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    PARP11 inhibition inactivates tumor-infiltrating regulatory T cells and improves the efficacy of immunotherapies
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    A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
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  4. Jun 2024
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    Clonal hematopoiesis driven by mutated DNMT3A promotes inflammatory bone loss
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    sciencedirect.com/science/article/pii/S0092867424004926
  6. May 2024
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    Metabolic coordination between skin epithelium and type 17 immunity sustains chronic skin inflammation
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    Transient hydroxycholesterol treatment restrains TCR signaling to promote long-term immunity
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  9. Apr 2024
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    Spatial and temporal mapping of breast cancer lung metastases identify TREM2 macrophages as regulators of the metastatic boundary
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    aacrjournals.org/cancerdiscovery/article/13/12/2610/731625/Spatial-and-Temporal-Mapping-of-Breast-Cancer-Lung
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    IFNα-induced BST2+ tumor-associated macrophages facilitate immunosuppression and tumor growth in pancreatic cancer by ERK-CXCL7 signaling
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  12. Feb 2024
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    UFL1 ablation in T cells suppresses PD-1 UFMylation to enhance anti-tumor immunity
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    sciencedirect.com/science/article/pii/S1097276524000911
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    Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity
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    Stem-like progenitor and terminally differentiated TFH-like CD4+ T cell exhaustion in the tumor microenvironment
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    An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL
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    sciencedirect.com/science/article/pii/S2666379124000442
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    Tumor-secreted FGF21 acts as an immune suppressor by rewiring cholesterol metabolism of CD8+T cells
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  18. Dec 2023
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    Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
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    cd-23-0299-html.html
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  21. Nov 2023
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    Five Inhibitory Receptors Display Distinct Vesicular Distributions in Murine T Cells
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  23. Sep 2023
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    Ablation of ERO1A induces lethal endoplasmic reticulum stress responses and immunogenic cell death to activate anti-tumor immunity
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  25. Aug 2023
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    Protocol for the isolation of mouse senescence-associated CD4+ T cells using flow cytometry and functional assays
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    Five inhibitory receptors display distinct vesicular distributions in T cells
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  28. Jul 2023
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    QUAS-R: An SLC1A5-mediated glutamine uptake assay with single-cell resolution reveals metabolic heterogeneity with immune populations
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  30. Jun 2023
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    The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
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    Distinct bidirectional regulation of LFA1 and α4β7 by Rap1 and integrin adaptors in T cells under shear flow
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  33. May 2023
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    Exhaustion-associated cholesterol deficiency dampens the cytotoxic arm of antitumor immunity
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    Asymmetric cell division safeguards memory CD8 T cell development
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    cis-B7:CD28 interactions at invaginated synaptic membranes provide CD28 co-stimulation and promote CD8+ T cell function and anti-tumor immunity
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    Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion
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    sciencedirect.com/science/article/pii/S0304383523001593
  38. Mar 2023
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    Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation
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    Pyruvate dehydrogenase fuels a critical citrate pool that is essential for Th17 cell effector functions
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  41. Jan 2023
  42. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Low-Dose Radiotherapy Reverses Tumor Immune Desertification and Resistance to Immunotherapy
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      DOI: 10.1158/2159-8290.CD-21-0003

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    ncbi.nlm.nih.gov/pmc/articles/PMC9401506/
  43. Nov 2022
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    Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy
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    sciencedirect.com/science/article/pii/S2211124722015182
  45. Sep 2022
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    Protocol to isolate and enrich mouse splenic naive CD4+ T cells for in vitro CD4+CD8αα+ cell induction
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    sciencedirect.com/science/article/pii/S2666166722006086
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    cis interaction of CD153 with TCR/CD3 is crucial for the pathogenic activation of senescence-associated T cells
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    sciencedirect.com/science/article/pii/S2211124722012050
  48. Aug 2022
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    Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota, and T cell-induced inflammation
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    sciencedirect.com/science/article/pii/S1550413122003461
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    Succinate uptake by T cells suppresses their effector function via inhibition of mitochondrial glucose oxidation
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    sciencedirect.com/science/article/pii/S2211124722010105
  51. Jun 2022
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    Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence
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    sciencedirect.com/science/article/pii/S1535610822002318
  53. Apr 2022
  54. www.sciencedirect.com www.sciencedirect.com
    Binding of LAG-3 to stable peptide-MHC class II limits T cell function and suppresses autoimmunity and anti-cancer immunity
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      DOI: 10.1016/j.immuni.2022.03.013

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    sciencedirect.com/science/article/pii/S1074761322001364
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    Microbiota-dependent activation of the myeloid calcineurin-NFAT pathway inhibits B7H3- and B7H4-dependent anti-tumor immunity in colorectal cancer
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    sciencedirect.com/science/article/pii/S1074761322001315
  56. Mar 2022
  57. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes
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      DOI: 10.1016/j.isci.2022.104021

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    ncbi.nlm.nih.gov/pmc/articles/PMC8933710/
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    A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy
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    sciencedirect.com/science/article/pii/S1550413122000535
  59. Jan 2022
  60. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    A Bivalent Nanoparticle Vaccine Exhibits Potent Cross-protection against the Variants of SARS-CoV-2
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      RRID:AB_11147170

      DOI: 10.1016/j.celrep.2021.110256

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  61. Dec 2021
  62. www.sciencedirect.com www.sciencedirect.com
    Pre-existing chromatin accessibility and gene expression differences among naive CD4+ T cells influence effector potential
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      RRID:AB_11147170

      DOI: 10.1016/j.celrep.2021.110064

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    sciencedirect.com/science/article/pii/S2211124721015503
  63. Nov 2021
  64. www.sciencedirect.com www.sciencedirect.com
    Acsbg1-dependent mitochondrial fitness is a metabolic checkpoint for tissue Treg cell homeostasis
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      RRID:AB_11147170

      DOI: 10.1016/j.celrep.2021.109921

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    sciencedirect.com/science/article/pii/S2211124721013942
  65. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    6-Phosphogluconate dehydrogenase (6PGD), a key checkpoint in reprogramming of regulatory T cells metabolism and function
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    1. scibot 05 Nov 2021
      RRID:AB_11147170

      DOI: 10.7554/eLife.67476

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    ncbi.nlm.nih.gov/pmc/articles/PMC8553335/
  66. Sep 2021
  67. www.sciencedirect.com www.sciencedirect.com
    A Cre-driven allele-conditioning line to interrogate CD4+ conventional T cells
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    1. scibot 22 Sep 2021
      RRID:AB_11147170

      DOI: 10.1016/j.immuni.2021.08.029

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    sciencedirect.com/science/article/pii/S1074761321003630
  68. Jul 2021
  69. www.sciencedirect.com www.sciencedirect.com
    Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness
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    1. scibot 28 Jul 2021
      Ultra-LEAF Purified anti-mouse CD28

      DOI: 10.1016/j.immuni.2019.03.005

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    sciencedirect.com/science/article/pii/S1074761319300950
  70. Apr 2021
  71. www.sciencedirect.com www.sciencedirect.com
    UTX promotes CD8+ T cell-mediated antiviral defenses but reduces T cell durability
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    1. scibot 15 Apr 2021
      RRID:AB_11147170

      DOI: 10.1016/j.celrep.2021.108966

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    sciencedirect.com/science/article/pii/S2211124721002801
  72. Mar 2021
  73. www.sciencedirect.com www.sciencedirect.com
    Blockade of 6-phosphogluconate dehydrogenase generates CD8+ effector T cells with enhanced anti-tumor function
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    1. scibot 10 Mar 2021
      RRID:AB_11147170

      DOI: 10.1016/j.celrep.2021.108831

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    sciencedirect.com/science/article/pii/S2211124721001455
  74. Dec 2020
  75. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses
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    1. scibot 07 Dec 2020
      RRID:AB_11147170

      DOI: 10.1016/j.immuni.2020.11.015

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    pubmed.ncbi.nlm.nih.gov/33275896/
  76. Sep 2020
  77. onlinelibrary.wiley.com onlinelibrary.wiley.com
    Heparin affects the induction of regulatory T cells independent of anticoagulant activity and suppresses the allogeneic immune responses
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      AB_11147170

      DOI: 10.1111/cei.13480

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    onlinelibrary.wiley.com/doi/10.1111/cei.13480
  78. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov
    CD49a Regulates Cutaneous Resident Memory CD8+ T Cell Persistence and Response
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    1. scibot 16 Sep 2020
      RRID:AB_11147170

      DOI: 10.1016/j.celrep.2020.108085

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  79. www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov
    Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms
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    1. scibot 13 Sep 2020
      RRID:AB_11147170

      DOI: 10.1016/j.immuni.2020.04.014

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    ncbi.nlm.nih.gov/pmc/articles/PMC8360766/
  80. Jan 2020
  81. www.sciencedirect.com www.sciencedirect.com
    STAT3 Activation-Induced Fatty Acid Oxidation in CD8+ T Effector Cells Is Critical for Obesity-Promoted Breast Tumor Growth
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    1. scibot 13 Jan 2020
      RRID:AB_11147170

      DOI: 10.1016/j.cmet.2019.10.013

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    sciencedirect.com/science/article/pii/S1550413119306047
  82. www.sciencedirect.com www.sciencedirect.com
    Systematic Immunotherapy Target Discovery Using Genome-Scale In Vivo CRISPR Screens in CD8 T Cells
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    1. scibot 13 Jan 2020
      RRID:AB_11147170

      DOI: 10.1016/j.cell.2019.07.044

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    sciencedirect.com/science/article/pii/S009286741930844X
  83. Nov 2018
  84. www.sciencedirect.com www.sciencedirect.com
    Untitled document
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    sciencedirect.com/science/article/pii/S2211124718310854