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    Base editing rescues acid α-glucosidase function in infantile-onset Pompe disease patient-derived cells
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  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin reduces endoplasmic reticulum stress‐induced apoptosis by decreasing mitochondrial hyperpolarization and caspase‐12 in INS‐1 pancreatic β‐cells
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    K29-linked free polyubiquitin chains affect ribosome biogenesis and direct ribosomal proteins to the intranuclear quality control compartment
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    Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer
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    Imaging brain glucose metabolism in vivo reveals propionate as a major anaplerotic substrate in pyruvate dehydrogenase deficiency
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    A comparative analysis of paxillin and Hic-5 proximity interactomes
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    Nesfatin-1 and nesfatin-1-like peptide attenuate hepatocyte lipid accumulation and nucleobindin-1 disruption modulates lipid metabolic pathways
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  10. May 2024
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    Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro
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    Tissue-specific landscape of protein aggregation and quality control in an aging vertebrate
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    Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals
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    Development of nitroalkene-based inhibitors to target STING-dependent inflammation
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    TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
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    Characterization of a novel HDAC2 pathogenetic variant: a missing puzzle piece for chromatinopathies
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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Neuroprotective effects of G9a inhibition through modulation of peroxisome-proliferator activator receptor gamma-dependent pathways by miR-128
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  18. 52.53.155.43 52.53.155.43
    β-adrenergic stimulation-induced PVAT dysfunction in male sex: a role for 11β-hydroxysteroid dehydrogenase-1
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    FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice
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    SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells
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    Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation
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    Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission
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  23. Apr 2024
  24. www.sciencedirect.com www.sciencedirect.com
    Accumulation of APP C-terminal fragments causes endolysosomal dysfunction through the dysregulation of late endosome to lysosome-ER contact sites
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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    Duodenal mucosa of untreated celiac disease patients has altered expression of the GAS6 and PROS1 and the negative regulator tyrosine kinase TAM receptors subfamily
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    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
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    Kit Ligand and Kit receptor tyrosine kinase sustain synaptic inhibition of Purkinje cells
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  29. Mar 2024
  30. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Local mitochondrial replication in the periphery of neurons requires the eEF1A1 protein and thetranslation of nuclear-encoded proteins
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    Prolactin promotes the recruitment of main olfactory bulb cells and enhances the behavioral exploration toward a socio-sexual stimulus in female mice
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    A gut-derived hormone regulates cholesterol metabolism
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    Unmoving and uninflamed: Characterizing neuroinflammatory dysfunction in the Wistar-Kyoto rat model of depression
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    A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development
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  36. www.nature.com www.nature.com
    Combinatorial selective ER-phagy remodels the ER during neurogenesis
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  37. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
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    Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology
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  39. Feb 2024
  40. dx.doi.org dx.doi.org
    Role for Non-Genomic Estrogen Signaling in Male Fertility
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      DOI: 10.1210/endocr/bqad180

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  41. aacrjournals.org aacrjournals.org
    Engagement of CD99 activates distinct programs in Ewing sarcoma and macrophages
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      DOI: 10.1158/2326-6066.CIR-23-0440

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    aacrjournals.org/cancerimmunolres/article/12/2/247/733768/Engagement-of-CD99-Activates-Distinct-Programs-in
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    Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells
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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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    Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting
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    Simulated Microgravity Enhances Adipocyte Maturation and Glucose Uptake via Increased Cortical Actin Remodeling
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    Influenza A virus propagation requires the activation of the unfolded protein response and the accumulation of insoluble protein aggregates
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    Retrospective identification of cell-intrinsic factors that mark pluripotency potential in rare somatic cells
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    Cytotoxin-mediated silk gland organ dysfunction diverts resources to enhance silkworm fecundity by potentiating nutrient-sensing IIS/TOR pathways
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    Collaborative regulation of yeast SPT-Orm2 complex by phosphorylation and ceramide
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    Glioblastoma and its treatment are associated with extensive accelerated brain aging
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    Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion
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    A Mosaic Variant in CTNNB1/β-catenin as a Novel Cause for Osteopathia Striata With Cranial Sclerosis
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    OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB
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    Protein 4.1N plays a cell-type specific role in hippocampal glutamatergic synapse regulation
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    The male pachynema-specific protein MAPS drives phase separation in vitro and regulates sex body formation and chromatin behaviors in vivo
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  57. Dec 2023
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    MEK-inhibitors decrease Nfix in muscular dystrophy but induce unexpected calcifications, partially rescued with Cyanidin diet
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    FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration
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    A novel patient-derived meningioma spheroid model as a tool to study and treat epithelial-to-mesenchymal transition (EMT) in meningiomas
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  61. journals.plos.org journals.plos.org
    The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages
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    Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33
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    The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells
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    Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke
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  65. Nov 2023
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    The γ-secretase substrate proteome and its role in cell signaling regulation
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    Coexistence of apoptosis, pyroptosis, and necroptosis pathways in Celiac Disease
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    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
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    MRTX1719 Is an MTA-Cooperative PRMT5 Inhibitor That Exhibits Synthetic Lethality in Preclinical Models and Patients with MTAP-Deleted Cancer
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  70. Oct 2023
  71. link.springer.com link.springer.com
    Serotonin 2C receptors are also important in head-twitch responses in male mice
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    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
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    Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury
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  75. Sep 2023
  76. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Generation of a human Tropomyosin 1 knockout iPSC line
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  77. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Histone bivalency regulates the timing of cerebellar granule cell development
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    Base editing corrects the common Salla disease SLC17A5 c.115C>T variant
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  79. Aug 2023
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    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    A Zpr1 co-chaperone mediates folding of eukaryotic translation elongation factor 1A via a GTPase cycle
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    FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
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  84. Jul 2023
  85. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    5‐Hydroxymethylfurfural reduces skeletal muscle superoxide production and modifies force production in rats exposed to hypobaric hypoxia
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  86. 52.53.155.43 52.53.155.43
    Generation of a human Tropomyosin 1 knockout iPSC line
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    Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons
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    The integrated stress response effector ATF4 is an obligatory metabolic activator of NRF2
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  89. Jun 2023
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    Chemical genomics reveals targetable programs of human cancers rooted in pluripotency
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    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
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    Characterization of Hofbauer cell polarization and VEGF localization in human term placenta from active and inactive pregnant individuals
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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  95. May 2023
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    Protocol for biallelic tagging of an endogenous gene using CRISPR-Cas9 in human cells
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    Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons
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    Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
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  99. Apr 2023
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    A hyper-quiescent chromatin state formed during aging is reversed by regeneration
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    Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis
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    Particulate matter exposure and chronic cerebral hypoperfusion promote oxidative stress and induce neuronal and oligodendrocyte apoptosis in male mice
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    Boosting BDNF in muscle rescues impaired in vivo axonal transport in a mouse model of DI-CMTC peripheral neuropathy
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis
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    The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage
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  107. Mar 2023
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    NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
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    A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
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    FAM193A is a positive regulator of p53 activity
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    Bullatine A Has an Antidepressant Effect in Chronic Social Defeat Stress Mice; Implication of Microglial Inflammasome
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    TGF-β in the microenvironment induces a physiologically occurring immune-suppressive senescent state
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    Cofilin promotes tau pathology in Alzheimer’s disease
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    PHGDH-mediated endothelial metabolism drives glioblastoma resistance to chimeric antigen receptor T cell immunotherapy
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    CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD2
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    Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria
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    RIF1 suppresses the formation of single-stranded ultrafine anaphase bridges via protein phosphatase 1
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  119. Jan 2023
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    A circadian clock translational control mechanism targets specific mRNAs to cytoplasmic messenger ribonucleoprotein granules
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    Abl2 Kinase Differentially Regulates iGluRs Current Activity and Synaptic Localization
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    Hippocampal dentate gyri proteomics reveals Wnt signaling involvement in the behavioral impairment in the THRSP-overexpressing ADHD mouse model
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    Neoadjuvant chemotherapy is associated with an altered metabolic profile and increased cancer stemness in patients with pancreatic ductal adenocarcinoma
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    Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
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    Allosteric Inhibition of c-Abl to Induce Unfolded Protein Response and Cell Death in Multiple Myeloma
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    In vitro-derived medium spiny neurons recapitulate human striatal development and complexity at single-cell resolution
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    Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy
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    Vibrio parahaemolyticus prey targeting requires autoproteolysis-triggered dimerization of the type VI secretion system effector RhsP
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  132. Nov 2022
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    Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression
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    Antiviral function and viral antagonism of the rapidly evolving dynein activating adaptor NINL
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    hnRNP A1 dysfunction in oligodendrocytes contributes to the pathogenesis of multiple sclerosis
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  137. www.researchsquare.com www.researchsquare.com
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  138. academic.oup.com academic.oup.com
    Angiotensin II regulates mitochondrial mTOR pathway activity dependent on acyl CoA synthetase 4 in adrenocortical cells
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      DOI: 10.1210/endocr/bqac170

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    Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
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  140. Oct 2022
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    The mineralocorticoid receptor functions as a key glucose regulator in the skeletal muscle of zebrafish
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      DOI: 10.1210/endocr/bqac149

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  142. www.nature.com www.nature.com
    Co-alterations of circadian clock gene transcripts in human placenta in preeclampsia
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      DOI: 10.1038/s41598-022-22507-3

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  143. Sep 2022
  144. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Meprin β expression modulates the interleukin-6 mediated JAK2-STAT3 signaling pathway in ischemia/reperfusion-induced kidney injury
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    Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo
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      DOI: 10.1007/s00401-022-02491-8

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    Genetic- and diet-induced ω-3 fatty acid enrichment enhances TRPV4-mediated vasodilation in mice
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  147. Aug 2022
  148. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    GSK3β Inhibition Is the Molecular Pivot That Underlies the Mir-210-Induced Attenuation of Intrinsic Apoptosis Cascade during Hypoxia
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Septin7 is indispensable for proper skeletal muscle architecture and function
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  150. Jul 2022
  151. www.sciencedirect.com www.sciencedirect.com
    GPCR kinases generate an APH1A phosphorylation barcode to regulate amyloid-β generation
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    Ubiquitin profiling of lysophagy identifies actin stabilizer CNN2 as a target of VCP/p97 and uncovers a link to HSPB1
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  153. Jun 2022
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    Prkn knockout mice show autistic-like behaviors and aberrant synapse formation
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  155. www.sciencedirect.com www.sciencedirect.com
    UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth
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  156. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ANGT_HUMAN[448–462], an Anorexigenic Peptide Identified using Plasma Peptidomics
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      DOI: 10.1210/jendso/bvac082

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  157. www.sciencedirect.com www.sciencedirect.com
    The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
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    Cryo-EM structure of the entire FtsH-HflKC AAA protease complex
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    Unexpected short- and long-term effects of chronic adolescent HU-210 exposure on emotional behavior
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      DOI: 10.1016/j.neuropharm.2022.109155

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  160. May 2022
  161. www.sciencedirect.com www.sciencedirect.com
    The oocyte spindle midzone pauses Cdk1 inactivation during fertilization to enable male pronuclear formation and embryo development
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  162. royalsocietypublishing.org royalsocietypublishing.org
    A novel methodological approach to simultaneously extract high-quality total RNA and proteins from cortical and trabecular bone
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      DOI: 10.1098/rsob.210387

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  163. journals.sagepub.com journals.sagepub.com
    Regulation of clock and clock-controlled genes during morphine reward and reinforcement: Involvement of the period 2 circadian clock - Raly James Perez Custodio, Mikyung Kim, Leandro Val Sayson, Darlene Mae Ortiz, Danilo Buctot, Hyun Jun Lee, Jae Hoon Cheong, Hee Jin Kim, 2022
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  164. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
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      DOI: 10.1096/fj.202200154R

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  165. Apr 2022
  166. www.sciencedirect.com www.sciencedirect.com
    RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development
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    Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors
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  168. physoc.onlinelibrary.wiley.com physoc.onlinelibrary.wiley.com
    Loss of cardiac myosin light chain kinase contributes to contractile dysfunction in right ventricular pressure overload
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    FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
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  170. Mar 2022
  171. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Melatonin prevents early pituitary dysfunction induced by sucrose-rich diets
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    Late Onset Cardiovascular Dysfunction in Adult Mice Resulting from Galactic Cosmic Ray Exposure
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    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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    Parallel kinase pathways stimulate actin polymerization at depolarized mitochondria
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  175. www.nature.com www.nature.com
    Symmetric and asymmetric receptor conformation continuum induced by a new insulin
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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  177. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Baicalein—A Potent Pro-Homeostatic Regulator of Microglia in Retinal Ischemic Injury
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  178. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice
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  179. Feb 2022
  180. journals.plos.org journals.plos.org
    FluoRNT: A robust, efficient assay for the detection of neutralising antibodies against yellow fever virus 17D
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    Paternal transmission of the Wolbachia CidB toxin underlies cytoplasmic incompatibility
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  182. www.sciencedirect.com www.sciencedirect.com
    PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways
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    Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
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    Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly
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  185. Jan 2022
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    Tissue differences in the exosomal/small extracellular vesicle proteome and their potential as indicators of altered tissue metabolism
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    Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice
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    Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1
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    Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods
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    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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  191. Dec 2021
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    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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  193. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
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    Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity
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    Regulation of AKT signaling in mouse uterus
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    Suppression of MYC transcription activators by the immune cofactor NPR1 fine-tunes plant immune responses
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    REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion
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    Closantel is an allosteric inhibitor of human Taspase1
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    Association of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 With Angiotensin II Type 1 Receptor Impacts Mitochondrial Quality Control, Offering Promise for the Treatment of Vascular Senescence
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  200. Nov 2021
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    Sensor histidine kinases mediate ABA and osmostress signaling in the moss Physcomitrium patens
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    AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells
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    TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
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    A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction
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    Nanobody-mediated macromolecular crowding induces membrane fission and remodeling in the African trypanosome
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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  209. Oct 2021
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    Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila
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    Adrenergically induced translocation of red blood cell β-adrenergic sodium-proton exchangers has ecological relevance for hypoxic and hypercapnic white seabass
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    Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
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    Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience
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  214. Sep 2021
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    Low striatal T3 is implicated in inattention and memory impairment in an ADHD mouse model overexpressing thyroid hormone-responsive protein
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    Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons
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    Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
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    A hydride transfer complex reprograms NAD metabolism and bypasses senescence
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    Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis
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    Homeostatic control of nuclear-encoded mitochondrial gene expression by the histone variant H2A.Z is essential for neuronal survival
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    Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors
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    Characterization of the subunit composition and structure of adult human glycine receptors
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    KDM6B epigenetically regulated-interleukin-6 expression in the dorsal root ganglia and spinal dorsal horn contributes to the development and maintenance of neuropathic pain following peripheral nerve injury in male rats
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  227. academic.oup.com academic.oup.com
    Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Female Mice During Chronic Undernutrition
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