334 Matching Annotations
  1. Last 7 days
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    Base editing rescues acid α-glucosidase function in infantile-onset Pompe disease patient-derived cells
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      DOI: 10.1016/j.omtn.2024.102220

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    ncbi.nlm.nih.gov/pmc/articles/PMC11214518/
  3. Jun 2024
  4. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Insulin reduces endoplasmic reticulum stress‐induced apoptosis by decreasing mitochondrial hyperpolarization and caspase‐12 in INS‐1 pancreatic β‐cells
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      DOI: 10.14814/phy2.16106

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    ncbi.nlm.nih.gov/pmc/articles/PMC11181300/
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    Nesfatin-1 and nesfatin-1-like peptide attenuate hepatocyte lipid accumulation and nucleobindin-1 disruption modulates lipid metabolic pathways
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      DOI: 10.1038/s42003-024-06314-2

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    nature.com/articles/s42003-024-06314-2
  6. May 2024
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    Protocol for identifying OXCT1-mediated LACTB succinylation sites in vitro
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    1. scibot 30 May 2024
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      DOI: 10.1016/j.xpro.2024.103088

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    sciencedirect.com/science/article/pii/S2666166724002533
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    An evolutionarily conserved mechanism controls reversible amyloids of pyruvate kinase via pH-sensing regions
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    1. scibot 24 May 2024
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    sciencedirect.com/science/article/pii/S1534580724002715
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    TDP1 mutation causing SCAN1 neurodegenerative syndrome hampers the repair of transcriptional DNA double-strand breaks
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    sciencedirect.com/science/article/pii/S2211124724005424
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    Acyl-CoA synthetase 4 modulates mitochondrial function in breast cancer cells
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    sciencedirect.com/science/article/pii/S2405844024066702
  11. 52.53.155.43 52.53.155.43
    SIRT1 mediates the antagonism of Wnt/β-catenin pathway by vitamin D in colon carcinoma cells
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  12. 52.53.155.43 52.53.155.43
    Phenotype-specific melanoma uptake of fatty acid from human adipocytes activates AXL and CAV1-dependent β-catenin nuclear accumulation
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    Activity-driven synaptic translocation of LGI1 controls excitatory neurotransmission
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    1. scibot 03 May 2024
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  14. Apr 2024
  15. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Cross-species human disease modeling using patient-derived extracellular vesicles
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      DOI: 10.1242/dmm.050412

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    ncbi.nlm.nih.gov/pmc/articles/PMC11007864/
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    A senescence restriction point acting on chromatin integrates oncogenic signals
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  17. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Targeting of vulnerabilities of drug-tolerant persisters identified through functional genetics delays tumor relapse
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      DOI: 10.1016/j.xcrm.2024.101471

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    ncbi.nlm.nih.gov/pmc/articles/PMC10983104/
  18. Mar 2024
  19. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Doxorubicin‑induced cardiomyopathy is mitigated by empagliflozin via the modulation of endoplasmic reticulum stress pathways
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    1. scibot 27 Mar 2024
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      DOI: 10.3892/mmr.2024.13198

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    ncbi.nlm.nih.gov/pmc/articles/PMC10958136/
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    Lysosomal damage sensing and lysophagy initiation by SPG20-ITCH
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    sciencedirect.com/science/article/pii/S1097276524001722
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    A gut-derived hormone regulates cholesterol metabolism
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      DOI: 10.1016/j.cell.2024.02.024

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    sciencedirect.com/science/article/pii/S0092867424002265
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    A surge in cytoplasmic viscosity triggers nuclear remodeling required for Dux silencing and pre-implantation embryo development
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    sciencedirect.com/science/article/pii/S2211124724002456
  23. www.nature.com www.nature.com
    Combinatorial selective ER-phagy remodels the ER during neurogenesis
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      DOI: 10.1038/s41556-024-01356-4

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    nature.com/articles/s41556-024-01356-4
  24. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    ALK upregulates POSTN and WNT signaling to drive neuroblastoma
    1
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  25. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A technique for repeated blood and cerebrospinal fluid sampling from individual rats over time without the need for repeated anesthesia
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      DOI: 10.1038/s41598-024-55666-6

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    ncbi.nlm.nih.gov/pmc/articles/PMC10908789/
  26. Feb 2024
  27. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The hypothalamic–pituitary–thyroid axis is intact in male Irs4 knockout mice
    1
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      DOI: 10.1530/ETJ-23-0054

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    ncbi.nlm.nih.gov/pmc/articles/PMC10895334/
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    Bacterial host adaptation through sequence and structural variations of a single type III effector gene
    4
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      DOI: 10.1016/j.isci.2024.109224

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    sciencedirect.com/science/article/pii/S2589004224004450
  29. link.springer.com link.springer.com
    Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells
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      DOI: 10.1038/s41598-024-54758-7

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    A synergistic two-drug therapy specifically targets a DNA repair dysregulation that occurs in p53-deficient colorectal and pancreatic cancers
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      DOI: 10.1016/j.xcrm.2024.101434

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    sciencedirect.com/science/article/pii/S2666379124000570
  31. www.biorxiv.org www.biorxiv.org
    Simulated Microgravity Enhances Adipocyte Maturation and Glucose Uptake via Increased Cortical Actin Remodeling
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      DOI: 10.1101/2024.01.30.578049

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  32. link.springer.com link.springer.com
    Targeting of H19/cell adhesion molecules circuitry by GSK-J4 epidrug inhibits metastatic progression in prostate cancer
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      DOI: 10.1186/s12935-024-03231-6

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  33. Jan 2024
  34. www.jneurosci.org www.jneurosci.org
    Synaptotagmin 9 Modulates Spontaneous Neurotransmitter Release in Striatal Neurons by Regulating Substance P Secretion
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      DOI: 10.1523/JNEUROSCI.1857-22.2023

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    jneurosci.org/content/43/9/1475
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    OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB
    1
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      DOI: 10.1016/j.molcel.2023.11.042

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    sciencedirect.com/science/article/pii/S1097276523010195
  36. Dec 2023
  37. www.sciencedirect.com www.sciencedirect.com
    FEZ1 participates in human embryonic brain development by modulating neuronal progenitor subpopulation specification and migration
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      DOI: 10.1016/j.isci.2023.108497

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    sciencedirect.com/science/article/pii/S2589004223025749
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    FANCD2-dependent mitotic DNA synthesis relies on PCNA K164 ubiquitination
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      DOI: 10.1016/j.celrep.2023.113523

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    sciencedirect.com/science/article/pii/S2211124723015358
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    HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function
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      DOI: 10.1016/j.devcel.2023.11.012

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    sciencedirect.com/science/article/pii/S153458072300610X
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    Cell stretching activates an ATM mechano-transduction pathway that remodels cytoskeleton and chromatin
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      DOI: 10.1016/j.celrep.2023.113555

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    sciencedirect.com/science/article/pii/S221112472301567X
  41. journals.plos.org journals.plos.org
    The circadian regulator PER1 promotes cell reprogramming by inhibiting inflammatory signaling from macrophages
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      DOI: 10.1371/journal.pbio.3002419

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    journals.plos.org/plosbiology/article
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Epigenetic priming of an epithelial enhancer by p63 and CTCF controls expression of a skin-restricted gene XP33
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      DOI: 10.1038/s41420-023-01716-3

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    ncbi.nlm.nih.gov/pmc/articles/PMC10709559/
  43. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells
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      DOI: 10.3389/fcell.2023.1222809

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    ncbi.nlm.nih.gov/pmc/articles/PMC10687637/
  44. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Leakage beyond the primary lesion: A temporal analysis of cerebrovascular dysregulation at sites of hippocampal secondary neurodegeneration following cortical photothrombotic stroke
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      DOI: 10.1111/jnc.16008

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    onlinelibrary.wiley.com/doi/10.1111/jnc.16008
  45. Nov 2023
  46. www.sciencedirect.com www.sciencedirect.com
    The γ-secretase substrate proteome and its role in cell signaling regulation
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    Autophagy-mediated control of ribosome homeostasis in oncogene-induced senescence
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    Serotonin 2C receptors are also important in head-twitch responses in male mice
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    Effector memory T cells induce innate inflammation by triggering DNA damage and a non-canonical STING pathway in dendritic cells
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    Distinct mechanisms drive sequential internalization and degradation of GABAARs during global ischemia and reperfusion injury
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    APE1-dependent base excision repair of DNA photodimers in human cells
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    Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement
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    Sertoli Cell–Conditioned Medium Induces Differentiation of Bone Marrow–Derived Mesenchymal Stem Cells to Male Germ-Like Cells in Busulfan-Induced Azoospermic Mouse Model
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    Base editing corrects the common Salla disease SLC17A5 c.115C>T variant
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    Anillin forms linear structures and facilitates furrow ingression after septin and formin depletion
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  60. Aug 2023
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    A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
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    TTBK1 and CK1 inhibitors restore TDP-43 pathology and avoid disease propagation in lymphoblast from Alzheimer’s disease patients
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    FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging
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  66. Jul 2023
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    PLEKHS1 drives PI3Ks and remodels pathway homeostasis in PTEN-null prostate
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    Marchf6 E3 ubiquitin ligase critically regulates endoplasmic reticulum stress, ferroptosis, and metabolic homeostasis in POMC neurons
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    Uterine-specific Ezh2 deletion enhances stromal cell senescence and impairs placentation, resulting in pregnancy loss
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    Ex vivo immunocapture and functional characterization of cell-type-specific mitochondria using MitoTag mice
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    MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
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    ATF3 stimulates FSHβ expression in vitro, but is dispensable for FSH production in murine gonadotropes in vivo
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    The E3 ubiquitin ligase FBXL6 controls the quality of newly synthesized mitochondrial ribosomal proteins
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  75. May 2023
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    Protocol for biallelic tagging of an endogenous gene using CRISPR-Cas9 in human cells
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    Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype
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    Mitofusin 2 sustains the axonal mitochondrial network to support presynaptic Ca2+ homeostasis and the synaptic vesicle cycle in rat hippocampal axons
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    Tumor treating fields affect mesothelioma cell proliferation by exerting histotype-dependent cell cycle checkpoint activations and transcriptional modulations
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  80. Apr 2023
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    Changes in nascent chromatin structure regulate activation of the pro-fibrotic transcriptome and myofibroblast emergence in organ fibrosis
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    PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection
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    VGLL2-NCOA2 leverages developmental programs for pediatric sarcomagenesis
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    The mitochondrial protease OMA1 acts as a metabolic safeguard upon nuclear DNA damage
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  85. Mar 2023
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    NLRC5 affects diet-induced adiposity in female mice and co-regulates peroxisome proliferator-activated receptor PPARγ target genes
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    A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy
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    Intracytoplasmic-membrane development in alphaproteobacteria involves the homolog of the mitochondrial crista-developing protein Mic60
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    Cofilin promotes tau pathology in Alzheimer’s disease
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    3D human induced pluripotent stem cell–derived bioengineered skeletal muscles for tissue, disease and therapy modeling
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    Synaptic vesicle proteins are selectively delivered to axons in mammalian neurons
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    Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome
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    UBP12 and UBP13 deubiquitinases destabilize the CRY2 blue light receptor to regulate Arabidopsis growth
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    The focal adhesion protein β-parvin controls cardiomyocyte shape and sarcomere assembly in response to mechanical load
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    Regulation of clock and clock-controlled genes during morphine reward and reinforcement: Involvement of the period 2 circadian clock - Raly James Perez Custodio, Mikyung Kim, Leandro Val Sayson, Darlene Mae Ortiz, Danilo Buctot, Hyun Jun Lee, Jae Hoon Cheong, Hee Jin Kim, 2022
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    A myosin chaperone, UNC-45A, is a novel regulator of intestinal epithelial barrier integrity and repair
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  139. Apr 2022
  140. www.sciencedirect.com www.sciencedirect.com
    RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development
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    Bacterial-type ferroxidase tunes iron-dependent phosphate sensing during Arabidopsis root development
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    Septin filament compaction into rings requires the anillin Mid2 and contractile ring constriction
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    Functional elements of the cis-regulatory lincRNA-p21
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    Genome-wide functional perturbation of human microsatellite repeats using engineered zinc finger transcription factors
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    FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer
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  146. Mar 2022
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    A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
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    Targeting HNRNPM inhibits cancer stemness and enhances antitumor immunity in Wnt-activated hepatocellular carcinoma
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  149. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intermittent bolus feeding does not enhance protein synthesis, myonuclear accretion, or lean growth more than continuous feeding in a premature piglet model
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    Liquid-liquid phase separation of RBGD2/4 is required for heat stress resistance in Arabidopsis
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  151. onlinelibrary.wiley.com onlinelibrary.wiley.com
    BET protein inhibition in macrophages enhances dorsal root ganglion neurite outgrowth in female mice
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  152. Feb 2022
  153. www.sciencedirect.com www.sciencedirect.com
    PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP dependent lipid uptake and fatty acid synthesis pathways
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    Fat3 acts through independent cytoskeletal effectors to coordinate asymmetric cell behaviors during polarized circuit assembly
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  155. Jan 2022
  156. bpspubs.onlinelibrary.wiley.com bpspubs.onlinelibrary.wiley.com
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    Differential light-dependent regulation of soybean nodulation by papilionoid-specific HY5 homologs
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      DOI: 10.1016/j.cub.2021.12.041

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    Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals
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    Identification of G protein-coupled receptor 55 (GPR55) as a target of curcumin
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    The Alzheimer’s disease drug candidate J147 decreases blood plasma fatty acid levels via modulation of AMPK/ACC1 signaling in the liver
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    Addition of a carboxy-terminal tail to the normally tailless gonadotropin-releasing hormone receptor impairs fertility in female mice
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    Coordinated post-transcriptional control of oncogene-induced senescence by UNR/CSDE1
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    Constitutive deficiency of the neurogenic hippocampal modulator AP2γ promotes anxiety-like behavior and cumulative memory deficits in mice from juvenile to adult periods
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    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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      DOI: 10.1126/sciadv.abl4391

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  165. Dec 2021
  166. www.science.org www.science.org
    TGFBR3L is an inhibin B co-receptor that regulates female fertility
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  167. faseb.onlinelibrary.wiley.com faseb.onlinelibrary.wiley.com
    ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway
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      DOI: 10.1096/fj.202002031RR

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    Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity
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    Secretory IgA and T cells targeting SARS-CoV-2 spike protein are transferred to the breastmilk upon mRNA vaccination
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    REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion
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    Knockdown of heterogeneous nuclear ribonucleoprotein A1 results in neurite damage, altered stress granule biology and cellular toxicity in differentiated neuronal cells
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  172. Nov 2021
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    AXL cooperates with EGFR to mediate neutrophil elastase-induced migration of prostate cancer cells
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    TNF leads to mtDNA release and cGAS/STING-dependent interferon responses that support inflammatory arthritis
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  176. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A role for SMARCB1 in synovial sarcomagenesis reveals that SS18-SSX induces canonical BAF destruction
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    The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
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    FARP1, ARHGEF39, and TIAM2 are essential receptor tyrosine kinase effectors for Rac1-dependent cell motility in human lung adenocarcinoma
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  179. Oct 2021
  180. www.sciencedirect.com www.sciencedirect.com
    Glutamate metabolism directs energetic trade-offs to shape host-pathogen susceptibility in Drosophila
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  181. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Mechanistic Insights into COVID-19 by Global Analysis of the SARS-CoV-2 3CLpro Substrate Degradome
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    A MYT1L syndrome mouse model recapitulates patient phenotypes and reveals altered brain development due to disrupted neuronal maturation
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    Mitophagy in the basolateral amygdala mediates increased anxiety induced by aversive social experience
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  184. academic.oup.com academic.oup.com
    Rescue of cell surface expression and signalling of mutant follicle-stimulating hormone receptors
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      DOI: 10.1210/endocr/bqab134

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    Synaptotagmin 7 is targeted to the axonal plasma membrane through γ-secretase processing to promote synaptic vesicle docking in mouse hippocampal neurons
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    Adaptive mechanoproperties mediated by the formin FMN1 characterize glioblastoma fitness for invasion
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    Endosomal trafficking and DNA damage checkpoint kinases dictate survival to replication stress by regulating amino acid uptake and protein synthesis
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    Dynamic interplay of two molecular switches enabled by the MEK1/2-ERK1/2 and IL-6-STAT3 signaling axes controls epithelial cell migration in response to growth factors
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    Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors
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    PTEN Regulates PI(3,4)P2 Signaling Downstream of Class I PI3K
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    Gtf2i and Gtf2ird1 mutation do not account for the full phenotypic effect of the Williams syndrome critical region in mouse models
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    Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe
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    CD109 Restrains Activation of Cutaneous IL-17-Producing γδ T Cells by Commensal Microbiota
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    Single-Cell Transcriptomic Analysis of Cardiac Differentiation from Human PSCs Reveals HOPX-Dependent Cardiomyocyte Maturation
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  227. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Proline-arginine poly-dipeptide encoded by the C9orf72 repeat expansion inhibits adenosine deaminase acting on RNA
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    1. scibot 29 Jul 2021
      RRID:AB_11125547

      DOI: 10.1111/jnc.15445

      Resource: (Bio-Rad Cat# 170-6516, RRID:AB_11125547)

      Curator: @scibot

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15445
  228. pubs.acs.org pubs.acs.org
    Differential Sensitivity to CDK2 Inhibition Discriminates the Molecular Mechanisms of CHK1 Inhibitors as Monotherapy or in Combination with the Topoisomerase I Inhibitor SN38
    1
    1. scibot 27 Jul 2021
      RRID:AB_11125547

      DOI: 10.1021/acsptsci.9b00001

      Resource: (Bio-Rad Cat# 170-6516, RRID:AB_11125547)

      Curator: @scibot

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    pubs.acs.org/doi/full/10.1021/acsptsci.9b00001