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34 Matching Annotations

Aug 2025
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A method for the detection and enrichment of endogenous cereblon substrates

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1. scibot 09 Aug 2025
  
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  DOI: 10.1016/j.chembiol.2025.07.002
  
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sciencedirect.com/science/article/pii/S2451945625002259
Jul 2025
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Site-resolved assessment of targeted protein degradation

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1. scibot 03 Jul 2025
  
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  DOI: 10.1016/j.chembiol.2025.06.002
  
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sciencedirect.com/science/article/pii/S2451945625001977
Jun 2025
elifesciences.org elifesciences.org

Targeted protein degradation by KLHDC2 ligands identified by high-throughput screening

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1. scibot 17 Jun 2025
  
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  DOI: 10.7554/eLife.106844
  
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elifesciences.org/articles/106844
Apr 2025
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CD36-mediated endocytosis of proteolysis-targeting chimeras

1
1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.cell.2025.03.036
  
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sciencedirect.com/science/article/pii/S0092867425003861
Mar 2025
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BMP9 enhances osteogenic differentiation in rheumatoid arthritis: a potential therapeutic approach

1
1. scibot 07 Mar 2025
  
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  DOI: 10.1186/s12967-025-06309-5
  
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link.springer.com/article/10.1186/s12967-025-06309-5
Jan 2025
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The efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.chembiol.2024.11.009
  
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sciencedirect.com/science/article/pii/S2451945624004896
Apr 2024
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Dual-role transcription factors stabilize intermediate expression levels

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1. scibot 18 Apr 2024
  
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  DOI: 10.1016/j.cell.2024.03.023
  
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sciencedirect.com/science/article/pii/S0092867424003143
Feb 2024
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Enhancer-promoter activation by the Kaposi sarcoma-associated herpesvirus episome maintenance protein LANA

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1. scibot 29 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113888
  
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sciencedirect.com/science/article/pii/S221112472400216X
Dec 2023
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Repetitive CREB-DNA interactions at gene loci predetermined by CBP induce activity-dependent gene expression in human cortical neurons

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1. scibot 22 Dec 2023
  
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  DOI: 10.1016/j.celrep.2023.113576
  
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sciencedirect.com/science/article/pii/S2211124723015887
Nov 2023
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Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells

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1. scibot 28 Nov 2023
  
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  DOI: 10.1016/j.chembiol.2023.10.005
  
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sciencedirect.com/science/article/pii/S2451945623003665
Sep 2023
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A twin UGUA motif directs the balance between gene isoforms through CFIm and the mTORC1 signaling pathway

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1. scibot 06 Sep 2023
  
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  DOI: 10.7554/eLife.85036
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10476966/
Jul 2023
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Chromatin regulation of transcriptional enhancers and cell fate by the Sotos syndrome gene NSD1

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1. scibot 06 Jul 2023
  
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  DOI: 10.1016/j.molcel.2023.06.007
  
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sciencedirect.com/science/article/pii/S1097276523004306
May 2023
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Viral E protein neutralizes BET protein-mediated post-entry antagonism of SARS-CoV-2

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1. scibot 05 May 2023
  
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  DOI: 10.1016/j.celrep.2022.111088
  
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sciencedirect.com/science/article/pii/S2211124722008907
Mar 2023
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Linking chromatin acylation mark-defined proteome and genome in living cells

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1. scibot 03 Mar 2023
  
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  DOI: 10.1016/j.cell.2023.02.007
  
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sciencedirect.com/science/article/pii/S0092867423001095
Jan 2022
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Identification and functional characterization of transcriptional activators in human cells

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1. scibot 11 Jan 2022
  
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  DOI: 10.1016/j.molcel.2021.12.008
  
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sciencedirect.com/science/article/pii/S1097276521010704
Aug 2021
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Untitled document

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1. scibot 11 Aug 2021
  
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  DOI: 10.1016/j.molcel.2017.04.027
  
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ncbi.nlm.nih.gov/pmc/articles/PMC5446411/
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BET Inhibition Induces HEXIM1- and RAD51-Dependent Conflicts between Transcription and Replication

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1. scibot 09 Aug 2021
  
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  DOI: 10.1016/j.celrep.2018.10.079
  
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sciencedirect.com/science/article/pii/S2211124718316838
Jul 2021
onlinelibrary.wiley.com onlinelibrary.wiley.com

Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats

1
1. scibot 29 Jul 2021
  
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  DOI: 10.1111/jnc.15439
  
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onlinelibrary.wiley.com/doi/10.1111/jnc.15439
May 2021
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CD276 expression enables squamous cell carcinoma stem cells to evade immune surveillance

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1. scibot 04 May 2021
  
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  DOI: 10.1016/j.stem.2021.04.011
  
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sciencedirect.com/science/article/pii/S1934590921001685
Mar 2021
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TRIP12 promotes small-molecule-induced degradation through K29/K48-branched ubiquitin chains

1
1. scibot 29 Mar 2021
  
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  DOI: 10.1016/j.molcel.2021.01.023
  
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sciencedirect.com/science/article/pii/S1097276521000435
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Chemoproteomics-enabled discovery of covalent RNF114-based degraders that mimic natural product function

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1. scibot 15 Mar 2021
  
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  DOI: 10.1016/j.chembiol.2021.01.005
  
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sciencedirect.com/science/article/pii/S2451945621000052
Feb 2021
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Translation in amino-acid-poor environments is limited by tRNAGln charging

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1. scibot 27 Feb 2021
  
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  DOI: 10.7554/eLife.62307
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7744096/
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An acetyl-histone vulnerability in PI3K/AKT inhibition-resistant cancers is targetable by both BET and HDAC inhibitors

1
1. scibot 24 Feb 2021
  
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  DOI: 10.1016/j.celrep.2021.108744
  
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sciencedirect.com/science/article/pii/S2211124721000577
www.cell.com www.cell.com

Single-cell resolved imaging reveals intra-tumor heterogeneity in glycolysis, transitions between metabolic states, and their regulatory mechanisms

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1. scibot 24 Feb 2021
  
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  DOI: 10.1016/j.celrep.2021.108750
  
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cell.com/cell-reports/fulltext/S2211-1247(21)00063-2
Jan 2021
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

BRD4-mediated repression of p53 is a target for combination therapy in AML

1
1. scibot 24 Jan 2021
  
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  RRID:AB_11145462
  
  DOI: 10.1038/s41467-020-20378-8
  
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ncbi.nlm.nih.gov/pmc/articles/PMC7801601/
Sep 2020
pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov

BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation

1
1. scibot 25 Sep 2020
  
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  DOI: 10.1016/j.celrep.2020.108166
  
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pubmed.ncbi.nlm.nih.gov/32966794/
elifesciences.org elifesciences.org

NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency

1
1. scibot 17 Sep 2020
  
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  DOI: 10.7554/eLife.54993
  
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elifesciences.org/articles/54993
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PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

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1. scibot 08 Sep 2020
  
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  DOI: 10.1016/j.molcel.2019.12.013
  
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sciencedirect.com/science/article/pii/S1097276519309268
Jan 2020
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AUTACs: Cargo-Specific Degraders Using Selective Autophagy

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.molcel.2019.09.009
  
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sciencedirect.com/science/article/pii/S109727651930694X
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Epigenetic Control of Mitochondrial Fission Enables Self-Renewal of Stem-like Tumor Cells in Human Prostate Cancer

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1. scibot 13 Jan 2020
  
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  DOI: 10.1016/j.cmet.2019.05.004
  
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sciencedirect.com/science/article/pii/S155041311930244X
Nov 2018
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DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4

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1. scibot 05 Nov 2018
  
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sciencedirect.com/science/article/pii/S1097276518305112
Nov 2017
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The Short Isoform of BRD4 Promotes HIV-1 Latency by Engaging Repressive SWI/SNF Chromatin-Remodeling Complexes

1
1. scibot 08 Nov 2017
  
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  Curator: @Jmenke
  
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sciencedirect.com/science/article/pii/S109727651730549X
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Proteasome Activation by Small Molecules

1
1. scibot 08 Nov 2017
  
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  Curator: @Zeljana_Babic
  
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sciencedirect.com/science/article/pii/S2451945617301526
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Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function

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1. scibot 08 Nov 2017
  
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sciencedirect.com/science/article/pii/S109727651730312X