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    Proteomic atlas of T cell exhaustion defines proteostatic collapse
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  3. Sep 2026
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    Targeting RPL4 improves the therapeutic efficacy of PD-L1 blockade in liver fibrosis
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    Aging microenvironment induces CD8+ T cell exhaustion by suppressing hepatic β-hydroxybutyrylate synthesis
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    sciencedirect.com/science/article/pii/S1550413126003347
  6. Aug 2026
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    Macrophage PABPC4-SPP1 Axis Orchestrates Immunosuppression in Colorectal Cancer
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    Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis
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    nature.com/articles/s41418-026-01846-y
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    Targeting CCR1 remodels the tumor microenvironment and relieves immune suppression in pancreatic cancer
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  10. Jul 2026
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    An Optimized Platform Overcomes Excessive Tumor Immune Rejection Induced by the CRISPR/Cas9 Lentiviral System
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  12. Jun 2026
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    CpG 1018 augments mRNA vaccine-induced anti-tumor immunity by potentiating CD8+ T cell responses
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    pmc.ncbi.nlm.nih.gov/articles/PMC13233743/
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    PLA2G12A-driven extracellular vesicle-lipid signaling amplifies pathogenic T cell responses in inflammatory diseases
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    Oat-β-glucan potentiates anti-PD-1 efficacy through Faecalibacterium prausnitzii-derived butyrate and indole-3-propionic acid
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  16. May 2026
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    Immunomodulation of Pancreatic Cancer via Inhibition of SUMOylation and CD155/TIGIT Pathway
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    Dendritic cell redundancy enables priming of anti-tumor CD4+ T cells in pancreatic cancer
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    Metabolic and transcriptional plasticity supports CD8+ T cell resilience and anti-tumor immunity under nutrient stress
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  20. Apr 2026
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  22. Mar 2026
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    Neutrophil Antigen Presentation Reprograms the Tumor Microenvironment and Elicits Durable and Broad Antitumor Immunity
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    Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity
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    Mitochondrial transfer to granulocytic myeloid-derived suppressor cells augments immunosuppressive activity
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    FGF19/FGFR4 axis drives immunosuppressive macrophage plasticity in hepatocellular carcinoma
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  27. Feb 2026
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    Law-NQO1 redox boosts the pentose phosphate pathway to confer stem-like properties and antitumor durability in effector CD8+ T cells
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    Protocol for intranuclear Nrf2 detection in activated mouse, human, and Jurkat T cells by spectral flow cytometry
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    16-h fasting optimizes cancer immunotherapy in mice and humans
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    Divergent tumor immunity determined by bacteria-cancer cell engagement
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  32. Jan 2026
  33. www.cell.com www.cell.com
    Sympathetic-epithelial crosstalk governs tissue-resident memory T cell immunosurveillance in the skin
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    DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling
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  35. Dec 2025
  36. www.sciencedirect.com:5037 www.sciencedirect.com:5037
    HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion
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    The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration
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  38. Nov 2025
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    Cancer-associated adipocytes mediate CD8+T cell dysfunction via FGF21-driven lipolysis
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  40. Sep 2025
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    T cell-intrinsic cGAS-CTCF regulation maintains regulatory T cell development and function
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    Glycogen synthase kinase-3 is essential for Treg development and function
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  43. Aug 2025
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    Nrf2 drives activation-driven expansion of CD4+T cells by modulating glucose and glutamine metabolism
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    Lymphoma accelerates T cell and tissue aging
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    Succinate preserves CD8+ T cell fitness to augment antitumor immunity
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    Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease
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    Polyamines regulate adaptive antitumor immunity by functional specialization of regulatory T cells
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  49. Jul 2025
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    Alistipes finegoldii augments the efficacy of immunotherapy against solid tumors
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    Adoptively transferred Th17 cells cooperate with host B cells to achieve durable tumor immunity
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  52. Jun 2025
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    KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression
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    pmc.ncbi.nlm.nih.gov/articles/PMC12302258/
  55. Apr 2025
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    Treatment of IL-18-binding protein biologics suppresses fibrotic progression in metabolic dysfunction-associated steatohepatitis
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    ZEB2 is a master switch controlling the tumor-associated macrophage program
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    Ultrastable and versatile multimeric ensembles of FoxP3 on microsatellites
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  59. Mar 2025
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    Targeting tumor monocyte-intrinsic PD-L1 by rewiring STING signaling and enhancing STING agonist therapy
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  61. Jan 2025
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    Targeted localization of the mother centrosome in CD8+ T cells undergoing asymmetric cell division promotes memory formation
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  63. Dec 2024
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    Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function
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    link.springer.com/article/10.1007/s00125-024-06329-8
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    Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity
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  66. Nov 2024
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    HDAC1 fine-tunes Th17 polarization in vivo to restrain tissue damage in fungal infections
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  68. Sep 2024
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    Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection
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    Immune isolation-enabled nanoencapsulation of donor T cells: a promising strategy for mitigating GVHD and treating AML in preclinical models
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  71. Aug 2024
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    PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis
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    LAG-3 and PD-1 synergize on CD8+ T cells to drive T cell exhaustion and hinder autocrine IFN-γ-dependent anti-tumor immunity
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  74. Jul 2024
  75. www.cell.com www.cell.com
    Fecal microbiota transplantation improves anti-PD-1 inhibitor efficacy in unresectable or metastatic solid cancers refractory to anti-PD-1 inhibitor
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  76. www.biorxiv.org www.biorxiv.org
    Inhibition of CD226 Co-Stimulation Suppresses Diabetes Development in the NOD Mouse by Augmenting Tregs and Diminishing Effector T Cell Function
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    biorxiv.org/content/10.1101/2024.07.16.603756v1
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    PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies
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    A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
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  79. Jun 2024
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    Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
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  81. May 2024
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    Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation
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    Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity
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  84. Apr 2024
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    Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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  87. Feb 2024
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
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    Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity
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    Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment
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    An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  93. Dec 2023
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    Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
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  96. Nov 2023
  97. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells
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  98. Sep 2023
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    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
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  100. Aug 2023
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    Protocol for the isolation of mouse senescence-associated CD4+ T cells using flow cytometry and functional assays
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    ncbi.nlm.nih.gov/pmc/articles/PMC10400959/
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    Five inhibitory receptors display distinct vesicular distributions in T cells
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  103. Jul 2023
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    QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
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  105. Jun 2023
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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    Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow
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  108. May 2023
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    Asymmetric cell division safeguards memory CD8 T cell development
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    cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity
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    Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion
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  113. Mar 2023
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    Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation
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    Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
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  116. Jan 2023
  117. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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    ncbi.nlm.nih.gov/pmc/articles/PMC9401506/
  118. Nov 2022
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    Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy
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  120. Sep 2022
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    Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction
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    cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells
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  123. Aug 2022
  124. www.sciencedirect.com www.sciencedirect.com
    Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation
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    Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation
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    sciencedirect.com/science/article/pii/S2211124722010105
  126. Jun 2022
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    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
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    sciencedirect.com/science/article/pii/S1535610822002318
  128. Apr 2022
  129. www.sciencedirect.com www.sciencedirect.com
    Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
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    sciencedirect.com/science/article/pii/S1074761322001364
  130. www.sciencedirect.com www.sciencedirect.com
    Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
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  131. Mar 2022
  132. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes
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    ncbi.nlm.nih.gov/pmc/articles/PMC8933710/
  133. www.sciencedirect.com www.sciencedirect.com
    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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  134. Jan 2022
  135. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Bivalent Nanoparticle Vaccine Exhibits Potent Cross-protection against the Variants of SARS-CoV-2
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    ncbi.nlm.nih.gov/pmc/articles/PMC8695190/
  136. Dec 2021
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    Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential
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  138. Nov 2021
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    Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis
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  140. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function
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  141. Sep 2021
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    A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells
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  143. Jul 2021
  144. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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  145. Apr 2021
  146. www.sciencedirect.com www.sciencedirect.com
    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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  147. Mar 2021
  148. www.sciencedirect.com www.sciencedirect.com
    Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
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    sciencedirect.com/science/article/pii/S2211124721001455
  149. Dec 2020
  150. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses
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  151. Sep 2020
  152. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heparin affects the induction of regulatory T cells independent of anticoagulant activity and suppresses the allogeneic immune responses
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    onlinelibrary.wiley.com/doi/10.1111/cei.13480
  153. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response
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  154. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov
    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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  155. Jan 2020
  156. www.cell.com www.cell.com
    STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
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    Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells
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  158. Nov 2018
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    Untitled document
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