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Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway

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1. scibot 20 May 2026
  
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  DOI: 10.1158/1535-7163.MCT-25-0129
  
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May 2026
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Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer

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Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress

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  DOI: 10.1016/j.immuni.2026.04.004
  
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Apr 2026
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Mar 2026
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Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity

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pmc.ncbi.nlm.nih.gov/articles/PMC13012031/
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Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity

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  DOI: 10.1016/j.celrep.2026.117123
  
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Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity

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FGF19/FGFR4 axis drives immunosuppressive macrophage plasticity in hepatocellular carcinoma

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Feb 2026
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Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells

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1. scibot 26 Feb 2026
  
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  DOI: 10.1016/j.chembiol.2026.02.001
  
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Protocol for intranuclear Nrf2 detection in activated mouse, human, and Jurkat T cells by spectral flow cytometry

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1. scibot 21 Feb 2026
  
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  DOI: 10.1016/j.xpro.2026.104360
  
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16-h fasting optimizes cancer immunotherapy in mice and humans

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  DOI: 10.1016/j.cmet.2026.01.015
  
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Divergent tumor immunity determined by bacteria-cancer cell engagement

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1. scibot 05 Feb 2026
  
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  DOI: 10.1016/j.cell.2025.12.044
  
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sciencedirect.com/science/article/pii/S009286742501493X
Jan 2026
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Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin

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1. scibot 30 Jan 2026
  
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  DOI: 10.1016/j.cell.2025.12.043
  
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116796
  
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sciencedirect.com/science/article/pii/S2211124725015682
Dec 2025
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HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion

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1. scibot 16 Dec 2025
  
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  DOI: 10.1016/j.cell.2025.11.020
  
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The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration

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1. scibot 11 Dec 2025
  
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  DOI: 10.1016/j.immuni.2025.11.009
  
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Nov 2025
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Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis

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1. scibot 05 Nov 2025
  
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  DOI: 10.1016/j.celrep.2025.116526
  
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Sep 2025
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T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function

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1. scibot 17 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116302
  
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Glycogen synthase kinase-3 is essential for Treg development and function

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1. scibot 12 Sep 2025
  
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  DOI: 10.1016/j.celrep.2025.116256
  
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Aug 2025
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Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116177
  
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Lymphoma accelerates T cell and tissue aging

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1. scibot 26 Aug 2025
  
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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

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  DOI: 10.1016/j.immuni.2025.07.017
  
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Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease

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  DOI: 10.1016/j.celrep.2025.116156
  
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Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells

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  DOI: 10.1016/j.immuni.2025.07.007
  
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Jul 2025
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Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors

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1. scibot 25 Jul 2025
  
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Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity

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sciencedirect.com/science/article/pii/S1535610825002727
Jun 2025
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  DOI: 10.1158/2159-8290.cd-24-1033
  
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KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression

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  DOI: 10.1016/j.celrep.2025.115775
  
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Apr 2025
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Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis

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ZEB2 is a master switch controlling the tumor-associated macrophage program

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Ultrastable and versatile multimeric ensembles of FoxP3 on microsatellites

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  DOI: 10.1016/j.molcel.2025.03.005
  
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Mar 2025
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Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy

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  DOI: 10.1016/j.ccell.2025.02.014
  
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Jan 2025
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Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation

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1. scibot 07 Jan 2025
  
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  DOI: 10.1016/j.celrep.2024.115127
  
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Dec 2024
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Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function

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1. scibot 13 Dec 2024
  
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  DOI: 10.1007/s00125-024-06329-8
  
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Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

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1. scibot 06 Dec 2024
  
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  DOI: 10.1016/j.ccell.2024.11.003
  
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HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections

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Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection

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Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models

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PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis

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LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity

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Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor

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Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function

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PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies

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A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation

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Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss

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Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation

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Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity

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Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary

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IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling

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UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity

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Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity

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Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment

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An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL

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Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells

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Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure

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cd-23-0299-html.html

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Nov 2023
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Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells

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Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity

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Protocol for the isolation of mouse senescence-associated CD4+ T cells using flow cytometry and functional assays

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ncbi.nlm.nih.gov/pmc/articles/PMC10400959/
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Five inhibitory receptors display distinct vesicular distributions in T cells

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Jul 2023
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QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations

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The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells

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Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow

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Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity

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Asymmetric cell division safeguards memory CD8 T cell development

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cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity

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Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion

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  DOI: 10.1016/j.canlet.2023.216208
  
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Mar 2023
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Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation

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Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions

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Jan 2023
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Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy

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Nov 2022
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Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy

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Sep 2022
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Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction

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cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells

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  DOI: 10.1016/j.celrep.2022.111373
  
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Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation

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Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation

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  DOI: 10.1016/j.celrep.2022.111193
  
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sciencedirect.com/science/article/pii/S2211124722010105
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Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

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  DOI: 10.1016/j.ccell.2022.06.001
  
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Apr 2022
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Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity

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  DOI: 10.1016/j.immuni.2022.03.013
  
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Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer

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Mar 2022
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Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes

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  DOI: 10.1016/j.isci.2022.104021
  
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A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

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Jan 2022
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A Bivalent Nanoparticle Vaccine Exhibits Potent Cross-protection against the Variants of SARS-CoV-2

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ncbi.nlm.nih.gov/pmc/articles/PMC8695190/
Dec 2021
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Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential

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  DOI: 10.1016/j.celrep.2021.110064
  
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Nov 2021
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Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis

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6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function

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  DOI: 10.7554/eLife.67476
  
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ncbi.nlm.nih.gov/pmc/articles/PMC8553335/
Sep 2021
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A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells

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  DOI: 10.1016/j.immuni.2021.08.029
  
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Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness

1
1. scibot 28 Jul 2021
  
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  Ultra-LEAF Purified anti-mouse CD28
  
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sciencedirect.com/science/article/pii/S1074761319300950
Apr 2021
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UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability

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  DOI: 10.1016/j.celrep.2021.108966
  
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Mar 2021
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Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function

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  RRID:AB_11147170
  
  DOI: 10.1016/j.celrep.2021.108831
  
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Dec 2020
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Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses

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pubmed.ncbi.nlm.nih.gov/33275896/
Sep 2020
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Heparin affects the induction of regulatory T cells independent of anticoagulant activity and suppresses the allogeneic immune responses

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  AB_11147170
  
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onlinelibrary.wiley.com/doi/10.1111/cei.13480
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CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response

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  DOI: 10.1016/j.celrep.2020.108085
  
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Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms

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pmc.ncbi.nlm.nih.gov/articles/PMC8360766/
Jan 2020
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STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth

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cell.com/cell-metabolism/fulltext/S1550-4131(19)30604-7
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Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells

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  RRID:AB_11147170
  
  DOI: 10.1016/j.cell.2019.07.044
  
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sciencedirect.com/science/article/pii/S009286741930844X
Nov 2018
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Untitled document

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