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Nectin-4 reduces T cell effector function and is a therapeutic target in pancreatic cancer

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1. scibot 14 Feb 2026
  
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  DOI: 10.1172/jci.insight.194290
  
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pmc.ncbi.nlm.nih.gov/articles/PMC12892910/
Jan 2026
advanced.onlinelibrary.wiley.com advanced.onlinelibrary.wiley.com

Cholesterol-DNA Origami Nanostructures for Synthetic Lipid Rafts Induce Early T Cell Activation Signals

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1. scibot 29 Jan 2026
  
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  DOI: 10.1002/admi.202500806
  
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advanced.onlinelibrary.wiley.com/doi/full/10.1002/admi.202500806
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Tunable differentiation of human CD4+ and CD8+ T cells from pluripotent stem cells

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.stem.2025.12.010
  
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cell.com/cell-stem-cell/fulltext/S1934-5909(25)00444-8
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DNA-PKcs controls the cytotoxic T cell response to cancer and transplant allograft through regulating LAT-dependent signaling

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1. scibot 09 Jan 2026
  
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  DOI: 10.1016/j.celrep.2025.116796
  
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sciencedirect.com/science/article/pii/S2211124725015682
Dec 2025
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An IL-12 partial agonist sustains intratumoral lymphocyte activation and detoxifies systemic IL-12 therapy

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1. scibot 20 Dec 2025
  
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  DOI: 10.1016/j.celrep.2025.116757
  
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sciencedirect.com:5037/science/article/pii/S2211124725015293
Nov 2025
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Macrophage-targeted immunocytokine leverages myeloid, T, and NK cell synergy for cancer immunotherapy

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1. scibot 22 Nov 2025
  
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  DOI: 10.1016/j.cell.2025.10.030
  
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sciencedirect.com/science/article/pii/S0092867425012358
Sep 2025
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Monocyte/macrophage-derived interleukin-15 mediates the pro-inflammatory phenotype of CD226+ B cells in type 1 diabetes

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1. scibot 19 Sep 2025
  
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  DOI: 10.1016/j.ebiom.2025.105946
  
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sciencedirect.com/science/article/pii/S2352396425003901
Aug 2025
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ssrn-5392833-html.html

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1. scibot 28 Aug 2025
  
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  DOI: 10.1159/000356084
  
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52.53.155.43/431e598a8892a5aba66714972854717b5ad2e9e1/ssrn-5392833-html.html
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Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity

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1. scibot 26 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102307
  
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sciencedirect.com/science/article/pii/S2666379125003805
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Enhanced formation of tertiary lymphoid structures shapes the anti-tumor microenvironment in hepatocellular carcinoma after FOLFOX-HAIC therapy

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1. scibot 19 Aug 2025
  
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  DOI: 10.1016/j.xcrm.2025.102298
  
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sciencedirect.com/science/article/pii/S2666379125003714
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Succinate preserves CD8+ T cell fitness to augment antitumor immunity

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1. scibot 15 Aug 2025
  
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  DOI: 10.1016/j.immuni.2025.07.017
  
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sciencedirect.com/science/article/pii/S1074761325003267
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Caveolin-1/PPARα axis suppresses T follicular helper cell response in primary Sjögren disease

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1. scibot 13 Aug 2025
  
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  DOI: 10.1016/j.celrep.2025.116156
  
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sciencedirect.com/science/article/pii/S2211124725009271
www.biorxiv.org www.biorxiv.org

Potassium channels mediate the inhibitory effect of exosomes on anti-tumor immunity in head and neck cancer

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1. scibot 01 Aug 2025
  
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  DOI: 10.1101/2025.07.25.666838
  
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biorxiv.org/content/10.1101/2025.07.25.666838v1
Jun 2025
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Non-canonical PRC1.1 licenses transcriptional response to enable Treg plasticity in immune adaptation

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1. scibot 17 Jun 2025
  
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  DOI: 10.1016/j.molcel.2025.05.029
  
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sciencedirect.com/science/article/pii/S109727652500468X
Apr 2025
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An open-label study on the safety and immunogenicity of a PD-1-enhanced DNA vaccine used as a T cell booster for COVID-19

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1. scibot 19 Apr 2025
  
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  DOI: 10.1016/j.ebiom.2025.105699
  
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sciencedirect.com/science/article/pii/S2352396425001434
Dec 2024
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Mannose metabolism reshapes T cell differentiation to enhance anti-tumor immunity

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1. scibot 06 Dec 2024
  
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  DOI: 10.1016/j.ccell.2024.11.003
  
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sciencedirect.com/science/article/pii/S1535610824004380
Oct 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

MerTK+ macrophages promote melanoma progression and immunotherapy resistance through AhR-ALKAL1 activation

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1. scibot 08 Oct 2024
  
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  DOI: 10.1126/sciadv.ado8366
  
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ncbi.nlm.nih.gov/pmc/articles/PMC11451552/
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NK Receptor Signaling Lowers TCR Activation Threshold, Enhancing Selective Recognition of Cancer Cells by TAA-Specific CTLs

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1. scibot 08 Oct 2024
  
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  DOI: 10.1158/2326-6066.CIR-24-0061
  
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aacrjournals.org/cancerimmunolres/article/12/10/1421/748722/NK-Receptor-Signaling-Lowers-TCR-Activation
Aug 2024
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PD-1 signaling limits expression of phospholipid phosphatase 1 and promotes intratumoral CD8+ T cell ferroptosis

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1. scibot 29 Aug 2024
  
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  DOI: 10.1016/j.immuni.2024.08.003
  
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sciencedirect.com/science/article/pii/S1074761324003765
Jul 2024
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Personalized drug screening using patient-derived organoid and its clinical relevance in gastric cancer

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1. scibot 19 Jul 2024
  
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  DOI: 10.1016/j.xcrm.2024.101627
  
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sciencedirect.com/science/article/pii/S2666379124003318
Apr 2024
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Protocol for isolation of tumor-derived extracellular vesicles and functional studies on human T cell subsets

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1. scibot 19 Apr 2024
  
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  DOI: 10.1016/j.xpro.2024.103011
  
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sciencedirect.com/science/article/pii/S266616672400176X
Mar 2024
www.ncbi.nlm.nih.gov www.ncbi.nlm.nih.gov

The guanine nucleotide exchange factor Rin-like controls Tfh cell differentiation via CD28 signaling

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1. scibot 16 Mar 2024
  
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  DOI: 10.1084/jem.20221466
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10499045/
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Microbial metabolite enhances immunotherapy efficacy by modulating T cell stemness in pan-cancer

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  DOI: 10.1016/j.cell.2024.02.022
  
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cell.com/cell/fulltext/S0092-8674(24)00224-1
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Bile acids modified by the intestinal microbiota promote colorectal cancer growth by suppressing CD8+ T cell effector functions

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1. scibot 13 Mar 2024
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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  DOI: 10.1016/j.immuni.2024.02.014
  
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Circulation immune cell landscape in canonical pathogenesis of colorectal adenocarcinoma by CyTOF analysis

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1. scibot 10 Mar 2024
  
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  DOI: 10.1016/j.isci.2024.109229
  
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ncbi.nlm.nih.gov/pmc/articles/PMC10918214/
Feb 2024
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Suppression of the METTL3-m6A-integrin β1 axis by extracellular acidification impairs T cell infiltration and antitumor activity

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1. scibot 21 Feb 2024
  
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  DOI: 10.1016/j.celrep.2024.113796
  
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  DOI: 10.1016/j.celrep.2024.113796
  
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sciencedirect.com/science/article/pii/S2211124724001244
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Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks

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1. scibot 14 Feb 2024
  
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  DOI: 10.1016/j.immuni.2024.01.011
  
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  DOI: 10.1016/j.immuni.2024.01.011
  
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sciencedirect.com/science/article/pii/S1074761324000360
Jan 2024
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Surface CD52, CD84, and PTGER2 mark mature PMN-MDSCs from cancer patients and G-CSF-treated donors

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  DOI: 10.1016/j.xcrm.2023.101380
  
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sciencedirect.com/science/article/pii/S2666379123006092
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Mitochondria-ER contact mediated by MFN2-SERCA2 interaction supports CD8+ T cell metabolic fitness and function in tumors

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1. scibot 10 Jan 2024
  
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  DOI: 10.1126/sciimmunol.abq2424
  
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52.53.155.43/93ebbe5a83b6a28b0d01edad42fa81f437079176/sciimmunol.abq2424_sm-html.html
Dec 2023
www.science.org www.science.org

T cell responses to SARS-CoV-2 infection and vaccination are elevated in B cell deficiency and reduce risk of severe COVID-19

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1. scibot 02 Dec 2023
  
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  DOI: 10.1126/scitranslmed.adh4529
  
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science.org/doi/10.1126/scitranslmed.adh4529
Sep 2023
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Systemic immune profiling of Omicron-infected subjects inoculated with different doses of inactivated virus vaccine

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1. scibot 30 Sep 2023
  
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  DOI: 10.1016/j.cell.2023.08.033
  
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sciencedirect.com/science/article/pii/S0092867423009649
Aug 2023
52.53.155.43 52.53.155.43

Targeting TCF19 sensitizes MSI endometrial cancer to anti-PD-1 therapy by alleviating CD8+ T cell exhaustion via TRIM14-IFN-β axis

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1. scibot 17 Aug 2023
  
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  RRID:AB_11148949
  
  DOI: 10.1016/j.celrep.2023.112944
  
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2. scibot 11 Aug 2023
  
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  DOI: 10.1016/j.celrep.2023.112944
  
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Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects

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1. scibot 16 Aug 2023
  
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  RRID:AB_11148949
  
  DOI: 10.1016/j.xcrm.2023.101157
  
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Mar 2023
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Galectin-3 expression in donor T cells reduces GvHD severity and lethality after allogeneic hematopoietic cell transplantation

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1. scibot 16 Mar 2023
  
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  DOI: 10.1016/j.celrep.2023.112250
  
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Cytotoxic CD161−CD8+ TEMRA cells contribute to the pathogenesis of systemic lupus erythematosus

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1. scibot 09 Mar 2023
  
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  DOI: 10.1016/j.ebiom.2023.104507
  
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sciencedirect.com/science/article/pii/S2352396423000725
Jan 2023
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The human placenta shapes the phenotype of decidual macrophages

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1. scibot 12 Jan 2023
  
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  DOI: 10.1016/j.celrep.2022.111977
  
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Dec 2022
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Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation

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1. scibot 01 Dec 2022
  
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  DOI: 10.1016/j.celrep.2022.111741
  
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Nov 2022
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Chronic type I interferon signaling promotes lipid-peroxidation-driven terminal CD8+ T cell exhaustion and curtails anti-PD-1 efficacy

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1. scibot 16 Nov 2022
  
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  DOI: 10.1016/j.celrep.2022.111647
  
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Oct 2022
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MiRNA-103 downmodulates CCR5 expression reducing human immunodeficiency virus type-1 entry and impacting latency establishment in CD4+ T cells

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1. scibot 26 Oct 2022
  
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  DOI: 10.1016/j.isci.2022.105234
  
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Apr 2022
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HIV-1 Vpr drives a tissue residency-like phenotype during selective infection of resting memory T cells

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1. scibot 14 Apr 2022
  
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  DOI: 10.1016/j.celrep.2022.110650
  
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Jan 2022
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Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers

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  DOI: 10.1016/j.chom.2021.12.010
  
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Nov 2021
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The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age

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1. scibot 10 Nov 2021
  
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  DOI: 10.1016/j.celrep.2021.109981
  
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Sep 2021
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Functional impairment of HIV-specific CD8+ T cells precedes aborted spontaneous control of viremia

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  DOI: 10.1016/j.immuni.2021.08.007
  
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Aug 2021
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Tandem bispecific antibody prevents pathogenic SHIVSF162P3CN infection and disease progression

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Apr 2021
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HIV-infected macrophages resist efficient NK cell-mediated killing while preserving inflammatory cytokine responses

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  DOI: 10.1016/j.chom.2021.01.006
  
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Feb 2021
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Hematopoietic Progenitor Kinase1 (HPK1) Mediates T Cell Dysfunction and Is a Druggable Target for T Cell-Based Immunotherapies

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  DOI: 10.1016/j.ccell.2020.08.001
  
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cell.com/cancer-cell/abstract/S1535-6108(20)30375-5