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Targeting TMED4 enhances CD8+ T cell function and CAR T cell efficacy in solid tumors through the IRE1α-autophagy axis

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1. scibot 16 Jun 2026
  
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  DOI: 10.1126/sciadv.aee0517
  
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science.org/doi/10.1126/sciadv.aee0517
Mar 2026
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Tuft cells promote reactivation of memory Th2 cells and are required for protective immunity to intestinal helminth re-infection

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1. scibot 31 Mar 2026
  
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  DOI: 10.1016/j.immuni.2026.02.022
  
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sciencedirect.com/science/article/pii/S1074761326000920
Feb 2026
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16-h fasting optimizes cancer immunotherapy in mice and humans

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1. scibot 20 Feb 2026
  
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  DOI: 10.1016/j.cmet.2026.01.015
  
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sciencedirect.com/science/article/pii/S1550413126000148
Jan 2026
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Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer

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1. scibot 06 Jan 2026
  
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  DOI: 10.1016/j.xcrm.2025.102534
  
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sciencedirect.com/science/article/pii/S266637912500607X
Dec 2025
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Activated T cells degrade extracellular proteins to enhance effector functions

1
1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116797
  
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sciencedirect.com/science/article/pii/S2211124725015694
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Tumor-produced ammonia is metabolized by regulatory T cells to further impede anti-tumor immunity

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1. scibot 25 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.034
  
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sciencedirect.com/science/article/pii/S0092867425013698
Sep 2025
www.biorxiv.org www.biorxiv.org

Lactate Blocks Tertiary Lymphoid Structure Formation by Inhibiting B Cell Chemotaxis

1
1. scibot 10 Sep 2025
  
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  DOI: 10.1101/2025.08.30.673054
  
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biorxiv.org/content/10.1101/2025.08.30.673054v1
pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov

Assessing the impact of TET2 and TET3 deletion in TCRalpha and TCRbeta repertoire in murine CD4 T cells in physiological and pathophysiological conditions

1
1. scibot 07 Sep 2025
  
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  RRID:AB_11124344
  
  DOI: 10.3389/fimmu.2025.1638500
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12405334/
Aug 2025
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Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

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1. scibot 01 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.007
  
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sciencedirect.com/science/article/pii/S1074761325003164
Jun 2025
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Prolonged but finite antigen presentation promotes reversible defects of “helpless” memory CD8+ T cells

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1. scibot 26 Jun 2025
  
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  DOI: 10.1016/j.immuni.2025.05.025
  
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sciencedirect.com/science/article/pii/S1074761325002468
Apr 2025
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Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity

1
1. scibot 01 Apr 2025
  
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  DOI: 10.1016/j.immuni.2025.03.004
  
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sciencedirect.com/science/article/pii/S1074761325001232
Feb 2025
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In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313

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1. scibot 06 Feb 2025
  
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  DOI: 10.1016/j.immuni.2025.01.009
  
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sciencedirect.com/science/article/pii/S1074761325000342
Dec 2024
www.nature.com www.nature.com

Concomitant loss of TET2 and TET3 results in T cell expansion and genomic instability in mice

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1. scibot 06 Dec 2024
  
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  RRID:AB_11124344
  
  DOI: 10.1038/s42003-024-07312-0
  
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nature.com/articles/s42003-024-07312-0
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EZH2 inhibition enhances T cell immunotherapies by inducing lymphoma immunogenicity and improving T cell function

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1. scibot 06 Dec 2024
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.ccell.2024.11.006
  
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sciencedirect.com/science/article/pii/S1535610824004410
Aug 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SOX10 loss sensitizes melanoma cells to cytokine-mediated inflammatory cell death

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1. scibot 18 Aug 2024
  
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  RRID:AB_11124344
  
  DOI: 10.1158/1541-7786.MCR-23-0290
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10842433/
May 2024
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IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy

1
1. scibot 14 May 2024
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.xcrm.2024.101567
  
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sciencedirect.com/science/article/pii/S2666379124002593
Jan 2024
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Fc-fused IL-7 provides broad antiviral effects against respiratory virus infections through IL-17A-producing pulmonary innate-like T cells

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1. scibot 21 Jan 2024
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.xcrm.2023.101362
  
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sciencedirect.com/science/article/pii/S2666379123005797
Dec 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

FGFR3 alterations in bladder cancer stimulate serine synthesis to induce immune-inert macrophages that suppress T-cell recruitment and activation

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1. scibot 20 Dec 2023
  
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  RRID:AB_11124344
  
  DOI: 10.1158/0008-5472.CAN-23-1065
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10722136/
52.53.155.43 52.53.155.43

can-23-1065-html.html

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1. scibot 01 Dec 2023
  
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  AB_11124344
  
  DOI: 10.1158/0008-5472.can-23-1065
  
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2. scibot 01 Dec 2023
  
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  AB_11124344
  
  DOI: 10.1158/0008-5472.can-23-1065
  
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52.53.155.43/9a4ebc518d925889ddaa33b397b4737aebb3357f/can-23-1065-html.html
Nov 2023
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An engineered immunocytokine with collagen affinity improves the tumor bioavailability, tolerability, and therapeutic efficacy of IL-2

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1. scibot 22 Nov 2023
  
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  DOI: 10.1016/j.xcrm.2023.101289
  
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sciencedirect.com/science/article/pii/S2666379123004834
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FBXO38 mediates FGL1 ubiquitination and degradation to enhance cancer immunity and suppress inflammation

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1. scibot 17 Nov 2023
  
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  DOI: 10.1016/j.celrep.2023.113362
  
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sciencedirect.com/science/article/pii/S2211124723013748
Aug 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

Original research: Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

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1. scibot 12 Aug 2023
  
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  DOI: 10.1136/jitc-2022-006457
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10414095/
Jan 2023
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

SARS-CoV-2 variants induce distinct disease and impact in the bone marrow and thymus of mice

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1. scibot 27 Jan 2023
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.isci.2023.105972
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9838028/
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Lymphatic PD-L1 Expression Restricts Tumor-Specific CD8+ T-cell Responses

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1. scibot 12 Jan 2023
  
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  DOI: 10.1158/0008-5472.CAN-21-0633
  
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ncbi.nlm.nih.gov/pmc/articles/PMC9398148/
Sep 2022
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Tumor-associated macrophages are shaped by intratumoral high potassium via Kir2.1

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1. scibot 15 Sep 2022
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.cmet.2022.08.016
  
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sciencedirect.com/science/article/pii/S155041312200359X
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Balance between immunoregulatory B cells and plasma cells drives pancreatic tumor immunity

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1. scibot 13 Sep 2022
  
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  DOI: 10.1016/j.xcrm.2022.100744
  
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sciencedirect.com/science/article/pii/S2666379122002932
Apr 2022
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Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory

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1. scibot 14 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110632
  
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sciencedirect.com/science/article/pii/S2211124722003849
Feb 2022
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Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics

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1. scibot 02 Feb 2022
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.celrep.2022.110334
  
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sciencedirect.com/science/article/pii/S221112472200050X
Jan 2022
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Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis

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1. scibot 12 Jan 2022
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.isci.2021.103677
  
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sciencedirect.com/science/article/pii/S2589004221016473
Dec 2021
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SOX10 requirement for melanoma tumor growth is due, in part, to immune-mediated effects

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1. scibot 08 Dec 2021
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.celrep.2021.110085
  
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sciencedirect.com/science/article/pii/S221112472101576X
Jun 2021
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A novel mouse AAV6 hACE2 transduction model of wild-type SARS-CoV-2 infection studied using synDNA immunogens

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1. scibot 26 Jun 2021
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.isci.2021.102699
  
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sciencedirect.com/science/article/pii/S2589004221006672
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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

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1. scibot 22 Jun 2021
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.cell.2021.05.027
  
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sciencedirect.com/science/article/pii/S0092867421006577
Jan 2020
www.cell.com www.cell.com

Re-education of Tumor-Associated Macrophages by CXCR2 Blockade Drives Senescence and Tumor Inhibition in Advanced Prostate Cancer

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1. scibot 13 Jan 2020
  
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  RRID:AB_11124344
  
  DOI: 10.1016/j.celrep.2019.07.068
  
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  RRID:AB_11124344 RRIDCUR:Validated
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cell.com/cell-reports/fulltext/S2211-1247(19)30972-6
Nov 2018
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Non-conventional Inhibitory CD4+Foxp3−PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S153561081830223X