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  1. Last 7 days
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    The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
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    1. scibot 07 Jan 2025
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      DOI: 10.1016/j.chembiol.2024.11.009

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    sciencedirect.com/science/article/pii/S2451945624004896
  3. Apr 2024
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    Dual-role transcription factors stabilize intermediate expression levels
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      DOI: 10.1016/j.cell.2024.03.023

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    sciencedirect.com/science/article/pii/S0092867424003143
  5. Feb 2024
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    Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA
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    1. scibot 29 Feb 2024
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      DOI: 10.1016/j.celrep.2024.113888

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    sciencedirect.com/science/article/pii/S221112472400216X
  7. Dec 2023
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    Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons
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    1. scibot 22 Dec 2023
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      DOI: 10.1016/j.celrep.2023.113576

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    sciencedirect.com/science/article/pii/S2211124723015887
  9. Nov 2023
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    Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells
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    1. scibot 28 Nov 2023
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      DOI: 10.1016/j.chembiol.2023.10.005

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    sciencedirect.com/science/article/pii/S2451945623003665
  11. Sep 2023
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    A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway
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      DOI: 10.7554/eLife.85036

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    ncbi.nlm.nih.gov/pmc/articles/PMC10476966/
  13. Jul 2023
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    Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1
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      DOI: 10.1016/j.molcel.2023.06.007

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    sciencedirect.com/science/article/pii/S1097276523004306
  15. May 2023
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    Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2
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      DOI: 10.1016/j.celrep.2022.111088

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    sciencedirect.com/science/article/pii/S2211124722008907
  17. Mar 2023
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    Linking chromatin acylation mark-defined proteome and genome in living cells
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      DOI: 10.1016/j.cell.2023.02.007

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    sciencedirect.com/science/article/pii/S0092867423001095
  19. Jan 2022
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    Identification and functional characterization of transcriptional activators in human cells
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    1. scibot 11 Jan 2022
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      DOI: 10.1016/j.molcel.2021.12.008

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    sciencedirect.com/science/article/pii/S1097276521010704
  21. Aug 2021
  22. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Untitled document
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    1. scibot 11 Aug 2021
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      DOI: 10.1016/j.molcel.2017.04.027

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    ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
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    BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication
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    1. scibot 09 Aug 2021
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      DOI: 10.1016/j.celrep.2018.10.079

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    sciencedirect.com/science/article/pii/S2211124718316838
  24. Jul 2021
  25. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats
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    1. scibot 29 Jul 2021
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      DOI: 10.1111/jnc.15439

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    onlinelibrary.wiley.com/doi/10.1111/jnc.15439
  26. May 2021
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    CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance
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    1. scibot 04 May 2021
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      DOI: 10.1016/j.stem.2021.04.011

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    sciencedirect.com/science/article/pii/S1934590921001685
  28. Mar 2021
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    TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains
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    1. scibot 29 Mar 2021
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      DOI: 10.1016/j.molcel.2021.01.023

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    sciencedirect.com/science/article/pii/S1097276521000435
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    Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function
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      DOI: 10.1016/j.chembiol.2021.01.005

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    sciencedirect.com/science/article/pii/S2451945621000052
  31. Feb 2021
  32. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Translation in amino-acid-poor environments is limited by tRNAGln charging
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    1. scibot 27 Feb 2021
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      DOI: 10.7554/eLife.62307

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    ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
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    An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors
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      DOI: 10.1016/j.celrep.2021.108744

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    sciencedirect.com/science/article/pii/S2211124721000577
  34. www.cell.com www.cell.com
    Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms
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    cell.com/cell-reports/fulltext/S2211-1247(21)00063-2
  35. Jan 2021
  36. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    BRD4-mediated repression of p53 is a target for combination therapy in AML
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    1. scibot 24 Jan 2021
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      DOI: 10.1038/s41467-020-20378-8

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    ncbi.nlm.nih.gov/pmc/articles/PMC7801601/
  37. Sep 2020
  38. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation
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    1. scibot 25 Sep 2020
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      DOI: 10.1016/j.celrep.2020.108166

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    pubmed.ncbi.nlm.nih.gov/32966794/
  39. elifesciences.org elifesciences.org
    NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency
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    1. scibot 17 Sep 2020
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      DOI: 10.7554/eLife.54993

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    elifesciences.org/articles/54993
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    PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network
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    1. scibot 08 Sep 2020
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      DOI: 10.1016/j.molcel.2019.12.013

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    sciencedirect.com/science/article/pii/S1097276519309268
  41. Jan 2020
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    AUTACs: Cargo-Specific Degraders Using Selective Autophagy
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.molcel.2019.09.009

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    sciencedirect.com/science/article/pii/S109727651930694X
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    Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer
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    1. scibot 13 Jan 2020
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      DOI: 10.1016/j.cmet.2019.05.004

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    sciencedirect.com/science/article/pii/S155041311930244X
  44. Nov 2018
  45. www.sciencedirect.com www.sciencedirect.com
    DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4
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    1. scibot 05 Nov 2018
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    sciencedirect.com/science/article/pii/S1097276518305112
  46. Nov 2017
  47. www.sciencedirect.com www.sciencedirect.com
    The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes
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    1. scibot 08 Nov 2017
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      Curator: @Jmenke

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    sciencedirect.com/science/article/pii/S109727651730549X
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    Proteasome Activation by Small Molecules
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    1. scibot 08 Nov 2017
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      Curator: @Zeljana_Babic

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    sciencedirect.com/science/article/pii/S2451945617301526
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    Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function
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    sciencedirect.com/science/article/pii/S109727651730312X