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AIM2 in tregs restrains anti-PD-1 efficacy by reinforcing immune suppression in MC38 colorectal cancer

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1. scibot 27 Sep 2026
  
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  DOI: 10.1016/j.isci.2026.116082
  
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sciencedirect.com/science/article/pii/S2589004226014574
Jul 2026
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GABA promotes resistance to immunotherapy in patients with TLS-positive tumors

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1. scibot 11 Jul 2026
  
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  DOI: 10.1016/j.ccell.2026.06.006
  
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sciencedirect.com/science/article/pii/S153561082600293X
May 2026
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Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

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1. scibot 27 May 2026
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.celrep.2026.117409
  
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sciencedirect.com/science/article/pii/S2211124726004870
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Proteostasis sustains T cell differentiation potential and tumor-infiltrating lymphocyte function

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1. scibot 01 May 2026
  
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  DOI: 10.1016/j.cell.2026.02.019
  
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pmc.ncbi.nlm.nih.gov/articles/PMC13235417/
Mar 2026
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Gut microbiota-derived indole-3-lactic acid suppresses anti-PD-1 efficacy in esophageal squamous cell carcinoma

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1. scibot 26 Mar 2026
  
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  DOI: 10.1016/j.chom.2026.02.019
  
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sciencedirect.com/science/article/pii/S1931312826000879
Feb 2026
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Cytokine mRNA-based therapy alleviates dendritic cell and T cell paucity to eliminate aggressive pancreatic cancer in preclinical mouse models

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1. scibot 05 Feb 2026
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.ebiom.2026.106137
  
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sciencedirect.com/science/article/pii/S2352396426000186
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

PD-1 suppresses CAR signaling by forming the inhibitory signalosome colocalizing to CAR microclusters

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1. scibot 04 Feb 2026
  
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  DOI: 10.1038/s42003-025-09415-8
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12855910/
Dec 2025
www.nature.com www.nature.com

Dietary restriction reprograms CD8+ T cell fate to enhance anti-tumour immunity and immunotherapy responses

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1. scibot 14 Dec 2025
  
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  RRID:AB_1107747
  
  DOI: 10.1038/s42255-025-01415-6
  
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  Curator: @dhovakimyan1
  
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nature.com/articles/s42255-025-01415-6
Mar 2025
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Ligand-induced ubiquitination unleashes LAG3 immune checkpoint function by hindering membrane sequestration of signaling motifs

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1. scibot 20 Mar 2025
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.cell.2025.02.014
  
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sciencedirect.com/science/article/pii/S0092867425001990
Feb 2025
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FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma

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1. scibot 28 Feb 2025
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.ccell.2025.02.001
  
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sciencedirect.com/science/article/pii/S1535610825000534
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Synergism Between IL21 and Anti-PD-1 Combination Therapy is Underpinned by the Coordinated Reprogramming of the Immune Cellular Network in the Tumor Microenvironment

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1. scibot 10 Aug 2023
  
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  RRID:AB_1107747
  
  DOI: 10.1158/2767-9764.CRC-23-0012
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10402650/
Dec 2022
aacrjournals.org aacrjournals.org

Depletion of conventional type-1 dendritic cells in established tumors suppresses immunotherapy efficacy

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1. scibot 03 Dec 2022
  
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  RRID:AB_1107747
  
  DOI: 10.1158/0008-5472.CAN-22-1046
  
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aacrjournals.org/cancerres/article/82/23/4373/710691/Depletion-of-Conventional-Type-1-Dendritic-Cells
52.53.155.43 52.53.155.43

can-22-1046-html.html

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1. scibot 01 Dec 2022
  
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  RRID:AB_1107747
  
  DOI: 10.1158/0008-5472.CAN-22-1046
  
  Resource: (Bio X Cell Cat# BE0033-2, RRID:AB_1107747)
  
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52.53.155.43/31121aea6deac1c0e5bfa6acfce4eeee5d0658c1/can-22-1046-html.html
Jun 2022
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Neuropilin-1 cooperates with PD-1 in CD8+ T-cells predicting outcomes in melanoma patients treated with anti-PD1

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1. scibot 17 Jun 2022
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.isci.2022.104353
  
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sciencedirect.com/science/article/pii/S2589004222006241
Apr 2022
aacrjournals.org aacrjournals.org

Tankyrase Inhibitor OM-153 Demonstrates Antitumor Efficacy and a Therapeutic Window in Mouse Models

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1. scibot 27 Apr 2022
  
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  RRID:AB_1107747
  
  DOI: 10.1158/2767-9764.CRC-22-0027
  
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aacrjournals.org/cancerrescommun/article/2/4/233/694510/The-Tankyrase-Inhibitor-OM-153-Demonstrates
Mar 2022
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Tumor-derived Jagged1 promotes cancer progression through immune evasion

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1. scibot 09 Mar 2022
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.celrep.2022.110492
  
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sciencedirect.com/science/article/pii/S221112472200225X
Oct 2021
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Inhibition of the BTK-IDO-mTOR axis promotes differentiation of monocyte-lineage dendritic cells and enhances anti-tumor T cell immunity

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1. scibot 06 Oct 2021
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.immuni.2021.09.005
  
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sciencedirect.com/science/article/pii/S1074761321003903
Sep 2020
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

GPC1 specific CAR-T cells eradicate established solid tumor without adverse effects and synergize with anti-PD-1 Ab

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1. scibot 17 Sep 2020
  
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  RRID:AB_1107747
  
  DOI: 10.7554/eLife.49392
  
  Resource: (Bio X Cell Cat# BE0033-2, RRID:AB_1107747)
  
  Curator: @evieth
  
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  RRID:AB_1107747 RRIDCUR:Validated
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ncbi.nlm.nih.gov/pmc/articles/PMC7108862/
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Small Molecule Inhibition of GSK-3 Specifically Inhibits the Transcription of Inhibitory Co-receptor LAG-3 for Enhanced Anti-tumor Immunity

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1. scibot 05 Sep 2020
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.celrep.2020.01.076
  
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  Curator: @ethanbadger
  
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  RRID:AB_1107747 RRIDCUR:Validated
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sciencedirect.com/science/article/pii/S2211124720301017
Jan 2020
www.cell.com www.cell.com

Acylglycerol Kinase Maintains Metabolic State and Immune Responses of CD8+ T Cells

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1. scibot 13 Jan 2020
  
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  RRID:AB_1107747
  
  DOI: 10.1016/j.cmet.2019.05.016
  
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  Curator: @ethanbadger
  
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  RRID:AB_1107747 RRIDCUR:Validated
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cell.com/cell-metabolism/fulltext/S1550-4131(19)30256-6
Nov 2018
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The Mevalonate Pathway Is a Druggable Target for Vaccine Adjuvant Discovery

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1. scibot 05 Nov 2018
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S0092867418311711
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Co-inhibitory Molecule B7 Superfamily Member 1 Expressed by Tumor-Infiltrating Myeloid Cells Induces Dysfunction of Anti-tumor CD8+ T Cells

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1074761318301158
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Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c+CD103+ Monocytic Antigen-Presenting Cells in Tumors

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1. scibot 05 Nov 2018
  
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  BP0033-2
  
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sciencedirect.com/science/article/pii/S1074761317305721