockade

1
1. scibot 25 Sep 2024
  
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  RRID:AB_516844
  
  DOI: 10.1016/j.cell.2019.07.019
  
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sciencedirect.com/science/article/pii/S0092867419307846
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SGLT2 inhibitor promotes ketogenesis to improve MASH by suppressing CD8+ T cell activation

1
1. scibot 10 Sep 2024
  
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  DOI: 10.1016/j.cmet.2024.08.005
  
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sciencedirect.com/science/article/pii/S1550413124003322
Aug 2024
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Secreted PTEN binds PLXDC2 on macrophages to drive antitumor immunity and tumor suppression

1
1. scibot 28 Aug 2024
  
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  DOI: 10.1016/j.devcel.2024.08.003
  
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sciencedirect.com/science/article/pii/S1534580724004866
www.cell.com www.cell.com

SETDB1 suppresses NK cell-mediated immunosurveillance in acute myeloid leukemia with granulo-monocytic differentiation

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1. scibot 18 Aug 2024
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.celrep.2024.114536
  
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cell.com/cell-reports/fulltext/S2211-1247(24)00865-9
Jul 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

VHL loss enhances antitumor immunity by activating the anti-viral DNA-sensing pathway

1
1. scibot 27 Jul 2024
  
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  DOI: 10.1016/j.isci.2024.110285
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11267025/
Jun 2024
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A CD36-dependent non-canonical lipid metabolism program promotes immune escape and resistance to hypomethylating agent therapy in AML

1
1. scibot 06 Jun 2024
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.xcrm.2024.101592
  
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sciencedirect.com/science/article/pii/S2666379124002842
May 2024
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Tumor cells impair immunological synapse formation via central nervous system-enriched metabolite

2
1. scibot 31 May 2024
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.ccell.2024.05.006
  
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2. scibot 31 May 2024
  
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  RRID:AB_1107737
  
  DOI: 10.1016/j.ccell.2024.05.006
  
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sciencedirect.com/science/article/pii/S1535610824001697
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Deletion of the mRNA endonuclease Regnase-1 promotes NK cell anti-tumor activity via OCT2-dependent transcription of Ifng

2
1. scibot 31 May 2024
  
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  DOI: 10.1016/j.immuni.2024.05.006
  
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Immunotherapy-activated T cells recruit and skewlate-stage activated M1-like macrophagesthat are critical for therapeutic efficacy

1
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  DOI: 10.1016/j.ccell.2024.04.011
  
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Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

1
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  DOI: 10.1016/j.xcrm.2024.101531
  
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IGSF8 is an innate immune checkpoint and cancer immunotherapy target

1
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  DOI: 10.1016/j.cell.2024.03.039
  
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Mar 2024
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Clinical drug screening reveals clofazimine potentiates the efficacy while reducing the toxicity of anti-PD-1 and CTLA-4 immunotherapy

2
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Long-lasting mRNA-encoded interleukin-2 restores CD8+ T cell neoantigen immunity in MHC class I-deficient cancers

1
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Retinoic acid receptor activation reprograms senescence response and enhances anti-tumor activity of natural killer cells

3
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  DOI: 10.1016/j.ccell.2024.02.004
  
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Maternal inflammation regulates fetal emergency myelopoiesis

1
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Dec 2023
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NK cells propagate T cell immunity following in situ tumor vaccination

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  DOI: 10.1016/j.celrep.2023.113556
  
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Nov 2023
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TIGIT contributes to the regulation of 4-1BB and does not define NK cell dysfunction in glioblastoma

1
1. scibot 29 Nov 2023
  
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  DOI: 10.1016/j.isci.2023.108353
  
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Mice with FVB-derived sequence on chromosome 17 succumb to disseminated virus infection due to aberrant NK cell and T cell responses

1
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  DOI: 10.1016/j.isci.2023.108348
  
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TIM-3 blockade in diffuse intrinsic pontine glioma models promotes tumor regression and antitumor immune memory

1
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STING signaling promotes NK cell antitumor immunity and maintains a reservoir of TCF-1+ NK cells

2
1. scibot 16 Sep 2023
  
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  DOI: 10.1016/j.celrep.2023.113108
  
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Targeting nucleic acid sensors in tumor cells to reprogram biogenesis and RNA cargo of extracellular vesicles for T cell-mediated cancer immunotherapy

1
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  DOI: 10.1016/j.xcrm.2023.101171
  
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Aug 2023
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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC

1
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  DOI: 10.1016/j.xcrm.2023.101150
  
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Membrane-localized neoantigens predict the efficacy of cancer immunotherapy

2
1. scibot 12 Aug 2023
  
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  DOI: 10.1016/j.xcrm.2023.101145
  
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Jul 2023
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A genetic method specifically delineates Th1-type Treg cells and their roles in tumor immunity

1
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Jun 2023
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Natural killer cells and innate lymphoid cells 1 tune anxiety-like behavior and memory in mice via interferon-γ and acetylcholine

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May 2023
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Context-dependent activation of STING-interferon signaling by CD11b agonists enhances anti-tumor immunity

1
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Tumor eradication by hetIL-15 locoregional therapy correlates with an induced intratumoral CD103intCD11b+ dendritic cell population

1
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Apr 2023
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Macrophage-Targeted Therapy Unlocks Antitumoral Cross-talk between IFNγ-Secreting Lymphocytes and IL12-Producing Dendritic Cells

1
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  DOI: 10.1158/2326-6066.CIR-21-0326
  
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Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis

1
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T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants

1
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  DOI: 10.1016/j.cell.2023.03.007
  
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Mar 2023
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IFNγ is a central node of cancer immune equilibrium

1
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  DOI: 10.1016/j.celrep.2023.112219
  
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Jan 2023
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SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

1
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  DOI: 10.1158/0008-5472.CAN-21-3523
  
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Dec 2022
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Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

1
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  DOI: 10.1016/j.cmet.2022.11.003
  
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The ectromelia virus virulence factor C15 facilitates early viral spread by inhibiting NK cell contact

1
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  DOI: 10.1016/j.isci.2022.105510
  
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Nov 2022
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Cancer immunotherapies transition endothelial cells into HEVs that generate TCF1+ T lymphocyte niches through a feed-forward loop

1
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  DOI: 10.1016/j.ccell.2022.11.002
  
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Jun 2022
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Very-low-density lipoprotein receptor-enhanced lipid metabolism in pancreatic stellate cells promotes pancreatic fibrosis

1
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  DOI: 10.1016/j.immuni.2022.06.001
  
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May 2022
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Lymph node colonization induces tumor-immune tolerance to promote distant metastasis

1
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  DOI: 10.1016/j.cell.2022.04.019
  
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Apr 2022
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ILC precursors differentiate into metabolically distinct ILC1-like cells during Mycobacterium tuberculosis infection

1
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  DOI: 10.1016/j.celrep.2022.110715
  
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The interferon-stimulated gene RIPK1 regulates cancer cell intrinsic and extrinsic resistance to immune checkpoint blockade

1
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  DOI: 10.1016/j.immuni.2022.03.007
  
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mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment

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Mar 2022
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Type 1 innate lymphoid cells regulate the onset of Toxoplasma gondii-induced neuroinflammation

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Bacterial infection disrupts established germinal center reactions through monocyte recruitment and impaired metabolic adaptation

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Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

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Microbiota-specific T follicular helper cells drive tertiary lymphoid structures and anti-tumor immunity against colorectal cancer

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Reprogramming NK cells and macrophages via combined antibody and cytokine therapy primes tumors for elimination by checkpoint blockade

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Live Imaging of SARS-CoV-2 Infection in Mice Reveals that Neutralizing Antibodies Require Fc Function for Optimal Efficacy

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The pivotal role of cytotoxic NK cells in mediating the therapeutic effect of anti-CD47 therapy in mycosis fungoides

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Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA

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NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines

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Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1+ Dendritic Cells

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  Anti-mouse NK1.1 clone PK136
  
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Untitled document

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Pharmacologic modulation of RNA splicing enhances anti-tumor immunity

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Reliance on Cox10 and oxidative metabolism for antigen-specific NK cell expansion

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May 2021
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Viral infection of the ovaries compromises pregnancy and reveals innate immune mechanisms protecting fertility

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Group 1 innate lymphoid-cell-derived interferon-γ maintains anti-viral vigilance in the mucosal epithelium

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Interleukin-10 Prevents Pathological Microglia Hyperactivation following Peripheral Endotoxin Challenge

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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

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  DOI: 10.1016/j.stem.2021.04.011
  
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Genetically engineered myeloid cells rebalance the core immune suppression program in metastasis

1
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Telomere Stress Potentiates STING-Dependent Anti-tumor Immunity

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The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies

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Feb 2021
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Cytomegalovirus restricts ICOSL expression on antigen-presenting cells disabling T cell co-stimulation and contributing to immune evasion

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  DOI: 10.7554/eLife.59350
  
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Antagonistic Inflammatory Phenotypes Dictate Tumor Fate and Response to Immune Checkpoint Blockade

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Acute Plasmodium Infection Promotes Interferon-Gamma-Dependent Resistance to Ebola Virus Infection

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Natural killer cells modulate motor neuron-immune cell cross talk in models of Amyotrophic Lateral Sclerosis

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  DOI: 10.1038/s41467-020-15644-8
  
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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer

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The Immunological Organ Environment Dictates the Molecular and Cellular Pathways of Cytotoxic Antibody Activity

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Untitled document

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Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies

1
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  DOI: 10.1016/j.celrep.2019.04.091
  
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Untitled document

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Untitled document

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Interleukin-15 Complex Treatment Protects Mice from Cerebral Malaria by Inducing Interleukin-10-Producing Natural Killer Cells

1
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